检索结果-南通市图书馆

Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control

World Journal of Gastroenterology 2012年第9期18卷 930-937页

作者： Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini Edoardo Poli Adriano De Santis Aldo roda Carolina Colliva Patrizia Simoni Adolfo Francesco Attili Gastroenterology Division Department of Clinical MedicineSapienza University of RomeViale dell' Universita' 37 Department of Medical Sciences and Biotechnology Vascular Medicine and Atherothrombosis LaboratorySapienza University of Rome Direzione Sanitaria Terme di Chianciano Department of Pharmaceutical Science Alma Mater-University of Bologna Department of Clinical Medicine Alma MaterUniversity of Bologna

AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone ***:Postmenopausal women with functional dy-spepsia and/or constipation underwent a 12 d cycle of thermal (n=20) or tap (n=20) water controlled *** fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the *** consumption,stool frequency and body weight were recorded ***:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water *** gallbladder volume was significantly (P<0.005) smaller at the end of the study than at baseline in the TW (15.7±1.1 mL vs 20.1±1.7 mL) but not in the tap water group (19.0±1.4 mL vs 19.4±1.5 mL).Total serum BA concentration was significantly (P<0.05) higher at the end of the study than at baseline in the TW (5.83±1.24μmol vs 4.25±1.00μmol) but not in the tap water group (3.41±0.46μmol vs 2.91±0.56μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic *** number of pasta (P<0.001),meat (P<0.001) and vegetable (P<0.005) portions consumed during the study and of bowel movements per day (P<0.05) were significantly higher in the TW than in the tap water *** weight did not change at the end of the study as compared to baseline in both ***:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake.

关键词：碳酸氢钙饮用水硫酸盐控制体重胆结石风险动脉粥样硬化危险因素

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of gallstone disease in first-degree relatives of patients with cholelithiasis

引用

World Journal of Gastroenterology 2005年第41期11卷 6508-6511页

作者： Adolfo Francesco Attili Adriano De Santis Fabia Attili Enrico roda Davide Festi Nicola Carulli GI Unit Department of Clinical Medicine University of Roma "La Sapienza"Italy Department of Internal Medicine University of Bologna Italy Department of Internal Medicine University of Modena Italy

AIM: To evaluate the influence of familiality on the prevalence of gallstone disease (GD) in ***: Families of 79 subjects with gallstones (cases) and of 79 subjects without gallstones (controls)were investigated for the presence of gallstones by ultrasonography. Index cases and index controls were matched for age, sex, and operative unit. Sixty-three and sixty-two husbands and wives of index cases and index controls, respectively, were also ***: Overall,the prevalence of GD was significantly higher (X2=14.52, P＜0.001) in the 202 first-degree relatives of subjects with gallstones than that in the 201 first-degree relatives of subjects without gallstones (28.6% vs 12.4%, relative risk (RR) 1.80, 95% confidence interval (CI) 1.29-2.63). In particular,prevalence of GD was significantly higher in mothers,fathers, and sisters of index cases than that in the respective family members of index controls. The highest RR was observed in mothers (RR=2.35, 95%CI 1.38-4.3).Prevalence of GD was not obviously different in brothers and also in husbands and wives of index cases and index controls. Family members of index cases did not differ from family members of control cases with respect to the most important risk factors for gallstones (age, diabetes,BMI, and number of pregnancies) with an exception of a higher prevalence of diabetes in fathers of index controls than in fathers of index ***: This study confirms that familiality plays a very important role in the pathogenesis of gallstones.

关键词：胆结石病理机制治疗临床表现

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocellular carcinoma prevention:A worldwide emergence between the opulence of developed countries and the economic constraints of developing nations

引用

World Journal of Gastroenterology 2006年第45期12卷 7239-7249页

作者： Francesca Lodato Giuseppe Mazzella Davide Festi Francesco Azzaroli Antonio Colecchia Enrico roda Department of Internal Medicine and Gastroenterology Gas- troenterology Unit University of Bologna Italy

Hepatocellular carcinoma (HCC) is the fifth most common neoplasm, the major cause of death in patients with liver cirrhosis, and the third most common cause of cancer-related death in the world. The geographic distribution of HCC varies significantly and 80% of cases occur in developing countries (Far East and South Asia) where the prevalence of viral hepatitis is higher. The treatment of HCC is difficult because most patients are diagnosed when the tumour is in an advanced stage and is not amenable to potential curative therapy, thus prevention is the key to reducing HCC and its related morbidity and mortality. HCC is unique among cancers, occurring mostly in patients with a known risk factor. Ninety percent of HCCs develop in the context of chronic liver diseases and mainly in patients with cirrhosis. Viral hepatitis is the most common cause of HCC worldwide, followed by alcoholic liver disease (ALD) and other causes such as non-alcoholic fatty liver disease (NAFLD), genetic haemocromatosis (GH) and primary biliary cirrhosis in an advanced stage (Ⅲ- Ⅴ). In certain areas of the People’s Republic of China, exposure to aflatoxin and HBV infection are thought to be responsible for the extraordinary high risk of HCC. Substantial progresses in the prevention of virusl-related hepatitis (screening of blood units, use of disposable sanitary tools, HBV vaccination) have been achieved in developed countries, but in the same areas, alcohol- and dysmetabolism-related HCCs are emerging problems which require specific interventions in terms of public health measures. In developing countries, economic constraints limit the development of any program for the prevention of viral hepatitis transmission (including health education campaigns, healthcare politics, primary prevention and the improvement of hygienic and sanitary conditions). When viral liver disease is established, only a minority of patients are treated worldwide and benefit a possible preventive effect of medical trea

关键词：肝癌病毒性肝炎治疗方法预防性措施

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic,uncomplicated colonic diverticular disease

引用

World Journal of Gastroenterology 2007年第2期13卷 264-269页

作者： Antonio Colecchia Amanda Vestito Francesca Pasqui Giuseppe Mazzella Enrico roda Francesca Pistoia Giovanni Brandimarte Davide Festi Department of Internal Medicine and Gastroenterology University of Bologna Cristo Re Hospital Rome Italy Department of Surgery University of L’Aq- uila Cristo Re Hospital Rome Italy Department of Internal Medicine Cristo Re Hospital Rome Italy

AIM: To comparatively evaluate the long term efficacy of Rifaximin and dietary fibers in reducing symptoms and/or complication frequency in symptomatic, uncomplicated diverticular disease. METHODS: 307 patients (118 males, 189 females, age range: 40-80 years) were enrolled in the study and randomly assigned to: Rifaximin (400 mg bid for 7 d every month) plus dietary fiber supplementation (at least 20 gr/d) or dietary fiber supplementation alone. The study duration was 24 mo; both clinical examination and symptoms’ questionnaire were performed every two months. RESULTS: Both treatments reduced symptom frequency, but Rifaximin at a greater extent, when compared to basal values. Symptomatic score declined during both treatments, but a greater reduction was evident in the Rifaximin group (6.4 ± 2.8 and 6.2 ± 2.6 at enrollment, P = NS, 1.0 ± 0.7 and 2.4 ± 1.7 after 24 mo, P < 0.001, respectively). Probability of symptom reduction was higher and complication frequency lower (Kaplan-Meyer method) in the Rifaximin group (P < 0.0001 and 0.028, respectively). CONCLUSION: In patients with symptomatic, uncomplicated diverticular disease, cyclic administration of Rifaximin plus dietary fiber supplementation is more effective in reducing both symptom and complication frequency than simple dietary fiber supplementation. Long term administration of the poorly absorbed antibiotic Rifaximin is safe and well tolerated by the patients,confirming the usefulness of this therapeutic strategy in the overall management of diverticular disease.

关键词：结肠疾病症状抗生素并发症

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project

引用

World Journal of Gastroenterology 2013年第14期19卷 2208-2216页

作者： Aldo roda Mara Mirasoli Massimo Guardigli Patrizia Simoni Davide Festi Boris Afonin Galina Vasilyeva Department of Chemistry "G.Ciamician" University of Bologna-Alma Mater Studiorum Department of Medical and Surgical Sciences University of Bologna-Alma Mater Studiorum State Scientific Center of Russian Federation-Institute of Biomedical Problems of the Russian Academy of Sciences(IBMP)

AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term ***:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 *** particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid *** addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal *** no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the ***:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external *** evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy *** contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same *** variability suggested that the H 2-breath

关键词： Breath test Gastrointestinal inflammation Gastrointestinal motility Spaceflight Stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diverticular disease of the colon:New perspectives in symptom development and treatment

引用

World Journal of Gastroenterology 2003年第7期9卷 1385-1389页

作者： Antonio Colecchia Lorenza Sandri Simona Caoodicasa Amanda Vestito Giuseppe Mazzella Tommaso Staniscia Enrico roda Davide Festi Department of Internal Medicine and Gastroenterology University of BolognaItaly Department of Medicine and Aging University G.d'AnnunzioChietiItaly

Diverticular disease of the colon is a common disease worldwide. Although the disease is asymptomatic in about 70-80 % of patients, it represents, at least in Western countries, one of the most important gastrointestinal diseases in terms of direct and indirect health costs. Pathocenesis of the disease is still unknown. However, it is the result of complex interactions between colonic structure, intestinal motility, diet and genetic factors. Whilst efficacious preventive strategies remain to be identified, fibre supplementation in the diet is recommended. Why symptoms develop is still unclear. Results of recent experimental studies on irritable bowel syndrome speculated that low grade inflammation of colonic mucosa, induced by changes in bacterial microflora,could affect the enteric nervous system, which is crucial for normal gut function, thus favouring symptom *** hypothesis could be extrapolated also for diverticular disease, since bacterial overgrowth is present, at least in a subgroup of patients. These perspectives on symptom development are reviewed and new therapeutic approaches are hypothesized.

关键词：结肠憩室疾病临床表现发病机理炎症

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Production of reactive oxygen species and expression of inducible nitric oxide synthase in rat isolated Kupffer cells stimulated by Leptospira interrogans and Borrelia burgdorfen

引用

World Journal of Gastroenterology 2006年第19期12卷 3077-3081页

作者： Antonella Marangoni Silvia Accardo Rita Aldini Massimo Guardigli Francesca Cavrini Vittorio Sambri Marco Montagnani Aldo roda Roberto Cevenini Sezione di Microbiologia DMCSS University of Bologna BolognaItaly Istituto di Scienze Chimiche University of Bologna BolognaItaly Dipartimento di Scienze Farmaceutiche University of Bologna BolognaItaly Dipartimento di Medicina Interna e Gastroenterologia University of Bologna BolognaItaly

瞄准：为了评估反应的氧种类(ROS ) 和可诱导的氮的氧化物的表示的生产，在老鼠的 synthase (i NOS ) 孤立肾脏钩端螺旋体和包柔氏螺旋体属 burgdorferi 刺激的 Kupffer 房间(KC ) 。方法：老鼠 Kupffer 房间被肝的灌注用 0.05% 胶原酶... 详细信息

瞄准：为了评估反应的氧种类(ROS ) 和可诱导的氮的氧化物的表示的生产，在老鼠的 synthase (i NOS ) 孤立肾脏钩端螺旋体和包柔氏螺旋体属 burgdorferi 刺激的 Kupffer 房间(KC ) 。方法：老鼠 Kupffer 房间被肝的灌注用 0.05% 胶原酶分开，并且由 Percoll 坡度净化了。净化的 Kupffer 房间是有活着的 L 的测试在试管内。interogans 和 B。burgdorferi 准备。ROS 的生产被化合光决定，而 i NOS 蛋白质表达式被西方的污点试金用 anti-iNOS 抗体计算。结果：B。burgdorferi 并且到一更少的程度 L。interrogans 与一座山峰导致了 ROS 生产在感染以后的 35 min。化合光信号日益增多地减少了并且由孵化的 180 min 是无法发现的。Leptospirae 和 borreliae 在在 6 个小时达到顶点并且仍然是明显的 Kupffer 房间导致了增加的 i NOS 表情在感染以后的 22 h。结论：螺旋菌的两个类在老鼠 Kupffer 细胞导致了 ROS 和 i NOS 生产。自从在 leptospiral 以及在 borrelial 感染的肝损坏的原因，仍然是未知的，我们建议那螺旋体和肝的包柔氏螺旋体属损坏能被氧激进分子开始调停，并且然后被氮的氧化物部分地至少维持。

关键词：一氧化氮合酶钩端螺旋体包柔氏螺旋体菌细菌感染

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电针四关穴联合tDCS治疗中风后抑郁症临床研究

电针四关穴联合tDCS治疗中风后抑郁症临床研究

引用

作者：石洲（Sergio Renato Leigue roda）上海中医药大学

学位级别：硕士

目的:中风后抑郁症是中风后最常见的精神病并发症,本研究通过观察电针四关穴联合t DCS治疗卒中后抑郁,评估其疗效。方法:36例脑卒中后中重度抑郁患者按随机数字表法分为对照组(18例)、治疗组(18例),对照组患者给予口服盐酸舍曲林50 mg,... 详细信息

目的:中风后抑郁症是中风后最常见的精神病并发症,本研究通过观察电针四关穴联合t DCS治疗卒中后抑郁,评估其疗效。方法:36例脑卒中后中重度抑郁患者按随机数字表法分为对照组(18例)、治疗组(18例),对照组患者给予口服盐酸舍曲林50 mg,每天一次,给予t DCS治疗,并给予假电针治疗。治疗组患者在对照组基础上给予电针四关穴;所有患者治疗8w,于治疗前、治疗后2周、4周、8周进行HAMD评分,治疗前与治疗8周后进行血清Th17/Treg、BI评分。结果:治疗前两组患者HAMD评分、BI评分、Th17、Treg水平比较,差异无统计学意义(P>0.05);治疗组治疗后2周与对照组相比,HAMD评分改善有统计学意义(P<0.05)。治疗组治疗8周后Treg数量较治疗前明显上升,,Th17/Treg水平较治疗前明显下降(P<0.05),治疗组Th17/Treg较对照组明显下降(P<0.05),治疗组BI指数改善与对照组相比,差异有统计学意义(P<0.05)。结论:电针四关穴联合t DCS可改善脑卒中后中重度抑郁患者临床症状,其机制可能是调节血清Th17/Treg水平。

关键词：电针卒中后抑郁 HAMD评分 Th17/Treg BI指数

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

对生产调度的最新综述

引用

杭州电子工业学院译丛 1992年第2期 28-38页

作者： roda.,FA 余桂宁

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients

引用

World Journal of Gastroenterology 2006年第33期12卷 5336-5343页

作者： A Colecchia G Mazzella L Sandri F Azzaroli M Magliuolo P Simoni ML Bacchi-Reggiani E roda D Festi Department of Internal Medicine and Gastroenterology University of Bologna Bologna Italy Department of Pharmaceutical Sciences University of Bologna Bologna Italy Department of Cardiovascular Diseases University of Bologna Bologna Italy

AIM: To simultaneously evaluate the presence of defects in gallbladder and gastric emptying, as well as in intestinal transit in gallstone patients (GS) and the effect of chronic ursodeoxycholic acid (UDCA) administration on these parameters and on serum bile acids and clinical outcome in GS and controls (CTR). METHODS: After a standard liquid test meal, gallbla-dder and gastric emptying (by ultrasound), oroileal transit time (OITT) (by an immunoenzymatic technique) and serum bile acids (by HPLC) were evaluated before and after 3 mo of UDCA (12 mg/kg bw/d) or placebo administration in 10 symptomatic GS and 10 matched healthy CTR. RESULTS: OITT was longer in GS than in CTR (P < 0.0001); UDCA significantly reduced OITT in GS (P < 0.0001), but not in CTR. GS had longer gastric half-emptying time (t1/2) than CTR (P < 0.0044) at baseline; after UDCA, t1/2 significantly decreased (P < 0.006) in GS but not in CTR. Placebo administration had no effect on gastric emptying and intestinal transit in both GS and CTR. CONCLUSION: The gallstone patient has simultaneous multiple impairments of gallbladder and gastric emptying, as well as of intestinal transit. UDCA administration restores these defects in GS, without any effect in CTR. These results confirm the pathogenetic role of gastrointestinal motility in gallstone disease and suggest an additional mechanism of action for UDCA in reducing bile cholesterol supersaturation.

关键词：胃肠运动胆结石治疗病理机制

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：