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Chronic Enterovirus D68 Bronchiolitis Causing Severe Respiratory Insufficiency

Open Journal of Respiratory Diseases 2016年第3期6卷 47-51页

作者： John Chia Andrew Chia David Wang rabiha el-habbal Deren Sinkowitz EV Med Research Torrance USA Peninsula Pulmonary Medical Associates Torrance USA

Human enteroviruses are less well-known causes of acute bronchiolitis. In recent years, Enterovirus D68 [EV D68] has emerged as significant cause of epidemic viral bronchiolitis and pneumonia in the United States and other countries. Chronic bronchiolitis has not been previously attributed to EV D68. We documented EV D68 in open lung biopsies of a young adult patient who was frequently admitted to the hospital for severe exacerbation of respiratory infections and subsequently developed progressive respiratory insufficiency. The difficulty of diagnosis and potential economic impact of this illness is discussed.

关键词： Enterovirus D68 Chronic Bronchiolitis

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Functional Dyspepsia and Chronic Gastritis Associated with Enteroviruses

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Open Journal of Gastroenterology 2015年第4期5卷 21-27页

作者： John K. Chia Andrew Y. Chia David Wang rabiha el-habbal EV Med Research LLC Lomita USA

After decades of research, functional dyspepsia (FD) remains one of the most elusive gastrointestinal disorders. Endoscopic appearance of mild inflammation of the gastric mucosa without ulceration and microscopic evidence of mild chronic inflammation are often considered as normal findings since no etiology could be found other than H. Pylori. Enteroviruses infect the gastrointestinal tract and have been shown to persist in the stomach of symptomatic patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In this study, we evaluated FD patients with and without the diagnosis of ME/CFS, and were able to support the viral protein staining with finding of double-stranded RNA in 63% of the same stomach biopsies by immunoperoxidase staining. Furthermore, we clarified the possible cross-reaction with creatine kinase brain subtype (CKB), present in parietal cells, using antibody competition experiments and western blot analysis of stomach proteins. Viral protein+ and dsRNA+ biopsies were infectious in SCID mice. More research is needed to elucidate the mechanism of enterovirus infection of the stomach associated with FD and chronic gastritis.

关键词： Functional Dyspepsia Chronic Gastritis Enterovirus Double Stranded RNA

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Echovirus 18 Infection Is Associated with Crohn’s Disease

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Open Journal of Gastroenterology 2019年第8期9卷 174-183页

作者： John Chia Andrew Chia David Wang rabiha el-habbal Sitaraman Jyotheeswaran Eric McCloud EV Med Research Lomita CA USA Adult Gastroenterology Torrance CA USA Pediatric Gastroenterology Torrance CA USA

Background: Enterovirus (EV) can cause gastroenteritis and are known to replicate in Peyer’s patches of terminal ileum. EV has been found in the intestinal specimens from immunocompromised patients with regional enteritis, and another study demonstrates the presence of enterovirus in the resected terminal ileum of immunocompetent pediatric patients with Crohn’s disease (CD). Cluster outbreaks of CD have also been reported in the literature but the cause of the disease remains elusive. Materials and Methods: A small cluster of pathologically proven CD occurred in our geographic area in 2004-2005, concurrently with an epidemic of Echovirus 18 (E18) meningitis. Serum samples of these and other CD patients and control subjects were tested for neutralizing antibodies of 11 common typeable enteroviruses and Echovirus 18;and tissue samples of CD patients, and terminal ileum and colon biopsies of normal controls were tested for the presence of viral capsid protein 1 (VP1) by immunoperoxidase staining. Results: Immunoperoxidase staining demonstrated VP1 in a rare epithelial granuloma, in diseased muscle of terminal ileum and also in colon biopsies of CD patients. Significantly elevated E18 neutralizing antibody was found in patients with pathologically-proven Crohn’s disease, as compared to control subjects. Conclusion: In this small observational study, EV VP1 is consistently demonstrated in tissue samples of CD patients as compared to control subjects;and neutralizing antibody for E18 was found in all of the patients with available serum samples. Larger cross-sectional studies will be needed to define the role of E18 in this chronic disease.

关键词： Enterovirus Crohn’s Disease Neutralizing Antibody Immunoperoxidase Staining

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Antibacterial activity of Lawsonia inermis Linn(Henna) against Pseudomonas aeruginosa

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 173-176页

作者： habbal O Hasson SS el-Hag AH Al-Mahrooqi Z Al-Hashmi N Al-Bimani Z MS Al-Balushi Al-Jabri AA Department of Human & Clinical Anatomy College of Medicine and Health Sciences.Sultan Qaboos University Division of Immunology Department of Microbiology and ImmunologyCollege of Medicine and Health Sciences.Sultan Qaboos University Division of Microbiology Department of Microbiology and ImmunologyCollege of Medicine and Health SciencesSultan Qaboos University

Objective:To investigate the antibacterial activity of henna(Lawsonia inermis Linn) obtained from different regions of Oman against a wide array of ***:fresh henna samples were obtained from different regions of Oman as leaves and seeds,100 g fresh and dry leaves and SO g of fresh and dry seeds were separately soaked in 500 mL of ethanol for three days,respectively,with frequent *** mixture was filtered,and the crude extract was *** crude extract was then heated,at 48 ℃ in a water bath to evaporate its liquid *** dry crude henna extract was then tested for its antibacterial activity using well-diffusion antibiotic susceptibility *** extracts were investigated for their antibacterial activity at different concentrations against a wide array of different micro-organisms including a laboratory standard bacterial strain of Pseudomonas aeruginosa(NCTC 10662)(A aeruginosa) and eleven fresh clinical isolates of *** obtained from patients attending the Sultan Qaboos University Hospital(SQUH).2-Hydroxy-p-Nathoqinone-Tech(2-HPNT, MW=174.16,C_(10)H_40_3) was included as control(at 50%concentration) along with the henna samples ***:Henna samples demonstrated antibacterial activity against all isolates but the highest susceptibility was against *** with henna samples obtained from Al-sharqyia ***:Omani henna from Al-sharqyia region demonstrates high in vitro anti-P. aeruginosa activity compared with many henna samples from different regions of Oman.

关键词： Pseudomonas aeruginosa Lawsonia inermis Linn Henna Antibacterial activity Oman Antibiotic susceptibility Micro-organism Bacterial strain Clinical isolate Crude extract

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