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Production of Functional Materials Derived from Regenerated Silk Fibroin by Utilizing 3D Printing and Biomimetic Enzyme-induced Mineralization

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Chinese Journal of Polymer Science 2024年第3期42卷 299-310,I0005页

作者： Ni Chen Fei-Yu Luo Gong-Wen Yang Jin-rong yao Xin Chen Zheng-Zhong Shao State Key Laboratory of Molecular Engineering of Polymers Laboratory of Advanced Materials and Department of Macromolecular ScienceFudan UniversityShanghai 200433China

Critical-sized bone defects, commonly encountered in clinical orthopedic surgery, present a significant challenge. One of the promising solutions is to prepare synthetic bone substitute materials with precise structural control, mechanical compatibility, and enhanced osteogenic induction performance, nevertheless the successful preparation of such materials remains difficult. In this study, a two-step technique,integrating an extrusion-based printing process with biomimetic mineralization induced by alkaline phosphatase(ALP), was developed. Initially,a pre-cured hydrogel of regenerated silk fibroin(RSF) with a small quantity of hydroxypropyl cellulose(HPC) and ALP was prepared through heating the mixed aqueous solution. This pre-cured hydrogel demonstrated thixotropic property and could be directly extruded into predetermined structures through a 3D-printer. Subsequently, the 3D-printed RSF-based materials with ALP underwent biomimetic in situ mineralization in calcium glycerophosphate(Ca-GP) mineralizing solution, utilizing the polymer chains of RSF as templates and ALP as a trigger for cleaving phosphate bonds of Ca-GP. The resulting 3D-printed RSF-mineral composites including hydrogel and sponge possessed adjustable compression modulus of megapascal grade and variable hydroxyapatite content, which could be controlled by manipulating the duration of the mineralization ***, these 3D-printed RSF-mineral composites demonstrated non-cytotoxicity towards rat bone marrow mesenchymal stem cells. Therefore, they may hold great potential for applications involving the replacement of tissues characterized by osteoinductivity and intricate structures.

关键词： Silk protein Alkaline phosphatase Extrusion-based printing Biomineralization

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Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： yao rong Song-Hua Liu Ming-Zheng Tang Zhi-Hang Wu Guo-rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer

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Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： yao rong Ming-Zheng Tang Song-Hua Liu Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

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Local and Parallel Finite Element Algorithms Based on Two-grid Discretizations for the Unsteady MHD Equations with Low Electromagnetic Reynolds Number

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Acta Mathematicae Applicatae Sinica 2024年

作者： Shi-lin MI Guang-zhi DU yao rong Li-yun ZUO School of Mathematics and Statistics Shandong Normal University College of Engineering Physics Shenzhen Technology University School of Mathematical Sciences University of Jinan

This paper mainly presents and studies some local and parallel finite element methods for the unsteady magnetohydrodynamic equations with low electromagnetic Reynolds number. Firstly, both the semi discrete and fully discrete local algorithms are provided and investigated, and the theoretical tool crucial to the analysis of the fully discrete local algorithm is obtained. Subsequently, we generalize the fully discrete local algorithm to the fully discrete parallel algorithm. At the end, some numerical experiments are provided to validate the effectiveness and efficiency of our algorithms.

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Transition Metal/Lanthanide-Nitrogen Double Bonds Co-stabilized in a Carbon Cage

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Precision Chemistry 2024年第5期2卷 193-199页

作者： Zhanxin Jiang Ziqi Hu Yang-rong yao Wenhao Xiang Xinyi Han Jinpeng Xin Huaimin Jin Shangfeng Yang Key Laboratory of Precision and Intelligent Chemistry Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)Department of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

Metal−nitrogen double bonds have been commonly reported for conventional metal complexes,but the coexistence of both transition metal−nitrogen and lanthanide−nitrogen double bonds bridged by nitrogen within one compound has never been ***,by encapsulating a ternary transition metallanthanide heteronuclear dimetallic nitride into a C_(84) fullerene cage,transition metal−nitrogen and lanthanide-nitrogen double bonds are costabilized simultaneously within the as-formed clusterfullerene TiCeN@C_(1)(12)-C_(84),which is a representative heteronuclear dimetallic nitride *** molecular structure was unambiguously determined by single-crystal X-ray diffraction,revealing a slightly bentμ2-bridged nitride cluster with short Ti−N(1.761Å)and Ce−N(2.109Å)bond lengths,which are comparable to the corresponding Ti=N and Ce=N double bonds of reported metal complexes and consistent with the theoretically predicted values,confirming their coexistence within TiCeN@C_(1)(12)-C_(84).Density functional theory(DFT)calculations unveil three-center two-electron(3c-2e)bonds delocalized over the entire TiCeN cluster,which are responsible for costabilization of Ti�N and Ce�N double *** electronic configuration of Ti4+Ce^(3+)N^(3−)@C_(84)^(4−)is proposed featuring an intramolecular four-electron transfer,drastically different from the analogous actinide dimetallic nitride clusterfullerene(U_(2))^(9+)N^(3−)@C_(80)^(6−)and trimetallic nitride clusterfullerene(Sc_(2))^(6+)Ti^(3+)^(N3−)@C_(80)^(6−),indicating the peculiarity of 4-fold negatively charged fullerene cage in stabilizing the heteronuclear dimetallic nitride cluster.

关键词： Fullerene metallofullerene transitionmetal lanthanide metal−nitrogen multiplebond

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高等教育支撑引领强国建设的法治保障:国际经验与中国道路

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重庆高教研究 2024年第4期12卷 42-54页

作者：姚荣华东师范大学高等教育研究所上海200062

构建与高等教育强国建设相匹配的国家治理体制与法律制度体系,推动高等教育的良法善治,成为发达国家高等教育强国建设的核心要义。在以德国为代表的大陆法系国家,公法视野下的大学法范式顺应了小科学时代学术创新的基本规律。与此相比,... 详细信息

构建与高等教育强国建设相匹配的国家治理体制与法律制度体系,推动高等教育的良法善治,成为发达国家高等教育强国建设的核心要义。在以德国为代表的大陆法系国家,公法视野下的大学法范式顺应了小科学时代学术创新的基本规律。与此相比,私法视野下的英美大学法范式更加契合大科学时代学术创业的价值诉求。法治发达国家高等教育改革与发展的经验表明,当高等教育法律制度体系与高等教育和科学研究的阶段性特征相契合时,国家高等教育与科学研究的实力将会产生实质性跃升。世界高等教育中心、科技中心、人才中心转移的背后,离不开高等教育法律制度优势的作用发挥。对于中国而言,促进高等教育支撑引领强国建设,呼唤更加健全的法律制度保障:一方面,要明确国家与大学之间的法理关系,厘清高校依法自主办学这一法律制度的内涵,明晰公法与民法两种语境下高校法人的权利能力及其责任;另一方面,要激发高校教师作为专业人员的活力,明晰高校教师作为特殊劳动者的法律地位,摒弃高权管制框架对教师知识产权与创新自由的束缚。

关键词：高等教育强国学术自由公私法合作理论高校法人制度

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诗歌追和与元人诗学崇尚

古代文学理论研究

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古代文学理论研究 2024年第1期 232-254页

作者：彭健姚蓉上海大学文学院

追和酬唱在元代备受文人青睐。元代留存126位诗人作追和诗1017首，追和对象涉及先唐、唐、宋金及本朝诗人诗作。元诗人的追和崇尚，以唐及唐前诗家诗作为主，宋金及本朝诗人次之。其中，陶渊明、苏轼、杜甫等诗人作品频繁受到追和，是... 详细信息

追和酬唱在元代备受文人青睐。元代留存126位诗人作追和诗1017首，追和对象涉及先唐、唐、宋金及本朝诗人诗作。元诗人的追和崇尚，以唐及唐前诗家诗作为主，宋金及本朝诗人次之。其中，陶渊明、苏轼、杜甫等诗人作品频繁受到追和，是元人追和热点诗人的代表。诗歌追和是元诗人仰慕、取法先贤的重要途径，其创作既受时人高度的文学文化自信下逞才使气、竞技争雄心理的影响，也与先贤情感共鸣下追和自释的需求相关。元人的诗歌追和活动，包含了追和者对原作的阅读、理解、接受、批评、宣扬和反思，提升了元人的诗学素养，助力元代诗学体系的多元建构，对文学经典化的形成起到重要的作用。

关键词：追和崇尚 “热点”诗人追和动机诗学史意义宗唐得古

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Neutron star core-crust transition and the crustal moment of inertia in the nonlinear relativistic Hartree approximation

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Chinese Physics C 2024年第3期48卷 133-141页

作者：李牛韦斯纳杨荣瑶叶婧蒋维洲 School of Physics Southeast UniversityNanjing 211189China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

We investigate the effects of theσmeson mass(m_(σ)),symmetry energy,and slope of the symmetry energy on the neutron star core-crust transition density and the crustal moment of inertia(ΔI/I)in the nonlinear relativistic Hartree approach(RHA),which includes vacuum *** the core-crust transition density(ρ_(t)),pressure(P_(t)),and neutron star radius(R),which are all dependent on the symmetry energy,contribute to determiningΔI/I,we find that changing only the slope of symmetry energy within a reasonable range is not sufficient to reachΔI/I≥7%to achieve the large glitches of the Vela ***,since all three factors(ρ_(t),P_(t),and R)increase with the increase in mσthrough scalar vacuum polarization,adjusting mσcan easily achieveΔI/I≥7%.

关键词： symmetry energy relativistic Hartree approximation random phase approximation core-crust transition density pulsar glitch

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智能网联公交车出站强制换道的演化博弈机制

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吉林大学学报（工学版） 2024年第1期54卷 124-135页

作者：杜筱婧姚荣涵大连理工大学交通运输学院辽宁大连116024

为缓解智能网联公交车出站强制换道时与社会车辆之间的冲突,分析了智能网联公交车与社会车辆行为决策的演化博弈机制。考虑社会车辆为人工驾驶社会车辆和智能网联社会车辆两种场景,从安全效用、时间效用和节能效用角度构建演化博弈效用... 详细信息

为缓解智能网联公交车出站强制换道时与社会车辆之间的冲突,分析了智能网联公交车与社会车辆行为决策的演化博弈机制。考虑社会车辆为人工驾驶社会车辆和智能网联社会车辆两种场景,从安全效用、时间效用和节能效用角度构建演化博弈效用函数,并以此建立演化博弈的复制动态方程。根据动态博弈系统的雅克比矩阵的行列式和迹,分析不同情况下博弈的均衡点及其稳定性,并探讨动态博弈系统对合作策略与非合作策略差值的灵敏度。结果表明,动态博弈系统可能的演化方向包括“智能网联公交车换道、社会车辆让路”“,智能网联公交车不换道、社会车辆不让路”和“智能网联公交车不换道、社会车辆让路”。从整体最优的角度看,调整社会车辆安全效用和时间效用的相关变量,能够保证更多车辆在智能网联公交车出站强制换道过程中的安全和效率。节能效用对(换道,让路)策略组合有促进作用,对(不换道,不让路)策略组合有抑制作用。

关键词：交通工程智能网联公交车强制换道演化博弈行为决策

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比较词源学视阈下西方自由逻辑批判与马克思的超越

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党政研究 2024年第2期 68-78,M0006页

作者：李刚荣瑶中共四川省委党校马克思主义学院四川成都610071

“自由”是人类共同价值追求,但人们对“自由”的诠释却未达成共识,特别是在西方存在纷繁复杂的历史迷雾。当代中国的马克思主义研究不但要批判西方自由观,还要破除笼罩西方自由的历史迷雾,这需要深入探究马克思主义最初形成的理论土壤... 详细信息

“自由”是人类共同价值追求,但人们对“自由”的诠释却未达成共识,特别是在西方存在纷繁复杂的历史迷雾。当代中国的马克思主义研究不但要批判西方自由观,还要破除笼罩西方自由的历史迷雾,这需要深入探究马克思主义最初形成的理论土壤,从而真正把握马克思对西方自由思想的批判性和革命性本质。本文通过比较词源学的分析发现,西方“自由”的两种不同词汇表达(即“freedom”和“liberty”),具有不同的词源语境,同时对西方政治思想的自由逻辑产生了历史迷雾般的影响。只有揭示这些形成历史迷雾的源流本质,才能实现对西方自由思想的批判,而马克思正是用科学世界观和方法论破除历史迷雾,才形成具有批判性与革命性的自由观,对我们在新时代新征程增强实现人自由而全面发展的信心,具有重要的现实意义。

关键词：比较词源学马克思自由观批判性革命性

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