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Adaptation of Federated Explainable Artificial Intelligence for Efficient and Secure E-Healthcare Systems

Computers, Materials & Continua 2024年第3期78卷 3413-3429页

作者： rabia Abid Muhammad Rizwan Abdulatif Alabdulatif Abdullah Alnajim Meznah Alamro Mourade Azrour Department of Computer Science Kinnaird College for WomenLahorePakistan College of Science and Engineering University of DerbyDerbyDE221GBUK Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Information Technology College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia STI Laboratory IDMS TeamFaculty of Sciences and TechniquesMoulay Ismail University of MeknèsMeknesMorocco

Explainable Artificial Intelligence(XAI)has an advanced feature to enhance the decision-making feature and improve the rule-based technique by using more advanced Machine Learning(ML)and Deep Learning(DL)based *** this paper,we chose e-healthcare systems for efficient decision-making and data classification,especially in data security,data handling,diagnostics,laboratories,and *** Machine Learning(FML)is a new and advanced technology that helps to maintain privacy for Personal Health Records(PHR)and handle a large amount of medical data *** this context,XAI,along with FML,increases efficiency and improves the security of e-healthcare *** experiments show efficient system performance by implementing a federated averaging algorithm on an open-source Federated Learning(FL)*** experimental evaluation demonstrates the accuracy rate by taking epochs size 5,batch size 16,and the number of clients 5,which shows a higher accuracy rate(19,104).We conclude the paper by discussing the existing gaps and future work in an e-healthcare system.

关键词： Artificial intelligence data privacy federated machine learning healthcare system security

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Adult neurogenesis:a real hope or a delusion?

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Neural Regeneration Research 2024年第1期19卷 6-15页

作者： Ghulam Hussain rabia Akram Haseeb Anwar Faiqa Sajid Tehreem Iman Hyung Soo Han Chand Raza Jose-Luis Gonzalez De Aguilar Neurochemicalbiology and Genetics Laboratory(NGL) Department of PhysiologyFaculty of Life SciencesGovernment College UniversityFaisalabadPunjabPakistan Department of Physiology School of MedicineClinical Omics InstituteKyungpook National UniversityDaeguKorea Department of Zoology Faculty of Chemistry and Life SciencesGovernment College UniversityLahorePakistan INSERM U1118Mécanismes Centraux et Péripheriques de la NeurodégénérescenceStrasbourgFranceUniversitéde StrasbourgStrasbourgFrance

Adult neurogenesis,the process of creating new neurons,involves the coordinated division,migration,and differentiation of neural stem *** process is restricted to neurogenic niches located in two distinct areas of the brain:the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle,where new neurons are generated and then migrate to the olfactory *** has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem ***,recent years have seen tremendous progress in our understanding of adult brain neurogenesis,bridging the knowledge gap between embryonic and adult ***,we discuss the current status of adult brain neurogenesis in light of what we know about neural stem *** this notion,we talk about the importance of intra cellular signaling molecules in mobilizing endogenous neural stem cell prolife *** on the current understanding,we can declare that these molecules play a role in targeting neurogenesis in the mature ***,to achieve this goal,we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints,which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

关键词： adult neurogenesis aging brain-derived neurotrophic factor dentate gyrus hippocampus neural stem cells neurotrophic factors Notch oxidative stress stem cells subgranular zone

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Automated screening of primary cell-based aptamers for targeting and therapy of pancreatic cancer

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Chinese Chemical Letters 2024年第2期35卷 300-304页

作者： Zhukang Guo Baijiang Jin Yile Fang Lian Jin Song Li Yan Deng Zhu Chen Hui Chen Yuanying Zhang rabia Usman Nongyue He State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of TechnologyZhuzhou 412007China Department of Molecular Biology Jiangsu Cancer HospitalNanjing 210009China

Although it has been developed for many years, nucleic acid aptamer screening technology still fails to be widely used, a considerable part of it is due to the variability of tumor cell morphology, which leads to the use of immortalized cell lines in the laboratory to screen nucleic acid aptamers for recognition ability of tumor cells in the diseased *** address this, primary cells that can be stably passaged were isolated and extracted from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice in this ***, an automated screening instrument for nucleic acid aptamers developed autonomously by our group was used to perform efficient aptamer screening using a limited number of cells, and the obtained nucleic acid aptamers were affinity verified at the cellular ***, to answer the question of the cell growth environment difference on the recognition ability of nucleic acid aptamers, we verified its targeting ability to tumors in vivo on a nude mice xenograft tumor model, and further used a common antitumor drug doxorubicin combined with nucleic acid aptamers to verify the drug loading ability of this aptamer combined with the targeting therapeutic ability.

关键词： Aptamer Cell-SELEX Automatic instrument Combination therapy Pancreatic cancer

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Capparis spinosa L waste activated carbon as an efficient adsorbent for crystal violet toxic dye removal: Modeling, optimization by experimental design, and ecological analysis

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Chinese Journal of Chemical Engineering 2024年第7期71卷 283-302页

作者： Mohammed Benjelloun Youssef Miyah Salma Ssouni Soulaiman Iaich Mohamed El-habacha Salek Lagdali Khadija Saka El Mustafa Iboustaten Abdelaziz Ait Addi Sanae Lairini rabia Bouslamti Laboratory of Materials ProcessesCatalysisand EnvironmentHigher School of TechnologySidi Mohamed Ben Abdellah UniversityFez 30070Morocco Ministry of Health and Social Protection Higher Institute of Nursing Professions and Health TechniquesFez/Meknes 30070Morocco Laboratory of Biochemistry Faculty of MedicinePharmacy and DentistrySidi Mohamed Ben Abdellah UniversityFez 30070Morocco Laboratory of Applied Chemistry and Environment Faculty of SciencesIbnou Zohr UniversityAgadir 80322Morocco Research Team of Energy and Sustainable Development Higher School of TechnologyIbnou Zohr UniversityGuelmim 81000Morocco Organic Chemistry and Physical Chemistry Laboratory Faculty of SciencesIbnou Zohr UniversityAgadir 80322Morocco

Textile dyes are dramatic sources of pollution and non-aesthetic disturbance of aquatic life and therefore represent a potential risk of bioaccumulation that can affect living *** is imperative to reduce or eliminate these dyes from liquid effluents with innovative biomaterials and ***,this research aims to highlight the performance of Capparis spinosa L waste-activated carbon(CSLW-AC)adsorbent to remove crystal violet(CV)from an aqueous *** mechanism of CV adsorption on CSLW-AC was evaluated based on the coupling of experimental data and different characterization *** efficiency of the CSLW-AC material reflected by the equilibrium adsorption capacity of CV could reach more than 195.671 mg·g^(–1) when 0.5 g·L^(–1) of CSLW-AC(Particle size≤250μm)is introduced into the CV of initial concentration of 100 mg·L^(–1) at pH 6 and temperature 65℃ and in the presence of potassium ions after 60 min of contact time according to the one parameter at a time *** adsorption behavior of CV on CSLW-AC was found to be consistent with the pseudo-second-order kinetic model and Frumkin's linear isothermal *** thermodynamic aspects indicate that the process is physical,spontaneous,and *** optimization of the process by the Box Behnken design of experiments resulted in an adsorption capacity approaching 183.544 mg·g^(–1)([CV]=100 mg·L^(–1) and[CSLW-AC]=0.5 g·L^(–1) at 35 min).The results of the Lactuca sativa seeds germination in treated CV(70%),adsorbent solvent and thermal regeneration(more than 5 cycles),and process cost analysis(1.0484 USD·L^(–1))tests are encouraging and promising for future exploitations of the CSLW-AC material in different industrial fields.

关键词： Box Behnken Capparis spinosa L waste-activated carbon Cost analysis Isotherm Kinetic Regeneration

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Effect of pulsed corticosteroids and tocilizumab on hyperinflammation in COVID-19 patients with acute respiratory distress syndrome

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Journal of Acute Disease 2021年第5期10卷 195-201页

作者： Murat Aslan Mehmet Süleyman Sabaz rabia yilmaz Sinan Aşar Yasemin TekdöşŞeker Gülsüm Oya Hergünsel Health Sciences University Bakırköy Dr Sadi Konuk Training and Research HospitalAnesthesia and Reanimation ClinicIstanbulTurkey Marmara University Pendik Training and Research Hospital Anesthesia and Reanimation ClinicIstanbulTurkey

Objective:To compare the efficacy of pulsed-dose corticosteroids(≥250 mg methylprednisolone,3 days)and tocilizumab in treating COVID-19-related ***:This prospective observational study included RT-PCR positive COVID-19 patients with acute respiratory distress syndrome,who were admitted to the COVID-19 Adult Intensive Care Unit of Prof *** Dilmener Emergency Hospital(Istanbul,Turkey)between December 1,2020 and February 28,***,laboratory and radiological examinations were used to diagnose COVID-19 associated *** cohort groups were formed:the pulsed-dose corticosteroids group(250 mg methylprednisolone for 3 days),the tocilizumab group(8 mg/day single dose or 400 mg/day for 2 days),and the combined group(pulsed-dose corticosteroid+tocilizumab).The difference in mortality rates among the groups was compared *** most common cause(s)of death was ***,adverse events(secondary infection,acute kidney injury,arrhythmia,gastrointestinal system bleeding)for 28 days were ***:A total of 60 patients were included in this study,with 20 patients in each *** was no statistically significant difference between the 3 groups in mortality rates(55%in the pulsed corticosteroid group,60%in the tocilizumab group,50%in the combined group,χ2=0.404,P=0.817).Infectious causes were found to be the most common cause of mortality in all the three groups,and no difference was found between them(χ2=0.404,P=0.817).There was also no difference in the development of adverse events such as secondary infection,acute kidney injury,arrhythmia,and gastrointestinal bleeding among the groups(P>0.05).Conclusions:Corticosteroids can be used instead of tocilizumab to treat hyperinflammation in COVID-19 patients with acute respiratory distress syndrome.

关键词： COVID-19 Acute respiratory distress syndrome Hyperinflammation Pulse dose steroid Tocilizumab

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Analysis of cerium substitution in Co-Sr based spinel ferrites for high frequency application

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Journal of Rare Earths 2024年第9期42卷 1755-1763页

作者： Laura Khudaysh Inas A.Ahmed Syeda rabia Ejaz Sajjad Ahmad Khan Yasir A.Haleem Mohamed M.Ibrahim Mahmood Ali Hafiz Muhammad Tahir Farid Zeinhom M.El-Bahy Department of Physics Faculty of ScienceJazan University Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics The Government Sadiq College Women University Institute of Physics Khwaja Fareed University of Engineering and Information Technology Department of Chemistry College of ScienceTaif University Centre of Excellence in Solid State Physics University of the Punjab Department of Physics Government College Department of Chemistry Faculty of ScienceAl-Azhar University

Spinel ferrites exhibit exceptional magnetic properties,making them a distinctive class of magnetic *** sol-gel technique was utilized for the synthesis of spinel ferrites with the chemical formula Co0.6Sr0.4CexFe2-xO4. Following that,a comprehensive X-ray diffraction analysis unveiled the crystalline cubic structure of the synthesized *** the utilization of the M-H loop approach,the ferromagnetic attributes of ferrites were assessed,and the assimilation of rare earth elements led to substantial enhancements in saturation magnetization,remanence,and *** ferrites with a high concentration of rare earth elements have improved direct current resistivity and activation *** logarithm of a material's resistance increased from 5.29 to 8.12 Ω·cm as cerium is *** a change in the amount of cerium,the activation energy goes up from 0.19 to *** changing the frequency from 5.5 to 9.5 GHz,the dielectric characteristics were *** the frequency goes up,the dielectric constant goes *** ferrites that have been made better in every way can be used in high-frequency applications.

关键词： Activation energy DC electrical resistance Remanence magnetization Cobalt strontium spinel ferrites High frequency application Rare earths

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Return to Dialysis after Kidney Graft Failure

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Open Journal of Nephrology 2024年第2期14卷 240-252页

作者： Ikram Ftaimi Soukaina Sakab Manal Chattahi Tarik Bouattar Loubna Benamar rabia Bayahia Naima Ouzeddoun Service de Nphrologie-Dialyse-Transplantationrnale CHU Ibn Sina Rabat Universit Mohammed V Rabat Morocco

Introduction: The transition period from renal transplantation to dialysis is associated with high morbidity and mortality. The aim of this study is to describe the clinical and paraclinical characteristics, therapeutic management and evolutionary profile of patients returning to dialysis after kidney graft failure. Material and Methods: This was a retrospective, descriptive study conducted in the Nephrology-Dialysis-Renal Transplant Department at university hospital IbnSina between January 1998 and December 2021. We included all renal transplant recipients who had experienced kidney graft dysfunction and returned to dialysis. Patients with a follow-up after return to dialysis of less than 1 year were excluded. Results: Among 166 renal transplant recipients, 20 returned to dialysis after a median renal graft life of 85.5 months [42 - 186], corresponding to a prevalence of 12%. The mean age of our patients was 38.7 ± 11.9 years, with a M/F sex ratio of 2.3. Dialysis was initiated urgently in 10 patients (50%). Hemodialysis was the most commonly used modality (75%). Central venous catheterization was used in 35% of cases, including tunneled catheters. General condition is impaired in all patients, with persistent hypertension in 70% of cases. Mean uremia was 2.35 ± 0.8 g/l, mean creatinine 116 ± 48.3 mg/l, giving a mean GFR of 5.1 ± 2.2 ml/min. Mean albuminemia was 32.9 ± 6 g/l and mean hemoglobinemia 8.6 ± 1.9 g/dl. During the first year of follow-up, none of the patients died. However, 13 patients required hospitalization, with a mean length of stay of 15 days. Eight patients were hospitalized for infections and 5 for renal graft intolerance syndrome. After a mean follow-up of 22 months, 6 patients were detransplanted following graft necrosis. Conclusion: Return to dialysis after RT is fraught with a high rate of complications. The management of these patients must be optimized to improve their vital prognosis and quality of life.

关键词： Kidney Graft Failure Dialysis Detransplantation Immunosuppression

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Partial Fusion (F) Gene Analysis of Newcastle Disease Virus Detected in Pakistan during 2021-2022

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Journal of Biosciences and Medicines 2024年第5期12卷 256-275页

作者： Muhammad Danish Mehmood Huma Anwar Ul-Haq Rauf Khalid Yasir Amin Muhammad Usman Ghani Muhammad Ismail rabia Habib Fareeha Arshed Abdul Rasheed Shaukat Institute of Molecular Biology & Biotechnology University of Lahore Lahore Pakistan Research & Development Division Ottoman Pharma Lahore Pakistan Quality Assurance Department Ottoman Pharma Lahore Pakistan Veterinary Research and Disease Investigation Center Abbottabad Pakistan Quality Control Department Ottoman Pharma Immuno Lahore Pakistan Production Department Ottoman Pharma Lahore Pakistan Poultry Production Department Sabir&#8217s Poultry Pvt. Ltd. Sabroso Pakistan

Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and marks severe gastrointestinal lesions leading to heavy mortality in short-living birds and substantial losses in layers and breeders. The continuous emergence and evolution of the virus made it inclined to evade the humoral response and indirectly the circumvention of artificial active immunization. Newcastle disease is caused by the orthoavula genus of the paramyxoviridae family and has shown high genetic diversity even in their genotypes while information regarding enzootic trends of the virus is scanty in Pakistan. A total of 40 tracheal samples of NDV were collected from different commercial broiler farms and 11 isolates of NDV were identified. In the current study, we determined the genetic diversity of the Newcastle disease virus based on the partial sequencing of the fusion protein gene available in the NCBI database. Genetic analysis showed that seven isolates belonged to class I genotype VII and four belonged to class II genotype II. Interestingly, two isolates had epidemiological connections with vaccine-like class II genotype II. Our findings, concerning the recent outbreaks of class I genotype VII and class II genotype II of NDV in vaccinated commercial flocks, suggest possible potential partial mutations in the fusion protein gene. Genetic diversity and formation of the new cleavage site in an important neutralizing protein of wild strain are linked with the potency of artificial active immunization and a major cause of vaccine failure.

关键词： Newcastle Disease Virus Haemagglutination Inhibition Polymerase Chain Reaction Phylogenetic Tree Mutation Analysis

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Tribological and Electrochemical Corrosion Properties of CNT-Incorporated Plasma Electrolytic Oxidation(PEO)Coatings on AZ80 Magnesium Alloy

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Acta Metallurgica Sinica(English Letters) 2022年第7期35卷 1195-1206页

作者： rabia Kara Huseyin Zengin Department of Metallurgical and Materials Engineering Karabuk University78050 KarabukTurkey

Plasma electrolytic oxidation(PEO)coatings were carried out in silicate-based electrolyte embedded with various amounts of carbon nanotube(CNT)additives(0,0.5,1,2 and 4 g/L)on AZ80 magnesium alloy ***,tribological and electrochemical corrosion properties of the coated specimens were *** results demonstrated that the increasing CNT additions into the electrolyte resulted in a gradual increase in the thickness of PEO-coating *** CNT addition to the electrolyte by 0.5 g/L resulted in a slight decrease in the roughness of PEO-coating above which it continually *** resistance of the PEO-coated specimens showed a gradual improvement with increasing CNT-incorporation within the *** electrochemical corrosion tests revealed that the best corrosion resistance was found after the CNT addition into the electrolyte by 0.5 g/L due to the better roughness values,more homogenous coating layers and less pore formation.

关键词： Coating Electrochemical corrosion Magnesium alloy Plasma electrolytic oxidation(PEO) Wear

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制造企业数字化转型对企业成长性的影响研究

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安徽商贸职业技术学院学报 2024年第2期23卷 7-13页

作者：热比亚·吐尔逊王哲易芯竹新疆财经大学工商管理学院乌鲁木齐830000

以A股上市制造业企业2012—2021年数据为基础,借助Python技术收集上市企业中关于“数字化转型”的关键词,通过实证研究探讨数字化转型对企业成长性的影响及其作用机制。研究表明,数字化转型显著促进企业的成长性,该结论在一系列稳健性... 详细信息

以A股上市制造业企业2012—2021年数据为基础,借助Python技术收集上市企业中关于“数字化转型”的关键词,通过实证研究探讨数字化转型对企业成长性的影响及其作用机制。研究表明,数字化转型显著促进企业的成长性,该结论在一系列稳健性检验的作用下仍然成立。同时,数字化转型对企业成长性的促进作用在非国有和中小型企业中效果更为显著。通过进一步分析发现,企业数字化转型程度的提升,一是能够缓解企业内外部融资约束,二是能够提高企业运营效率,增强企业内部协作,三是促进企业创新。

关键词：数字化转型企业成长融资约束企业运营效率技术创新

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