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Active spatial control of photothermal heating and thermo-actuated convective flow by engineering a plasmonic metasurface with heterodimer lattices

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Photonics Research 2022年第11期10卷 2642-2657页

作者： ZHIMIN JING PEIHANG LI CUIPING MA JIAYING WANG roberto caputo ALEXANDER OGOVOROV ARUP NEOGI HONGXING XU ZHIMING WANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Physics Department University of CalabriaRende I-87036Italy Department of Physics and Astronomy and Nanoscale and Quantum Phenomena Institute Ohio UniversityAthensOhio 45701USA School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Thermo-plasmonics, using plasmonic structures as heat sources, has been widely used in biomedical and microfluidic applications. However, a metasurface with single-element unit cells, considered as the sole heat source in a unit cell, functions at a fixed wavelength and has limited control over the thermo-plasmonically induced hydrodynamic effects. Plasmonic metasurfaces with metal disk heterodimer lattices can be viewed to possess two heat sources within a unit cell and are therefore designed to photo-actively control thermal distributions and fluid dynamics at the nanoscale. The locations of heat sources can be switched, and the direction of the convective flow in the central region of the unit cell can be reversed by shifting the wavelength of the excitation source without any change in the excitation direction or physical actuation of the structural elements. The temperature and velocity of a fluid are spatiotemporally controlled by the wavelength selectivity and polarization sensitivity of the plasmonic metasurface. Additionally, we investigate the effects of geometric parameters on the surface lattice resonances and their impact on the temperature and fluid velocity of the optofluidic system. Our results demonstrate excellent optical control of these plasmonic metasurface heating and thermal convection performances to design flexible platforms for microfluidics.

关键词： excitation reversed flow

Directional radiation enhancement of nanowire quantum dots based on line-array plasmonic antenna coupling

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Photonics Research 2022年第9期10卷 2178-2190页

作者： PEIHANG LI PENG YU JIACHEN SUN ZHIMIN JING JIANG WU LUCAS V.BESTEIRO roberto caputo ARUP NEOGI HONGXING XU ZHIMING WANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China College of Optoelectronic Technology Chengdu University of Information TechnologyChengdu 610225China CINBIO Universidade de VigoVigo 36310Spain Physics Department University of CalabriaRende I-87036Italy School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China Institute for Advanced Study Chengdu UniversityChengdu 610106China

The integration of a single III-V semiconductor quantum dot with a plasmonic nanoantenna as a means toward efficient single-photon sources(SPEs)is limited due to its weak,wide-angle emission,and low emission *** limitations can be overcome by designing a unique linear array of plasmonic antenna structures coupled to nanowire-based quantum dot(NWQD)emitters.A linear array of a coupled device composed of multiple plasmonic antennas at an optimum distance from the quantum dot emitter can be designed to enhance the directionality and the spontaneous emission rate of an integrated single-photon *** element modeling has been used to design these compact structures with high quantum efficiencies and directionality of single-photon emission while retaining the advantages of *** Purcell enhancement factor of these structures approaches 66.1 and 145.8,*** to a single NWQD of the same diameter,the fluorescence was enhanced by 1054 and *** predicted collection efficiencies approach 85%(numerical aperture,NA=0.5)and 80%(NA=0.5),*** single-photon emitters based on bulky conventional optics,this is a unique nanophotonic single-emission photon source based on a line-array configuration that uses a surface plasmon-enhanced design with minimum *** designs presented in this work will facilitate the development of SPEs with potential integration with semiconductor optoelectronics.

关键词： quantum coupling overcome

Whole-eye transplantation: Current challenges and future perspectives

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World Journal of Transplantation 2024年第2期14卷 28-39页

作者： Anna Scarabosio Pier Luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati Leopoldo Spadea Glenda caputo Pier Camillo Parodi Caterina Gagliano Jonathan M Winograd Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Plastic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye transplantation emerges as a frontier in ophthalmology,promising a transformative approach to irreversible *** advancements,formidable challenges *** of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell *** the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive,prompting the exploration of neurotrophic support and immunomodulatory *** tolerance,paramount for graft acceptance,confronts the distinc-tive immunogenicity of ocular tissues,driving research into targeted immunosup-pression *** and legal considerations underscore the necessity for stringent standards and ethical *** collaboration and ongoing research endeavors are imperative to navigate these ***,stem cell therapies,and precision immunomodulation represent promising avenues in this ***,the aim of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancements while delineating future directions for research and clinical *** concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalmic care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关键词： Eye Transplantation Optic nerve Nerve regeneration Immunological tolerance

Nanotechnology and pancreatic cancer management:State of the art and further perspectives

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 231-237页

作者： Damiano caputo Daniela Pozzi Tommaso Farolfi roberto Passa roberto Coppola Giulio Caracciolo Department of General Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of Molecular Medicine Sapienza University of RomeRome 00161Italy

Pancreatic ductal adenocarcinoma(PDAC)represents a leading cause of cancer death and is often diagnosticated too late to allow adequate *** of biomarkers have been discovered in lasts years but,to date,there is a lack of lowcost and non-invasive tools for PDAC early ***,drugs commonly used in PDAC treatment do not allow achieving long-term satisfying *** is gaining importance in both PDAC early detection and *** main implications of nanotechnology in cancer diagnosis lay in the ability that nanoparticles have on concentrate the alteration in human proteome caused by ***-enabled blood tests have been demonstrated to reach high rate of sensitivity(up to 85%)and specificity(up to 100%).In the field of cancer therapy nanoparticles can be used as nanocarriers able to reach specific tumour’s cells and selectively release the drug they contain into them.A literature review was carried out with the aim to assess the state of the art and highlight the future perspectives of nanotechnology in PDAC early detection and therapy.

关键词： Pancreatic ductal adenocarcinoma Biomarkers Nanotechnology Nanoparticles Protein corona Early detection

Validations of new cut-offs for surgical drains management and use of computerized tomography scan after pancreatoduodenectomy:The DALCUT trial

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World Journal of Clinical Cases 2022年第15期10卷 4836-4842页

作者： Damiano caputo Alessandro Coppola Vincenzo La Vaccara roberto Passa Ludovico Carbone Massimo Ciccozzi Silvia Angeletti roberto Coppola Department of Surgery University Campus Bio-Medico of RomeRome 00128Italy Unit of Medical Statistic and Molecular Epidemiology University Campus Bio-Medico of RomeRome 00128Italy Unit of Clinical Laboratory Science University Campus Bio-Medico of RomeRome 00128Italy

BACKGROUND Postoperative pancreatic fistula(POPF)is the most fearful complication after pancreatic surgery and can lead to severe postoperative complications such as surgical site infections,sepsis and bleeding.A previous study which identified cut-offs of drains amylase levels(DALs)determined on postoperative day(POD)1 and POD3,was able to significantly predict POPF,abdominal collections and biliary fistulas,when related to specific findings detected at the abdominal computerized tomography(CT)scan routinely performed on *** To validate the cut-offs of DALs in POD1 and POD3,established during the previous study,to assess the risk of clinically relevant POPF and confirm the usefulness of abdominal CT scan on POD3 in patients at increased risk of abdominal *** The DALCUT trial is an interventional prospective *** patients who will undergo pancreatoduodenectomy(PD)for periampullary neoplasms will be considered *** patients will receive clinical staging and,if eligible for surgery,will undergo routine preoperative *** the PD,daily DALs will be evaluated from *** removal and possible requirement of abdominal CT scans in POD3 will be managed on the basis of the outcome of DALs in the first three postoperative *** This prospective study could validate the role of DALs in the management of surgical drains and in assessing the risk or relevant complications after *** could be removed in POD3 in case of POD1 DALs<666 U/L and POD3 DALs<207 U/*** case of POD3 DALs≥252,abdominal CT scan will be performed in POD3 to identify abdominal collections≥5 *** this latter category of patients,drains could be maintained beyond *** The results of this trial will contribute to a better knowledge of POPF and management of surgical drains.

关键词： Pancreatic surgery Drains amylase Pancreatic fistula Postoperative complications Computerized tomography scan

Chronic intestinal pseudo-obstruction

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World Journal of Gastroenterology 2008年第19期14卷 2953-2961页

作者： Alexandra Antonucci Lucia Fronzoni Laura Cogliandro Rosanna F Cogliandro Carla caputo roberto De Giorgio Francesca Pallotti Giovanni Barbara roberto Corinaldesi Vincenzo Stanghellini Department of Internal Medicine and Gastroenterology University of Bologna

Chronic intestinal pseudo-obstruction (CIPO) is a se- vere digestive syndrome characterized by derangement of gut propulsive motility which resembles mechanical obstruction, in the absence of any obstructive process. Although uncommon in clinical practice, this syndrome represents one of the main causes of intestinal failure and is characterized by high morbidity and mortality. It may be idiopathic or secondary to a variety of diseases. Most cases are sporadic, even though familial forms with either dominant or recessive autosomal inheritance have been described. Based on histological features in- testinal pseudo-obstruction can be classified into three main categories:neuropathies, mesenchymopathies, and myopathies, according on the predominant involvement of enteric neurones, interstitial cells of Cajal or smooth muscle cells, respectively. Treatment of intestinal pseu- do-obstruction involves nutritional, pharmacological and surgical therapies, but it is often unsatisfactory and the long-term outcome is generally poor in the majority of cases.

关键词： Chronic intestinal pseudo-obstruction Smallbowel manometry Immunohistochemistry Prokinetics Intestinal transplantation

Hot topics in pancreatic cancer management

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World Journal of Gastrointestinal Surgery 2023年第2期15卷 121-126页

作者： Damiano caputo Department of General Surgery Fondazione Policlinico Universitario Campus Bio-MedicoRome 00128Italy General Surgery Research Unit University Campus Bio-Medico di RomaRome 00128Italy

Pancreatic ductal adenocarcinoma(PDAC)is a sneaky and lethal disease burdened by poor *** is often detected too late to be successfully cured,and it has been estimated that it will be a leading cause of cancer-related deaths in the near *** the last decade,multimodal treatments involving surgery,chemotherapy and radiotherapy have contributed to improving the prognosis of this disease;however,long-term results are still not *** morbidity and mortality rates remain high,and systemic treatments are burdened by toxicity in both neoadjuvant and adjuvant *** in technologies,targeted therapies,immunotherapy and PDAC microenvironment modulation strategies may represent useful potential weapons in the ***,in the fight against this dreadful disease,there is an urgent need for new,cheap and user-friendly tools for early *** this field,promising results have been found in nanotechnologies and“omics”analyses that search for new biomarkers to be used in primary and secondary ***,there are many issues that need to be solved before considering these tools in daily clinical *** editorial reported the state of the art of pancreatic cancer management.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Nanotechnology Neoadjuvant therapy Adjuvant therapy Omics

Osteopontin and the immune system:another brick in the wall

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Cellular & Molecular Immunology 2018年第4期15卷 405-407页

作者： Sara caputo Matteo Bellone Cellular Immunology Unit Department of ImmunologyTransplantation and Infectious DiseasesSan Raffaele Scientific Institute20132 MilanItaly

The innate and adaptive arms of the immune system are finely tuned to efficiently react to either endogenous or exogenous noxiae that perturb the function of our tissues and organs,thus rapidly returning to homeostasis with minimal collateral *** molecular mechanisms by which this occurs have been only partially *** work by Kanayama et al.1 contributes to the building of this wall of knowledge by adding an important *** show that osteopontin(OPN),a phosphorylated protein of the extracellular matrix(ECM),has a dominant role in balancing lymphoid and myeloid cells during emergency granulopoiesis(that is,an increased cellular output from the bone marrow to meet the acute demand for the respective blood cell type).2 OPN that is produced and released by bone marrow(BM)stromal cells negatively impacts the pool size of hematopoietic stem cells(that is,Lin−Sca-1+c-kit+).

关键词： organs al. endogenous

Utility of preoperative systemic inflammatory biomarkers in predicting postoperative complications after pancreaticoduodenectomy: Literature review and single center experience

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1216-1225页

作者： Alessandro Coppola Vincenzo La Vaccara Lorenza Caggiati Ludovico Carbone Silvia Spoto Massimo Ciccozzi Silvia Angeletti roberto Coppola Damiano caputo Department of Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of General Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of Internal Medicine University Campus Bio-Medico di RomaRome 00128Italy Medical Statistics and Epidemiology Unit University Campus Bio-Medico di RomaRome 00128Italy Unit of Clinical Laboratory Science University Campus Bio-Medico di RomaRome 00128Italy

BACKGROUND The role of preoperative inflammatory biomarkers(PIBs)in predicting postoperative morbidity has been assessed in colorectal and otorhinolaryngeal ***,data regarding the role that preoperative inflammatory biomarkers have on morbidity after pancreaticoduodenectomiy(PD)are less *** To assess the utility of PIBs in predicting postoperative complications after *** A database of 317 consecutive pancreaticoduodenectomies performed from April 2003 to November 2018 has been retrospectively *** regarding preoperative neutrophil-to-lymphocyte ratio(NLR),derived NLR and C-reactive protein(CRP),and postoperative complications of 238 cases have been *** criteria were:age8.81 mg/dL were at higher risk of both overall complications and abdominal

关键词： Preoperative inflammatory markers Pancreaticoduodenectomy Complications Neutrophil-to-lymphocyte ratio Derived neutrophil-to-lymphocyte ratio