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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 292-296页

作者： Sahib singh Vishnu Charan Suresh Kumar Ganesh Aswath Department of internal Medicine Sinai HospitalBaltimoreMD 21215United States Division of Gastroenterology and Hepatology State University of New York Upstate Medical UniversitySyracuseNY 13210United States

Glucagon-like peptide receptor agonists(GLp-1ra)are used to treat type 2 diabetes mellitus and,more recently,have garnered attention for their effect-iveness in promoting weight *** have been associated with several gastrointestinal adverse effects,including nausea and *** side effects are presumed to be due to increased residual gastric *** the potential risk of aspira.ion and based on limited data,the American Society of Anesthesi-ologists updated the guidelines concerning the preopera.ive management of patients on GLp-1ra.in *** included the dura.ion of mandated cessation of GLp-1ra before sedation and usage of“full stomach”precautions if these medications were not appropriately held before the *** has led to additional challenges,such as extended waiting time,higher costs,and increased risk for *** this editorial,we review the current societal guidelines,clinical practice,and future directions regarding the usage of GLp-1ra.in patients undergoing an endoscopic procedure.

关键词： Glucagon-like peptide receptor agonists Endoscopy Adverse events intubation Aspira.ion Semaglutide Healthcare burden Guidelines

ion emission from warm dense matter produced by irra.iation with a soft x-ray free-electron laser

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Matter and ra.iation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar singh Vojtech Vozda Ludek Vysín MichalŠmíd pablo perez-Martin Marion Kühlman Juan pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas preston Mikako Makita Motoaki Nakatsutsumi Xiayun pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of ra.iation and Chemical physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY photon Science Notkestraße 85D-22607 HamburgGermany institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL ra.iation attenuation length in different materials.

关键词： electrostatic emitted chemi

Metabolic and cardiovascular benefits with combination therapy of SGLT-2 inhibitors and GLp-1 receptor agonists in type 2 diabetes

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World Journal of Cardiology 2022年第6期14卷 329-342页

作者： Awadhesh Kumar singh Ritu singh Department of Diabetes and Endocrinology G.D Hospital and Diabetes InstituteKolkata 700013India Department of Reproductive Endocrinology G.D Hospital and Diabetes InstituteKolkata 700013India

Both GLp-1 receptor agonists(GLp-1ra)and SGLT-2 inhibitors(SGLT-2i)are newer classes of anti-diabetic agents that lower HbA1c moderately and decrease body weight and systolic blood pressure(SBp)*** therapy with GLp-1ra plus SGLT-2i have shown a greater reduction in HbA1c,body weight,and SBp compared to either agent alone without any significant increase in hypoglycemia or other side *** several agents from each class of these drugs have shown an improvement in cardiovascular(CV)and renal outcomes in their respective cardiovascular outcome trials(CVOT),combination therapy is theoretically expected to have additional CV and renal *** this comprehensive opinion review,we found HbA1c lowering with GLp-1ra plus SGLT-2i to be less than additive compared to the sum of HbA1c lowering with either agent alone,although body weight lowering was nearly additive and the SBp lowering was more than *** additional meta-analysis of CV outcomes with GLp1ra plus SGLT-2i combination therapy from the pooled data of five CVOT found a similar reduction in three-point major adverse cardiovascular events compared to GLp-1ra or SGLT-2i alone,against ***,a greater benefit in reduction of heart failure hospitalization with GLp-1ra plus SGLT-2i combination therapy was noted in the pooled meta-analysis of two randomized controlled *** adequately powered trials can confirm whether additional CV or renal benefit is truly exerted by GLp-1ra plus SGLT-2i combination therapy.

关键词： GLp-1 receptor agonists SGLT-2 inhibitors Combination therapy,Metabolic outcomes Cardiovascular outcomes Renal outcomes

Surface Characteristics Measurement Using Computer Vision:A Review

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Computer Modeling in Engineering & Sciences 2023年第5期135卷 917-1005页

作者： AbdulWahab Hashmi Harlal singh Mali Anoj Meena Mohammad Farukh Hashmi Neeraj Dhanraj Bokde Department of Mechanical Engineering Advanced Manufacturing and Mechatronics LabMalaviya National Institute of TechnologyJaipur302017India Department of Electronics and Communication Engineering National Institute of TechnologyWarangal506004India Department of Civil and Architectural Engineering Aarhus UniversityAarhus8000Denmark Center for Quantitative Genetics and Genomics Aarhus UniversityAarhus8000Denmark

Computer vision provides image-based solutions to inspect and investigate the quality of the surface to be *** any components to execute their intended functions and opera.ions,surface quality is considered equally significant to dimensional *** Roughness(ra.is a widely recognized measure to evaluate and investigate the surface quality of machined *** conventional methods and approaches to measure the surface roughness are not feasible and appropriate in industries claiming 100%inspection and examination because of the time and efforts involved in performing the ***,Machine vision has emerged as the innovative approach to executing the surface roughness *** can provide economic,automated,quick,and reliable *** paper discusses the characterization of the surface texture of surfaces of tra.itional or non-tra.itional manufactured parts through a computer/machine vision approach and assessment of the surface characteristics,i.e.,surface roughness,waviness,flatness,surface texture,etc.,machine vision *** paper will also discuss multiple machine vision techniques for different manufacturing processes to perform the surface characterization measurement.

关键词： Machine vision surface roughness computer vision machining parameters surface characterization

Effect of induced magnetic field on natural convection in vertical concentric annuli

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Acta Mechanica Sinica 2012年第2期28卷 315-323页

作者： R.K.singh A.K.singh Department of Mathematics Central University of BiharPatnaIndia Department of Mathematics Banaras Hindu UniversityVaranasiIndia

in the present paper, we have considered the steady fully developed laminar natural convective flow in open ended vertical concentric annuli in the presence of a ra- dial magnetic field. The induced magnetic field produced by the motion of an electrically conducting fluid is taken into account. The transport equations concerned with the con- sidered model are first recast in the non-dimensional form and then unified analytical solutions for the velocity, induced magnetic field and temperature field are obtained for the cases of isothermal and constant heat flux on the inner cylin- der of concentric annuli. The effects of the various phys- ical parameters appearing into the model are demonstrated through graphs and tables. it is found that the magnitude of maximum value of the fluid velocity as well as induced magnetic field is greater in the case of isothermal condition compared with the constant heat flux case when the gap be- tween the cylinders is less or equal to 1.70 times the ra.ius of inner cylinder, while reverse trend occurs when the gap between the cylinders is greater than 1.71 times the ra.ius of inner cylinder. These fields are almost the same when the gap between the cylinders is equal to 1.71 times the ra.ius of inner cylinder for both the cases. it is also found that as the Hartmann number increases, there is a flattening ten- dency for both the velocity and the induced magnetic field. The influence of the induced magnetic field is to increase the velocity profiles.

关键词： Natural convection isothermal Heat flux Skin-friction induced magnetic field Magnetohydrody- namics

Double Deep Q-Network Method for Energy Efficiency and Throughput in a UAV-Assisted Terrestrial Network

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Computer Systems Science & Engineering 2023年第7期46卷 73-92页

作者： Mohamed Amine Ouamri Reem Alkanhel Daljeet singh El-sayed M.El-kenaway Sherif S.M.Ghoneim University Grenoble Alpes CNRSGrenoble INPLIGDRAKKAR Teams38000GrenobleFrance Laboratoire d’informatique Médical Universitéde BejaiaTarga OuzemourQ22R+475Algeria Department of information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Research and Development Centre for Space ResearchSchool of Electronics and Electrical EngineeringLovely Professional UniversityPhagwara144411India Department of Communication and Electronics Delta Higher Institute of Engineering and TechnologyMansouraEgypt Electrical Engineering Department College of EngineeringTaif UniversityP.O.BOX 11099Taif21944Saudi Arabia

increasing the coverage and capacity of cellular networks by deploying additional base stations is one of the fundamental objectives of fifth-genera.ion(5G)***,it leads to performance degradation and huge spectral consumption due to the massive densification of connected devices and simultaneous access *** meet these access conditions and improve Quality of Service,resource allocation(ra)should be carefully ***,ra problems are nonconvex optimizations,which are performed using heuristic methods,such as genetic algorithm,particle swarm optimization,and simulated ***,the application of these approaches remains computationally expensive and unattractive for dense cellular ***,artificial intelligence algorithms are used to improve tra.itional ra *** learning is a promising tool for addressing resource management problems in wireless *** this study,we investigate a double deep Q-network-based ra framework that maximizes energy efficiency(EE)and total network throughput in unmanned aerial vehicle(UAV)-assisted terrestrial ***,the system is studied under the constraints of ***,the optimization problem is formulated as a mixed integer nonlinear *** this framework,we evaluated the effect of height and the number of UAVs on EE and ***,in accordance with the experimental results,we compare the proposed algorithm with several artificial intelligence *** results indicate that the proposed approach can increase EE with a considerable throughput.

关键词： UAV terrestrial network reinforcement learning mmWave resource allocation

The effects of disturbance on forest structure and diversity at different altitudes in Garhwal Himalaya

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生态学杂志 2009年第3期28卷 424-432页

作者： Munesh KUMAR Chandra Mohan SHARMA Govind singh ra JWAR Department of Forestry Henwati Nandan BahugunaGarhwal University Department of Botany Henwati Nandan BahugunaGarhwal University Department of Botany Government Post Graduate College

The effects of disturbance on forest structure and diversity along an altitudinal gra.ient in the temperate,sub-tropical,and tropical regions of Garhwal Himalaya were *** region was further categorized into undisturbed(UD),mildly disturbed(MD),and highly disturbed(HD)sites on the basis of magnitude of disturbance in these *** UD sites of temperate,sub-tropical and tropical regions,Quercus leucotrichophora,Anogeissus latifolia and Holoptelea integrifolia were the dominant tree species *** highest values of tree density(1028 ind·hm-2)and total basal cover at breast height(31.70 m2 ·hm-2)were recorded for UD site of temperate region,whereas maximum species diversity(3.128)and equitability(14.09)values were observed for HD site of tropical *** structure and composition of the forests were greatly affected by the degree of disturbance.

关键词：植物多样性生物结构森林生态系统

Numerical Analysis of Unsteady Natural Convection Flow and Heat Transfer in the Existence of Lorentz Force in Suddenly Expanded Cavity Using OpenFOAM

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Journal of Thermal Science 2020年第6期29卷 1513-1530页

作者： singh ranjit J. GOHiL Trushar B. Department of Mechanical Engineering Visvesvaraya National Institute of TechnologyNagpur 440010India

The present study reveals the significance of the magnetic field or Lorentz force on the unsteady natural convection flow and heat transfer in the suddenly expanded *** Lorentz force based magnetohydrodynamics(MHD)solver using electric potential formulation coupled with the energy equation by the means of Boussinesq approximation is developed in the open-source CFD tool *** unsteady flow is generated by the buoyancy force keeping the rayleigh number(ra)at 109,at the fixed prandtl number(pr)of *** effects of the magnetic field on the flow and heat transfer are explained for various orientations of magnetic field(Bx,B45,and By)in terms of Hartmann number(Ha=0,50,100,300 and 500).The increase in the magnetic field increases the strength of the Lorentz force,which regulates the flow pattern and suppresses down the unsteady nature of flow and heat transfer into the *** is perceived that the average Nusselt number decreases as the intensity of Bx and B45 magnetic field ***,for By magnetic field the average Nusselt number increases up to Ha of 100 as compared to the non-MHD case(Ha=0).The distribution of Lorentz force in the domain plays a significant role in the governing of the fluid flow and heat transfer.

关键词： OpenFOAM Lorentz force Boussinesq approximation natural convection

Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells

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international Journal of Ophthalmology(English edition) 2017年第5期10卷 696-704页

作者： Mahavir singh Suresh C Tyagi Department of physiology University of Louisville School of Medicine Louisville KY 40202 USA

AiM：To test whether homocysteine（Hcy） can influence the transcriptional profile, we hypothesized that Hcy can lead to the induction of proinflammatory molecules in the retinal cells of aging ***：An unbiased in vitro inflammatory pathway focused study was designed employing retinal pigment epithelial（RpE） cell line, ARpE-19. Cells were cultured in the presence or absence of Hcy to capture target genes＇ expression profile. Three different concentra.ions of Hcy were added in the culture medium of confluent monolayers. c RNAs were made from the isolated total RNAs and the labeled c RNA probes were hybridized to microarrays specific for human disease pathway inflammatory cytokines, chemokines and their receptor gene micro-array panels as per manufacture＇s recommendations. Two Hcy up-regulated molecules：iL6 and CEBpB were further validated via Western blot analysis. Hcy＇s effect on ARpE-19 cellular morphology and genomic DNA integrity were also ***：Gene microarray analyses of RpE cells in response to Hcy treatment revealed altera.ions in the expressions of several inflammatory gene transcripts such as CCL5, CEBpB, iL13ra2, iL15 ra, iL6, iL8 and CXCL3 that were up-regulated. The transcripts for C3, CCL2, iL11 ra and iL18 genes exhibited down-regulation. The iL6 and CEBpB expressions were subsequently validated at the protein levels. Treatment of the retinal cells with increasing Hcy concentra.ion influenced their density in culture however their morphology and DNA integrity remained unaffected. CONCLUSiON：These findings suggest that Hcy can potentially mediate the expression of chemokines,cytokines and interleukins receptors in the retinal cells without having any debilitating effects on their morphology and the genomic DNA integrity.

关键词： chemokine choroidal neovascularization cytokine gene expression hyperhomocysteinemia inflammation macular degenera.ion retinal remodeling

Multi-Scale investigation on Concrete prepared with Recycled Aggregates from Different parent Concrete

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Journal of Renewable Materials 2020年第11期8卷 1375-1390页

作者： Zhenhua Duan Nv Han Amardeep.singh Jianzhuang Xiao Department of Structural Engineering Tongji UniversityShanghai200092China

Recycled aggregates(ra)are frequently obtained from various unknown sources,which caused variation in properties among recycled aggregates concrete(raC).This paper investigated the macro and microscopic properties of raC prepared with ras originated from different parent concretes with 90-day strength ranging from 30 Mpa to 100 *** parent concretes were prepared in advance and crushed to produce ra of distinct *** attached mortar content can reach up to 69%in the concrete with highest strength *** microscopic investigation on different raC was conducted with the X-ray Micro-Computed Tomography scanning technique and image ***mental results showed that the properties of ra derived from various parent concrete varied because of the amount of residual *** development of mechanical properties and chloride-ion penetra.ion of raCs all followed a binomial trend with the strength grades of the parent concrete because of the different quantity and quality of ras.

关键词： Recycled aggregate recycled aggregate concrete parent concrete mechanical property CT scanning image process