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Cytogenetic Investigation in Patients with Clinical Suspicion of Genetic Syndrome in Manaus, Brazil

Journal of Pharmacy and Pharmacology 2022年第3期10卷 72-78页

作者： Débora Pinto Denise Corrêa Benzaquem rachel cardoso nunes Vânia Mesquita Gadelha Prazeres Cleiton Fantin Hospital Universitário Getúlio Vargas ManausAmazonas 69020-170Brasil Human Genetics Laboratory State University of AmazonasManausAmazonas 69065-001Brazil Federal University of Amazonas.Manaus Amazonas 69067-005Brazil

Chromosomal alterations can cause a number of diseases;therefore,early detection of these alterations is fundamental in the prevention and treatment of various *** this sense,the objective of this study was to perform cytogenetic analysis of patients with phenotypic characteristics not yet clarified in order to determine the frequency of chromosomal alterations in patients treated in the public health system in Manaus,Brazil.A total of 98 patients with clinical suspicion of genetic syndrome were referred to the public health system in Manaus,Amazonas *** analyses were performed from lymphocyte culture and subsequent *** data were obtained through referral files and chromosomal a *** the 98 karyotypes analyzed,65(66.3%)presented normal karyotype,18(18.4%)presented chromosomal alterations and 15(15.3%)were *** the alterations found,11(61.1%)corresponded to alterations of the numerical type and 7(38.9%)of the structural *** the chromosomal alterations identified,the one with the highest frequency was aneuploidy,which was significantly represented by 9 patients with Down’s syndrome,and different karyotypic mechanisms related to this syndrome were *** was also one case of deletion,one case of pericentric inversion,and two involving the sex *** etiological confirmation of congenital anomalies is extremely important for the patient’s prognosis,and it is necessary to invest in cytomolecular tests,such as FISH and microarray in order to increase the rate of diagnosis.

关键词： Karyotype chromosomes banding karyotypic formula Down’s syndrome

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Parkinson's Disease:A Multisystem Disorder

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Neuroscience Bulletin 2023年第1期39卷 113-124页

作者： Helena nunes Costa Ana Raquel Esteves Nuno Empadinhas Sandra Morais cardoso CNC–Center for Neuroscience and Cell Biology and CIBB–Center for Innovative Biomedicine and Biotechnology University of Coimbra3004-504CoimbraPortugal IIIUC–Institute for Interdisciplinary Research University of Coimbra3004-504CoimbraPortugal Faculty of Medicine University of Coimbra3004-504CoimbraPortugal

The way sporadic Parkinson's disease(PD)is perceived has undergone drastic changes in recent *** a long time,PD was considered a brain disease characterized by motor disturbances;however,the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional ***,after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution,there is a greater understanding of the involvement of other organ *** this reason,PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline.

关键词： Parkinson's disease Gut microbiome Intestinal barrier α-Synuclein Blood-brain barrier

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The influence of disturbance on driving carbon stocks and tree dynamics of riparian forests in Cerrado

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Journal of Plant Ecology 2018年第3期11卷 401-410页

作者： Matheus Henrique nunes Marcela de Castro nunes Santos Terra Izabela Regina cardoso de Oliveira Eduardo van den Berg Department of Plant Sciences University of CambridgeDowning StreetCambridge CB23EAUK Department of Forest Sciences Federal University of Lavras1001Doutor Sylvio Menicucci AvenueLavras 37200-000Brazil Department of Exact Science Federal University of Lavras1001Doutor Sylvio Menicucci AvenueLavras 37200-000Brazil Department of Biology Federal University of Lavras1001Doutor Sylvio Menicucci AvenueLavras 37200-000Brazil

Aims Riparian forests in the Brazilian Cerrado,also known as gallery forests,are very heterogeneous in structure,species composition and ecological features due to strong and abrupt variations of soil,hydrological and topographic ***,what are the variables driving forest carbon stock and productivity,mortality and recruitment in disturbed gallery forests?Methods We used 36 permanent plots data from a gallery forest in the Brazilian *** investigated how tree community dynam-ics vary in a gallery forest on two contrasting disturbance levels-logged and non-logged-across a topographic gradient intrinsically related to differences in moisture conditions,edge effects,as well as soil fertility and *** Findings Soil variables were reduced into principal components and we used structural equation modelling to disentangle covarying *** also included carbon stocks as a determinant variable of dynamics *** forest had 50%higher productivity than non-logged forest and streamside forest had aboveground carbon stocks 70%higher than the forest *** logging and natural disturbance drove variation in the carbon stocks which contributed to shaping productivity and recruitment *** from the river also drove mortality and carbon stock *** with high-carbon stocks favoured higher competition and lessened produc-tivity and recruitment *** soil fertility and texture are considered crucial components shaping forest dynamics,there was no clear influence of those variables on the present forest,probably because the strong effects of soil moisture,forest edge and distur-bance disrupted the correlation between soil and forest dynamics.

关键词： riparian vegetation topography soil properties disturbance gallery forest structural equation modelling

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Tracheobronchial Polyflex stents for the management of benign refractory hypopharyngeal strictures

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World Journal of Gastroenterology 2012年第6期18卷 551-556页

作者： Rui Almeida Silva Nuno Mesquita Pedro Pimentel nunes Elisabete cardoso Ricardo Marcos Pinto Luís Moreira Dias Department of Gastroenterology Instituto Português de Oncologia do Porto Francisco GentilR.Doutor António Bernardino de Almeida 4200-072PortoPortugal Department of Gastroenterology Centro Hospitalar do PortoLargo Prof.Abel Salazar 4099-001PortoPortugal

AIM:To describe a modified technique for placement of a tracheobronchial self-expanding plastic stent(SEPS) in patients with benign refractory hypopharyngeal strictures in order to improve dysphagia and allow stricture ***:A case series of four consecutive patients with complex hypopharyngeal strictures after combinedtherapy for laryngeal cancer,previously submitted to multiple sessions of dilation without lasting improvement,is *** patients underwent placement of a small diameter and unflared tracheobronchial *** outcome measurements were improvement of dysphagia and avoiding of repeated ***:The modified introducer system allowed an easy and technically successful deployment of the tracheobronchial Polyflex stent through the *** four patients developed complications related to stent *** patients had stent migration(one proximal and one distal),two patients developed phanryngocutaneous fistulas and all patients with stents in situ for more than 8 wk had hyperplastic tissue growth at the upper end of the *** recurrence was observed at 4 wk follow-up after stent removal in all patients CONCLUSION:Although technically feasible,placement of a tracheobronchial SEPS is associated with a high risk of *** diameter stents must be kept in place for longer than 3 mo to allow adequate time for stricture remodeling.

关键词：塑料支架耐火材料狭窄气管管理改性技术保持时间导引系统

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Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review

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World Journal of Gastroenterology 2021年第27期27卷 4413-4428页

作者： Diogo Alpuim Costa Carla Espiney Amaro Ana nunes Joana Santos cardoso Pedro Modas Daniel Isabel Rosa João Vieira Branco Department of Haematology and Oncology CUF OncologiaLisboa 1998-018Portugal Centro de Medicina Subaquática e Hiperbárica(CMSH) Portuguese NavyLisboa 1649-020Portugal Centro de Investigação Naval(CINAV) Portuguese NavyBase Naval do AlfeiteAlmada 2810-001Portugal OVA Medical School Faculdade de Ciências MédicasLisboa 1169-056Portugal Department of Otorhinolaryngology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Gastroenterology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Vascular Surgery Centro Hospitalar Universitário de Lisboa CentralHospital de Santa MartaLisboa 1169-024Portugal Department of Intensive Care Unit Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of General Surgery Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal

Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer *** new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is *** symptoms may resolve spontaneously or require conservative *** the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment *** the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBOT).Currently,the evidence regarding the impact of HBOT on RP and its benefits is *** prospective and randomised studies are necessary to validate HBOT’s effectiveness in the‘real world’clinical *** article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT.

关键词： Radiation proctitis Radiation proctopathy Radiotherapy Radio-induced lesion Late radiation tissue injury Delayed radiation injury Late sequelae Hyperbaric oxygen therapy Hyperbaric oxygen Review

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Microcephaly prevalence after the 2015 to 2016 Zika outbreak in Tangará da Serra, Brazil: a population-based study

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Reproductive and Developmental Medicine 2022年第2期6卷 98-103页

作者： Juliana Herrero da Silva Ana Claudia Pereira Tercas-Trettel Juliano Andre Boquett Giovanny Vinicius Araujo Franca Augusto Cesar cardoso-dos-Santos Marina Atanaka Marcelo Zagonel Oliveira Anna Pires Terra Viviane Karoline Vivi Lucia Andreia nunes de Oliveira Lucia Schaedler Ronaldo Fernandes Santos Alves Lavinia Schuler-Faccini Prefeitura Municipal de Tangara da Serra Secretaria de SaudeVigilancia EpidemiologicaTangara da SerraBrazil Programa de Pos-Graduacao em Genetica e Biologia Molecular Universidade Federal do Rio Grande do SulPorto AlegreBrazil Universidade do Estado de Mato Grosso Tangara da SerraBrazil Programa de Pos-Graduagcao em Saude Coletiva Universidade Federal de Mato GrossoCuiabaBrazil Instituto Nacional de Genetica Medica Populacional-INaGeMP Servico de Genetica MedicaHospital de Clinicas de Porto Alegre(HCPA)Porto AlegreBrazil Programa de Pos-Graduacao em Saude da Crianga e do Adolescente Universidade Federal do Rio Grande do SulPorto AlegreBrazil Secretaria de Vigilancia em Saude Ministerio da SaudeBrasiliaBrazil Laboratorio de Visualizacao Avangada e Geoinformatica(VIZLab) Programa de Pos-Graduacao em Computacao AplicadaUniversidade do Vale do Rio dos SinosSao LeopoldoBrazil Programa de Pos-Graduacao em Ciencia da Informacao Universidade Federal do Rio Grande do SulPorto AlegreBrazil Clinica Santa Luzia Tangara da SerraBrazil

Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth ***::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth ***::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before ***::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.

关键词： Epidemiology Live births Microcephaly Zika virus

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Fishermen and Territorial Trends in the Brazilian Fisheries Policies

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International Journal of Geosciences 2015年第4期6卷 339-349页

作者： Christian nunes da Silva Eduardo Schiavone cardoso Federal University of Pará (UFPA) Belém Brazil Federal University on Santa Maria (UFSM) Santa Maria Brazil

The fishing activity has been known for centuries by man and is configured as an important source of livelihood and income for many families of Brazilian fishermen. This article tries to do a brief contextualization of fishing in Brazil, as well as discuss the notion of territoriality of sector policies. The trend shown for the future is the need for a planning/mapping of operation areas of productive agents in the country, so that fish stocks can be managed more appropriately. One of the proposals that comes with acceptance and is already being applied in some municipalities is fishing agreements, using co-management mechanisms for planning and use of fisheries resources.

关键词： Fishing and Fishermen Colony of Fishermen Brazil Agreements

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Biochar produced from Amazonian agro-industrial wastes:properties and adsorbent potential of Cd^(2+) and Cu^(2+)

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Biochar 2019年第4期1卷 389-400页

作者： Yan nunes Dias Edna Santos Souza Hercilia Samara cardoso da Costa Leônidas Carrijo Azevedo Melo Evanise Silva Penido Cristine Bastos do Amarante Orivan Maria Marques Teixeira Antonio Rodrigues Fernandes Institute of Agricultural Sciences Federal Rural University of Amazon(ICA-UFRA)C.P.917BelemPara 66077-530Brazil Department of Soil Science Federal University of LavrasCP 3037Campus UFLALavrasMinas Gerais 37200-000Brazil Department of Chemistry Federal University of LavrasCP 3037Campus UFLALavrasMinas Gerais 37200-000Brazil Museu Paraense Emílio Goeldi Coordination of Earth Sciences and EcologyBelémPará66077-830Brazil Soil and Plant Laboratory Brazilian Agricultural Research Corporation-Embrapa Eastern AmazoniaBelémPará66000-000Brazil

In the Amazon region,several residues that have been misused can serve as feedstocks for biochar production with the aim of recovering soils contaminated by heavy ***,these biochars need to be firstly tested for their adsorption capacity as well as their physicochemical attributes prior to field ***,this study aimed to characterize and evaluate the adsorption capacities of Cd^(2+) and Cu^(2+) of biochars produced from acai(BA),Brazil nut(BN),and palm kernel cake(BK)*** were produced by slow pyrolysis at four different temperatures(400,500,600,and 700℃).The physicochemical properties of the biochars,such as cation exchange capacity,ash,recalcitrance index,and aromaticity were enhanced with increased pyrolysis *** adsorption capacities of Cd^(2+) and Cu^(2+) showed high correlations with the physicochemical properties of biochar,indicating the importance of these characteristics in the adsorption ***,the adsorption of Cd^(2+) and Cu^(2+) also increased with the increase in the pyrolysis *** a competitive system,Cd^(2+)exhibited higher adsorption capacity than Cu^(2+) for all *** general,BN showed the highest adsorption capacity,followed by BK and *** produced from the Amazonian residues have the potential to improve soil quality when used as amendments in the recovery of soils contaminated with Cd and Cu,representing an environmentally sound technology for the reuse of these residues.

关键词： Pyrolysis Environmental contamination Adsorption

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Solar spectral conversion based on plastic films of lanthanide-doped ionosilicas for photovoltaics:Down-shifting layers and luminescent solar concentrators

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Journal of Rare Earths 2020年第5期38卷 531-538页

作者： M.A.cardoso S.F.H.Correia A.R.Frias H.M.R.Goncalves R.F.P.Pereira S.C.nunes M.Armand P.S.André V.de Zea Bermudez R.A.S.Ferreira Department of Physics and CICECO-Aveiro Institute of Materials University of Aveiro3810-193AveiroPortugal Department of Chemistry and CQ-VR University of Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Instituto de Telecomunicacoes University of Aveiro3810-193AveiroPortugal REQUIMTE Instituto Superior de Engenharia do Porto4200-072PortoPortugal Chemistry Centre and Chemistry Department University of Minho4710-057BragaPortugal CICS-Health Sciences Research Center and Chemistry Department University of Beira Interior6201-001CovilhaPortugal Electrical Energy Storage Department CIC EnergiguneParque Tecnologico de AlavaMinano01510Spain Department of Electrical and Computer Engineering Instituto de TelecomunicacoesInstituto Superior TecnicoUniversidade de Lisboa1049-001LisbonPortugal

The mismatch between the photovoltaic(PV)cells absorption and the solar irradiance on earth is one of the major limitations towards more efficient PV energy *** aspect was addressed by downshifting the solar irradiance on Earth through luminescent down-shifting layers based on lanthanidedoped surface-functionalized ionosilicas(ISs)embedded in poly(methyl methacrylate)(PMMA)coated on the surface of commercial Si-based PV *** IS-PMMA hybrid materials exhibit efficient solar radiation harvesting(spectral overlap of^9.5×10^19 photons/(s·m2))and conversion(quantum yield^52%).The direct solar radiation and the down-shifted radiation are partially guided and lost through total internal reflection to the layer edges being unavailable for PV conversion of the coated PV *** tuning the down-shifting layer thickness,it also acts as luminescent solar concentrator enabling the collection of the guided radiation by flexible PV cells applied on the borders of the down-shifting layer leading to an enhancement of the PV energy conversion from^5%(in the case of the single-use of the luminescent down-shifting layer)to^13%comparing with the bare PV *** overall electrical output of the device resulted in an absolute external quantum efficiency increase of^32%for the optimized Eu^3+-based films in the UV spectral region(compared with the bare PV device,which is among the best values reported so far).

关键词： Ionosilicas Lanthanides Photovoltaics Luminescent solar concentrators Down-shifting layers Silicon photovoltaic cells

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Capsule enteroscopy is useful for the therapeutic management of Crohn's disease

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World Journal of Gastroenterology 2015年第44期21卷 12660-12666页

作者： Joao Santos-Antunes Hélder cardoso Susana Lopes Margarida Marques Amadeu CR nunes Guilherme Macedo Gastroenterology Department Faculty of Medicine Hospital de Sao Joao Department of Biochemistry (U38-FCT) Faculty of Medicine University of Porto

AIM: To analyze therapeutic changes in Crohn's disease(CD) patients following video capsule endoscopy(VCE) and to assess the usefulness of Lewis score and the Patency ***: Patency Capsule was performed in every patient that had indication for VCE, and those with negative patency did not undergo VCE. Patients with established CD that underwent VCE between January 2011 and February 2014 were selected for this study; those with suspected CD were excluded, independent of VCE results, since our purpose was to address differences in therapeutic regimen in CD patients before and after VCE. Patients with inconclusive VCE were also excluded. Patients had to be free of non-steroidal anti-inflammatories for at least 1 mo. Those patients who met these criteria were allocated into one of three groups: Staging group(asymptomatic CD patients that underwent VCE for staging of CD), Flare group(patients with active CD), or Post-op group(CD patients evaluated for post-operative recurrence). Lewis score was calculated for every VCE procedure. Statisticalanalysis was performed to address the impact of VCE findings on the therapeutic management of CD patients and to evaluate the utility of the Lewis ***: From a total of 542 VCEs, 135 were performed in patients with CD. Patency capsule excluded nearly 25% of the patients who were supposed to undergo VCE. No videocapsule retention during VCE was reported. From these 135 patients, 29 were excluded because CD diagnosis was not established at the time of VCE. Therefore, a total of 106 patients were included in the final analysis. From these, the majority were in the Staging group(n = 73, 69%), and the remaining were in the Flare(n = 23, 22%) or Post-op(n = 10, 9%) group. Median time between diagnosis and VCE was 5.5 years. Overall, VCE determined changes in the treatment of 40% of patients: only 21% remained free of immunosuppressors after VCE compared to 44% before VCE(P < 0.001). The differences in therapy before and a

关键词： Capsule enteroscopy Crohn's disease Treatment modification Patency capsule Lewis score

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