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膝关节软骨缺损的微骨折软骨面重建手术技术

骨科动态 2007年第1期3卷 49-57页

作者： KAI MITHOEf.R RILEY J. WILLIAMS Ⅲ russell f. warren HOLLIS G. POTTER CHRISTOPHER R. SPOCK EDWARD C. JONES THOMAS L. WICKIEWICZ ROBERT G. MARX 张春礼（译） Investigtion perf.rmed at the Institute f.r Cartilage Repair Hospital for Special Surgery New York NY The original scientific article in which the surgical technique was presented was published in JBJS Vol. 87-A pp 1911-1920 September 2005 西安第四军医大学西京医院骨科 710032

背景：微骨折是常用于修复膝关节软骨病损的技术。尽管该项技术应用很普遍，但有关远期临床结果的信息仍很有限。本研究的目的是找出该项软骨修复技术临床疗效的影响因素。方法：采用微骨折技术治疗48例膝关节稳定、股骨髁孤立、全层软... 详细信息

背景：微骨折是常用于修复膝关节软骨病损的技术。尽管该项技术应用很普遍，但有关远期临床结果的信息仍很有限。本研究的目的是找出该项软骨修复技术临床疗效的影响因素。方法：采用微骨折技术治疗48例膝关节稳定、股骨髁孤立、全层软骨缺损并有症状的患者。最短随访24个月，采用公认的疗效评分和主观临床评级及软骨敏感NRI扫描对患者的结果进行前瞻性评估。结果：末次随访时，膝关节功能优、良32例（67％），可12例（25％），差4例（8％）。日常活动评分、国际膝关节信息委员会（IKDC）评分、Sf.36体格检查评分术后均有显著性增加（p〈0.05），体重指数（BM）较低，则日常活动评分Sf.36体格检查评分较高，BMI〉30kg/m^2则效果最差。术前症状时间少于12个月，则日常活动评分显著增加（p〈0.05）。24膝中MRI证实缺损填充，修复良好13例（54%），中等填充7例（29%），填充不良4例（17%），填充度与膝关节功能评分相关。全部缺损填充良好的膝关节，功能均有改善，而填充不良的关节，功能改善有限，且24个月后功能评分下降。结论：微骨折技术修复膝关节软骨病损在最短2年的随访期间功能有显著改善，软骨缺损填充良好，BMI较低，术前症状期短者可取得最佳短期疗效；高BMI对短期疗效有负面影响，软件缺损填充不良则短期疗效较差。

关键词：膝关节软骨缺损软骨面重建微骨折手术技术膝关节软骨病损功能评分膝关节功能 Sf.36

A Novel Coupling between the Electron Structure and Properties of.Perovskite Transition Metal Oxides

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Applied Mathematics 2013年第9期4卷 1320-1325页

作者： Ghous Narejo warren f. Perger Electrical Engineering Department Michigan Tech University Houghton USA

The ab-initio computational techniques are employed to extract the coupling between the electronic structure and magnetic properties f.r a wide variety of.transition metal oxides. Optimized crystalline structures are computed by employing Hartree f.ck (Hf. and Density f.nctional Theory (Df.) techniques. The hydrostatic pressure is employed upon the optimized cubic crystalline structures of.BaScO3, BaTiO3, BaVO3, BaCrO3, BaMnO3 and Baf.O3 to extract the coupling between the electronic structures and magnetic properties originating due to electron spin polarizations.

关键词： Coupling Spin Strain

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Management : 7th ed.

Scientif.c evidence is just the starting point: A generalizable process f.r developing sports injury prevention interventions

2002年

作者： warren R. Plunkett Raymond f. Attner Gemmy S. Al

来源：畅想之星图书光盘版（南... 评论

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Journal of.Sport and Health Science 2016年第3期5卷 334-341页

作者： Alex Donaldson David G.Lloyd Belinda J.Gabbe Jill Cook warren Young Peta White Caroline f.f.nch Australian Centre f.r Research into Injury in Sport and its Prevention (ACRISP) Federation University Australia Centre f.r Musculoskeletal Research Griffith Health Institute Griffith University Department of.Epidemiology and Preventive Medicine Monash University La Trobe Sport and Exercise Medicine Research Centre La Trobe University School of.Health Sciences Federation University Australia

Background: The 2 most cited sports injury prevention research f.ameworks incorporate intervention development, yet little guidance is available in the sports science literature on how to undertake this complex process. This paper presents a generalizable process f.r developing implementable sports injury prevention interventions, including a case study applying the process to develop a lower limb injury prevention exercise training program(f.oty f.rst) f.r community Australian ***: The intervention development process is underpinned by 2 complementary premises:(1) that evidence-based practice integrates the best available scientif.c evidence with practitioner expertise and end user values and(2) that research evidence alone is insuf.icient to develop implementable ***: The generalizable 6-step intervention development process involves(1) compiling research evidence, clinical experience, and knowledge of.the implementation context;(2) consulting with experts;(3) engaging with end users;(4) testing the intervention;(5) using theory; and(6)obtaining f.edback f.om early implementers. f.llowing each step, intervention content and presentation should be revised to ensure that the f.nal intervention includes evidence-inf.rmed content that is likely to be adopted, properly implemented, and sustained over time by the targeted intervention deliverers. f.r f.oty f.rst, this process involved establishing a multidisciplinary intervention development group, conducting 2targeted literature reviews, undertaking an online expert consensus process, conducting f.cus groups with program end users, testing the program multiple times in dif.erent contexts, and obtaining f.edback f.om early implementers of.the ***: This systematic yet pragmatic and iterative intervention development process is potentially applicable to any injury prevention topic across all sports settings and levels. It will guide researchers wishing to undertake interventio

关键词： Australian f.otball Implementation Intervention development Lower limb injuries Research-to-practice Sports injury prevention Translation

Optimal laser intensity prof.les f.r a unif.rm target illumination in direct-drive inertial conf.nement f.sion

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High Power Laser Science and Engineering 2014年第4期2卷 62-67页

作者： Mauro Temporal Benoit Canaud warren J.Garbett Raf.el Ramis Centre de Mathématiques et de Leurs Applications ENS Cachan and CNRS 61 Av.du President WilsonF-94235 Cachan Cedex France CEA DIF F-91297 Arpajon Cedex France AWE plc Aldermaston ReadingBerkshire RG7 4PR United Kingdom ETSI Aeronuticos Universidad Polit'ecnica de Madrid28040 Madrid Spain

A numerical method providing the optimal laser intensity prof.les f.r a direct-drive inertial conf.nement f.sion scheme has been developed. The method provides an alternative approach to phase-space optimization studies, which can prove computationally expensive. The method applies to a generic irradiation conf.guration characterized by an arbitrary number NBof.laser beams provided that they irradiate the whole target surf.ce, and thus goes beyond previous analyses limited to symmetric conf.gurations. The calculated laser intensity prof.les optimize the illumination of.a spherical *** paper f.cuses on description of.the method, which uses two steps: f.rst, the target irradiation is calculated f.r initial trial laser intensities, and then in a second step the optimal laser intensities are obtained by correcting the trial intensities using the calculated illumination. A limited number of.example applications to direct drive on the Laser Mega Joule(LMJ) are described.

关键词： direct drive inertial conf.nement f.sion laser system

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Population dif.erentiation at a regional scale in spadef.ot toads： contributions of.distance and divergent selective environments

作者： (Mcf.rlan f. warren)麦克法兰杨斌

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Current Zoology 2016年第2期62卷 193-206页

作者： Amber M. RICE Michael A. MCQUILLAN Heidi A. SEEARS Joanna A. warren Department of.Biological Sciences Lehigh University BethLehem PA 18015 USA

The causes of.population dif.erentiation can provide insight into the origins of.early barriers to gene f.ow. Two key drivers of.population dif.erentiation are geographic distance and local adaptation to divergent selective environments. When reproductive isolation arises because some populations of.a species are under selection to avoid hybridization while others are not, population dif.erentiation and even speciation can result. Spadef.ot toad populations that are sympatric with a congener have undergone reinf.rcement. This reinf.rcement has resulted not only in increased reproductive isolation f.om the congener, but also in the evolution of.reproductive isolation f.om nearby and distant conspecif.c allopatric populations. We used multiple approaches to evaluate the contributions of.geographic distance and divergent selective environments to population structure across this regional scale in , based on genotypes f.om six nuclear microsatellite markers. We compared groups of.populations varying in both geographic location and in the presence of.a congener. Hierarchical f.statistics and results f.om cluster analyses and discriminant analyses of.principal components all indicate that geographic distance is the stronger contributor to genetic dif.erentiation among populations at a regional scale. However, we f.und evidence that adaptation to divergent selective environments also contributes to population structure. Our f.ndings highlight how variation in the balance of.evolutionary f.rces acting across a species' range can lead to variation in the relative contributions of.geographic distance and local adaptation to population dif.erentiation across dif.erent spatial scales.

关键词：种群分化距离和环境蟾蜍人口结构地理位置生殖隔离标记基因型

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全球信息经济中的治理

信息系统学报 2007年第1期1卷 8-15页

作者： MCf.RLAN f.warren 哈佛大学商学院美国

治理是信息技术领域的永恒话题,在21世纪之初这一问题显得尤为重要。在这个新时代哪些保持不变?哪些又发生了改变?为了深入探讨组织面临的IT治理问题,两个重要的框架:战略网格和技术学习,被引入作为分析方法。在这些框架下,本文还讨论了... 详细信息

治理是信息技术领域的永恒话题,在21世纪之初这一问题显得尤为重要。在这个新时代哪些保持不变?哪些又发生了改变?为了深入探讨组织面临的IT治理问题,两个重要的框架:战略网格和技术学习,被引入作为分析方法。在这些框架下,本文还讨论了在IT治理中起到积极作用的四个群组及它们在不同类型企业中面对IT治理问题的不同应对。

关键词： IT治理战略网格技术学习

MiR-130a regulates and dendritic spine MeCP2 neurite outgrowth density by targeting

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Protein & Cell 2016年第7期7卷 489-500页

作者： Yunjia Zhang Mengmeng Chen Zilong Qiu Keping Hu warren McGee Xiaoping Chen Jianghong Liu Li Zhu Jane Y. Wu State Key Laboratory f.r Brain & Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of.Chinese Academy of.Sciences Beijing 100049 China Laboratory of.Molecular Basis of.Neural Plasticity Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 China Institute of.Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences Beijing 100193 China Department of.Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

MicroRNAs （miRNAs） are critical f.r both development and f.nction of.the central nervous system. Signif.cant evidence suggests that abnormal expression of.miRNAs is associated with neurodevelopmental disorders. MeCP2 protein is an epigenetic regulator repressing or activating gene transcription by binding to methylated DNA. Both loss-of.f.nction and gain-of.f.nction muta- tions in the MECP2 gene lead to neurodevelopmental disorders such as Rett syndrome, autism and MECP2 duplication syndrome. In this study, we demonstrate that miR-130a inhibits neurite outgrowth and reduces dendritic spine density as well as dendritic complexity. Bioinf.rmatics analyses, cell cultures and biochemical experiments indicate that miR-130a targets MECP2 and down-regulates MeCP2 protein expression. f.rther- more, expression of.the wild-type MeCP2, but not a loss- of.f.nction mutant, rescues the miR-130a-induced phe- notype. Our study uncovers the MECP2 gene as a pre- vious unknown target f.r miR-130a, supporting that miR-130a may play a role in neurodevelopment by reg- ulating MeCP2. Together with data f.om other groups,our work suggests that a f.edback regulatory mecha- nism involving both miR-130a and MeCP2 may serve to ensure their appropriate expression and f.nction in neural development.

关键词： miR-130a MECP2 neurite outgrowth,dendritic spines dendrite morphology