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IRE1-raCK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver

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Journal of Molecular Cell Biology 2016年第2期8卷 144-156页

作者： Dong liu Xing liu ti Zhou William Yao Jun Zhao Zhigang Zheng Wei Jiang Fengsong Wang Felix O.Aikhionbare Donald l.Hill Nerimah Emmett Zhen Guo Dongmei Wang Xuebiao Yao Yong Chen Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Anhui Key laboratory of Cellular Dynamics and Hefei National laboratory for Physical Sciences at Nanoscale Hefei 230027China Atlanta Clinical&Translational Science Institute AtlantaGA 30310USA Department of Pathology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Biochemistry Anhui Medical UniversityHefei 230027China Comprehensive Cancer Center University of Alabama at BirminghamBirminghamAL 35294USA Department of Hepatobiliary Surgery Navy General HospitalBeijing 100048China

Endoplasmic reticulum(ER)stress is involved in ischemic preconditioning that protects various organs from ischemia/reperfusion(I/R)*** established an in vivo ER stress preconditioning model in which tunicamycin was injected into rats before hepatic I/*** hepatic I/R injury,demonstrated by serum aminotransferase level and the ultra-structure of the liver,was alleviated by administration of tunicamycin,which induced ER stress in rat liver by activating inositol-requiring enzyme1(IRE1)andupregulating78 kDaglucose-regulated protein(GRP78).The proteomic identification for IRE1 binders revealed interaction and cooperation among receptor for activated C kinase 1(raCK1),phosphorylated AMPK,and IRE1 under ER stress conditions in a spatiotemporal ***,in vitro ER stress preconditioningwas induced by thapsigargin and tunicamycin in l02 and Hep G2 ***,BCl2 was found to bephosphorylated by IRE1 under ER stress conditions to prevent apoptotic process by activation of *** conclusion,ER stress preconditioning protects against hepatic I/R injury,which is orchestrated by IRE1-raCK1 axis through the activation of *** findings provide novel insights into the molecular pathways underlying ER stress preconditioning-elicited cytoprotective effect against hepatic I/R injury.

关键词： IRE1 raCK1 AMPK BCl2 ER stress preconditioning ischemia/reperfusion injury

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Physico-Chemical and Microbiological Analysis of Water of the “Presa De los Patos” in the Desierto De los leones National Park, Mexico

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Advances in Biological Chemistry 2017年第2期7卷 122-138页

作者： luis ra.l Gutiérrez-lucas luz María Chávez-ramírez leticia Arregui Departamento de Ciencias Naturales DCNI Universidad Aut&oacute noma Metropolitana Unidad Cuajimalpa M&eacute xico City M&eacute xico Secretarí a de Salud Centro de Salud TI Memetla M&eacute xico City M&eacute xico

The Desierto de los leones National Park is a place that features recreational activities for residents and visitors to Mexico City. The Presa de los Patos (Ducks Dam) is one of the many bodies of water that are present in the park. By means of physico-chemical and microbiological analysis, it was determined that the water of the Presa de los Patos cannot be considered potable. The pH range was between 5.5 - 5.9. The turbidity exceeded the values established in the standards (10.7 - 32.3 Nephelometric Turbidity Units (NTU’s)). Chemical Oxygen Demand (COD) showed that large amounts of oxygen are needed to oxidize organic matter (106 - 450 mg/l). The amount of coliforms and fecal coliforms exceeds the values established by the standards used (total coliforms 98 - 956 Colony Forming Units (CFU’s), fecal coliforms 78 - 807 CFU’s). Five bacterial genera (Escherichia coli, Pseudomona, Klebsiella, Shigella and Salmonella) were isolated and identified. Most of the bacteria isolated were resistant to ampicillin (90%), while 25% were resistant to ciprofloxacin. The water consumption of the Presa de los Patos is a great risk for the habitants and visitors of the park.

关键词： Water Physico-Chemical Microbiological Antimicrobial Resistance Antibiotics

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Numerical Study of Mixed Convection in a Photovoltaic Trombe Wall Channel Coupled with a Solar Chimney Integrated into a Building for Habitats Passive Cooling

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Open Journal of Applied Sciences 2020年第12期10卷 844-863页

作者： Yawovi Nougbléga Koffi Sagna Hodo-Abalo Samah Kodjo Kpode laboratoire Sur l’Energie Solaire /Groupe Phénomène de Transfert et Energétique Université de Lomé Lomé Togo laboratoire Sur l’Energie Solaire/Chaire UNESCO sur les Energies Renouvelables Université de Lomé Lomé Togo Département de Physique Université de Kara Kara Togo

The solar chimney can generate airflow through the living space of the building to provide cooling. Hence, solar energy represents the best renewable, environmentally friendly source of energy that can be used for heating and cooling of houses. The present paper reports the numerical study of the performance of the mixed convection in the associated hybrid Photovoltaic/Thermal chimneys integrated into building for natural habitat ventilation. The front side glass plate of the chimneys is heated by a non-uniform daily solar radiation flux. Air is considered to be the cooling fluid. The stream fucntion-vorticity formulation with a finite difference numerical discretization solution scheme has been adopted. The system of algebraic governing equations is solved by Thomas algorithm method. The aim of the present paper is to study and to predict the dynamic fields and particularly of the mass flow rate of the air thermosiphon drawing in the associated hybrid Photovoltaic-Thermal chimneys integrated into a building for passive cooling in the habitats. The effects of the governing parameters, namely Reynolds number (30 ≤ Re ≤ 200), ra.leigh number (103 ≤ ra≤ 105), the integrated chimney width on the fluid flow and the heat transfer characteristics, are studied in detail. The local Nusselt number, streamlines, isotherms, Pv cells electrical efficiency and the outlet velocity at the top of the channels are the results represented versus the above controlling parameters.

关键词： Trombe Wall Passive Cooling Associated Chimneys Electrical Efficiency Thermal Comfort

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Alteration Typology and Geochemical Signatures of the Napélépéra Gold-Bearing Granodiorite in South-West Burkina Faso (West Africa)

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Open Journal of Geology 2023年第10期13卷 1162-1175页

作者： Théophile Ouédraogo Sâga Sawadogo Hermann Ilboudo Séta Naba laboratoire Géosciences et Environnement (laGE) Département des Sciences de la Terre Université Joseph KI-ZERBO Ouagadougou Burkina Faso

The characterization of the relationships between mineralization and hydrothermal alteration is an essential element in understanding gold deposits. In south-west Burkina Faso, the Napélépéra mineralisation, the mobility of chemical elements and alteration-mineralization relationships were studied by means of selected core drilling and geochemical analyses using ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and ICP-AES (Inductively coupled plasma atomic emission spectroscopy). The mineralised granodiorite is grey porphyroid with quartz, plagioclase, biotite and amphibole. It is metaluminous and located in the tholeiitic series. The Na2O + CaO versus Fe2O3 + MgO alteration diagram divides the samples according to alteration dominance. Chloritisation and carbonation are the main alterations. There is a relationship between gold mineralisation at Napélépéra and alteration, and the paragenesis of gold + pyrite ± carbonate ± silica ± sericite is the main characteristic. Carbonation is the result of fluid input in the shear corridor of the mineralised zone. The mass balance of comparative metals in the proximal and distal zones of the mineralisation shows the absence of metals, while As, Hg, Ag and Bi are strongly enriched from the distal zone to the mineralised zone. The oxides associated with the mineralisation are mainly NaO, SrO and CaO.

关键词： Gold Mineralization Alteration Mass Balance Granodiorite

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集成gaSA混合学习策略的BP神经网络优化研究

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西南大学学报（自然科学版） 2007年第7期29卷 168-171页

作者：汪璇谢德体吕家恪武伟西南大学计算机与信息科学学院重庆400716 重庆市数字农业重点实验室重庆400716 西南大学计算机与信息科学学院重庆400716

针对BP算法易于陷入局部极小值且收敛速度慢的缺陷,在BP神经网络训练过程中集合ga并行化群体搜索的特点和SA在局部极小处发生概率突跳的特性.基于gaSA混合学习策略对BP神经网络进行优化.优化后的BP神经网络被应用在农作物虫情预测中,实... 详细信息

针对BP算法易于陷入局部极小值且收敛速度慢的缺陷,在BP神经网络训练过程中集合ga并行化群体搜索的特点和SA在局部极小处发生概率突跳的特性.基于gaSA混合学习策略对BP神经网络进行优化.优化后的BP神经网络被应用在农作物虫情预测中,实验结果表明能够较大幅度提高网络学习的收敛性能和收敛速度,并一定程度上减少了算法的复杂性.

关键词：遗传算法(ga) 模拟退火算法(SA) 混合学习策略 BP神经网络

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鸡西矿区矸石山基质改良研究

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水土保持学报 2008年第5期22卷 134-137,216页

作者：王笑峰蔡体久东北林业大学林学院黑龙江哈尔滨150040 黑龙江大学水利电力学院黑龙江哈尔滨150086

以黑龙江省鸡西煤矿区为研究区,利用鸡西本地河道清淤土和电厂粉煤灰两种固体废弃物作为改良剂进行矸石山基质改良研究。结果表明:改良后基质的pH值平均由对照的8.26下降到6.90;饱和含水率平均比对照提高了59.84%,持水时间比对照延长了1... 详细信息

以黑龙江省鸡西煤矿区为研究区,利用鸡西本地河道清淤土和电厂粉煤灰两种固体废弃物作为改良剂进行矸石山基质改良研究。结果表明:改良后基质的pH值平均由对照的8.26下降到6.90;饱和含水率平均比对照提高了59.84%,持水时间比对照延长了11.5 d;速效氮含量达到316.05 mg/kg,比对照提高了4.38倍;速效磷含量达到24.224 mg/kg,比对照提高了43.53倍;对家榆、紫穗槐、紫花苜蓿的高生长、地径生长和冠幅增长等都有显著的促进作用。利用河道清淤土和电厂粉煤灰联合配施具有良好的基质改良效果,为东北地区矸石山基质改良提供了一条有效途径,也为固体废弃物合理再利用提出新的途径。

关键词：矸石山基质改良粉煤灰清淤土

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高寒山区采矿迹地植被恢复研究

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水土保持学报 2014年第3期28卷 29-36页

作者：谷金锋蔡体久杨业东北林业大学林学院哈尔滨150040 黑龙江科技大学哈尔滨150022

以漠河县胭脂沟金矿和古莲河露天煤矿为例对高寒山区典型采矿迹地进行植被恢复研究。通过对两处采矿迹地进行本底调查、基质重构、整地和植被恢复模式设计与试验,结果表明,金矿尾矿库经多次筛淘,细颗粒沙土已经被洗尽,土壤偏酸性,有机... 详细信息

以漠河县胭脂沟金矿和古莲河露天煤矿为例对高寒山区典型采矿迹地进行植被恢复研究。通过对两处采矿迹地进行本底调查、基质重构、整地和植被恢复模式设计与试验,结果表明,金矿尾矿库经多次筛淘,细颗粒沙土已经被洗尽,土壤偏酸性,有机质、全N、全P、速效P、全K和速效K含量很低,而Pb、Cu和Zn 3种重金属含量均较高,植被很难存活、生长,覆盖度不足30%,但通过基质重构、客土改良后采用樟子松、落叶松、柳树、沙棘、丁香和紫花苜蓿进行植被恢复效果较好,成活率均可达85%以上,可使土壤养分含量提高最大可达:有机质为236.6%,全N为50.0%,全P为64.7%,速效P为12.9%,全K为14.4%,速效K为20.0%;同时可使重金属含量降低最大可达:Mn为2.5%,Pb为15.2%,Cu为10.8%,Zn为4.1%;露天煤矿排土场的土壤条件稍好些,有机质、全N、全P、速效P、全K和速效K含量较金矿尾矿库要高,土壤的酸性较强,自然恢复植被覆盖度不足50%,但通过对排土场进行边坡和稳定性处理后,进行覆土,再客土栽植沙棘、樟子松、落叶松、白桦恢复效果较好,成活率可达80%以上,可使土壤养分含量提高最大可达:有机质为152.5%,全N为46.7%,全P为42.9%,全K为25.5%,速效K为46.2%,同时可使重金属含量降低最大可达:Mn为0.8%,Pb为21.9%,Cu为12.0%,Zn为7.7%。

关键词：高寒山区采矿迹地植被恢复

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砷化镓热氧化法制备β-ga_(2)O_(3)体块薄膜

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发光学报 2022年第7期43卷 1095-1101页

作者：刁肇悌陈威董鑫焦腾李政达吉林大学电子科学与工程学院集成光电子学国家重点联合实验室吉林长春130012

通过对p型砷化镓(p-gaAs)单晶衬底高温热氧化方法制备了β-ga_(2)O_(3)体块薄膜。探讨了高温氧化过程中O2流量对β-ga_(2)O_(3)体块薄膜形貌的影响。通过对体块薄膜的晶体质量、结构特性、光致发光特性的测试分析,可以发现在高温高氧环... 详细信息

通过对p型砷化镓(p-gaAs)单晶衬底高温热氧化方法制备了β-ga_(2)O_(3)体块薄膜。探讨了高温氧化过程中O2流量对β-ga_(2)O_(3)体块薄膜形貌的影响。通过对体块薄膜的晶体质量、结构特性、光致发光特性的测试分析,可以发现在高温高氧环境下gaAs转变为β-ga_(2)O_(3)体块薄膜的过程与langmuir蒸发相关。当O_(2)流量较低时(0.2 l/min),gaAs衬底处于缺氧状态,所制备样品呈现纳米线状形貌;而当通入O_(2)流量超过0.4 l/min时,gaAs衬底被完全氧化为具有纳米岛状结构的β-ga_(2)O_(3)体块薄膜,且晶体质量得到显著提高。本文提出的砷化镓单晶热氧化工艺可以高效、低成本地获得较高结晶质量的纳米结构β-ga_(2)O_(3)体块薄膜,对于β-ga_(2)O_(3)材料的应用具有极大的丰富作用。

关键词：热氧化纳米岛状体块薄膜 β-ga_(2)O_(3) 氧气流量

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Factors Associated with Prolonged Poor Glycemic Control in Type 2 Diabetes Mellitus (T2DM) Patients Followed in the Department of Internal Medicine at the Yalgado Ouedraogo Teaching Hospital, Ouagadougou (Burkina Faso)

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Open Journal of Internal Medicine 2021年第1期11卷 1-26页

作者： Solo Traoré Oumar Guira.lassané Zoungrana Yempabou Sagna Réné Bognounou Constant B. Paré Désiré l. Dabourou lassina Séré Daniel Zemba laurette S. Dembélé Patricia D. Somé Patrice P. C. Savadogo Aline Tondé tiéno Hervé Joseph Y. Drabo Training and Research Unit in Health Sciences Joseph Ki ZERBO University Ouagadougou Burkina Faso Department of Internal Medicine Yalgado Ouedraogo Teaching Hospital Ouagadougou Burkina Faso Higher Institute of Health Sciences/Nazi Boni University Bobo Dioulasso Burkina Faso Institute for Research in Health Sciences/National Center for Scientific and Technical Research Ouagadougou Burkina Faso Department of Internal Medicine Tengandogo Teaching Hospital Ouagadougou Burkina Faso Department of Internal Medicine Bogodogo Teaching Hospital Ouagadougou Burkina Faso

Background: Achieving and maintaining glycemic targets are a challenge for health practitioners around the world. We aimed to study the factors associated with prolonged poor diabetes control in the cohort of T2DM patients monitored and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital in Ouagadougou in order to optimize therapeutic education in these patients. Methodology: This was a descriptive and analytical cross-sectional study combining retrospective data collection from the last year of patient follow-up and prospective collection of some information. The study included all diabetic patients, aged at least 18 years old, followed and treated in the Department of Internal Medicine at the Yalgado OUEDRAOGO Teaching Hospital between January 1, 2010 and December 31, 2018 following a systematic random sampling with a sampling step of 10. The variables collected were sociodemographic, anthropometric, lifestyle, cardiovascular risk factors and diabetes-related characteristics. To determine the risk factors associated with prolonged poor glycemic control, we performed modeling using logistic regression. All variables associated with prolonged poor glycemic control, in bivariate logistic regression with a p-value less than 0.20 were included in the full model. Later, we used a stepwise descending method to obtain the final model, which was then tested by a receiver operating characteristic (ROC) curve. The significance threshold was set at 5%. Raw and fitted Odds-Ratio (OR) and 95% confidence interval were presented. Results: 270 patients were included. Prolonged poor control of diabetes mellitus was observed in 73.70%. The mean age was 55.97 years (SD: ±11.52) and the sex ratio was 0.6 in favor of female. The mean time since diabetes mellitus diagnoses was 5.85 years (SD: ±5.15). A monthly ga

关键词： Type 2 Diabetes Mellitus Prolonged Poor Control Prevalence Associated Factors Burkina Faso

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高良姜素与牛血清白蛋白作用的光谱研究

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天然产物研究与开发 2017年第6期29卷 903-908页

作者：乔华薛燕斌葛琳孙体健山西医科大学基础医学院山西医科大学药学院中国科学院山西煤炭化学研究所分析测试中心太原030001

采用荧光猝灭、同步荧光、三维荧光和圆二色谱,研究高良姜素与牛血清白蛋白(BSA)之间的相互作用。结果表明:高良姜素对BSA有较强的荧光猝灭作用,且为静态猝灭,并计算出不同温度下二者的结合常数(Ka)与结合位点数(n)分别为9.33×10~6l/mo... 详细信息

采用荧光猝灭、同步荧光、三维荧光和圆二色谱,研究高良姜素与牛血清白蛋白(BSA)之间的相互作用。结果表明:高良姜素对BSA有较强的荧光猝灭作用,且为静态猝灭,并计算出不同温度下二者的结合常数(Ka)与结合位点数(n)分别为9.33×10~6l/mol、1.17(290.15 K),2.34×10~6l/mol、1.09(296.15 K),4.57×10~5l/mol、1.01(303.15 K),1.02×10~5l/mol、0.99(310.15 K)。由热力学参数确定它们之间的作用力主要是氢键和范德华力,利用竞争结合实验推断高良姜素的结合位点为BSA疏水空腔的SiteⅠ。同步荧光、三维荧光和圆二色谱显示高良姜素与BSA作用时更靠近色氨酸残基,使其周围的疏水性减弱,而对蛋白α-螺旋结构影响较小。

关键词：高良姜素牛血清白蛋白同步荧光光谱三维荧光光谱圆二色谱

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