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Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice

Signal Transduction and Targeted Therapy 2023年第4期8卷 1842-1856页

作者： Zhiqiang Fang Hao Xu Juanli Duan Bai ruan Jingjing Liu Ping Song jian Ding Chen Xu Zhiwen Li Kefeng Dou Lin Wang Department of Hepatobiliary Surgery Xi-Jing HospitalFourth Military Medical UniversityXi’an 710032China Center of Clinical Aerospace Medicine&Department of Aviation Medicine Fourth Military Medical UniversityXi’an 710032China

Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic liver diseases lacks effective treatment. Tamoxifen hasbeen proven to be the first-line chemotherapy for several solid tumors in clinics, however, its therapeutic role in NAFLD has neverbeen elucidated before. In vitro experiments, tamoxifen protected hepatocytes against sodium palmitate-induced lipotoxicity. Inmale and female mice fed with normal diets, continuous tamoxifen administration inhibited lipid accumulation in liver, andimproved glucose and insulin intolerance. Short-term tamoxifen administration largely improved hepatic steatosis and insulinresistance, however, the phenotypes manifesting inflammation and fibrosis remained unchanged in abovementioned models. Inaddition, mRNA expressions of genes related to lipogenesis, inflammation, and fibrosis were downregulated by tamoxifentreatment. Moreover, the therapeutic effect of tamoxifen on NAFLD was not gender or ER dependent, as male and female mice withmetabolic disorders shared no difference in response to tamoxifen and ER antagonist (fulvestrant) did not abolish its therapeuticeffect as well. Mechanistically, RNA sequence of hepatocytes isolated from fatty liver revealed that JNK/MAPK signaling pathwaywas inactivated by tamoxifen. Pharmacological JNK activator (anisomycin) partially deprived the therapeutic role of tamoxifen intreating hepatic steatosis, proving tamoxifen improved NAFLD in a JNK/MAPK signaling-dependent manner.

关键词： tamoxifen hepatic inflammation

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Inverse Calculation and Regularization Process for the Solar Aspect System(SAS) of HXI Payload on ASO-S Spacecraft

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Research in Astronomy and Astrophysics 2024年第4期24卷 13-34页

作者： Ji-Rui Yu Ping ruan Yang Su Ying-Hong He Jin-You Tao Zhe Zhang Song Guo Bin Xue jian-Feng Yang Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi'an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 20034China School ofAstronomy and Space Science Universityof Science and Technology of ChinaHefei 230026China

For the ASO-S/HXI payload, the accuracy of the flare reconstruction is reliant on important factors such as the alignment of the dual grating and the precise measurement of observation orientation. To guarantee optimal functionality of the instrument throughout its life cycle, the Solar Aspect System (SAS) is imperative to ensure that measurements are accurate and reliable. This is achieved by capturing the target motion and utilizing a physical model-based inversion algorithm. However, the SAS optical system’s inversion model is a typical ill-posed inverse problem due to its optical parameters, which results in small target sampling errors triggering unacceptable shifts in the solution. To enhance inversion accuracy and make it more robust against observation errors, we suggest dividing the inversion operation into two stages based on the SAS spot motion model. First, the as-rigid-aspossible (ARAP) transformation algorithm calculates the relative rotations and an intermediate variable between the substrates. Second, we solve an inversion linear equation for the relative translation of the substrates, the offset of the optical axes, and the observation orientation. To address the ill-posed challenge, the Tikhonov method grounded on the discrepancy criterion and the maximum a posteriori (MAP) method founded on the Bayesian framework are utilized. The simulation results exhibit that the ARAP method achieves a solution with a rotational error of roughly±3 5 (1/2-quantile);both regularization techniques are successful in enhancing the stability of the solution, the variance of error in the MAP method is even smaller—it achieves a translational error of approximately±18μm (1/2-quantile) in comparison to the Tikhonov method’s error of around±24μm (1/2-quantile). Furthermore, the SAS practical application data indicates the method’s usability in this study. Lastly, this paper discusses the intrinsic interconnections between the regularization methods.

关键词： methods:data analysis Sun:flares Sun:X-rays gamma rays

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High-stability spherical lanthanide nanoclusters for magnetic resonance imaging

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National Science Review 2023年第4期10卷 123-132页

作者： Hai-Ling Wang Donglin Liu jian-Hua Jia Jun-Liang Liu Ze-Yu ruan Wei Deng Shiping Yang Si-Guo Wu Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of Chemistry Sun Yat-sen University College of Chemistry and Materials Science Shanghai Normal University

High-nuclear lanthanide clusters have shown great potential for the administration of high-dose mononuclear gadolinium chelates in magnetic resonance imaging(MRI). The development of high-nuclear lanthanide clusters with excellent solubility and high stability in water or solution has been challenging and is very important for expanding the performance of MRI. We used N-methylbenzimidazole-2-methanol(HL) and LnCl3·6H2O to synthesize two spherical lanthanide clusters, Ln32(Ln = Ho, Ho32; and Ln =Gd, Gd32), which are highly stable in solution. The 24 ligands L-are all distributed on the periphery of Ln32and tightly wrap the cluster core, ensuring that the cluster is stable. Notably, Ho32can remain highly stable when bombarded with different ion source energies in HRESI-MS or immersed in an aqueous solution of different pH values for 24 h. The possible formation mechanism of Ho32was proposed to be Ho(Ⅲ),(L)-and H2O → Ho3(L)3/Ho3(L)4→ Ho4(L)4/Ho4(L)5→ Ho6(L)6/Ho6(L)7→ Ho16(L)19→Ho28(L)15→ Ho32(L)24/Ho32(L)21/Ho32(L)23. To the best of our knowledge, this is the first study of the assembly mechanism of spherical high-nuclear lanthanide clusters. Spherical cluster Gd32, a form of highly aggregated Gd(Ⅲ), exhibits a high longitudinal relaxation rate(1 T, r1= 265.87 mM-1·s-1). More notably, compared with the clinically used commercial material Gd-DTPA, Gd32has a clearer and higher-contrast T1-weighted MRI effect in mice bearing 4T1 tumors. This is the first time that high-nuclear lanthanide clusters with high water stability have been utilized for MRI. High-nuclear Gd clusters containing highly aggregated Gd(Ⅲ) at the molecular level have higher imaging contrast than traditional Gd chelates; thus, using large doses of traditional gadolinium contrast agents can be avoided.

关键词： T1-weighted MRI lanthanide clusters high stability low toxicity assembly mechanism

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Serologic Response to SARS-CoV-2 in COVID-19 Patients with Different Severity

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Virologica Sinica 2020年第6期35卷 752-757页

作者： Wen-Hua Kong Rong Zhao Jun-Bo Zhou Fang Wang De-Guang Kong jian-Bin Sun Qiong-Fang ruan Man-Qing Liu Wuhan Center for Disease Control and Prevention Wuhan 430024China Wuhan Third Hospital Tongren Hospital of Wuhan UniversityWuhan 430060China

The immense patient number caused by coronavirus disease 2019(COVID-19)global pandemic brings the urge for more knowledge about its immunological features,including the profile of basic immune *** this study,eighty-eight reported COVID-19 patients in Wuhan were recruited from January to February,2020,including 32 severe/critical cases and56 mild/moderate *** mean age was 56.43 years(range 17–83)and gender ratio(male/female)was 43:*** tested SARS-CoV-2 RNA with commercial kits,investigated the level of serologic IgM and IgG antibodies against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using magnetic particle chemiluminescence immunoassays,and compared the results of serologic tests and nucleic acid test(NAT).Among 88 patients,95.45%were confirmed as positive by the combination of NAT and antibody test,which was significantly higher(P<0.001)than by single nucleic acid test(73.86%)or serologic test(65.91%).Then the correlation between temporal profile and the level of antibody response was *** showed that seroconversion started on day 5 after disease onset and IgG level was rose earlier than *** between patients with different disease severity suggested early seroconversion and high antibody titer were linked with less severe clinical *** results supported the combination of serologic testing and NAT in routine COVID-19 diagnosis and provided evidence on the temporal profile of antibody response in patients with different disease severity.

关键词： COVID-19 Nucleic acid test(NAT) Serologic test Real-time polymerase chain reaction(RT-PCT) Chemiluminescence immunoassay(CLIA)

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Endoscopic detection and diagnostic strategies for minute gastric cancer:A real-world observational study

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3529-3538页

作者： Xiao-Wei Ji Jie Lin Yan-Ting Wang Jing-Jing ruan Jing-Hong Xu Kai Song jian-Shan Mao Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

BACKGROUND Minute gastric cancers(MGCs)have a favorable prognosis,but they are too small to be detected by endoscopy,with a maximum diameter≤5 *** To explore endoscopic detection and diagnostic strategies for *** This was a real-world observational *** endoscopic and clinicopathological parameters of 191 MGCs between January 2015 and December 2022 were retrospectively *** discoverable opportunity and typical neoplastic features were emphatically *** All MGCs in our study were of a single pathological type,97.38%(186/191)of which were differentiated-type *** light endoscopy(WLE)detected 84.29%(161/191)of MGCs,and the most common morphology of MGCs found by WLE was ***-band imaging(NBI)secondary observation detected 14.14%(27/191)of MGCs,and the most common morphology of MGCs found by NBI was *** three MGCs were detected by indigo carmine third *** a well-demarcated border lesion exhibited a typical neoplastic color,such as yellowish-red or whitish under WLE and brownish under NBI,MGCs should be *** proportion with high diagnostic confidence by magnifying endoscopy with NBI(ME-NBI)was significantly higher than the proportion with low diagnostic confidence and the only visible groups(94.19%>56.92%>32.50%,P<0.001).CONCLUSION WLE combined with NBI and indigo carmine are helpful for detection of MGCs.A clear demarcation line combined with a typical neoplastic color using nonmagnifying observation is sufficient for diagnosis of *** improves the endoscopic diagnostic confidence of MGCs.

关键词： Minute gastric cancer White light endoscopy Narrow-band imaging endoscopy Indigo carmine Magnifying endoscopy Detection Diagnosis

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Dynamics of Soil and Grain Micronutrients as Affected by Long-Term Fertilization in an Aquic Inceptisol

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Pedosphere 2010年第6期20卷 725-735页

作者： LI Ben-Yin HUANG Shao-Min WEI Ming-Bao H. L. ZHANG SHEN A-Lin XU jian-Ming ruan Xin-Ling Institute of Plant Nutrition Agricultural Resources and Environmental Sciences Henan Academy of Agricultural Sciences Zhengzhou 450002 (China) College of Environment and Natural Resources Zhejiang University Hangzhou 310058 (China) Henan Provincial Key Lab of Surface and Interface Science Zhengzhou University of Light Industry Zhengzhou 450002 (China) Department of Plant and Soil Sciences Oklahoma State University Stillwater OK 74078 (USA) College of Environment and Planning Henan University Kaifeng 475000 (China)

Micronutrient status in soils can be affected by long-term fertilization and intensive cropping.A 19-year experiment (1990-2008) was carried out to investigate the influence of different fertilization regimes on micronutrients in an Aquic Inceptisol and maize and wheat grains in Zhengzhou,*** results showed that soil total Cu and Zn markedly declined after 19 years with application of N fertilizer *** total Fe and Mn were significantly increased mainly due to atmospheric *** of P and organic fertilizer with incorporation of straws resulted in dramatic increases in soil total Cu,Zn,Fe,and *** diethylenetriamine pentaacetic acid (DTPA)-extractable Cu in all treatments sharply decreased from initially 1.12 to about 0.8 mg kg -1 .The treatments with organic fertilizer had the highest soil DTPA-extractable Cu,Zn,Fe,and Mn after 19 years of cropping and fertilization,thus demonstrating the important role of organic fertilizer application in improving available micronutrient *** and Zn contents in wheat grains in the no-P treatments were significantly higher than those of the treatments with P *** addition,Fe and Mn contents in wheat grains were positively correlated with their soil DTPA-extractable *** indicated that the long-term application of organic fertilizer resulted in significant increases in soil total and available micronutrient concentrations and remarkable reduction in wheat grain Cu and Zn contents,which was due to high soil available P.

关键词： Cu organic fertilizer soil available P wheat Zn

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二维活塞泵用滚子-凸轮轨道机构的建模和验证（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第3期20卷 201-217页

作者： Ding-can JIN jian ruan Sheng LI Bin MENG Ling-feng WANG Key Laboratory of E&M Zhejiang University of Technology Beijing Aerospace Technology Institute

目的:由于液压行业对高速重载的要求越来越高,传统轴向柱塞泵中存在的润滑与泄漏的矛盾也越发明显。针对传统轴向柱塞泵中因结构产生的倾斜力、低功率密度、恶劣的摩擦副工况、较大的流量脉动等限制,本文旨在提出一种具有内力平衡、功... 详细信息

目的:由于液压行业对高速重载的要求越来越高,传统轴向柱塞泵中存在的润滑与泄漏的矛盾也越发明显。针对传统轴向柱塞泵中因结构产生的倾斜力、低功率密度、恶劣的摩擦副工况、较大的流量脉动等限制,本文旨在提出一种具有内力平衡、功率密度高、无纯粹的滑动摩擦副且工况优秀、能消除结构性流量脉动等优点的二维活塞泵,并通过对其工作原理的详细分析,探讨其具有上述优点的理论依据。创新点:1.提出二维活塞泵;该泵利用二维运动转换机构中活塞部件的二维运动,同时实现了吸排油功能和配流功能,提高了集成化;通过其活塞旋转1周可以使泵吸排油4次的结构设计,提高了功率密度;轴向与轴向对称的独特结构布局,实现了内力平衡,消除了传统轴向柱塞泵中无法消除的倾覆力偶;相对于传统轴向柱塞泵,吸排油与配流功能的集成减少了摩擦副的数量,且消除了纯粹的滑动摩擦副,打破了PV值的限制,意味着二维活塞泵有着实现更大流量压力分布的潜力。2.提出二维活塞泵运动转换机构中的锥滚子-凸轮接触结构,优化二维活塞泵运动转换机构的受力条件;3.建立二维活塞泵运动转换机构中锥滚子-凸轮接触副的通用型数学模型,通过运动学分析建立精确的凸轮表面模型(即二维活塞泵的运动学模型),为二维锥滚轮活塞泵的结构设计和进一步的静、动力学的研究提供理论基础。4.消除结构性流量脉动。方法:1.通过对二维活塞泵结构与工作原理的理论分析,讨论其相对于传统轴向柱塞泵所具有的优点。2.通过跑合实验,验证锥滚子-凸轮接触结构具有的受力条件。3.通过运动学分析与空间几何关系变换推导,得到运动转换机构中具有普遍指导意义的接触副的通用数学模型。4.通过实验曲线与理论曲线的对比,验证接触副数学模型的正确性与二维活塞泵所具有的消除结构流量脉动的潜力。5.通过滤波处理与模拟仿真,验证二维活塞泵能否消除结构性流量脉动。结论:1.二维活塞泵具有功能集成化高、内力平衡、功率密度高、无纯粹的滑动摩擦副且能消除流量脉动的优点。2.运动转换机构中锥滚子-凸轮接触结构具有更好的受力条件。3.建立的接触副数学模型可以指导二维活塞泵中运动转换机构的加工,且对二维活塞泵进一步的运动学与动力学的研究具有指导意义。4.二维活塞泵能消除结构性流量脉动。

关键词：二维活塞泵功能集成化滚子-凸轮机构数学模型无结构性流量脉动

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二维燃油泵的设计与研究

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航空学报 2019年第5期40卷 313-322页

作者：金丁灿阮健浙江工业大学机械工程学院杭州310000

提出一种新型的二维燃油泵,说明了其诸多优点。为研究其结构性流量脉动,利用仿真软件AMESIM建立了二维燃油泵的仿真模型进行理论研究,并进行了实验验证。通过齿轮泵与轴向柱塞泵的对比,说明了轴向柱塞泵在燃油系统应用中的优势。针对轴... 详细信息

提出一种新型的二维燃油泵,说明了其诸多优点。为研究其结构性流量脉动,利用仿真软件AMESIM建立了二维燃油泵的仿真模型进行理论研究,并进行了实验验证。通过齿轮泵与轴向柱塞泵的对比,说明了轴向柱塞泵在燃油系统应用中的优势。针对轴向柱塞泵中存在的一些不可避免的缺陷,提出了能避免这些缺陷的二维燃油泵。通过解释二维燃油泵的结构组成与工作原理,说明了二维燃油泵的优势,包括结构力平衡、工作效率高、无直接的滑动摩擦副和无结构性流量脉动等。为了解释无结构性流量脉动这一优点,进行了仿真分析与实验验证,验证了二维燃油泵具有无结构性流量脉动这一潜力。

关键词：二维燃油泵结构力平衡滑动摩擦副少 AMESIM 无结构性流量脉动

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晶向对铝合金构件微动疲劳初始起裂的影响研究

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振动与冲击 2023年第19期42卷 130-136页

作者：王建阮星源西南科技大学土木工程与建筑学院四川绵阳621010

交变荷载作用下铝合金板材及结构组件的微动疲劳问题是飞机安全服役所面临的主要挑战和技术难题,而微动疲劳影响因素辨识是微动疲劳评估及控制的关键。为促进飞机构件微动疲劳评估及控制技术的发展,利用晶体塑性有限元方法和子模型-全... 详细信息

交变荷载作用下铝合金板材及结构组件的微动疲劳问题是飞机安全服役所面临的主要挑战和技术难题,而微动疲劳影响因素辨识是微动疲劳评估及控制的关键。为促进飞机构件微动疲劳评估及控制技术的发展,利用晶体塑性有限元方法和子模型-全局模型耦合技术研究了飞机机身铆钉-平板结构在压、剪交变应力循环作用下裂纹萌生特征,探讨了以晶向表征的材料细观织构分布对铝合金试样微动疲劳的影响。研究发现,晶向分布将对晶体材料的弹性模量和屈服及硬化强度造成明显影响;晶向分布对微动疲劳接触面起裂部位的影响不明显,而对亚表面起裂部位影响比较显著;晶向分布对微动疲劳初始起裂寿命的影响比较明显。研究结果表明,晶向分布这一细观织构影响了晶体材料宏观尺度的弹性强度特征和塑性变形特征,并对金属构件微动疲劳初始起裂寿命、亚表面裂缝发轫位置及扩展特征均造成了影响。基于该研究结论,利用材料加工方法改变金属晶体试样浅表层的晶向分布状态,将可以对微动疲劳裂缝发轫及扩展起到抑制作用。

关键词：微动疲劳裂纹萌生初始起裂部位晶向晶体塑性有限元

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THE SECOND RECIPROCAL DERIVATIVE CHRONOPOTENTIOMETRY ANALYSIS

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Chinese Chemical Letters 1992年第3期3卷 205-206页

作者： Xiang Yuan ruan Ju Nan LI Yi Hen LI jian Cheng DENG Department of chemistry Xiangtan UniversityXiangtanHunan

Theories of the second reciprocal derivative chronopotentiometry analysis were deduced and experimentally *** in this study show that chronopotentiometry is significantly developed in both sensitivity and resolution f... 详细信息

关键词： CPA FRD SRD THE SECOND RECIPROCAL DERIVATIVE CHRONOPOTENTIOMETRY ANALYSIS

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