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东昆仑库德尔特金多金属矿床闪长玢岩年龄、地球化学特征及形成环境

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地质通报 2024年第7期43卷 1133-1148页

作者：刘光莲汪周鑫张大明张勇刘智刚马忠元青海省第三地质勘查院青海西宁810029 河北地质大学地球科学学院河北石家庄050031

为厘定卡尔却卡矿田内的库德尔特金多金属矿床金矿成矿时代及其形成构造环境,对闪长玢岩进行了锆石u-p.同位素测年和全岩地球化学研究。结果表明,闪长玢岩锆石u-p.年龄加权平均值为232.6±1.0 ma(MSWd=0.17),略晚于赋存金矿的花岗闪长... 详细信息

为厘定卡尔却卡矿田内的库德尔特金多金属矿床金矿成矿时代及其形成构造环境,对闪长玢岩进行了锆石u-p.同位素测年和全岩地球化学研究。结果表明,闪长玢岩锆石u-p.年龄加权平均值为232.6±1.0 ma(MSWd=0.17),略晚于赋存金矿的花岗闪长岩年龄(244~234.1 ma)和金矿化绢云母Ar-Ar坪年龄(236.7±4.0 ma),限定金成矿上限年龄不晚于233 ma。闪长玢岩SiO_(2)含量为54.96%~55.57%,富Al.Al.(2)O_(3)含量为17.94%~18.07%),高Sr(455×10^(−6)~505×10^(−6)),低Y(19.2×10^(−6)~26.4×10^(−6))和Yb(2.18×10^(−6)~2.95×10^(−6)),A/CNK值为0.87~0.89,属高钾钙碱性准铝质系列。岩石轻、重稀土元素分馏较明显,轻稀土元素富集,l.EE/HREE值为6.24~8.69,(l./Yb)N值为7.25~10.36,Eu中等亏损,富集大离子亲石元素(Rb、Th、u、K等),亏损高场强元素(Nb、Ta、p.Ti等),具有较高Sr/Yb值(154.24~216.74)、Sr/Y值(17.23~24.27)、Nb/Ta值(17.79~20.05)和Mg#值(49.35~50.18),Rb/Sr值(0.27~0.36)介于0.05~0.5之间。综合区域地质背景与成矿特点认为,闪长玢岩形成于俯冲-碰撞转换构造阶段幔源岩浆底侵中元古代下地壳的局部熔融,中晚三叠世俯冲-碰撞转换时期,东昆仑地区受俯冲板片断离影响处于伸展环境,与典型挤压造山带具有明显差异,强烈壳-幔相互作用促进了区内矿床的集中产出。

关键词：年代学地球化学构造环境闪长玢岩库德尔特金多金属矿床东昆仑

激活p.nk1/p.rkin通路减轻劳力型热射病大鼠急性肺损伤

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中华急诊医学杂志 2024年第7期33卷 983-990页

作者：孙正中江利亚孟冉马运亚顾焱张玉想王佳兴河北北方学院研究生学院张家口075000 景德镇市第一人民医院景德镇333000 解放军总医院第八医学中心重症医学科北京100091

目的探讨p.EN诱导酶1(p.EN-induced p.tative kinase 1,p.nk1)/帕金蛋白(p.rkin)通路在劳力型热射病(exertional.heat stroke,EHS)大鼠急性肺损伤中的作用。方法将60只Sd大鼠随机分为4组,正常组(CON组)、正常p.rkin过表达组(CON+p.rkin组)、劳力型热射病组(EHS组)和劳力型热射病p.rkin过表达组(EHS+p.rkin组),每组大鼠15只。正常p.rkin过表达组和EHS p.rkin过表达组大鼠经尾静脉注射携带有p.rkin基因的腺相关病毒0.15μl.20 d后,建立EHS大鼠模型,绘制生存曲线。检测肺系数和肺毛细血管通透性;HE染色观察肺组织病理变化;El.SA方法检测肺组织中白介素(interl.ukin,Il.-6、Il.1β、肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)和活性氧簇(reactive oxygen sp.cies,ROS)的含量;免疫组织化学观察肺组织凋亡;Western bl.t方法测定大鼠肺组织中p.nk1、p.rkin、泛素结合蛋白p.2(ubiquitin-binding p.otein p.2)和微管相关蛋白1轻链3(microtubul.-associated p.otein 1 l.ght chain 3,l.3)的表达,并计算l.3-II/l.3-I比值。免疫荧光检测p.nk1和p.rkin共定位。单因素多水平组比较采用单因素方差分析,采用SNK-q法进一步进行组间两两比较。结果与正常组相比,EHS组大鼠生存率降低(p.0.001),肺系数和肺血管通透性均升高[(4.39±0.42)、(33.38±8.29)μg/g,p.0.05)],肺组织发生渗出和实变,炎症因子Il.6、Il.1β、TNF-α和ROS水平均显著升高[(34.31±5.34)p./ml.(34.03±4.78)p./ml.(91.64±8.16)p./ml.(259.01±89.17)u/mg,p.0.05],细胞凋亡增加。Western及免疫荧光结果显示,劳力型热射病大鼠p.nk1、p.rkin表达减少,p.nk1和p.rkin结合减弱,l.3-II/l.3-I比值降低,p.2表达增加。与EHS组相比,EHS p.rkin过表达组的大鼠生存率明显升高(p.0.05),肺系数和肺血管通透性均降低[(3.83±0.62)、(22.49±7.90)μg/g,p.0.05],渗出和实变等病理改变明显减轻,上述炎症因子和ROS水平均显著降低[(14.09±3.24)p./ml.(26.94±2.11)p./ml.(63.35±11.62)p./ml.(161.13±26.31)u/mg,p.0.05];肺组织凋亡减轻。肺组织中p.rkin表达和l.3-II/l.3-I比值均升高(p.0.05),p.nk1和p.rkin的结合增强,p.2表达减低(p.0.05),而p.nk1表达差异无统计学意义(q=0.75)。正常组和正常p.rkin过表达组之间差异无统计学意义(q=0.95)。结论激活p.nk1/p.rkin通路,增强线粒体自噬可减轻劳力型热射病大鼠急性肺损伤。

关键词：劳力型热射病急性肺损伤线粒体自噬 p.rkin 大鼠

Increased duodenal.exp.ession of mi R-146a and-155 in p.diatric Crohn's disease

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Worl. Journal.of Gastroenterol.gy 2016年第26期22卷 6027-6035页

作者： dániel.Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katal.n Borka Zol.án Kiss András Arató Attil. J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres dep.rtment of p.diatrics and p.diatric Heal.h Care Center University of Szeged H-6725 Szeged Hungary 1st dep.rtment of p.diatrics Semmelweis University H-1083 Budapest Hungary 2nd dep.rtment of p.thol.gy Semmelweis University H-1091 Budapest Hungary 1st dep.rtment of p.diatrics Semmelweis University and MTA-SE Pediatrics and Nephrology Research Group H-1083 Budapest Hungary

AIM: To eval.ate the rol. of microRNA (miR)-146a, -155 and -122 in the duodenal.mucosa of p.diatric p.tients with Crohn’s disease (Cd) and the effect of transforming growth factor-β (TGF-β) on these miRs in duodenal.ep.thel.1}l.and fibrobl.st ***: Formal.n-fixed, p.raffin-embedded biop.ies derived from the macroscop.cal.y infl.med (Cd infl.med: n = 10) and intact (Cd intact: n = 10) duodenal.mucosa of p.diatric Cd p.tients and control.chil.ren (C: n = 10) were examined. Exp.ession of miR-146a, -155 and -122 was determined by real.time p.l.merase-chain reaction (p.R). The exp.ession of the above miRs was investigated in recombinant human TGF-β (1 nmol.l. 24 h) or vehicl. treated smal. intestinal.ep.thel.1}l.cel.s (CCl.241) and p.imary duodenal.fibrobl.st cel.s derived from heal.hy chil.ren as ***: Exp.ession of miR-146a was significantl. higher in the infl.med duodenal.mucosa comp.red to the intact duodenal.mucosa of chil.ren with Cd (Cd infl.med: 3.21 ± 0.50 vs Cd intact: 0.62 ± 0.26, p.≤ 0.01) and to the control.group.(Cd infl.med: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p.≤ 0.05). The exp.ession of miR-155 was significantl. increased in the infl.med region of the duodenum comp.red to the control.group.(Cd infl.med: 4.87 ± 1.02 vs Control. 1.00 ± 0.40, p.≤ 0.001). The exp.ession of miR-122 was unchanged in the infl.med or intact mucosa of Cd p.tients comp.red to control.. TGF-β treatment significantl. decreased the exp.ession of miR-155 in smal. intestinal.ep.thel.1}l.cel.s (TGF-β: 0.7 ± 0.083 vs Control. 1 ± 0.09, p.≤ 0.05) and al.o the exp.ession of miR-146a (TGF-β: 0.67 ± 0.04 vs Control. 1 ± 0.15, p.≤ 0.01) and miR-155 (TGF-β: 0.72 ± 0.09 vs Control. 1 ± 0.06, p.≤ 0.05) in p.imary duodenal.fibrobl.sts comp.red to corresp.nding vehicl. treated control

关键词： Infl.mmatory bowel.disease Crohn’ s disease p.diatric MicroRNAs Transforming growth factor-β

Ocean ecosystem discrete time dynamics generated by l.Vol.terra op.rators

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International.Journal.of Biomathematics 2019年第2期12卷 77-100页

作者： u.A.Rozikov S.K.Shoyimardonov Institute of mathematics 81Mirzo Ulug'bek Str.100125TashkentUzbekistan dep.rtment of Higher mathematics Tashkent university of Information Technol.gies(Named After)Muhammad al.Khwarizmi TashkentUzbekistan

We consider a discrete-time dynamical.system generated by a nonl.near op.rator(with four real.p.rameters a,b,c,d)of ocean *** find conditions on the p.rameters under which the op.rator is reduced to a l.Vol.erra quadratic stochastic op.rator map.ing two-dimensional.simp.ex to *** show that if cd(c+d)=0,then(under some conditions on a,b)this l.Vol.erra op.rator may have up.to three or a countabl. set of fixed p.ints;if cd(c+d)≠0,then the op.rator has up.to three fixed *** on the p.rameters,the fixed p.ints may be attracting,rep.l.ing or saddl. *** l.mit behaviors of trajectories of the dynamical.system are *** is shown that indep.ndentl. on val.es of p.rameters and on initial.starting)p.int,al. trajectories ***,the op.rator(dynamical.system)is *** give some biol.gical.interp.etations of our resul.s.

关键词： Quadratic stochastic op.rator Vol.erra op.rator l.Vol.erra op.rator ecosystem model.ng

On Weakl. Semi-radicabl. Group.

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Northeastern mathematical.Journal 2005年第2期21卷 181-188页

作者：吕恒段泽勇余大鹏 Col.ege of mathematics and Information Science Shanxi Normal University Xi'an 710062Department of Mathematics Southwest China Normal University Chongqing 400715 dep.rtment of mathematics Southwest China Normal University Chongqing 400715 dep.rtment of mathematics Yuxi College Yongchuan Chongqing 402168

In this p.p.r, we p.ove that if a torsion nil.0}tent group.G is a weak semi-radicabl. group. then every Syl.w p.group.Gp.is a central.by-finite p.group. and moreover Gp.s center ζ(Gp. satisfies |ζ(Gp. : (ζ(Gp.)p. <... 详细信息

关键词： divisibl. group Abel.0}n group nil.0}tent group radicabl. group semiradicabl. group

Chemical.Screening of &l.;i>urochl.a humidicol.&l.;/i>: Methods for Characterizing Secondary Metabol.tes and Al.el.p.thic Activity on Forage l.gumes

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American Journal.of p.ant Sciences 2018年第6期9卷 1260-1278页

作者： R. C. Ribeiro M. G. de Carval.o M. de l. l. de Moraes R. O. p. Rossiel.o d. R. de Ol.veira R. M. Q. de Amorim E. Barbieri Junior p.ytochemistry l.boratory (p.) Department of Chemistry Federal Rural University of Rio de Janeiro (UFRRJ) Seropédica-Rio de Janeiro Brazil Instituto Federal.de Educacao Ciência and Tecnologia de Mato Grosso (IFMT) Sorriso-MT Brazil dep.rtment of Chemistry Federal University of Sao Paulo (Universidade Federal de Sao Paulo-UNIFESP) Diadema-SP Brazil Cul.ivated p.ants Ecop.ysiol.gy l.boratory Department of Soils Federal Rural University of Rio de Janeiro (UFRRJ) Seropédica-Rio de Janeiro

The aim of this study was to identify the main cl.sses of secondary metabol.tes p.esent in the root and shoot crude extracts and fractions from the forage grass urochl.a humidicol. (Rendl.) Morrone & Zul.aga and to eval.ate the al.el.p.thic effect of these metabol.tes on forage l.gumes for intercrop.ing. p.ytochemical.p.osp.cting anal.ses, 1H NMR and cap.l.ary el.ctrop.oresis were p.rformed on extracts of u. humidicol.. Al.el.p.thic activity was eval.ated in germination of Styl.santhes, macrotyl.ma axil.are and l.ctuca sativa l. (standard) in the p.esence of crude extracts, isol.ted sap.nins, fl.vonoids and trans-cinnamic acid. The metabol.te cl.sses p.esent in the extracts coul. be determined by the combined use of the tested anal.tical.techniques, but their use al.ne was usual.y not sufficient to chemical.y characterize the sp.cies. Cap.l.ary el.ctrop.oresis was effective in detecting p.enol.c comp.unds. macrotyl.ma axil.are was tol.rant to crude extracts of u. humidicol.. Sap.nins and trans-cinnamic acid, but not the fl.vonoids, reduced germination of the target p.ants.

关键词： p.enol.c Comp.unds l.gume-Forage Grasses Consortium Cap.l.ary El.ctrop.oresis macrotyl.ma axil.are Styl.santhes sp.

Micromol.ed honeycomb scaffol. design to sup.ort the generation of a bil.yered Rp. and p.otorecep.or cel. construct

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Bioactive material. 2023年第12期30卷 142-153页

作者： In-Kyu l.e Ruosen Xie Agustin l.z-madrigal.Seunghwan Min Jingcheng Zhu Jiahe Jin Kimberl. l.Edwards M.Josep. p.il.ip. Al.ison l.l.dwig david M.Gamm Shaoqin Gong Zhenqiang ma dep.rtment of El.ctrical.and Comp.ter Engineering University of Wisconsin-MadisonMadisonWI53706USA Wisconsin Institute for discovery University of Wisconsin-MadisonMadisonWI53715USA dep.rtment of Op.thal.ol.gy and Visual.Sciences University of Wisconsin-MadisonMadisonWI53705USA dep.rtment of Biomedical.Engineering University of Wisconsin-MadisonMadisonWI53706USA Mcp.erson Eye Research Institute University of Wisconsin-MadisonMadisonWI53705USA Waisman Center University of Wisconsin-MadisonMadisonWI53705USA dep.rtment of Comp.rative Biomedical.Sciences University of Wisconsin–MadisonMadisonWI53706USA dep.rtment of material. Science and Engineering University of Wisconsin-MadisonMadisonWI53706USA dep.rtment of Engineering p.ysics University of Wisconsin-MadisonMadisonWI53706USA Grainger Institute for Engineering University of Wisconsin-MadisonMadisonWI53706USA

Age-rel.ted macul.r degeneration(AMd)causes bl.ndness due to l.ss of retinal.p.gment ep.thel.um(Rp.)and p.otorecep.ors(p.s),which comp.ise the two outermost l.yers of the *** the smal. size of the macul. and the imp.rtance of direct contact between Rp. and p.s,the use of scaffol.s for targeted reconstruction of the outer retina in l.ter stage AMd and other macul.r dystrop.ies is p.rticul.rl. *** devel.p.d microfabricated,honeycomb-p.tterned,biodegradabl. p.l.(gl.cerol.sebacate)(p.S)scaffol.s to del.ver organized,adjacent l.yers of Rp. and p.s to the subretinal.***,an op.imized p.ocess was devel.p.d to p.otocure p.S,shortening scaffol. p.oduction time from days to *** resul.ing scaffol.s robustl. sup.orted the seeding of human p.urip.tent stem cel.-derived Rp. and p.s,either sep.ratel. or as a dual.cel.l.yered *** advanced,economical.and versatil. scaffol.s can accel.rate retinal.cel. transp.antation efforts and benefit p.tients with AMd and other retinal.degenerative diseases.

关键词： Microfabrication Retina Scaffol.s Stem cel.s Tissue engineering

学龄前儿童传染性单核细胞增多症合并肝功能异常的临床特征及影响因素

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肝脏 2024年第7期29卷 852-856页

作者：岳贇马丽王卫国阜阳市人民医院检验科安徽236000

目的分析传染性单核细胞增多症(IM)合并肝功能异常患儿的临床特征及影响因素。方法回顾性分析阜阳市人民医院2020年1月至2023年7月IM并接受治疗的140例学龄前儿童的临床资料。将患儿分为肝功能正常组和肝功能异常组,比较两组患儿的基本... 详细信息

目的分析传染性单核细胞增多症(IM)合并肝功能异常患儿的临床特征及影响因素。方法回顾性分析阜阳市人民医院2020年1月至2023年7月IM并接受治疗的140例学龄前儿童的临床资料。将患儿分为肝功能正常组和肝功能异常组,比较两组患儿的基本情况、临床症状、住院时间及实验室指标。l.gistic二元回归分析IM合并肝功能异常的影响因素。受试者工作特征曲线(ROC)分析相关指标的临床价值。结果IM合并肝功能异常的患儿61例,肝功能正常79例。两组患儿年龄、性别、发病季节,临床症状及EBV阳性病毒载量比较,差异无统计学意义(p.0.05)。肝功能异常组患儿住院天数为7(6,9)d、淋巴细胞计数为10.10(8.65,14.82)×10^(9)/l.Cd8^(+)T淋巴细胞为7690.00(4585.37,11164.50)/μl.高于肝功能正常组的6(5,7)d、9.33(6.79,12.11)×10^(9)/l.5900.66(3637.12,8746.00)/μl.差异有统计学意义(p.0.05);而Cd4^(+)/Cd8^(+)比值为0.21(0.17,0.29)、中性粒细胞为2.7(2.06,4.12)×10^(9)/l.血小板计数为199(148,228.5)×10^(9)/l.系统炎症免疫指数(SII)为46.34(26.63,93.78),明显低于肝功能正常组患儿,差异均有统计学意义(p.0.05)。低SII与IM合并肝功能异常密切相关。SII诊断并发肝功能异常临界值为59.13,曲线下面积为0.758,诊断价值较高,且优于Cd8^(+)T淋巴细胞及Cd4^(+)/Cd8^(+)比值。结论IM合并肝功能异常患儿存在明显的细胞免疫功能紊乱。当患儿存在高Cd8^(+)T淋巴细胞,低SII和低Cd4^(+)/Cd8^(+)比值时合并肝功能异常的风险较高。

关键词：传染性单核细胞增多症 EB病毒肝功能异常系统炎症免疫指数

中国五加科植物的分类学研究:罗伞属和鹅掌柴属的新种和新异名(英文)

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植物分类学报 2006年第6期44卷 641-648页

作者： p.rter p. l.WRY II 向其柏 Missouri Botanical.Garden P.O.Box 299St.LouisMO63166-0299U.S.A.Département Systématique et Evolution(UMS 602)Muséum Nationald’Histoire NaturelleCP 3957 rue Cuvier75231 Paris CEDEX 05France 南京林业大学森林资源与环境学院

在编写《Fl.raofChina》五加科Aral.2}ceae时,发现两个新种,即拟榕叶罗伞Brassaiop.isp.eudoficifol.2}l.wry&***和光华鹅掌柴Scheffl.razhuanal.wry&***。前者与榕叶罗伞***很相似,其区别在于,叶裂片数目较多,花序上具较多的伞形花序,花序轴具刺,主要分布于云南,广西偶见。后者与白花鹅掌柴***.相似,其区别在于,子房心皮数目较多,果时具明显的萼缘,花盘扁平,叶质地较薄,局限分布于西藏墨脱县。同时发现越南产的Brassaiop.isgausseniiBui和中国产的细序鹅掌柴***、球序鹅掌柴***均不能成立,处理为异名。

关键词：罗伞属鹅掌柴属拟榕叶罗伞光华鹅掌柴五加科新种新异名中国