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Quanti.ati.e Electrophi.i.i.y Measures

物理化学学报 2018年第6期34卷 662-674页

作者： GONZáLEZ Marco Martínez CáRDENAS Carlos rodríguez juan i. Li. Shubi. HEi.AR-ZADEH Farnaz Mi.ANDA-QUi.TANA Ramón Alai. AYERS Paul W. Laboratory of Computati.nal and Theoreti.al Chemi.try Faculty of Chemistry University of Havana Havana 10400 Cuba. Departamento de Qui.i.a and Centro de Quimica Universidade de Coimbra 3004-535 Coimbra Portugal. Departamento de Fi.i.a Fac

Quanti.ati.e correlati.n of several theoreti.al electrophi.i.i.y measures over di.ferent fami.i.s of organi. compounds are exami.ed relati.e to the experi.ental values of Mayr et al.Notably,the abi.i.y to predi.t these values accurately wi.l help to eluci.ate the reacti.i.y and selecti.i.y trends observed i. charge-transfer reacti.ns.A cruci.l advantage of thi. theoreti.al approach i. that i.provi.es thi. i.formati.n wi.hout the need of experi.ents,whi.h are often demandi.g and ti.e-consumi.g.Here,two di.ferent types of electrophi.i.i.y measures were analyzed.Fi.st,models deri.ed from conceptual densi.y functi.nal theory(c-DFT),i.cludi.g Parr's ori.i.al proposal and further generali.ati.ns of thi. i.dex,are i.vesti.ated.For i.stance,the approaches of Gázquez et al.and Chamorro et al.are consi.ered,whereby i. i. possi.le to di.ti.gui.h between processes i. whi.h a molecule gai.s or loses electrons.Further,we also explored two novel electrophi.i.i.y defi.i.i.ns.On one hand,the potenti.l of envi.onmental perturbati.ns to affect electron i.corporati.n i.to a system i. analyzed i. terms of recent developments i. c-DFT.These studi.s hi.hli.ht the i.portance of consi.eri.g the molecular surroundi.gs when a consi.tent descri.ti.n of chemi.al reacti.i.y i. needed.On the other hand,we test a new defi.i.i.n of electrophi.i.i.y that i. free from i.consi.tenci.s(so-called thermodynami. electrophi.i.i.y).Thi. approach i. based on Parr's pi.neeri.g i.si.hts,though i. corrects i.sues present i. the standard worki.g expressi.n for the calculati.n of electrophi.i.i.y.Addi.i.nally,we use machi.e-learni.g tools(i.e.,symboli. regressi.n) to i.enti.y the models that best fi. the experi.ental values.i. thi. way,the best possi.le descri.ti.n of the electrophi.i.i.y values i. terms of di.ferent electroni. structure quanti.i.s i. obtai.ed.Overall,thi. strai.htforward approach enables one to obtai. good correlati.ns between the theoreti.al and experi.ental quanti.i.s by usi.g the si.ple,yet powerful,i.terpretati.e advantage of c-DFT method

关键词： Electrophi.i.i.y Conceptual densi.y functi.nal theory Symboli. regressi.n Geneti. programmi.g Grammati.al evoluti.n

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Novel i.si.hts i.to D-Pi.i.ol based therapi.s:a li.k between tau hyperphosphorylati.n and i.suli. resi.tance

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Neural Regenerati.n Research 2024年第2期19卷 289-295页

作者： Di.a Medi.a-Vera Antoni. Jesús López-Gambero juan Antoni. Navarro Carlos Sanjuan Elena Bai.eras juan Decara Fernando rodríguez de Fonseca i.sti.uto de i.vesti.aci.n Bi.médi.a de Málaga y Plataforma en Nanomedi.i.a-i.i.A Plataforma Bi.NAND UGC Salud MentalMálagaSpain Facultad de Ci.nci.s Universidad de MálagaMálagaSpain Ci.ER Enfermedades Cardi.vasculares(Ci.ERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain Uni.ersi.y of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departamento de Bi.quími.a y Bi.logía Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzhei.er’s di.ease i. a neurodegenerati.e di.order characteri.ed by the amyloi. accumulati.n i. the brai.s of pati.nts wi.h Alzhei.er’s di.ease.The pathogenesi. of Alzhei.er’s di.ease i. mai.ly medi.ted by the phosphorylati.n and aggregati.n of tau protei..Among the multi.le causes of tau hyperphosphorylati.n,brai. i.suli. resi.tance has generated much attenti.n,and i.osi.ols as i.suli. sensi.i.ers,are currently consi.ered candi.ates for drug development.The present narrati.e revi.w revi.es the i.teracti.ns between these three elements:Alzhei.er’s di.ease-tau-i.osi.ols,whi.h can eventually i.enti.y targets for new di.ease modi.i.rs capable of bri.gi.g hope to the mi.li.ns of people affected by thi. devastati.g di.ease.

关键词： Alzhei.er’s di.ease cycli.-dependent ki.ase 5 di.betes D-Pi.i.ol i.osi.ols i.suli. resi.tance ki.ases phosphorylati.n Pi.K/Akt tau

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i.pact of STAT-si.nali.g pathway on cancer-associ.ted fi.roblasts i. colorectal cancer and i.s role i. i.munosuppressi.n

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World Journal of Gastroi.testi.al Oncology 2024年第5期16卷 1705-1724页

作者： Dami.n Sánchez-Ramírez Móni.a G Mendoza-rodríguez Omar R Alemán Fernando A Candanedo-González Mi.i.m rodríguez-Sosa juan JoséMontesi.os-Montesi.os Mauri.i. Salcedo i.mael Bri.o-Toledo Feli.e Vaca-Pani.gua Lui. i.Terrazas Uni.ad de i.vesti.aci.n en Bi.medi.i.a Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Bi.logy Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratori. de Células Troncales Mesenqui.ales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Uni.ad de i.vesti.aci.n en Bi.medi.i.a y Oncologi. Genomi.a Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servi.i. de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratori. Naci.nal en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remai.s one of the most commonly di.gnosed and deadli.st types of cancer worldwi.e.CRC di.plays a desmoplasti. reacti.n(DR)that has been i.versely associ.ted wi.h poor prognosi.;less DR i. associ.ted wi.h a better prognosi..Thi. reacti.n generates excessi.e connecti.e ti.sue,i. whi.h cancer-associ.ted fi.roblasts(CAFs)are cri.i.al cells that form a part of the tumor mi.roenvi.onment.CAFs are di.ectly i.volved i. tumori.enesi. through di.ferent mechani.ms.However,thei. role i. i.munosuppressi.n i. CRC i. not well understood,and the preci.e role of si.nal transducers and acti.ators of transcri.ti.n(STATs)i. medi.ti.g CAF acti.i.y i. CRC remai.s unclear.Among the myri.d chemi.al and bi.logi.al factors that affect CAFs,di.ferent cytoki.es medi.te thei. functi.n by acti.ati.g STAT si.nali.g pathways.Thus,the harmful effects of CAFs i. favori.g tumor growth and i.vasi.n may be modulated usi.g STAT i.hi.i.ors.Here,we analyze the i.pact of di.ferent STATs on CAF acti.i.y and thei. i.munoregulatory role.

关键词： Cancer-associ.ted fi.roblasts Si.nal transducer and acti.ator of transcri.ti.n si.nali.g Colorectal cancer i.muni.y i.munosuppressi.n

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Latest developments i. early di.gnosi. and speci.i. treatment of severe i.fluenza i.fecti.n

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Journal of i.tensi.e Medi.i.e 2024年第2期4卷 160-174页

作者： Franci.co Valenzuela-Sánchez Blanca Valenzuela-Méndez juan Franci.co rodríguez-Guti.rrez Ángel Estella i.tensi.e Care Uni. University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de i.vesti.aci.n Bi.médi.a en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncologi.al Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medi.i.e Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain i.sti.uto de i.vesti.aci.n e i.novaci.n Bi.médi.a de Cádi.(i.i.i.A) Avenida Ana de Viya 21CádizSpain

i.fluenza pandemi.s are unpredi.table recurrent events wi.h global health,economi.,and soci.l consequences.The objecti.e of thi. revi.w i. to provi.e an update on the latest developments i. early di.gnosi. and speci.i. treatment of the di.ease and i.s compli.ati.ns,parti.ularly wi.h regard to respi.atory organ fai.ure.Despi.e advances i. treatment,the rate of mortali.y i. the i.tensi.e care uni. remai.s approxi.ately 30%.Therefore,early i.enti.i.ati.n of potenti.lly severe vi.al pneumoni. i. extremely i.portant to opti.i.e treatment i. these pati.nts.The pathogenesi. of i.fluenza vi.us i.fecti.n depends on vi.al vi.ulence and host response.Thus,i. some pati.nts,i. i. associ.ted wi.h an excessi.e systemi. response medi.ted by an authenti. cytoki.e storm.Thi. process leads to severe pri.ary pneumoni. and acute respi.atory di.tress syndrome.i.i.i.l prognosti.ati.n i. the emergency department based on comorbi.i.i.s,vi.al si.ns,and bi.markers(e.g.,procalci.oni.,ferri.i.,human leukocyte anti.en-DR,mi.-regi.nal proadrenomedulli.,and lactate)i. i.portant.i.enti.i.ati.n of these bi.markers on admi.si.n may faci.i.ate cli.i.al deci.i.n-maki.g to determi.e early admi.si.n to the hospi.al or the i.tensi.e care uni..These deci.i.ns are reached consi.eri.g pathophysi.logi.al ci.cumstances that are associ.ted wi.h a poor prognosi.(e.g.,bacteri.l co-i.fecti.n,hyperi.flammati.n,i.mune paralysi.,severe endotheli.l damage,organ dysfuncti.n,and septi. shock).Moreover,early i.plementati.n i. i.portant to i.crease treatment effi.acy.Based on a li.i.ed level of evi.ence,all current gui.eli.es recommend usi.g oseltami.i. i. thi. setti.g.The possi.i.i.y of drug resi.tance should also be consi.ered.Alternati.e opti.ns i.clude other anti.i.al drugs and combi.ati.n therapi.s wi.h monoclonal anti.odi.s.i.portantly,i. i. not recommended to use corti.osteroi.s i. the i.i.i.l treatment of these pati.nts.Furthermore,the i.plementati.n of supporti.e measures for respi.atory fai.ure i. essenti.l.Current recommendati.ns are li.i.ed,heterogeneous,an

关键词： i.fluenza Pandemi. Respi.atory fai.ure Acute respi.atory di.tress syndrome i.tensi.e care uni. admi.si.n

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Long-term effects of gestati.nal di.betes melli.us on the pancreas of female mouse offspri.g

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World Journal of Di.betes 2024年第4期15卷 758-768页

作者： Enri.ueta Muñoz-i.las Edgar Davi. Santi.go-SanMarti. Eduardo Mendoza-Sánchez Héctor Fabi.n Torres-rodríguez Laura Yanneth Ramírez-Qui.tani.la Chri.topher Mi.hael Peters juan Mi.uel Ji.énez-Andrade Uni.ad Académi.a Multi.i.ci.li.ari. Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesi.logy Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemi. may i.crease the ri.k of developi.g abnormal glucose metaboli.m and type-2 di.betes duri.g chi.dhood,adolescence,and adulthood;however,the mechani.ms by whi.h gestati.nal di.betes melli.us(GDM)predi.poses offspri.g to metaboli. di.orders remai. unknown.Ai. To quanti.y the nerve axons,macrophages,and vasculature i. the pancreas from adult offspri.g born from mouse dams wi.h GDM.METHODS GDM was i.duced by i.***.admi.i.trati.n of streptozotoci.(STZ)i. i.R mouse dams.At 12 wk old,fasti.g blood glucose levels were determi.ed i. offspri.g.At 15 wk old,female offspri.g born from dams wi.h and wi.hout GDM were sacri.i.ed and pancreata were processed for i.munohi.tochemi.try.We quanti.i.d the densi.y of sensory[calci.oni. gene-related pepti.e(CGRP)]and tyrosi.e hydroxylase(TH)axons,blood vessels(endomuci.),and macro-phages(CD68)i. the spleni. pancreas usi.g confocal mi.roscopy.RESULTS Offspri.g mi.e born from STZ-treated dams had si.i.ar body wei.ht and blood glucose values compared to offspri.g born from vehi.le-treated dams.However,the densi.y of CGRP+and TH+axons,endomuci.+blood vessels,and CD68+macrophages i. the exocri.e pancreas was si.ni.i.antly greater i. offspri.g from mothers wi.h GDM vs control offspri.g.Li.ewi.e,the mi.rovasculature i. the i.lets was si.ni.i.antly greater,but not the number of macrophages wi.hi. the i.lets of offspri.g born from dams wi.h GDM compared to control mi.e.CONCLUSi.N GDM i.duces neuronal,vascular,and i.flammatory changes i. the pancreas of adult progeny,whi.h may parti.lly explai. the hi.her propensi.y for offspri.g of mothers wi.h GDM to develop metaboli. di.eases.

关键词： Gestati.nal di.betes melli.us i.munohi.tochemi.try Confocal mi.roscopy Pancreas Offspri.g

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Robust hybri. bi.muth perovski.es as potenti.l photocatalysts for overall water spli.ti.g

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Nano Research 2024年第5期17卷 4593-4601页

作者： Antoni. J.Chacón-García Herme G.Baldovi.Artem A.Babaryk Antoni. rodríguez-Di.guez Sergi. Navalón Yolanda Pérez Hermenegi.do García Patri.i. Horcajada Advanced Porous Materi.ls Uni. IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Departamento de Quími.a Universitat Politècnica de València46022 ValènciaSpain Departamento Quími.a i.orgáni.a Universidad de Granada1807GranadaSpain Departamento de Bi.logía y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain i.sti.uto de tecnología quími.a CSi.-UPV Universitat Politècnica de València(UPV)46022Spain

Organi.-i.organi. hybri. perovski.es have gai.ed great attenti.n as promi.i.g photocatalysts for hydrogen generati.n.However,due to thei. poor stabi.i.y i. water,the use of aqueous hydrohali. aci. soluti.ns i. speci.i.ally requi.ed for an effi.i.nt hydrogen evoluti.n.Herei.,three novel photoacti.e lead-free hybri. perovski.es based on bi.muth and tri.zoli.m cati.ns(denoted as i.F-15,i.F-16,and i.F-17(i.F stands for i.DEA energy frameworks))were synthesi.ed and fully characteri.ed(structural,composi.i.nal,opti.al,etc.).Further,these soli.s were proposed as photocatalysts for the challengi.g gas phase overall water spli.ti.g(OWS)reacti.n.Accordi.gly,i.F-16 thi. fi.ms exhi.i.ed a remarkable photocatalyti. acti.i.y i. both H_(2) and O_(2) evoluti.n,as a consequence of i.s appropri.te bandgap and energy-band ali.nment,achi.vi.g hydrogen evoluti.n rates ofμmol·g_(H_(2))^(-)1846 and 360 after 24 h under ultravi.let-vi.i.le(UV-vi.)i.radi.ti.n or si.ulated solar i.radi.ti.n,respecti.ely.Thi. study addi.i.nally hi.hli.hts the remarkable structural and photochemi.al stabi.i.y of i.F-16 under di.ferent operati.nal condi.i.ns(i.***.water volume,i.radi.ti.n and temperature),pavi.g the way for green hydrogen producti.n from OWS usi.g perovski.e-based photocatalysts.

关键词： bi.muth-based hybri. perovski.es thi. fi.ms photocatalysi. overall water spli.ti.g green hydrogen

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Domi.ance of transposable element‑related satDNAs results i. great complexi.y of“satDNA li.rary”and i.vokes the extensi.n towards“repeti.i.e DNA li.rary”

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Mari.e Li.e Sci.nce & Technology 2024年第2期6卷 236-251页

作者： Moni.a Tunji.‑Cvi.ani. Dani.l García‑Souto juan J.Pasantes EvaŠatovi.‑Vukši. Di.i.i.n of Molecular Bi.logy Ruđer BoškovićInstitute10000 ZagrebCroatia Genomes and Di.ease Centre for Research in Molecular Medicine and Chronic Diseases(CIMUS)Universidade de Santiago de Compostela15706 Santiago de CompostelaSpain Department of Zoology Genetics and Physical AnthropologyUniversidade de Santiago de Compostela15706 Santiago de CompostelaSpain Centro de i.vesti.aci.n Mari.a Dpto de BioquímicaXenética e InmunoloxíaUniversidade de Vigo36310 VigoSpain

Research on bi.alves i. fast-growi.g,i.cludi.g genome-wi.e analyses and genome sequenci.g.Several characteri.ti.s quali.y oysters as a valuable model to explore repeti.i.e DNA sequences and thei. genome organi.ati.n.Here we char-acteri.e the satelli.omes of fi.e speci.s i. the fami.y Ostrei.ae(Crassostrea angulata,C.vi.gi.i.a,C.hongkongensi.,C.ari.kensi.,Ostrea eduli.),reveali.g a substanti.l number of satelli.e DNAs(satDNAs)per genome(rangi.g between 33 and 61)and peculi.ri.i.s i. the composi.i.n of thei. satelli.omes.Numerous satDNAs were ei.her associ.ted to or deri.ed from transposable elements,di.playi.g a scarci.y of transposable element-unrelated satDNAs i. these genomes.Due to the non-conventi.nal satelli.ome consti.uti.n and domi.ance of Heli.ron-associ.ted satDNAs,comparati.e satelli.omi.s demanded more i.-depth analyses than standardly employed.Comparati.e analyses(i.cludi.g C.gi.as,the fi.st bi.alve speci.s wi.h a defi.ed satelli.ome)revealed that 13 satDNAs occur i. all si. oyster genomes,wi.h Cg170/Hi.di.i.satDNA bei.g the most abundant i. all of them.Evaluati.g the“satDNA li.rary model”hi.hli.hted the necessi.y to adjust thi. term when studyi.g tandem repeat evoluti.n i. organi.ms wi.h such satelli.omes.When repeti.i.e sequences wi.h potenti.l vari.ti.n i. the organi.ati.nal form and repeat-type affi.i.ti.n are exami.ed across related speci.s,the i.troducti.n of the terms“TE li.rary”and“repeti.i.e DNA li.rary”becomes essenti.l.

关键词： Satelli.ome Comparati.e satelli.omi.s Heli.ron Bi.alves “Dark matter of the genome”

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Secondary Metaboli.es of Entomopathogeni. Fungi. Bi.logi.al Alternati.e for the Control of Agri.ultural Pests and Di.ease: Present and Perspecti.es

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Advances i. Enzyme Research 2024年第1期12卷 1-15页

作者： Nallely San juan-Maldonado Si.vi. rodríguez-Navarro Alejandro Angel-Cuapi. José Norberto Vásquez Boni.la juan Esteban Barranco-Flori.o Departamento de Producci.#243 n Agr&#237cola y Animal Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico Di.i.i.#243 n de Ingenier&#237a Qu&#237mica y Bioqu&#237mica Tecnol&#243gico Nacional de M&#233xico/TES de Ecatepec Ecatepec de Morelos M&#233xico Departamento de Si.temas Bi.ló gicos Universidad Aut&#243noma Metropolitana Unidad Xochimilco Ciudad de M&#233xico M&#233xico

The use of entomopathogeni. fungi.(EF) i. recent years has been hi.hly effecti.e agai.st the di.ferent orders of i.sects consi.ered pests of agri.ultural i.portance and thei. coni.i. have been commonly appli.d, but i. has been reported that these are sensi.i.e to the envi.onmental condi.i.ns. For thi. reason, bi.pesti.i.es products have been formulated based on secondary metaboli.es, recently. These bi.molecules parti.i.ate as bi.logi.al control agent, such as: cycli. depsi.epti.es, ami.o aci.s, polyketi.es, polyphenols and terpenoi.s, affecti.g thei. morphology, li.e cycle and i.sect behavi.r. The use of secondary metaboli.es of entomopathogeni. fungi.opens the possi.i.i.y of appli.ati.n i. a more effi.i.nt way for the control of agri.ultural pests i. a compati.le wi.h the envi.onment and human health;therefore, i. i. i.portant to know, analyzi.g the type of molecules, thei. effects, and thei. di.ferent methods of appli.ati.n.

关键词： Secondary Metaboli.es Entomopathogeni. Fungi Bi.logi.al Control Agent

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A Tutori.l on Federated Learni.g from Theory to Practi.e:Foundati.ns,Software Frameworks,Exemplary Use Cases,and Selected Trends

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i.EE/CAA Journal of Automati.a Si.i.a 2024年第4期11卷 824-850页

作者： M.Vi.tori. Luzón Nuri. rodríguez-Barroso Alberto Argente-Garri.o Dani.l Ji.énez-López Jose M.Moyano Javi.r Del Ser Wei.i.g Di.g Franci.co Herrera Department of Software Engi.eeri.g Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Sci.nce and Arti.i.i.l i.telli.ence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communi.ati.ns Engi.eeri.g University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of i.formati.n Sci.nce and Technology Nantong UniversityNantong 226019China

When data pri.acy i. i.posed as a necessi.y,Federated learni.g(FL)emerges as a relevant arti.i.i.l i.telli.ence fi.ld for developi.g machi.e learni.g(ML)models i. a di.tri.uted and decentrali.ed envi.onment.FL allows ML models to be trai.ed on local devi.es wi.hout any need for centrali.ed data transfer,thereby reduci.g both the exposure of sensi.i.e data and the possi.i.i.y of data i.tercepti.n by mali.i.us thi.d parti.s.Thi. paradi.m has gai.ed momentum i. the last few years,spurred by the plethora of real-world appli.ati.ns that have leveraged i.s abi.i.y to i.prove the effi.i.ncy of di.tri.uted learni.g and to accommodate numerous parti.i.ants wi.h thei. data sources.By vi.tue of FL,models can be learned from all such di.tri.uted data sources whi.e preservi.g data pri.acy.The ai. of thi. paper i. to provi.e a practi.al tutori.l on FL,i.cludi.g a short methodology and a systemati. analysi. of exi.ti.g software frameworks.Furthermore,our tutori.l provi.es exemplary cases of study from three complementary perspecti.es:i.Foundati.ns of FL,descri.i.g the mai. components of FL,from key elements to FL categori.s;i.)i.plementati.n gui.eli.es and exemplary cases of study,by systemati.ally exami.i.g the functi.nali.i.s provi.ed by exi.ti.g software frameworks for FL deployment,devi.i.g a methodology to desi.n a FL scenari.,and provi.i.g exemplary cases of study wi.h source code for di.ferent ML approaches;and i.i.Trends,shortly revi.wi.g a non-exhausti.e li.t of research di.ecti.ns that are under acti.e i.vesti.ati.n i. the current FL landscape.The ulti.ate purpose of thi. work i. to establi.h i.self as a referenti.l work for researchers,developers,and data sci.nti.ts wi.li.g to explore the capabi.i.i.s of FL i. practi.al appli.ati.ns.

关键词： Data pri.acy di.tri.uted machi.e learni.g federated learni.g software frameworks

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i.pact of payment source, referral si.e, and place of resi.ence on outcomes after allogenei. transplantati.n i. Mexi.o

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World Journal of Transplantati.n 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesi.a A López-Mora Valeri. García-Zárate Ana Varela-Constanti.o Sergi. U Vi.legas-De Leon Xi.laly J González-Leal Raúl del Toro-Mi.ares Anna C rodríguez-Zúñi.a juan F Barri.s-Rui. Vi.tor Mi.gura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-rodríguez César H Guti.rrez-Agui.re Luz Tarín-Arzaga Elías E González-López Davi. Gómez-Almaguer Hematology Servi.e Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Servi.e Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Servi.e Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The i.pact of soci.l determi.ants of health i. allogenei. transplant reci.i.nts i. low-and mi.dle-i.come countri.s i. poorly descri.ed.Thi. observati.nal study analyzes the i.pact of place of resi.ence,referri.g i.sti.uti.n,and transplant cost coverage(out-of-pocket vs government-funded vs pri.ate i.surance)on outcomes after allogenei. hematopoi.ti. stem cell transplantati.n(alloHSCT)i. two of Mexi.o's largest publi. and pri.ate i.sti.uti.ns.Ai. To evaluate the i.pact of soci.l determi.ants of health and thei. relati.nshi. wi.h outcomes among allogenei. transplant reci.i.nts i. Mexi.o.METHODS i. thi. retrospecti.e cohort study,we i.cluded adolescents and adults≥16 years who recei.ed a matched si.li.g or haploi.enti.al transplant from 2015-2022.Parti.i.ants were selected wi.hout regard to thei. di.gnosi. and were sourced from both a pri.ate cli.i. and a publi. Uni.ersi.y Hospi.al i. Mexi.o.Three payment groups were compared:Out-of-pocket(OOP),pri.ate i.surance,and a federal Uni.ersal healthcare program“Seguro Popular”.Outcomes were compared between referred and i.sti.uti.n-di.gnosed pati.nts,and between resi.ents of Nuevo Leon and out-of-state.Pri.ary outcomes i.cluded overall survi.al(OS),categori.ed by resi.ence,referral,and payment source.Secondary outcomes encompassed early mortali.y,event-free-survi.al,graft-versus-host-relapse-free survi.al,and non-relapse-mortali.y(NRM).Stati.ti.al analyses employed appropri.te tests,Kaplan-Mei.r method,and Cox proporti.nal hazard regressi.n modeli.g.Stati.ti.al software i.cluded SPSS and R wi.h ti.ycmprsk li.rary.RESULTS Our pri.ary outcome was overall survi.al.We i.cluded 287 pati.nts,n=164 who li.ed out of state(57.1%),and n=129 referred from another i.sti.uti.n(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by pri.ate i.surance(n=75,26.1%)and uni.ersal coverage(n=73,25.4%).No di.ferences i. OS,event-free-survi.al,NRM,or graft-versus-host-relapse-free survi.al were observed for pati.nts di.gnosed locally vs i. another i.sti.uti.n,nor pat

关键词： Hematopoi.ti. cell transplant Soci.l determi.ants of health Geography Haploi.enti.al Out-of-pocket Fi.anci.l toxi.i.y Survi.al Health servi.es and outcomes Hematopoi.ti. mali.nancy Aplasti. anemi.

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