检索结果-南通市图书馆

Transient receptor potential channels as predictive marker and potential indicator of chemoresistance in colon cancer

引用

Oncology Research 2024年第1期32卷 227-239页

作者： WEI HU THOMAS WARTMANN MARCO STRECKER ARISTOTELIS PERRAKIS roland croner ARPAD SZALLASI WENJIE SHI ULF D.KAHLERT The Fourth Clinical Medical College of Yangzhou University Nantong Rich HospitalNantongChina Molecular and Experimental Surgery Clinic for General-Visceral-Vascular and Transplant SurgeryFaculty of Medicine and University Hospital MagdeburgOtto-von-Guericke UniversityMagdeburgGermany Department of Pathology and Experimental Cancer Research Semmelweis UniversityBudapestHungary

Transient receptor potential(TRP)channels are strongly associated with colon cancer development and *** study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature,with further validation of signature in real world samples from our hospital treated patient ***-Meier(K-M)survival analysis and receiver operating characteristic(ROC)curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts,***,the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration landscape and underlying functional *** support vector machine algorithm was applied to evaluate the signature’s potential in predicting chemotherapy *** findings unveiled a novel three TRP channels-related gene signature(MCOLN1,TRPM5,and TRPV4)in colon adenocarcinoma(COAD).The ROC and K-M survival curves in the training dataset(AUC=0.761;p=1.58e-05)and testing dataset(AUC=0.699;p=0.004)showed the signature’s robust predictive capability for the overall survival of COAD *** of the immune infiltration landscape associated with the signature revealed higher immune infiltration,especially an increased presence of M2 macrophages,in high-risk group patients compared to their low-risk ***-risk score patients also exhibited potential responsiveness to immune checkpoint inhibitor therapy,evident through increased CD86 and PD-1 expression ***,the TRPM5 gene within the signature was highly expressed in the chemoresistance group(p=0.00095)and associated with poor prognosis(p=0.036)in COAD patients,highlighting its role as a hub gene of ***,this signature emerged as an independent prognosis factor for COAD patients(p=6.48e-06)and expression of model gene are validated by public data a

关键词： Colon cancer Transient receptor potential channels Prognostic signature Chemotherapy efficiency TRPM5

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International consensus guidelines on robotic pancreatic surgery in 2023

引用

Hepatobiliary Surgery and Nutrition 2024年第1期13卷 89-104页

作者： Rong Liu Mohammed Abu Hilal Marc G.Besselink Thilo Hackert Chinnusamy Palanivelu Yupei Zhao Jin He Ugo Boggi Jin-Young Jang Fabrizio Panaro Brian K.P.Goh Mikhail Efanov Yuichi Nagakawa Hong-Jin Kim Xiaoyu Yin Zhiming Zhao Yi-Ming Shyr Shridhar Iyer Eli Kakiashvili Ho-Seong Han Jae Hoon Lee roland croner Marco Vito Marino Arun Prasad Wei Wang Songqing He Kehu Yang Qu Liu Zizheng Wang Mengyang Li Shuai Xu Kongyuan Wei Zhaoda Deng Yuze Jia Tess M.E.van Ramshorst Faculty of Hepatopancreatobiliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Department of Surgery Poliambulanza Foundation HospitalBresciaItaly Department of Surgery University Hospital Southampton NHS Foundation TrustSouthamptonUK Amsterdam UMC location University of AmsterdamDepartment of SurgeryAmsterdamThe Netherlands Cancer Center Amsterdam AmsterdamThe Netherlands Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburgGermany Department of Minimal Invasive Hernia Surgery GEM Hospital and Research CentreChennaiTamil NaduIndia Department of General Surgery Peking Union Medical College Hospital BeijingBeijingChina Department of Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA Division of General and Transplant Surgery University of PisaPisaItaly Department of Surgery Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Surgery/Division of HBP Surgery&Transplantation University of MontpellierMontpellierFrance Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and National Cancer Centre SingaporeSingaporeSingapore Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscowRussia Department of Gastrointestinal and Pediatric Surgery Tokyo Medical UniversityShinjukuTokyoJapan Department of Surgery Yeungnam University College of MedicineDaeguKorea Department of Pancreato-Biliary Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina 18 Division of Hepatobiliary Pancreatic Surgery and Liver TransplantationNational University HospitalSingaporeSingapore Department of Surgery Galilee Medical CenterNahariyaIsrael Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam-siKorea Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical Cente

Background:With the rapid development of robotic surgery,especially for the abdominal surgery,robotic pancreatic surgery(RPS)has been applied increasingly around the ***,evidence-based guidelines regarding its application,safety,and efficacy are still *** harvest robust evidence and comprehensive clinical practice,this study aims to develop international guidelines on the use of ***:World Health Organization(WHO)Handbook for Guideline Development,GRADE Grid method,Delphi vote,and the AGREE-II instrument were used to establish the Guideline Steering Group,Guideline Development Group,and Guideline Secretary Group,formulate 19 clinical questions,develop the recommendations,and draft the *** online meetings were held on 04/12/2020,30/11/2021,and 25/01/2022 to vote on the recommendations and get advice and suggestions from all involved *** the experts focusing on minimally invasive surgery from America,Europe and Oceania made great contributions to this consensus ***:After a systematic literature review 176 studies were included,19 questions were addressed and 14 recommendations were developed through the expert assessment and comprehensive judgment of the quality and credibility of the ***:The international RPS guidelines can guide current practice for surgeons,patients,medical societies,hospital administrators,and related social *** randomized trials are required to determine the added value of RPS as compared to open and laparoscopic surgery.

关键词： Robotic surgery guidelines pancreatectomy pancreaticoduodenectomy distal pancreatectomy(DP)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Is robotic pancreatic surgery finally ready for prime-time?

引用

Hepatobiliary Surgery and Nutrition 2020年第5期9卷 650-653页

作者： Andrew A.Gumbs roland croner Elie Chouillard Centre Hospitalier Intercommunal de Poissy/Saint-Germain-En-Laye PoissyFrance Department of General- Visceral-Vascular-and Transplantation SurgeryUniversity Hospital MagdeburgMagdeburgGermany

The white paper entitled,“International consensus statement on robotic pancreatic surgery”,has been devised by leading minimally invasive surgeons to evaluate the current state for robotic pancreatic *** experts started the process by developing guidelines of robotic pancreatic *** experts started the process by developing guidelines of robotic pancreatic *** guidelines were refined over a total of 4 meetings with the input and assistance of 20 additional international experts.A total of 19 recommendations involving the burgeoning field of robotic pancreatic surgery have been published in this *** the recent publication of the International Summit on Laparoscopic Pancreatic Resection(ISLPR)“Coimbatore Summit Statements”,and the LEOPARD-1 and 2 trials this paper is particularly timely(1-3).

关键词： robotic surgery finally

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-compliance in surveillance for patients with previous resection of large (≥ 1 cm) colorectal adenomas

引用

World Journal of Gastroenterology 2006年第45期12卷 7313-7318页

作者： Wolfgang M Brueckl Berit Fritsche Brigitte Seifert FrankBoxberger Heinz Albrecht roland S croner Axel Wein Eckhart G Hahn Department of Medicine 1 University Hospital of Erlangen91054 Erlangen Germany Department of Surgery University Hospital ofErlangen 91054 Erlangen Germany

AIM: To assess the extent and reasons of non- compliance in surveillance for patients undergoing polypectomy of large (≥ 1 cm) colorectal adenomas. METHODS: Between 1995 and 2002, colorectal adenomas ≥ 1 cm were diagnosed in 210 patients and subsequently documented at the Erlangen Registry of Colorectal Polyps. One hundred and fi fty-eight patients (75.2%) could be contacted by telephone and agreed to be interviewed. Additionally, records were obtained from the treating physicians. RESULTS: Fifty-four out of 158 patients (34.2%) neglected any surveillance. Reasons for non-compliance included lack of knowledge concerning surveillance intervals (45.8%), no symptoms (29.2%), fear of examination (18.8%) or old age/severe illness (6.3%). In a multivariate analysis, the factors including female gender (P = 0.036) and age > 62 years (P = 0.016) proved to be signif icantly associated with non-compliance in surveillance. CONCLUSION: Efforts to increase compliance in surveillance are of utmost importance. This applies particularly to women’s compliance. Effective strategies for avoiding metachronous colorectal adenoma and cancer should focus on both the improvement in awareness and knowledge of patients and information about physicians for surveillance.

关键词： Colorectal adenoma Colorectal cancer Surveillance colonoscopy, Non-compliance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases

引用

World Journal of Gastroenterology 2016年第28期22卷 6434-6443页

作者： Nathalie Britzen-Laurent Christian Herrmann Elisabeth Naschberger roland S croner Michael Stürzl Division of Molecular and Experimental Surgery Department of Surgery University Medical Center Erlangen Translational Research Center Friedrich-Alexander University of Erlangen-Nuremberg Physical Chemistry I Ruhr-University Bochum Department of Surgery University Medical Center Erlangen Friedrich-Alexander University of Erlangen-Nuremberg

Guanylate-binding proteins(GBPs) are interferonstimulated factors involved in the defense against cellular pathogens and inflammation. These proteins, particularly GBP-1, the most prominent member of the family, have been established as reliable markers of interferon-γ-activated cells in various diseases, including colorectal carcinoma(CRC) and inflammatory bowel diseases(IBDs). In CRC, GBP-1 expression is associated with a Th1-dominated angiostatic micromilieu and is correlated with a better outcome. Inhibition of tumor growth by GBP-1 is the result of its strong antiangiogenic activity as well as its direct anti-tumorigenic effect on tumor cells. In IBD, GBP-1 mediates the anti-proliferative effects of interferon-γ on intestinal epithelial cells. In addition, it plays a protective role on the mucosa by preventing cell apoptosis, by inhibiting angiogenesis and by regulating the T-cell receptor signaling. These functions rely to a large extent on the ability of GBP-1 to interact with and remodel the actin cytoskeleton.

关键词： Guanylate-binding proteins Colorectal carcinoma Inflammatory bowel diseases Interferon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International experts consensus guidelines on robotic liver resection in 2023

引用

世界胃肠病学杂志:英文版 2023年第32期29卷 4815-4830页

作者： Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin roland S croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau Faculty of Hepato-Pancreato-Biliary Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100000China Hepatobiliary Pancreatic Robotic&Laparoscopic SurgeryPoliambulanza Foundation HospitalBrescia 25100Italy Center for Advanced Treatment of HBP Diseases Ageo Central General HospitalSaitama 362-0075Japan Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeoul 03080South Korea GEM Hospital&Research Centre GEM Hospital&Research CentreCoimbatore 641045India Division of General and Transplant Surgery University of PisaPisa 56126Italy Department of General Visceral and Thoracic SurgeryUniversity Hospital Hamburg-EppendorfHamburg 20251Germany Department of Surgery Yeungnam University HospitalDaegu 42415South Korea Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China Division of Hepato-Biliary-Pancreatic Surgery Department of SurgerySeverance HospitalYonsei UniversityCollege of MedicineSeoul 03722South Korea Department of Surgery/Division of Robotic and HBP Surgery Montpellier University Hospital-School of MedicineMontpellier 34090France Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscow 111123Russia Department of Pancreatobiliary Surgery The First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of General VisceralVascular and Transplant SurgeryUniversity Hospital MagdeburgMagdeburg 39120Germany Department of Surgery City of Hope Medical CenterDuarteCA 91010United States Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100000China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary and Pancreatic Surgery The Affiliated Ho

The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still *** on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical *** guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation *** to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were *** them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM *** international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future.

关键词： Robotic liver resection Laparoscopic liver resection Guidelines Expert consensus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：