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Ocular penetration of topically applied 1% tigecycline in a rabbit model

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 679-683页

作者： Yasar Sakarya rabia Sakarya Muammer Ozcimen Sertan Goktas Serap Ozcimen ismail Alpfidan ismail Senol Ivacik Erkan Erdogan Servet Cetinkaya Abdulkadir Bukus Department of Ophthalmology Konya Training and Research Hospital Konya 42090 Turkey Department of Infectious Diseases and Clinical Microbiology Konya State Hospital Konya 42060 Turkey Department of Ophthalmology Konya Kizilay HospitalKonya 42200 Turkey

AIM：To evaluate ocular penetration of topically applied 1% ***：Forty-two New Zealand White rabbits were divided into 3 groups. A 50 μL drop of 1% tigecycline was administered in group 1. In groups 2 and 3, the drop was administered every 15 min for 60min（keratitis protocol）. Aqueous humor samples in groups 1 and 2 were collected under general anesthesia at 15, 30, 45, 60, 120, and 180 min after the last drop. All animals in group 3 were euthanatized. Cornea, vitreous and blood samples were collected 60 and 120 min after the last drop. Tigecycline concentrations were measured using high performance liquid chromatography-mass spectrometry（LC-MS/MS）.RESULTS：The peak aqueous humor tigecycline concentration [mean 0.73±0.14 mg/L（SD） and 2.41±0.14 mg/L, respectively] occurred 45 min after topical drug application in groups 1 and 2. Group 3 mean values in the cornea, and vitreous, were 3.27±0.50 μg/g, and 0.17±0.10 mg/L at 60 min and 3.17±0.77 μg/g and 0.20±0.07 mg/L at 120 min, respectively. Tigecycline serum concentrations were ***：Tigecycline levels in the aqueous humor in groups 1 and 2, and in the cornea in group 3 exceeded the minimum inhibitory concentrations of most grampositive organisms that cause bacterial keratitis and endophthalmitis.

关键词： antibiotic cornea pharmacokinetics aqueoushumor rabbit eyes

Emotion processing in Parkinson's disease: a blood oxygenation level-dependent functional magnetic resonance imaging study

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Neural Regeneration Research 2019年第4期14卷 666-672页

作者： Mohammed Benzagmout Sa?d Boujraf Badreeddine Alami Hassane Ali Amadou Halima El Hamdaoui Amine Bennani Mounir Jaafari ismail Rammouz Mustapha Maaroufi rabia Magoul Driss Boussaoud Laboratory of Clinical Neuroscience Faculty of Medicine Department of Neurosurgery University Hospital of Fez Laboratory of Neuroendocrinology and Nutritional and Climatic Environment Faculty of Sciences Dhar El Mahraz Department of Biophysics and Clinical MRI Methods Faculty of Medicine Department of Radiology and Clinical Imaging University Hospital of Fez Department of Psychiatry University Hospital of Fez Aix Marseille Université INSERM INS Institut de Neurosciences des Systèmes

Parkinson's disease is a neurodegenerative disorder caused by loss of dopamine neurons in the substantia nigra pars compacta. Tremor, rigidity, and bradykinesia are the major symptoms of the disease. These motor impairments are often accompanied by affective and emotional dysfunctions which have been largely studied over the last decade. The aim of this study was to investigate emotional processing organization in the brain of patients with Parkinson's disease and to explore whether there are differences between recognition of different types of emotions in Parkinson's disease. We examined 18 patients with Parkinson's disease(8 men, 10 women) with no history of neurological or psychiatric comorbidities. All these patients underwent identical brain blood oxygenation level-dependent functional magnetic resonance imaging for emotion evaluation. Blood oxygenation level-dependent functional magnetic resonance imaging results revealed that the occipito-temporal cortices, insula, orbitofrontal cortex, basal ganglia, and parietal cortex which are involved in emotion processing, were activated during the functional control. Additionally, positive emotions activate larger volumes of the same anatomical entities than neutral and negative emotions. Results also revealed that Parkinson's disease associated with emotional disorders are increasingly recognized as disabling as classic motor symptoms. These findings help clinical physicians to recognize the emotional dysfunction of patients with Parkinson's disease.

关键词： Parkinson’s disease emotion processing Blood oxygenation level-dependent functional magnetic resonance imaging brain activation dopamine neural regeneration

Adaptation of Federated Explainable Artificial Intelligence for Efficient and Secure E-Healthcare Systems

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Computers, Materials & Continua 2024年第3期78卷 3413-3429页

作者： rabia Abid Muhammad Rizwan Abdulatif Alabdulatif Abdullah Alnajim Meznah Alamro Mourade Azrour Department of Computer Science Kinnaird College for WomenLahorePakistan College of Science and Engineering University of DerbyDerbyDE221GBUK Department of Computer Science College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Information Technology College of ComputerQassim UniversityBuraydah51452Saudi Arabia Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia STI Laboratory IDMS TeamFaculty of Sciences and TechniquesMoulay Ismail University of MeknèsMeknesMorocco

Explainable Artificial Intelligence(XAI)has an advanced feature to enhance the decision-making feature and improve the rule-based technique by using more advanced Machine Learning(ML)and Deep Learning(DL)based *** this paper,we chose e-healthcare systems for efficient decision-making and data classification,especially in data security,data handling,diagnostics,laboratories,and *** Machine Learning(FML)is a new and advanced technology that helps to maintain privacy for Personal Health Records(PHR)and handle a large amount of medical data *** this context,XAI,along with FML,increases efficiency and improves the security of e-healthcare *** experiments show efficient system performance by implementing a federated averaging algorithm on an open-source Federated Learning(FL)*** experimental evaluation demonstrates the accuracy rate by taking epochs size 5,batch size 16,and the number of clients 5,which shows a higher accuracy rate(19,104).We conclude the paper by discussing the existing gaps and future work in an e-healthcare system.

关键词： Artificial intelligence data privacy federated machine learning healthcare system security

Climate Change Impact on Sub-Surface Hydrology of Kaduna River Catchment

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Open Journal of Modern Hydrology 2013年第3期3卷 115-121页

作者： Haruna Garba Abubakar ismail rabia Lawal Batagarawa Saminu Ahmed Abdullahi Ibrahim Faustinus Bayang Department of Civil Engineering Nigerian Defence Academy Kaduna Nigeria Department of Water Resources and Environmental Engineering Ahmadu Bello University Zaria Nigeria.

This paper applied the use of a stochastic weather generator at the site of a hydrological model to simulate the impact of climate change on the sub-surface hydrological response of Kaduna River as a basis for a sustainable ground water development plan. Average time series of rainfall, temperature and gauge height observed readings were downscaled to the watershed flow volume and applied as forcing to simulate the ground water response as spatially lumped, ignoring the heterogeneous nature of the ground water aquifer. Future simulations indicate increase in base flow, ground storage and decrease soil storage throughout the summer and autumn months for the catchment.

关键词： Climate Change Simulation Ground Storage Soil Storage Base Flow

Partial Fusion (F) Gene Analysis of Newcastle Disease Virus Detected in Pakistan during 2021-2022

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Journal of Biosciences and Medicines 2024年第5期12卷 256-275页

作者： Muhammad Danish Mehmood Huma Anwar Ul-Haq Rauf Khalid Yasir Amin Muhammad Usman Ghani Muhammad ismail rabia Habib Fareeha Arshed Abdul Rasheed Shaukat Institute of Molecular Biology & Biotechnology University of Lahore Lahore Pakistan Research & Development Division Ottoman Pharma Lahore Pakistan Quality Assurance Department Ottoman Pharma Lahore Pakistan Veterinary Research and Disease Investigation Center Abbottabad Pakistan Quality Control Department Ottoman Pharma Immuno Lahore Pakistan Production Department Ottoman Pharma Lahore Pakistan Poultry Production Department Sabir&#8217s Poultry Pvt. Ltd. Sabroso Pakistan

Newcastle disease (ND) virus is a leading threat to commercial and domestic poultry in Pakistan. The virus infects and constitutes irreversible impairment to the nervous system, damages the respiratory system, and marks severe gastrointestinal lesions leading to heavy mortality in short-living birds and substantial losses in layers and breeders. The continuous emergence and evolution of the virus made it inclined to evade the humoral response and indirectly the circumvention of artificial active immunization. Newcastle disease is caused by the orthoavula genus of the paramyxoviridae family and has shown high genetic diversity even in their genotypes while information regarding enzootic trends of the virus is scanty in Pakistan. A total of 40 tracheal samples of NDV were collected from different commercial broiler farms and 11 isolates of NDV were identified. In the current study, we determined the genetic diversity of the Newcastle disease virus based on the partial sequencing of the fusion protein gene available in the NCBI database. Genetic analysis showed that seven isolates belonged to class I genotype VII and four belonged to class II genotype II. Interestingly, two isolates had epidemiological connections with vaccine-like class II genotype II. Our findings, concerning the recent outbreaks of class I genotype VII and class II genotype II of NDV in vaccinated commercial flocks, suggest possible potential partial mutations in the fusion protein gene. Genetic diversity and formation of the new cleavage site in an important neutralizing protein of wild strain are linked with the potency of artificial active immunization and a major cause of vaccine failure.

关键词： Newcastle Disease Virus Haemagglutination Inhibition Polymerase Chain Reaction Phylogenetic Tree Mutation Analysis