检索结果-南通市图书馆

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： run Song Shiyi Yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin Liu run Hou Chenghao Wu Ruishan Xie Shujun Chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of Beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

Lightweight Al-Nb-Ti-V-Cr high entropy alloys with high hardness and enhanced mechanical properties via doping Co

在线全文

学校读者我要写书评

暂无评论

China Foundry 2025年

作者： Fang-dong Xu De-zhi Chen Rui-run Chen Bin Gan Jing-yue Yu National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Suzhou Laboratory

To develop high-hardness and high-strength lightweight high entropy alloys （LHEAs）,a series of CoxAlNbTiVCr alloys were *** phase constitution,distribution,and crystal structure of the Laves phase in alloys can be altered by adjusting the composition of HEAs,which in turn influences their mechanical *** Nb Ti VCr （x=0,0.5,1,1.5,and 2,atomic ratio percentage） LHEAs were designed and prepared to characterize the microstructure and tailor the mechanical *** introduction of Co changes the microstructure of LHEAs from a single B2 structure to a mixture dendrite structure,which consists of B2 phase,C14 and C15 Laves *** the C14 and C15 Laves phases exhibit coupled *** parameters including mixing enthalpy (ΔHmix),valence electron concentration （VEC）,atomic radius size （δ）,mixing entropy （ΔS）,and electronegativity difference （Δχ） are used to predict the formation of B2 and Laves phase in *** the Co content increases from 0 to 1.5at.%,Laves phase volume fraction gradually increases,which leads to an enhancement in the compressive strength from 1,520.8 MPa to 1,844.4 ***1.5Al Nb Ti VCr alloy exhibits the maximum Vickers hardness of 699.4 *** improvement of mechanical properties mainly originates from solid solution strengthening and second phase strengthening.

关键词：

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang Dan-Dan Cui Kun-Rong Du Hong-run Zhang Sheng-Jie Xu Ya-Qi Li Zhi-Zhen Ren Liang Wang Wei-Chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

Investigation of edge states variation in valley photonic crystals by modulating the refractive index of domain walls

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Optoelectronics Letters 2025年第3期21卷 160-166页

作者： ZHANG run ZHONG Xingli LIN Zhongxi QIU Weibin SU Hui Key Laboratory of Optoelectronic Materials Chemistry and Physics Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Fujian Institute of Research on the Structure of Matter Chinese Academy of Science University of Chinese Academy of Sciences Chinese Academy of Sciences College of Information Science and Engineering Huaqiao University Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

Realizing the valley Hall effect by breaking the spatial inversion symmetry of photonic systems has become a cutting-edge field of micro-nano-optics, since the valley degree of freedom was introduced into photonic system. Various novel devices based on the domain walls of the valley photonic crystals have also been demonstrated. In this article,we investigate the variation of edge states by the modulation of refractive index within the domain walls, and the geometric difference between the dielectric columns of the sublattices. Straight photonic crystal waveguides with three types of domain walls (bearded, zigzag, armchair) are constructed. Simulation results show that the creation of a double-edge state in the band diagram results in two windows of stable transmission in tunable bands. Our findings might have significant implications in the field of novel optical devices.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

星形AB共聚物和A均聚物的共组装模拟研究

原子与分子物理学报 2025年第5期42卷 90-94页

作者：段润宇新疆大学物理科学与技术学院乌鲁木齐830017

具有独特结构的纳米粒子在高分子材料领域具有广泛的应用.本文采用耗散粒子动力学模型系统的研究了三臂星形AB二嵌段共聚物和A均聚物共混体系的共组装相行为.通过调节聚集体中星形共聚物浓度和AB嵌段的长度比有效地控制了AB/A共混体系... 详细信息

具有独特结构的纳米粒子在高分子材料领域具有广泛的应用.本文采用耗散粒子动力学模型系统的研究了三臂星形AB二嵌段共聚物和A均聚物共混体系的共组装相行为.通过调节聚集体中星形共聚物浓度和AB嵌段的长度比有效地控制了AB/A共混体系中聚集体的共组装形貌.预测了一些有趣的结构,比如,具有较厚壳层的核-壳-补丁结构、具有壳层的且中心凹陷的圆盘状结构以及不规则椭球的多室结构.本文还发现对于具有较长A嵌段的星形链,增大A均聚物在聚集体中的浓度能够消除聚集体内B嵌段形成的核;对于具有较短A嵌段的星形链,少量的A均聚物能够诱导聚集体共组装成具有长条状核的多室纳米粒子.

关键词：耗散粒子动力学星形二嵌段共聚物共组装纳米粒子

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

我国高中英语教材生态素养呈现研究

外语学刊 2025年第1期 57-63页

作者：李润怡张虹北京外国语大学中国外语与教育研究中心北京100089

本研究以7册我国高中英语教材作为研究对象,运用内容分析和生态话语分析方法,探究教材生态素养呈现及其话语表征。研究发现:教材中生态行为素养和生态知识素养的内容较多,生态伦理素养和生态情感素养的内容较少。各生态素养内容又有其... 详细信息

本研究以7册我国高中英语教材作为研究对象,运用内容分析和生态话语分析方法,探究教材生态素养呈现及其话语表征。研究发现:教材中生态行为素养和生态知识素养的内容较多,生态伦理素养和生态情感素养的内容较少。各生态素养内容又有其较为凸显的话语表征,包括:将专家作为言说主体、将自然标记为积极价值、将人与自然作为同类参与者角色、倡导保护自然的行动以及反思破坏自然的活动。基于研究发现,本研究从内容选择、话语建构、活动设计等方面为教材编写者和一线英语教师提供了建议。

关键词：生态知识素养生态情感素养生态伦理素养生态行为素养高中英语教材生态话语分析及物性

基于世界模拟的政治非稳态:Sora的智能影像生成与历史重塑

在线全文

学校读者我要写书评

暂无评论

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 70-78页

作者：高奇琦台润泽华东政法大学政府管理学院上海201620 华东政法大学政治学研究院上海201620

OpenAI发布的文字转视频模型Sora在智能影像生成领域取得突破,被认为具备“世界模拟”能力。这种对现实物理世界的逼真模拟能力,引发人类对“真实性”的重新评估。通过模拟现实场景和历史事件,Sora在展示其应用潜力的同时,对真实性、历... 详细信息

OpenAI发布的文字转视频模型Sora在智能影像生成领域取得突破,被认为具备“世界模拟”能力。这种对现实物理世界的逼真模拟能力,引发人类对“真实性”的重新评估。通过模拟现实场景和历史事件,Sora在展示其应用潜力的同时,对真实性、历史真相和公众信任等带来挑战。文本介绍了Sora的技术背景,探讨了智能影像与虚假信息结合的风险。这一结合可能通过社会媒介影响公众信念和政治秩序,引发社会极化和分化。此外,在重塑历史记忆与认同时,可能导致信息的扭曲和伪造问题,或将社会推向政治非稳态。为应对技术带来的挑战,文本强调在迈向通用人工智能时代的过程中平衡技术创新与社会责任的重要性。通过深入分析Sora等智能影像生成的可能影响与挑战,提醒社会关注生成式人工智能技术的监管和伦理,确保技术发展的同时维护历史的真实性,保障社会福祉。

关键词： Sora 智能影像生成人工智能政治秩序

Super-Resolution Reconstruction of Image Sequence Using Multiple Motion Estimation Fusion

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2004年第3期19卷 405-412页

作者： ChengWang run-ShengWang ATRNationalLaboratory NationalUniversityofDefenseTechnologyChangsha410073P.R.China

Super-resolution reconstruction algorithm produces a high-resolution imagefrom a low-resolution image sequence. The accuracy and the stability of the motion estimation (ME)are essential for the whole restoration. In this paper, a new super-resolution reconstructionalgorithm is developed using a robust ME method, which fuses multiple estimated motion vectorswithin the sequence. The new algorithm has two major improvements compared with the previousresearch. First, instead of only two frames, the whole sequence is used to obtain a more accurateand stable estimation of the motion vector of each frame; second, the reliability of the ME isquantitatively measured and introduced into the cost function of the reconstruction algorithm. Thealgorithm is applied to both synthetic and real sequences, and the results are presented in thepaper.

关键词： image sequence super resolution motion estimation fusion