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THE GREENING OF THE PARKING INDUSTRY–BEST PRACTICES,AND A NEW CERTIFICATION PROGRAM FOR PARKING STRUCTURES

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Journal of Green Building 2014年第4期9卷 61-77页

作者： rachel Yoka Program Development International Parking Institute

Sustainable building design is now *** United States Green Building Council(USGBC)and the LEED Ratings Systems have moved the market,proving that“a rising tide lifts all boats.”Consumers now factor environmental effect into their buying decisions,a trend that looks to continue and intensify with the millennial *** and homeowners are willing to pay more for high-performing and better quality housing based on environmental *** recognize that indoor air quality and daylighting improve employee performance and boost retention *** even bottom-line businesses are investing in benchmarking and efficiency projects that have the right return on investment *** Urban Land Institute’s Greenprint Center for Building Performance serves as a prime example of the ways developers implement benchmarking,energy efficiency,and high-performance standards in the major real estate sectors:office,retail,industrial,multifamily,and *** efficiency gains and higher-quality buildings in each of these sectors will be essential to reducing emissions and energy *** the transportation sector implements its own standards and benchmarking tools to achieve greater levels of sustainability across all modes of transportation,one industry that stands at the nexus of every building type and the transportation modes used to access them is *** is a key consideration that links land use and transportation:Parking is often the connection between where we are and where we want to *** may not have been at the forefront of the sustainability discussion or the media surrounding it in previous years,but the professionals who work in the world of parking know exactly how important the role of their industry is to the success of our cities,towns,institutions,and *** is big business;it is conservatively estimated to be a$30 billion *** directly contributes to the economic vitality and accessibility of where we

关键词： Sustainability triple bottom line rating system parking garages transportation TDM

On the effects of spatial resolution on effective distance measurement in digital landscapes

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Ecological Processes 2021年第1期10卷 659-677页

作者： rachel Mundeli Murekatete Takeshi Shirabe KTH Royal Institute of Technology School of Architecture and the Built EnvironmentTeknikringen 10A11428 StockholmSweden University of Rwanda College of Science and TechnologyCentre for Geographic Information Systems and Remote SensingKN 67 Street NyarugengeKigaliRwanda

Background:Connectivity is an important landscape attribute in ecological studies and conservation practices and is often expressed in terms of effective *** the cost of movement of an organism over a landscape is effectively represented by a raster surface,effective distances can be equated with the cost-weighted distance of least-cost *** is generally recognized that this measure is sensitive to the grid’s cell size,but little is known if it is always sensitive in the same way and to the same degree and if not,what makes it more(or less)*** conducted computational experiments with both synthetic and real landscape data,in which we generated and analyzed large samples of effective distances measured on cost surfaces of varying cell sizes derived from those *** particular focus was on the statistical behavior of the ratio—referred to as‘accuracy indicator’—of the effective distance measured on a lower-resolution cost surface to that measured on a higher-resolution cost ***:In the experiment with synthetic cost surfaces,the sample values of the accuracy indicator were generally clustered around 1,but slightly greater with the absence of linear sequences(or barriers)of high-cost or inadmissible cells and smaller with the presence of such *** latter tendency was more dominant,and both tendencies became more pronounced as the difference between the spatial resolutions of the associated cost surfaces *** two real satellite images(of different resolutions with fairly large discrepancies)were used as the basis of cost estimation,the variation of the accuracy indicator was found to be substantially large in the vicinity(1500 m)of the source but decreases quickly with an increase in distance from ***:Effective distances measured on lower-resolution cost surfaces are generally highly correlated with—and useful predictors of—effective distances measured on higher-resolution cost *** relationship t

关键词： Landscape connectivity Effective distance Raster-based least-cost path model Accuracy Spatial resolution

Pharmacological inhibition of cation-chloride cotransporters for neurological diseases

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Neural Regeneration Research 2015年第12期10卷 1924-1925页

作者： rachel Nepomuceno Dandan Sun Department of Neurology University of Pittsburgh Veterans Affairs Pittsburgh Health Care System Geriatric ResearchEducational and Clinical Center

γ-Aminobutyric acid（GABA）is a major neurotransmitter and plays important roles in both the developing and mature central nervous system（CNS）.One way that GABA can act is by binding to fast,ionotropic GABAA recept... 详细信息

关键词： Cl Pharmacological inhibition of cation-chloride cotransporters for neurological diseases GABAA

The key piece of the airway remodeling puzzle revealed-LIGHT signaling in the lung

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Genes & Diseases 2023年第4期10卷 1131-1132页

作者： Ziyan rachel Chen Jim Hu Programmes in Translational Medicine Research InstituteHospital for Sick ChildrenTorontoOntario M5G 0A4Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada Department of Paediatrics University of TorontoTorontoOntario M5S 1A8Canada

Asthma is a chronic lung disease that primarily affects the lower respiratory tract in more than 300 million people *** is often triggered by exposure to certain substances or conditions,such as allergens or cold *** overreaction to the allergens causes inflammation and narrowing of the airway,which leads to episodic or persistent symptoms including shortness of breath,nocturnal cough,chest tightness,and wheezing.

关键词： airway lung inflammation

Von Hippel-Lindau tumor suppressor pathways&corresponding therapeutics in kidney cancer

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Journal of Genetics and Genomics 2021年第7期48卷 552-559页

作者： Maxwell Shulman rachel Shi Qing Zhang Department of Pathology University of Texas Southwestern Medical CenterDallasTXUSA

The identification and application of the Von Hippel-Lindau(VHL)gene is a seminal breakthrough in kidney cancer *** and its protein p VHL are the root cause of most kidney cancers,and the cascading pathway below them is crucial for understanding hypoxia,in addition to the aforementioned tumorigenesis routes and *** reviewed the history and functions of VHL/pVHL and Hypoxia-inducible factor(HIF),their well-known activities under low-oxygen environments as an E3 ubiquitin ligase and as a transcription factor,respectively,as well as their non-canonical functions revealed ***,we discussed how their dysregulation promotes tumorigenesis:beginning with chromosome 3 p-arm(3p)loss/epigenetic methylation,followed by two-allele knockout,before the loss of complimentary tumor suppressor genes leads cells down predictable oncological *** different pathways can ultimately determine the grade,outcome,and severity of the deadliest genitourinary *** finished by investigating current and proposed schemes to therapeutically treat clear cell renal cell carcinoma(cc RCC)by manipulating the hypoxic pathway utilizing Vascular Endothelial Growth Factor(VEGF)inhibitors,mammalian target of rapamycin complex 1(mTORC1)inhibitors,small molecule HIF inhibitors,immune checkpoint blockade therapy,and synthetic lethality.

关键词： VHL HIF ccRCC Kidney cancer Hypoxia

The role of copper in enhancing the performance of heteronuclear diatomic catalysts for the electrochemical CO_(2)conversion to C_(1) chemicals

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Journal of Energy Chemistry 2023年第10期85卷 490-500,I0013页

作者： Qi Zhao rachel Crespo-Otero Devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondon E14NSUK Department of Chemistry University College LondonLondon WC1H 0AJUK

Diatomic catalysts(DACs)with two adjacent metal atoms supported on graphene can offer diverse functionalities,overcoming the inherent limitations of single atom catalysts(SACs).In this study,density functional theory calculations were conducted to investigate the reactivity of the carbon dioxide(CO_(2))reduction reaction(CO_(2)RR)on metal sites of both DACs and SACs,as well as their synergistic effects on activity and *** of the Gibbs free energies of CO_(2)RR and associated values of the limiting potentials to generate C_(1) products showed that Cu acts as a promoter rather than an active catalytic centre in the catalytic CO_(2)conversion on heteronuclear DACs(CuN_(4)-MN_(4)),improving the catalytic activity on the other metal compared to the related SAC MN_(4).Cu enhances the initial reduction of CO_(2)by promoting orbital hybridization between the key intermediate*COOH 2p-orbitals and the metals 3d-orbitals around the Fermi *** degree of hybridization in the DACs CuN_(4)-MN_(4) decreases from Fe to Co,Ni,and *** work demonstrates how Cu regulates the CO_(2)RR performance of heteronuclear DACs,offering an effective approach to designing practical,stable,and high-performing diatomic catalysts for CO_(2)electroreduction.

关键词： Electrocatalytic CO_(2)reduction Single atom catalysts Diatomic catalysts Graphene Density functional theory calculations

Suprathreshold compound action potential amplitude as a measure of auditory function in cochlear implant users

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Journal of Otology 2017年第1期12卷 18-28页

作者： rachel A.Scheperle Department of Communication Sciences and Disorders University of Iowa Department of Communication Sciences and Disorders Montclair State University

Electrically evoked compound action potential(e CAP) amplitudes elicited at suprathreshold levels were assessed as a measure of the effectiveness of cochlear implant(CI) stimulation. Twenty-one individuals participated; one was excluded due to facial stimulation during e CAP testing. For each participant, e CAPs were elicited with stimulation from seven electrodes near the upper limit of the individual's electrical dynamic range. A reduced-channel CI program was created using those same seven electrodes, and participants performed a vowel discrimination task. Consistent with previous reports, e CAP amplitudes varied across tested electrodes; the profiles were unique to each individual. In 6subjects(30%), e CAP amplitude variability was partially explained by the impedance of the recording electrode. The remaining amplitude variability within subjects, and the variability observed across subjects could not be explained by recording electrode impedance. This implies that other underlying factors, such as variations in neural status across the array, are responsible. Across-site mean e CAP amplitude was significantly correlated with vowel discrimination scores(r^2= 0.56). A single e CAP amplitude measured from the middle of the array was also significantly correlated with vowel discrimination, but the correlation was weaker(r^2= 0.37), though not statistically different from the acrosssite mean. Normalizing each e CAP amplitude by its associated recording electrode impedance did not improve the correlation with vowel discrimination(r^2= 0.52). Further work is needed to assess whether combining e CAP amplitude with other measures of the electrode-neural interface and/or with more central measures of auditory function provides a more complete picture of auditory function in CI recipients.

关键词： Cochlear implant Compound action potential Suprathreshold amplitude

The Fall and Rise of Tuberculosis： How Institutional Change Affected Health Outcomes in Shanghai, 1927--2013

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Fudan Journal of the Humanities and Social Sciences 2016年第1期9卷 65-90页

作者： rachel Core Stetson University DeLand FL USA

This paper examines the decline of tuberculosis and the faltering of TB in China. Specifically, I examine how institutional change--the construction and dismantling of the work-unit system--has affected TB control. The work-unit system was an employment system under which the vast majority of the population, in both urban and rural areas, had guaranteed employment and a host of benefits, including health insurance and access to the public health and health care systems. This system was created in the 1950s, which coincided with the decline of TB mortality and morbidity. The 1990s dismantling of the work-unit system has coincided with resurgent TB. This comparative historical sociological work examines TB control in Shanghai at three critical junctures： before the work-unit system was constructed, while it was in place, and since it has been dismantled. I examine both Shanghai＇s urban districts and rural counties, based on data gathered from archival sources and in-depth interviews during 17 months of field research. I argue that the work-unit system provided an effective basic-level infrastructure for the provision of public health and health care services that reached the entire population. This infrastructure was critical to the success of TB control efforts during the work-unit era, and its dismantling has been a key cause of the faltering of TB control in recent years.

关键词： Tuberculosis · Shanghai · Institutional change · Work-unit system · Public health

Genetics and pathophysiology of mammalian sulfate biology

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Journal of Genetics and Genomics 2017年第1期44卷 7-20页

作者： rachel Langford Elizabeth Hurrion Paul A. Dawson Mater Research Institute University of Queensland Woolloongabba 4102 Queensland Australia Mater Mothers' Hospital South Brisbane 4101 Queensland Australia

Nutrient sulfate is essential for numerous physiological functions in mammalian growth and development. Accordingly, disruptions to any of the molecular processes that maintain the required biological ratio of sulfonated and unconjugated substrates are likely to have detrimental consequences for mammalian physiology. Molecular processes of sulfate biology can be broadly grouped into four categories： firstly, intracellular sulfate levels are maintained by intermediary metabolism and sulfate transporters that mediate the transfer of sulfate across the plasma membrane; secondly, sulfate is converted to 3＇-phosphoadenosine 5＇-phosphosulfate （PAPS）, which is the universal sulfonate donor for all sulfonation reactions; thirdly, sulfotransferases mediate the intracellular sulfonation of endogenous and exogenous substrates; fourthly, sulfate is removed from substrates via sulfatases. From the literature, we curated 91 human genes that encode all known sulfate transporters, enzymes in pathways of sulfate generation, PAPS synthetases and transporters, sulfotransferases and sulfatases, with a focus on genes that are linked to human and animal pathophysiology. The predominant clinical features linked to these genes include neurological dysfunction, skeletal dysplasias, reduced fecundity and reproduction, and cardiovascular pathologies. Collectively, this review provides reference information for genetic investigations of perturbed mammalian sulfate biology.

关键词： Sulfate Pathogenetics Transport Sulfotransferase Sulfatase PAPS