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A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment

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Journal of Integrative Medicine 2023年第4期21卷 332-353页

作者： Chinmayee Priyadarsani Mandhata Chita Ranjan Sahoo rabindra nath Padhy Central Research Laboratory Institute of Medical Sciences and SUM HospitalSiksha O Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

Acquired immune deficiency syndrome(AIDS)is a worldwide epidemic caused by human immunodeficiency virus(HIV)*** medicines for eliminating the viral reservoir and eradicating the virus are urgently *** to locate relatively safe and non-toxic medications from natural resources are ongoing ***-product-based antiviral candidates have been exploited to a limited ***,antiviral research is inadequate to counteract for the resistant ***-derived bioactive compounds hold promise as powerful pharmacophore scaffolds,which have shown anti-HIV *** review focuses on a consideration of the virus,various possible HIV-controlling methods and the recent progress in alternative natural compounds with anti-HIV activity,with a particular emphasis on recent results from natural sources of anti-HIV agents.

关键词： HIV Latent reservoir Antiretroviral agents Plant extracts Phytochemicals Antiretroviral therapy Highly active Gene therapy

Role of hormone receptors and HER2 as prospective molecular markers for breast cancer:An update

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Genes & Diseases 2022年第3期9卷 648-658页

作者： Swati Sucharita Mohanty Chita Ranjan Sahoo rabindra nath Padhy Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswarOdisha 751004India Central Research Laboratory Institute of Medical Sciences&SUM HospitalSiksha'O’Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

This review provides an updated account on the current methods,principles and mechanism of action of therapies for the detection of molecular markers of therapeutic importance in the prognosis of breast cancer progression and recurrence,which includes estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor2(HER2).Indeed,hormone-receptors namely,ER,PR,proto-oncogene HER2 are the basic molecular markers that are recognized and established prognostic factors and predictors of response,for therapeutic *** markers can be detected by using immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH),which are established,faster and cost effective detection *** molecular markers along with clinicopathological prognostic parameters give the best prediction of the prognosis of cancer recurrence and ***,hormone receptors and HER2 as molecular markers are of prime therapeutic importance and have the capability to take part in future drug development techniques.

关键词： Breast cancer Molecular diagnostic Molecular markers Predictive markers Prognostic

Impacts of Rotation on Unsteady Fluid Flow and Energy Distribution through a Bending Duct with Rectangular Cross Section

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Energy Engineering 2022年第2期119卷 453-472页

作者： Mohammad Zohurul Islam rabindra nath Mondal Suvash C.Saha School of Mechanical and Mechatronic Engineering University of Technology SydneyUltimoNSW 2007Australia Department of Mathematics Jagannath UniversityDhaka1100Bangladesh

A depth understanding of fluid flow past a curved duct having rectangular cross-section with different aspect ratios(l)are essential for various engineering applications such as in chemical,mechanical,biomechanical and bio-medical *** highly ambitious researchers have given significant attention to study new characteristics of fluid flow in a curved *** flow characterization in the rectangular duct has been studied over a wide range of numerical and selective experimental ***,proper knowledge with the effects of Coriolis force for different aspect ratios is important for better understanding of the transitional behaviour and the subsequent heat generation,which is required to improve *** purpose of this study is to reveal insight into the transitional flow pattern and heat transfer in a curved rectangular *** Navier-Stokes equations are solved using the spectral method,while the Crank-Nicolson method is used to solve the energy *** in-house FORTRAN code is developed to get the numerical *** post-processing purposes,Tecplot-360 and Ghost-script tools are *** present study exposes development of Dean vortices that affect heat generation as well as thermal enhancement in the flow with underlying the flow controlling parameters,the Dean number(Dn),the Grashof number(Gr)and the Taylor number(Tr).Time-dependent results followed by phase spaces show that transient flow undergoes in the scenario‘chaotic→multi-periodic→periodic→steady-state’generating 2-to 8-vortices for the periodic/multi-periodic flow at 2000≤Tr≤2205 for l=2,whereas similar sort of flow is observed in the range of 3100≤Tr≤3195 for l=*** complicated 4-to 13-vortex solutions are obtained for the chaotic flow regime at l=2 in the range of 0≤Tr<2200 and at l=3 in the range of 0≤Tr<*** chaotic flow that occurs at the certain range of Tr proficiently intensifies the heat transfer than the unperturbed,periodic or multi-periodic *** over

关键词： Aspect ratio dean flow heat generation rotating duct transient flow

Forecasting of Software Reliability Using Neighborhood Fuzzy Particle Swarm Optimization Based Novel Neural Network

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1365-1383页

作者： Pratik roy Ghanshaym Singha Mahapatra Kashi nath Dey Department of Computer Science and Engineering University of CalcuttaKolkata-700106India Department of Mathematics National Institute of TechnologyPuducherryKaraikal-609609India

This paper proposes an artificial neural network(ANN) based software reliability model trained by novel particle swarm optimization(PSO) algorithm for enhanced forecasting of the reliability of software. The proposed ANN is developed considering the fault generation phenomenon during software testing with the fault complexity of different levels. We demonstrate the proposed model considering three types of faults residing in the software. We propose a neighborhood based fuzzy PSO algorithm for competent learning of the proposed ANN using software failure data. Fitting and prediction performances of the neighborhood fuzzy PSO based proposed neural network model are compared with the standard PSO based proposed neural network model and existing ANN based software reliability models in the literature through three real software failure data sets. We also compare the performance of the proposed PSO algorithm with the standard PSO algorithm through learning of the proposed ANN. Statistical analysis shows that the neighborhood fuzzy PSO based proposed neural network model has comparatively better fitting and predictive ability than the standard PSO based proposed neural network model and other ANN based software reliability models. Faster release of software is achievable by applying the proposed PSO based neural network model during the testing period.

关键词： Artificial neural network(ANN) fuzzy particle swarm optimization(PSO) reliability prediction software reliability

Exploring the merits of geographical diversification of solar PV power plants for a resilient PV-dominated electricity grid in India

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Clean Energy 2023年第4期7卷 885-910页

作者： Saikat Ghosh Jatindra nath roy Chandan Chakraborty Advanced Technology Development Centre Indian Institute of Technology Kharagpur721302India Department of Electrical Engineering Indian Institute of Technology Kharagpur721302India

India is highly dependent on solar photovoltaics(PV)to harness its vast solar resource potential and combat climate ***,∼90%of the installed PV capacity in India is concentrated in the top nine states,with the remaining states lagging *** research reveals that during monsoons,heavy cloud cover and rain lead to high solar resource variability,intermittency and the risk of very low PV generation,which can result in reliability issues in future PV-dominated electricity *** energy storage can help in overcoming high intermittency,there are multiple challenges associated with *** novelty of this study lies in demonstrating the benefits of combining multiple PV sites in various regions to mitigate the risks of low PV generation and high *** variability of individual sites was found to be up to∼3.5 times higher than the variability of combined *** noon,prominent solar park sites like Bhadla and NP Kunta experience a decrease in power generation to values as low as∼10%of the rated PV ***,the minimum generation of the large-scale dispersed PV generation is>30%.Furthermore,the research identifies other benefits of dispersing PV generation across the country,viz.,reduction of seasonal variability by adding PV capacity in the southern region,widening of the PV generation span,more room for PV capacity addition,reduction in storage and ramping needs,utilization of hydroelectric potential of the north-east and PV potential of Ladakh,and creating opportunities for sustainable development in rural agrarian regions through agrivoltaics.

关键词： decarbonization PV-based resilient grid PV variability and intermittency solar PV power plants

All-optical conversion scheme from binary to its MTN form with the help of nonlinear material based tree-net architecture

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Chinese Optics Letters 2007年第8期5卷 480-483页

作者： Anup Kumar Maiti Jitendra nath roy Sourangshu Mukhopadhyay Department of Electronics Panskura Banamali college MidnapurW.B.India Department of Physics College of Engineering & Management KolaghatKTPP Township.Midnapur(east)W.B.India Department of Physics University of Burdwan GolapbagBurdwanW.B.India

In the field of optical computing and parallel information processing, several number systems have been used for different arithmetic and algebraic operations. Therefore an efficient conversion scheme from one number system to another is very important. Modified trinary number （MTN） has already taken a significant role towards carry and borrow free arithmetic operations. In this communication, we propose a tree-net architecture based all optical conversion scheme from binary number to its MTN form. Optical switch using nonlinear material （NLM） plays an important role.

关键词： tree All-optical conversion scheme from binary to its MTN form with the help of nonlinear material based tree-net architecture net

All-optical adder/subtractor based on terahertz optical asymmetric demultiplexer

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Chinese Optics Letters 2009年第6期7卷 530-533页

作者： Dilip Kumar Gayen Rajat Kumar Pal Jitendra nath roy Department of Computer Science College of Engineering and Management Department of Computer Science and Engineering Calcutta University Department of Physics College of Engineering and ManagementKolaghat KTPP Township

An all-optical adder/subtractor （A/S） unit with the （TOAD） is proposed. The all-optical A/S unit with help of terahertz optical asymmetric demultiplexer a set of all-optical full-adders and optical exclusive- ORs （XORs）, can be used to perform a fast central processor unit using optical hardware components. We try to exploit the advantages of TOAD-based optical switch to design an integrated all-optical circuit which can perform binary addition and subtraction. With computer simulation results confirming the described methods, conclusions are given.

关键词： EDFA XOR All-optical adder/subtractor based on terahertz optical asymmetric demultiplexer mode

Surveillance of multidrug resistant uropathogenic bacteria in hospitalized patients in Indian

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Asian Pacific Journal of Tropical Biomedicine 2013年第4期3卷 315-324页

作者： Monali Priyadarsini Mishra Nagen Kumar Debata rabindra nath Padhy Department of Microbiology IMS & Sum HospitalSiksha 'O' Anusandhan UniversityKalinga Nagar.Bhubaneswar751003OdishaIndia Central Research Laboratory IMS & Sum HospitalSiksha 'O' Anusandhan UniversityKalinga Nagar.Bhubaneswar751003OdishaIndia

Objective:To record surveillance,antibiotic resistance of uropathogens of hospitalized patients over a period of 18 ***:Urine samples from wards and cabins were used for isolating urinary tract infection(UTI)-causing bacteria that were cultured on suitable selective media and identified by biochemical tests;and their antibiograms were ascertained by Kirby-Bauer's disc diffusion method,in each 6-month interval of the study period,using 18 antibiotics of five different ***:From wards and cabins,1 245 samples were collected,from which 996 strains of bacteria belonging to 11 species were isolated,during April 2011 to *** Gram-positive,Staphylococcus aureus(***)and Enterococcus faecalis(***),and nine Gram-negative bacteria,Acinetobacter baumannii,Citrobactcr sp.,Escherichia coli,Enterobacter aerogenes,Klebsiella *** oxytoca,Proteus mirabilis,Proteus vulgaris and Pseudomonas aeruginosa were *** *** and *** were vancomycin resistant,and resistant-strains of all pathogens increased in each 6-month period of ***,all Gram-negatives were resistant to nitrofurantoin and co-trimoxazole,the most preferred antibiotics of empiric therapy for ***:Antibiograms of 11 UTI-causing bacteria recorded in this study indicated moderately higher numbers of strains resistant to each antibiotic studied,generating the fear of precipitating fervent episodes in public health particularly with bacteria,Acinetobacter baumannii,Escherichia coli,Klebsiella pneumoniae and ***,vancomycin resistance in strains of *** and *** is a matter of concern.

关键词： UTI MDR bacteria Hospitalized patients Antibiograms Nosocomial infections Antibiotics Staphylococcus aureus Acinetobacter baumannii Escherichia coli Klebsiella pneumoniae

Designing of an all-optical time division multiplexing scheme with the help of nonlinear material based tree-net architecture

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Chinese Optics Letters 2006年第8期4卷 483-486页

作者： Jitendra nath roy Anup Kumar Maiti Sourangshu Mukhopadhyay College of Engineering & Management Kolaghat KTPP TownshipMidnapur (east) 721171 W.B.India Panskura Banamali College Midnapur W.B.India Department of Physics University of Burdwan GolapbagBurdwanW.B.India

In the field of optical interconnecting network and in super fast photonic computing system, the tree architecture and optical nonlinear materials can play a significant role. Nonlinear optical material may find important uses in optical switching. Optical switch using nonlinear material makes it possible for one optical signal to control and switch another optical signal through nonlinear interaction in a material. In this communication such materials have been successfully exploited to design an all-optical tree-net architecture, which can be utilized for time division multiplexing scheme in all-optical domain.

关键词： tree Designing of an all-optical time division multiplexing scheme with the help of nonlinear material based tree-net architecture time net