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Mast Cell Stabilizing,Antianaphylactic and Antihistaminic Activity of Coccinia grandis Fruits in Asthma

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中国天然药物 2011年第5期9卷 359-362页

作者： Dnyaneshwar J Taur ra.indra.y patil Department of Pharmacognosy SVPM's College of PharmacyMalegaon(bk)Baramati-413115MaharashtraIndia Department of Pharmacognosy PDEA's SU College of Pharmaceutical Sciences and Research CenterKharadiPune-411014MaharashtraIndia

Coccinia grandis Linn(Curcubitaceae) is a climber herb cultivated throughout *** traditional medicine fruits have been used to treat leprosy,fever,asthma,bronchitis and *** present study,ethanol extract of *** fruit(ECGF) at 100,125 and 150 mg·kg-1,i.p.,was evaluated for mast cell stabilizing,antianaphylactic and antihistaminic activity using egg albumin induced mast cell degranulation in mice;passive cutaneous anaphylaxis in rats and clonidine induced catalepsy in mice *** at(100-150 mg·kg-1,i.p.) significantly protected egg albumin induced degranulations of mast cells and caused reduction of blue dye leakage in passive cutaneous anaphylaxis in dose *** treatment ECGF also inhibited clonidine induced catalepsy in dose dependent *** studies observed presence of saponin,steroids,alkaloids,flavonoids and *** conclusion ECGF possesses mast cell stabilizing;anti anaphylactic and antihistaminic potential which might be used in treatment of asthma.

关键词： Coccinia grandis Allergy Asthma Clonidine Mast cell degranulations

Some medicinal plants with antiasthmatic potential:a current status

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 413-418页

作者： Dnyaneshwar J Taur ra.indra.y patil Department of Pharmacognosy SVPM's College of PharmacysMalegaon(bk) Department of Pharmacognosy PDEA's Shankarrao Ursal College of Pharmaceutical Sciences and Research Center

Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence in industrialized *** affect about 300 million people worldwide and it has been estimated that a further 100 million will be affected by *** the ancient times,plants have been exemplary sources of *** asthma therapy lack satisfactory success due to adverse effect,hence patients are seeking complementary and alternative medicine to treat their *** and other Indian literature mention the use of plants in various human *** has about 43 000 plant species and among them several thousand are claimed to possess medicinal *** conducted in the last few decades on the plants mentioned in ancient literature or used traditionally for asthma have shown antiasthmatic,antihistaminic and antiallergic *** review reveals that some plants and their extract have antiasthmatic,antihistaminic,anticholinergic and antiallergic activity.

关键词： Asthma Antiasthmatic plants Ayurveda Herbal medicines Antiallergic activity Medicinal property

Enhanced acetone sensing performance of nanostructured Sm2O3 doped SnO2 thick films

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Journal of rare Earths 2017年第8期35卷 813-823页

作者： F.I.Shaikh L.P.Chikhale J.y.patil I.S.Mulla S.S.Suryavanshi School of Physical Sciences Solapur University Solapur 413255 (M.S.) lndia Council of Scientific and Industrial Research Pashan Pune 411008 India

In the present work, we synthesized Sm2O3 doped SnO2 in order to prepare a selective acetone sensor with fast response, quick recovery and good repeatability. Pure as well as 2 mol.%, 4 mol.%, 6 mol.% and 8 mol.% Sm2O3 doped SnO2 nanostructured samples were synthesized by using a co-precipitation method. The characterization of the samples was done by thermogravimetric and differential thermo-gravimetric analysis（TG-DTA）, X-ray diffraction（XRD）, field emission gun-scanning electron microscopy（FEG-SEM）, energy dispersive analysis by X-rays（EDAX）, high resolution scanning electron microscopy（HR-TEM）, selected area X-ray diffraction（SAED）, Brunauer-Emmet-Teller（BET） and ultraviolet-visible-near infrared（UV-Vis-NIR） spectroscopy techniques. The gas response studies of liquid petroleum gas, ammonia, ethanol and acetone vapor were carried out. The results showed that Sm doping systematically lowered operating temperature and enhanced the gas response and selectivity for acetone. The response and recovery time for 6 mol.% Sm2O3 doped SnO2 thick film at the operating temperature of 250 °C were 15 and 24 s, respectively.

关键词： tin oxide samarium oxide screen printing thick film acetone sensor rare earths

Co^(2+) substituted Mg–Cu–Zn ferrite: Evaluation of structural,magnetic,and electromagnetic properties

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Journal of Advanced Ceramics 2018年第3期7卷 207-217页

作者： L.M.THOraT J.y.patil D.y.NADARGI U.R.GHODAKE R.C.KAMBALE S.S.SURyAVANSHI Department of Electronics S.M.Dnyandeo Mohekar Mahavidyalaya School of Physical Sciences Solapur University Department of Electronics Shri Shivaji Mahavidyalaya Department of Physics Savitribai Phule Pune University

We report the synthesis of Co^(2+)substituted Mg–Cu–Zn ferrite via citrate gel combustion process and thereby its structural,transport,and magnetic properties for the use in electromagnetic energy absorption *** polycrystalline ferrite system is investigated by interplay of stoichiometric composition with Mg_(0.25–x)Co_x Cu_(0.25)Zn_(0.5)Fe_2O_4(0≤x≤0.25).Structural investigations using X-ray diffraction(XRD)and selected area electron diffraction(SAED)reveal the formation of spinel structure with linear growth of lattice constant due to Co^(2+)*** microstructural analysis(TEM and SEM)depicts the dense microstructure with the average grain size of 0.42–1.25μ*** elemental analysis(EDS)confirms the elemental composition of the as-prepared ferrite with respect to the initial concentrations of the synthetic composition *** observed variations in initial permeability(μ_i)and magnetic moment(_Bn)are explained based on deviation in saturation magnetization(M_s),anisotropy constant(_1K),density values,and exchange *** temperature dependence of DC resistivity confirms the semiconducting behavior of the as-prepared ferrite material,with an increase in the DC resistivity by an incorporation of ***,the effects of adding Co^(2+)on the Curie temperature,frequency dependent dielectric properties of the ferrite material are also discussed.

关键词： Co-Mg-Cu-Zn ferrite spinel phase electrical resistivity saturation magnetization anisotropy constant Curie temperature

Inverse modelling of aquifer parameters in basaltic rock with the help of pumping test method using MODFLOW software

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Geoscience Frontiers 2017年第6期8卷 1385-1395页

作者： Kanak Moharir Chaitanya Pande Sanjay patil Sant Gadge Baba Amravati University AmravatiIndia Maharashtra Remote Sensing Application Center PuneIndia

The origin and movement of groundwater are the fundamental questions that address both the temporal and spatial aspects of ground water run and water supply related issues in hydrological *** groundwater flows through an aquifer,its composition and temperature may variation dependent on the aquifer condition through which it ***,hydrologic investigations can also provide useful information about the subsurface geology of a *** because such studies investigate processes that follow under the Earth's shallow,obtaining the information necessary to answer these questions is not continuously ***,which discharge groundwater table directly,afford to study subsurface hydrogeological *** present study of estimation of aquifer factors such as transmissivity(T)and storativity(S)are vital for the evaluation of groundwater *** are several methods to estimate the accurate aquifer parameters(*** analysis,pumping test,etc.).In initial days,these parameters are projected either by means of in-situ test or execution test on aquifer well samples carried in the *** simultaneous information on the hydraulic behavior of the well(borehole)that provides on this method,the reservoir and the reservoir boundaries,are important for efficient aquifer and well data management and *** most common in-situ test is pumping test performed on wells,which involves the measurement of the fall and increase of groundwater level with respect to *** alteration in groundwater level(drawdown/recovery)is caused due to pumping of water from the ***(1935)was first to propose method to evaluate aquifer parameters from the pumping test on a bore well in a confined *** is essential to know the transmissivity(T=Kb,where b is the aquifer thickness;pumping flow rate,Q=TW(dh/dl)flow through an aquifer)and storativity(confined aquifer:S=bS_s,unconfined:S=S_y),for the characterization of the aquifer parameters in an unkn

关键词： Pumping test Hantush method GPS MODFLOW Inverse modelling Hydraulic parameters

Fluorimetric study of the interaction between ATP and ciprofloxacin-y^(3+) complex and its application

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Journal of rare Earths 2010年第3期28卷 329-332页

作者： Shailaja R.patil Umesh S.Mote Shivajirao R.patil Sang-Hak Lee Govind B.Kolekar Fluorescence Spectroscopy Research Laboratory Department of ChemistryShivaji UniversityKolhapur-416 004MaharashtraIndia Department of Chemistry Kyungpook National UniversityDaeguS.Korea 133-791)

A simple spectrofluorimetric method was developed for determination of trace amount of adenosine disodium triphosphate(ATP).Under the optimum conditions,we studied the interaction between CIP-y3+-ATP complex by using absorption and fluorescence *** was observed that ATP remarkably enhanced the fluorescence intensity of the CIP-y3+ complex at λem=415 nm and the enhanced fluorescence intensity of y3+ ion remained proportional to the concentration of *** developed method was successfully applied for...

关键词： adenosine disodium triphosphate(ATP) ciprofloxacin(CIP) yttrium(y3+) spectrofluorimetric method rare earths

Antinociceptive activity of Ricinus communis ***

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 139-141页

作者： Dnyaneshwar J Taur Maruti G Waghmare rajendra S Bandal ra.indra.y patil Department of Pharmacognosy SVPM's College of Pharmacy Department of Pharmaceutical Chemistry SVPM's College of Pharmacy Department of Pharmacognosy PDEA's Shankarrao Ursal College of Pharmaceutical Sciences and Research Center

Objective:To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves(MRCL).Methods:Antinociceptive activity was evaluated using acetic acid induced writhing test,formalin induced paw licking and tail immersion method in mice at doses of 100,125 and 130 mg/kg ***:The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in *** phytochemical analysis suggested the presence of saponin,steroids and ***:It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin,steroids and alkaloids in it.

关键词： Ricinus communis Analgesic Antinociceptive Writhing Formalin

Pineapple Juice as a Natural Catalyst: An Excellent Catalyst for Biginelli Reaction

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International Journal of Organic Chemistry 2011年第3期1卷 125-131页

作者： Suresh patil Swati D. Jadhav Sanjeevani y. Mane 不详

An efficient and greener synthesis of a series of dihydropyrimidinone (DHPMs) derivatives were accomplished via three-component one-pot cyclocondensation between substituted aryl aldehydes, diketone/ke- toester and urea. This solvent free approach is totally nonpolluting having several advantages such as shorter reaction time, mild reaction conditions, simple workup and reduced environmental impact.

关键词： Biginelli Natural Catalyst Pineapple Juice Dihydropyrimidinone

Expeditious synthesis,antileishmanial and antioxidant activities of novel 3-substituted-4-hydroxycoumarin derivatives

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Chinese Chemical Letters 2016年第2期27卷 287-294页

作者： Zahid Zaheer Firoz A.Kalam Khan Jaiprakash N.Sangshetti rajendra H.patil Dr.rafiq Zakaria Campus Y.B.Chavan College of PharmacyAurangabad 431001MSIndia Department of Biotechnology Savitribai Phule Pune UniversityPune 411007MSIndia

A series of novel 3-substituted-4-hydroxycoumarin derivatives 6（a-1） were synthesized in high yield using one-pot three component coupling reaction catalyzed by ceric ammonium nitrate. These compounds were evaluated for antileishmanial activity against Leishmania donovani promastigotes and antioxidant activity（DPPH-radical scavenging activity）. Two compounds, 6h（IC50= 9.90 μmol/L） and 6i（IC50= 6.90 μmol/L） displayed potent antileishmanial activity when compared with standard antileishmanial agents pentamidine（IC50= 16.15 μmol/L） and miltefosine（IC50= 12.50 μmol/L）. Three compounds, 6c（IC50= 10.79 μmol/L）, 6h（IC50= 10.60 μmol/L）, and 6i（IC50= 10.73 μmol/L） showed significant antioxidant activity favorably with the antioxidant standards butylated hydroxy toluene（IC50= 16.47 μmol/L） and ascorbic acid（IC50= 12.69 μmol/L）. A molecular docking study of compounds 6（a-1） suggested a possible mode of binding with the Adenine phosphoribosyltransferase enzyme of ***. ADME properties were predicted in silico and support the potential of 6（a-1） to show favorable drug-like properties.

关键词： 4-Hydroxycoumarin Ceric ammonium nitrate Antileishmanial activity Antioxidant activity Molecular docking study ADME properties