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Role of hormone receptors and HER2 as prospective molecular markers for breast cancer:An update

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Genes & Diseases 2022年第3期9卷 648-658页

作者： Swati Sucharita Mohanty Chita Ranjan Sahoo rabindra nath padhy Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswarOdisha 751004India Central Research Laboratory Institute of Medical Sciences&SUM HospitalSiksha'O’Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

This review provides an updated account on the current methods,principles and mechanism of action of therapies for the detection of molecular markers of therapeutic importance in the prognosis of breast cancer progression and recurrence,which includes estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor2(HER2).Indeed,hormone-receptors namely,ER,PR,proto-oncogene HER2 are the basic molecular markers that are recognized and established prognostic factors and predictors of response,for therapeutic *** markers can be detected by using immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH),which are established,faster and cost effective detection *** molecular markers along with clinicopathological prognostic parameters give the best prediction of the prognosis of cancer recurrence and ***,hormone receptors and HER2 as molecular markers are of prime therapeutic importance and have the capability to take part in future drug development techniques.

关键词： Breast cancer Molecular diagnostic Molecular markers Predictive markers Prognostic

Surveillance of multidrug resistant uropathogenic bacteria in hospitalized patients in Indian

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Asian Pacific Journal of Tropical Biomedicine 2013年第4期3卷 315-324页

作者： Monali Priyadarsini Mishra Nagen Kumar Debata rabindra nath padhy Department of Microbiology IMS & Sum HospitalSiksha 'O' Anusandhan UniversityKalinga Nagar.Bhubaneswar751003OdishaIndia Central Research Laboratory IMS & Sum HospitalSiksha 'O' Anusandhan UniversityKalinga Nagar.Bhubaneswar751003OdishaIndia

Objective:To record surveillance,antibiotic resistance of uropathogens of hospitalized patients over a period of 18 ***:Urine samples from wards and cabins were used for isolating urinary tract infection(UTI)-causing bacteria that were cultured on suitable selective media and identified by biochemical tests;and their antibiograms were ascertained by Kirby-Bauer's disc diffusion method,in each 6-month interval of the study period,using 18 antibiotics of five different ***:From wards and cabins,1 245 samples were collected,from which 996 strains of bacteria belonging to 11 species were isolated,during April 2011 to *** Gram-positive,Staphylococcus aureus(***)and Enterococcus faecalis(***),and nine Gram-negative bacteria,Acinetobacter baumannii,Citrobactcr sp.,Escherichia coli,Enterobacter aerogenes,Klebsiella *** oxytoca,Proteus mirabilis,Proteus vulgaris and Pseudomonas aeruginosa were *** *** and *** were vancomycin resistant,and resistant-strains of all pathogens increased in each 6-month period of ***,all Gram-negatives were resistant to nitrofurantoin and co-trimoxazole,the most preferred antibiotics of empiric therapy for ***:Antibiograms of 11 UTI-causing bacteria recorded in this study indicated moderately higher numbers of strains resistant to each antibiotic studied,generating the fear of precipitating fervent episodes in public health particularly with bacteria,Acinetobacter baumannii,Escherichia coli,Klebsiella pneumoniae and ***,vancomycin resistance in strains of *** and *** is a matter of concern.

关键词： UTI MDR bacteria Hospitalized patients Antibiograms Nosocomial infections Antibiotics Staphylococcus aureus Acinetobacter baumannii Escherichia coli Klebsiella pneumoniae

Bayesian analysis of two methods MALDI-TOF-MS system and culture test in otomycosis infection

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 6-13页

作者： Sibanarayan Rath Saumya Ranjan Das rabindra nath padhy Central Research Laboratory Institute of Medical Sciences and Sum HospitalSiksha'O'Anusandhan UniversityOdishaIndia Department of Ear Nose and Throat Institute of Medical Sciences and Sum HospitalSiksha'O'Anusandhan UniversityOdishaIndia

Objective:Identification of otomycotic fungi using matrix-assisted laser desorption ionization (MALDI) time of flight (TOF) mass spectroscopy (MS) and to quantify pervasive errors with Bayes rule;values of sensitivity and specificity of culture test and MALDI-TOF-MS method are ***:Fungi cultured ear discharge samples were identified with culture test and MALDITOF-MS *** inhibitory concentration (MIC) or MEC (minimum effective concentration) for 6 antifungals were determined by antifungal susceptibility testing in *** Bayes rule,sensitivity and specificity of both MALDI-TOF MS and culture test methods were ***:Cultures yielded 42 fungal isolates which were confirmed as species (specified against each species) belonging to 8 genera,*** 22,Candida sp.7,*** 3,*** 3,mixed Aspergillus sp.3,Mucor sp.2,Rhizopus sp.1,and Scopulariopsis sp.1;and MALDITOF-MS system also confirmed those *** vitro antifungal susceptibility testing with terms of MIC 50 and MIC 90,isolates fungi were highly susceptible to 6 antifungals;and caspofungin was the most active *** high value of specificity 84.6%,suggested a limited loss of confidence on the culture test at the absence of an infection,in comparison to *** of the culture test was 87.5%;this high figure strongly approves the culture test to be the dependable method for the otomycosis diagnosis,when the infection is ***:Based on sensitivity and specificity together the culture test could be done in face of the gold-standardMALDI-TOF-MS system the estimating both methods.

关键词： Otomycosis MALDI-TOF-MS system Identification at species level Sensitivity Specificity

Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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Journal of Bio-X Research 2024年第1期7卷 36-43页

作者： Swati Sucharita Mohanty Sumit Subhadarshi Mohanty Soumya Surath Panda Chita Ranjan Sahoo Prafulla Kumar Mohanty rabindra nath padhy Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital BhubaneswarOdishaIndia Regional Medical Research Centre Bhubaneswar BhubaneswarOdishaIndia Khallikote Unitary University BrahmapurOdishaIndia

There were 2.3 million new cases of breast cancer registered in 2020,establishing it as the world’s leading *** regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages.A literature review was performed by downloading research articles from PubMed Central,with keywords such as breast cancer,hormone exposure in breast cancer,estrogen/progesterone exposure in breast cancer,and breast cancer risk *** breast cancer is a hormone-related disease,several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast ***,an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen *** these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime.A healthy lifestyle,a more extended breastfeeding period,and regular physical activity may help lower one’s *** review summarizes the factors that increase the risk of estrogen/progesterone(hormone receptor)receptor-positive breast cancer due to overall cumulative estrogen exposure,with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

关键词： alterations elevated exposure

Probit Analysis of Carbamate-Pesticide-Toxicity at Soil-Water Interface to N_2-Fixing Cyanobacterium Cylindrospermum sp.

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Rice science 2015年第2期22卷 89-98页

作者： rabindra N.padhy Shakti RATH Department of Botany BJB Autonomous College

Toxicity-data of two carbamate insecticides, carbaryl and carbofuran, and three fungicides, ziram, zineb and mancozeb with rice-field N2-fixing cyanobacterium Cylindrospermum sp., obtained by in vitro growth and at soil-water interface, were analyzed by the probit method. Growth enhancing concentration, no-observed effective concentration, minimum inhibitory concentration, the highest permissive concentration and lethal concentration100 （LCloo） were determined experimentally. The LC^o values of carbaryl, carbofuran, ziram, zineb and mancozeb in N2-fixing liquid medium were 56.2, 588.8, 0.07, 4.2 and 3.4 IJg/mL, respectively, whereas the corresponding LCloo values were 100.0, 1500.0, 0.17, 25.0 and 9.0 IJg/mL, respectively. The LC50 values of these pesticides in succession in N2-fixing agar medium were 44.7, 239.9, 0.07, 1.8 and 2.3 IJg/mL, respectively, whereas the corresponding LC100 values were 100.0, 600.0, 0.17, 10.0 and 7.0 IJg/mL, respectively. Similar results with nitrate supplemented liquid and agar media indicated that nitrate supplementation had toxicity reducing effect. The LCso and LC^oo values of toxicity in the N2-fixing liquid medium at soil-water interface were 91.2 and 200.0 IJg/mL for carbaryl, 2 317 and 6 000 pg/mL for carbofuran, 0.15 and 0.50 pg/mL for ziram, 16.4 and 50.0 pg/mL for zineb, and 7.2 and 25.0 pg/mL for mancozeb, respectively. Each LC^oo value at soil- water interface with a pesticide was significantly higher than its corresponding LCloo value at liquid/agar media. It can be concluded that, under the N2-fixing conditions, the cyanobacterium tolerated higher levels of each pesticide at soil-water interface.

关键词： carbamate pesticide Cylindrospermum sp. cyanobacterium lethal concentration probitanalysis soil-water interface

Growth, Metabolism and Yield of Rice Cultivated in Soils Amended with Fly Ash and Cyanobacteria and Metal Loads in Plant Parts

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Rice science 2016年第1期23卷 22-32页

作者： rabindra N.padhy Nabakishore NAYAK Rajesh R.DASH-MOHINI Shakti RATH Rajani K.SAHU Department of Botany and Biotechnology Buxi Jagabandhu Bidyadhar Autonomous College Central Research Laboratory Institute of Medical Sciences & Sum HospitalSiksha ‘O' Anusandhan University

Soil amendment with fly ash（FA） and combined supplementation with N_2-fixing cyanobacteria masses as biofertilizer were done in field experiments with rice. Amendments with FA levels, 0, 0.5, 1.0, 2.0, 4.0, 8.0 and 10.0 kg/m2, caused increase in growth and yield of rice up to 8.0 kg/m2, monitored with several parameters. Pigment contents and enzyme activities of leaves were enhanced by FA, with the maximum level of FA at 10.0 kg/m2. Protein content of rice seeds was the highest in plants grown at FA level 4.0 kg/m2. Basic soil properties, p H value, percentage of silt, percentage of clay, water-holding capacity, electrical conductivity, cation exchange capacity, and organic carbon content increased due to the FA amendment. Parallel supplementation of FA amended plots with 1.0 kg/m2 N_2-fixing cyanobacteria mass caused further significant increments of the most soil properties, and rice growth and yield parameters. 1000-grain weight of rice plants grown at FA level 4.0 kg/m2 along with cyanobacteria supplementation was the maximum. Cyanobacteria supplementation caused increase of important basic properties of soil including the total N-content. Estimations of elemental content in soils and plant parts（root and seed） were done by the atomic absorption spectrophotometry. Accumulations of K, P, Fe and several plant micronutrients（Mn, Ni, Co, Zn and Cu） and toxic elements（Pb, Cr and Cd） increased in soils and plant parts as a function of the FA gradation, but Na content remained almost unchanged in soils and seeds. Supplementation of cyanobacteria had ameliorating effect on toxic metal contents of soils and plant parts. The FA level 4.0 kg/m2, with 1.0 kg/m2 cyanobacteria mass supplementation, could be taken ideal, since there would be recharging of the soil with essential micronutrients as well as toxic chemicals in comparative lesser proportions, and cyanobacteria mass would cause lessening toxic metal loads with usual N_2-fixation.

关键词： soil property cyanobacteria fly ash growth heavy metal rice toxic element yield

Antibacterial efficacy of five medicinal plants against multidrug-resistant enteropathogenic bacteria infecting under-5 hospitalized children

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Journal of Integrative Medicine 2015年第1期13卷 45-57页

作者： Shakti Rath rabindra N.padhy Department of Botany and Biotechnology B.J.B. Autonomous College Central Research Laboratory IMS & Sum Hospital Medical College Siksha ‘O' Anusandhan University

OBJECTIVE： To evaluate in vitro antibacterial effectiveness of five medicinal plants used by an Indian aborigine, against 8 multidrug-resistant （MDR） enteropathogenic bacteria isolated from clinical samples of under-5 hospitalized children. METHODS： Antibiotic sensitivity patterns of eight clinically isolated strains of enteropathogenic bacteria, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Salmonella paratyphi, S. typhi, Shigella dysenteriae, S. sonnei and Vibrio cholerae were assessed by disc-diffusion method. Antibacterial activities of 8 solvent-extracts of leaves and bark of five medicinal plants were monitored by the agar-well diffusion method. The microbroth dilution method was used to assess minimum inhibitory concentration （MIC） and minimum bactericidal concentration （MBC）. Qualitative phytochemical analyses of active plant extracts were carried out. RESULTS： Ethanol, ethyl acetate and methanol extracts of Holarrhena antidysenterica leaf tissue were most effective against 8 MDR pathogens in vitro. Similarly, acetone, ethanol and methanol extracts of Terminalia alata leaf tissue; chloroform, ethyl acetate and methanol extracts of Terminalia aquna leaf tissue and ethyl acetate, ethanol and methanol extracts of Paederia foetida leaf tissue were most effective in inhibiting in vitro growth of the 8 MDR enteropathogens. Ethyl acetate and methanol extracts of H. antidysenterica bark tissue; acetone, ethanol and methanol extracts of T. alata bark tissue and acetone, ethanol and methanol extracts of T. arjuna bark tissue were most effective in controlling enteropathogen growth. The minimum inhibitory concentration and minimum bactericidal concentration values of the 3 most antimicrobial leaf and bark extracts from the five plants were in the range of 1.56 to 50 mg/mL. CONCLUSION： These 5 plants exhibited in vitro control over a cohort of 8 enteropathogenic bacteria strains isolated from clinical samples.

关键词： ethnomedicinal plants multidrug resistance enteropathogenic bacteria antibacterial assay phytochemical analysis plants, medicinal

A report on infection dynamics of inducible clindamycin resistance of Staphylococcus aureus isolated from a teaching hospital in India

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 148-153页

作者： Debasmita Dubey Shakti Rath Mahesh C.Sahu Subhrajita Rout Nagen K.Debata rabindra N.padhy Microbiology Department IMS & Sum HospitalSiksha 'O' Anusandhan University Central Research Laboratory IMS & Sum HospitalSiksha 'O' Anusandhan University

Objective:To investigate the infection of hospital-and community-acquired"erythromycininduced clindamycin resistant"strains or D-test positives of clinical isolates of Staphylococcus aureus(***)(with and without methicillin resistance)in a ***:Strains of *** isolated from clinical specimens were subjected to D-test and antibiotic ***:Of the total 278 isolates,140(50.35%)were D-test positives and the rest were D-test ***,of 140(100%)pesitives,87(62.14%)and 53(37.85%)strains were from males and females,*** 140(100%)pesitives,117(83.57%)were methicillin resistant *** and23(16.42%)were methicillin sensitive ***;of 140 strains,103(73.57%)strains front persons with and 37(26.42%)were without related infections;of 140 strains,91(65%)and 49(35%)were from hospital-and community-acquired samples,*** 140 strains,118(84.28%)with comorbidities and 22(15.71%)without comorbidities cases were recorded;similarly,persons with prior antibiotic uses contributed 108(77.14%)and without 32(22.85%)positive *** binary data of surveillance were analyzed by a univariate *** was evident that the prior antibiotic uses and comorbidities due to other ailments were the determinative factors in D-test positivity,corroborated by low P values,P=0.001 1 and 0.0024,*** isolates(278)were resistant to17 antibiotics of nine groups,in varying degrees;the minimum of 28%resistance for vancomycin and the maximum of 97%resistance for gentamicin were ***,of 278 strains,only42(15.1%)strains were resistant constitutively to both antibiotics,erythromycin resistant and clindamycin resistant,while 45(16.2%)strains were constitutively sensitive to both antibiotics(erythromycin sensitive,and clindamycin sensitive).Further,of the rest 191(68.7%)strains were with erythromycin resistant and clindamycin resistant,of which only 140(50.35%)strains were D-test positives,while the rest 51(18.34%)str

关键词： Antibiotics Community-acquired D-test Erythromycin resistance Hospital-acquired Inducible clindamycin resistance MRSA MSSA Staphylococcus aureus

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可以用作肥料和处理废物的蓝细菌

世界科学 1986年第7期 21-22页

作者： rabindra N.padhy 孙熙年

在自由生活的固氮微生物中,具分枝状异形细胞的蓝细菌(蓝绿藻)对生物固氮作出了最大的全球性贡献。在亚洲,它们能自然生长或被培养于稻田中以用作绿肥,在几个具有不同农业条件和土壤类型的国家内已经确知:稻田中的蓝细菌减少了为获得水... 详细信息

在自由生活的固氮微生物中,具分枝状异形细胞的蓝细菌(蓝绿藻)对生物固氮作出了最大的全球性贡献。在亚洲,它们能自然生长或被培养于稻田中以用作绿肥,在几个具有不同农业条件和土壤类型的国家内已经确知:稻田中的蓝细菌减少了为获得水稻高产所需要的以氮为基础的化肥量。更为有效的是利用满江红,一种与兰细菌即满江红鱼腥藻共生的水生蕨类,它能产生每天每公顷固定约3公斤的大气氮。不过由于在水稻栽培期间经常使用农药,导致其残留浓度增加到足以抑制蓝细菌生长的水平。最近分离得一些抗农药的固氮蓝细菌的突变型,它们能增加水稻栽培时使用的绿肥的效力,因此减少了对生产肥料时的昂贵

关键词：蓝细菌农药异形细胞固氮水稻栽培稻田化学污染物氮代谢水田化学物突变体突变型