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Remission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis:A systematic review with meta-analysis

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World Journal of Biological Chemistry 2021年第6期12卷 114-130页

作者： Sathish Muthu Madhan Jeyaraman rajni ranjan Saurabh Kumar jha Department of Biotechnology School of Engineering and TechnologySharda UniversityDelhi 201306Uttar PradeshIndia Department of Orthopaedics Government Medical College and HospitalDindigul 624001Tamil NaduIndia Department of Orthopaedics Faculty of MedicineSri Lalithambigai Medical College and HospitalChennai 600095Tamil NaduIndia Department of Orthopaedics School of Medical Sciences and ResearchGreater Noida 201306Uttar PradeshIndia

BACKGROUND Hematopoietic stem cell(HSC)transplantation(HSCT)is being accepted as a standard of care in various inflammatory *** treatment of rheumatoid arthritis(ra)has been closely evolving with the understanding of disease *** the rising resistance to the traditional disease-modifying antirheumatic drugs and targeted biological therapy,researchers are in pursuit of other methods for disease *** the ultimate goal of the ideal treatment of ra is to restore immune tolerance,HSCT attracts much attention considering its reparative,paracrine,and anti-inflammatory ***,a systematic review of studies on HSCT in ra is *** To investigate the role of HSCT in the management of *** A detailed search of PubMed,Scopus,EMBASE,Cochrane,and the Web of Science databases was made to identify the relevant articles till September 2020 following Cochrane and PRISMA *** extracted data including the number of patients,source of hematopoietic stem cells,their mobilization and conditioning regimens,results,and complications from the eligible *** were dichotomized into success(ACR 50/70)and failure(ACR 20)based on the improvement from baseline *** methodological quality of the included studies was also *** was performed using OpenMeta[Analysis]*** We included 17 studies(1 randomized controlled trial,11 prospective,and 5 retrospective studies)with 233 patients for *** provided a significantly beneficial overall improvement in the clinical grades of ACR criteria(Z=11.309,Pract the

关键词： Hematopoietic stem cell Rheumatoid arthritis Disease-modifying antirheumatic drug Biological therapy Systematic review Meta-analysis

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