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Glutamine metabolism in cancer therapy

cancer Drug Resistance 2018年第3期1卷 126-138页

作者： Tra-ly nguyen raúl V.durán Institut Européen de Chimie et Biologie INSERM U1218Universitéde Bordeaux2 Rue Robert Escarpit33607 PessacFrance.

The amino acid glutamine plays a key role in the metabolism of highly proliferating *** malignant transformation,cancer cells modify the consumption and processing of glutamine to sustain cell growth and *** some cases,these cancer cells become addicted to ***,targeting the metabolism of glutamine has been developed during last years as a potential strategy against *** this review,we summarized the last advances in our knowledge about the role of glutamine metabolism in cancer therapy.

关键词： cancer glutamine glutamoptosis metabolism mammalian target of rapamycin

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Higher cardiovascular risk scores and liver fibrosis risk estimated by biomarkers in patients with metabolic-dysfunction-associated fatty liver disease

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World Journal of Hepatology 2022年第8期14卷 1633-1642页

作者： Giovanni Alejandro Salgado Alvarez Samanta mayanin Pinto Galvez Uriel Garcia Mora Ana Delfina cano Contreras Cristina durán Rosas Bryan Adrián Priego-Parra Arturo Triana Romero Mercedes Amieva Balmori Federico Roesch Dietlen Sophia Eugenia martinez Vazquez Ines Osvely Mendez Guerrero luis Alberto Chi-Cervera raúl Bernal Reyes leonardo Alberto martinez Roriguez maria Eugenia Icaza Chavez Jose maria Remes Troche Instituto de Investigaciones Médico-biologicas Universidad VeracruzanaVeracruz 91700VeracruzMexico Department of Gastroenterología Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMéxico 14080MéxicoMexico Clínica de Especialidades Gastrointestinales y Hepáticas Hospital Star MedicaMerida 97133YucatanMexico Department of Gastroenterologia Sociedad Española de BeneficenciaPachuca 42000HidalgoMexico Department of Gastroenterologia Clínica de Rehabilitación Metabólica Digestiva y HepáticaMexico 14080MexicoMexico Department of Gastroenterologia Hospital Star Médica de MéridaMerida 97133YucatanMexico

BACKGROUnD The definition of metabolic-dysfunction-associated fatty liver disease(maFlD)allows identification of metabolically complicated *** risk scores are related to cardiovascular risk(CVR)scores and could be useful for the identification of patients at risk of systemic *** To evaluate the relationship between maFlD and CVR using the Framingham risk score in a group of Mexican *** Cross-sectional,observational and descriptive study carried out in a cohort of 585 volunteers in the state of Veracruz with maFlD *** risk of liver fibrosis was calculated with aspartate aminotransferase-to-platelet ratio index,nonalcoholic fatty liver disease score and fibrosis-4,as well as with transient hepatic elastography with Fibroscan~?.The CVR was determined by the Framingham *** One hundred and twenty-five participants(21.4%)with maFlD criteria were evaluated,average age 54.4 years,63.2%were women,body mass index 32.3 kg/m~*** Framingham CVR was high in 43 patients(33.9%).Transient elastography was performed in 55.2%of volunteers;39.1%with high CVR and predominance in advanced fibrosis(F3–F4).The logistic regression analysis showed that liver fibrosis,diabetes and hypertension independently increased *** One of every three patients with maFlD had a high CVR,and in those with high fibrosis risk,the CVR risk was even greater.

关键词： Fatty liver cardiovascular risk Hepatic steatosis Fibrosis liver disease

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Glucosamine increases the expression of YKl-40 and osteogenic marker genes in hMSC during osteogenic differentiation

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natural Products and Bioprospecting 2012年第2期2卷 87-91页

作者： ramona lIEDER Sigrídur Thóra REYnISDOTTIR Finnbogi THORMÓDSSOn Chuen-How nG Jon magnús EInARSSOn Jóhannes GÍSlASOn Jóhannes BJORnSSOn Sveinn GUDMUnDSSOn Pétur Henry PETERSEn Olafur Eysteinn SIGURJOnSSOn The Blood Bank Landspitali University HospitalSnorrabraut 60105 ReykjavikIceland School of Science and Engineering Reykjavik UniversityMenntavegi 1101 ReykjavikIceland Genis ehf Vatnagördum 18104 ReykjavikIceland Biomedical Center University of IcelandVatnsmyrarvegi 16101 ReykjavikIceland Department of Anatomy Medical FacultyUniversity of IcelandVatnsmyrarvegi 16101 ReykjavikIceland Department of Pathology Landspitali University HospitalBaronsstig101 ReykjavikIceland

Human mesenchymal stem cells(hMSC)can be expanded in vitro and differentiated towards osteogenic,chondrogenic or adipogenic lineages,making them an attractive source for tissue engineering and regenerative ***-like-proteins(ClPs)belong to the family 18 glycosyl hydrolases and are believed to play a role in inflammation and tissue *** aim of this study was to determine the effect of the aminosugar glucosamine on the expression of the ClP YKl-40 during osteogenic differentiation of *** did not affect multipotency of hMSC nor proliferation rate of undifferentiated ***-40 was expressed during both expansion of undifferentiated hMSC and during osteogenic differentiation.A slight but non-significant increase in YKl-40 expression was observed with glucosamine,accompanied by a pH-dependent delay in ***,glucosamine induced higher expression of osteogenic marker genes.

关键词： YKl-40 mesenchymal stem cells osteogenic differentiation chitinase-like-protein

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高危婴儿呼吸道合胞病毒感染的住院率:用帕利珠单抗预防的意义

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 28-29页

作者： Heikkinen T. ValkonenH. lehtonen l. 郭战宏 Department of Paediatrics Turku University Hospital FIN-20520 Turku FinlandDr.

Objectives: To determine the rates of hospital admission for respiratory syncy tial virus (RSV) infection among children born at different gestational ages. To assess the theoretical impact of palivizumab prophylaxis on admissions for RSV infection. Design: Retrospective cohort study of children born in *** tting: Tertiary care university hospital. Methods: Data on all children born dur ing the 10 year period were combined with information on laboratory confirmed RS V infections in these children until the end of *** theoretical impact of palivizumab on RSV associated admissions was estimated by applying the current r ecommendations for prophylaxis to the study population and using the observed ra tes of admission in the calculations. Interventions: none. main outcome measures : rates of RSV infection and hospital admission in different subgroups of childr en. Results: Children with chronic lung disease (ClD) were admitted for RSV infe ction at a rate of 12.0%. The corresponding rates in children born at ≤28 or 29-32 weeks gest ation were 7.1 %and 6.8%respectively. Children born at ≤32 weeks gestation accounted for 6.6%of all admissions due to RSV. Of 580 children who would have met the criteria for palivizumab prophylaxis, 27 (4.6%) were admitted with RS V during the presumed prophylactic period. The number needed to treat to prevent one admission for RSV infectionwas 15 for childrenwith ClD (with a total cost o f e75 000) and 43 for children without ClD born at ≤32 weeks gestation (with a total cost of e215 000). Conclusions: The rates of hospital admission for RSV in fection in premature infants were substantially lower than those in most previou s reports from other countries. Determination of the local rates of RSV admissio ns in different groups of children would be useful in making decisions about the use of palivizumab.

关键词：住院率呼吸道合胞病毒入院率出生胎龄应用观察三级医疗研究人群单克隆抗体未成熟儿芬兰马克

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