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Effects of drug-polymer dispersions on solubility and in vitro diffusion of artemisinin across a polydimethylsiloxane membrane

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Chinese Science Bulletin 2012年第14期57卷 1685-1692页

作者： SHAHZAD Yasser SHAH Syed Nisar Hussain ANSARI Muhammad Tayyab riaz romana SAFDAR Aasma HUSSAIN Talib MALIK Madeeha Faculty of Pharmacy Bahauddin Zakariya University Division of Pharmacy and Pharmaceutical Sciences School of Applied SciencesUniversity of Huddersfield Hamdard Institute of Pharmaceutical Sciences Hamdard University

Artemisinin(ART) is a sesquiterpene lactone with an endo-peroxide bridge that is thought to be responsible for its antimalarial *** has low oral bioavailability because of aqueous insolubility,which leads to local toxicity at the site of *** present work focused on increasing its solubility and evaluating its permeation across a model membrane to mimic transdermal delivery that bypasses the hepatic *** this purpose,physical mixtures(PM),solid dispersions(SD) and lyophilized dispersions(LD) with different drug-polymer ratios(1:0.5,1:1,1:2,1:4 and 1:9) were prepared using the hydrophilic polymer polyvinylpyrrolidone(PVP).Drug-polymer dispersions were characterized using X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Solubility was measured in three solvents:de-ionized water,phosphate buffered saline(PBS) and *** toluene-water partition coefficient was evaluated and compared with the literature and calculated logP *** vitro diffusion of ART was studied across a polydimethylsiloxane membrane from a saturated solution of drug-polymer *** patterns showed a gradual decrease in crystallinity of ART with increasing polymer concentration,while FTIR confirmed no interactions between ART and *** was increased up to 4-,5-and 8-fold for LD in water,PBS and methanol,*** logP for toluene-water was 2.65 ± 0.3,which is in good agreement with literature and calculated logP *** was enhanced,which is attributed to the decrease in crystallinity and increase in wettability of the *** ART flux was significantly higher than that of pure ART(0.12 ± 0.01) with increasing PVP concentration for SD and LD *** conclusion,drug-polymer dispersions with PVP improve the pharmaceutical properties of ART in the order LD>SD>PM.

关键词：聚合物分散体溶解度测定聚硅氧烷外扩散青蒿素药物傅里叶变换红外光谱水性高分子

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The quasi-Gramian solution of a non-commutative extension of the higher-order nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 51-61页

作者： H W A riaz J Lin Department of Physics Zhejiang Normal UniversityJinhua 321004China

The nonlinear Schr?dinger(NLS)equation,which incorporates higher-order dispersive terms,is widely employed in the theoretical analysis of various physical *** this study,we explore the non-commutative extension of the higher-order NLS *** treat real or complex-valued functions,such as g_(1)=g_(1)(x,t)and g_(2)=g_(2)(x,t)as non-commutative,and employ the Lax pair associated with the evolution equation,as in the commutation *** derive the quasi-Gramian solution of the system by employing a binary Darboux *** soliton solutions are presented explicitly within the framework of *** visually understand the dynamics and solutions in the given example,we also provide simulations illustrating the associated ***,the solution can be used to study the stability of plane waves and to understand the generation of periodic patterns within the context of modulational instability.

关键词： integrable systems Darboux transformation solitons

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ROBO-SPOT:Detecting Robocalls by Understanding User Engagement and Connectivity Graph

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Big Data Mining and Analytics 2024年第2期7卷 340-356页

作者： Muhammad Ajmal Azad Junaid Arshad Farhan riaz College of Comnputer Science Birmingham City UniversityBirminghamB55JUUK School of Computer Science University of LincolnLincolnLN67TSUK

Robo or unsolicited calls have become a persistent issue in telecommunication networks,posing significant challenges to individuals,businesses,and regulatory *** calls not only trick users into disclosing their private and financial information,but also affect their productivity through unwanted phone ringing.A proactive approach to identify and block such unsolicited calls is essential to protect users and service providers from potential ***,this paper proposes a solution to identify robo-callers in the telephony network utilising a set of novel features to evaluate the trustworthiness of callers in a *** trust score of the callers is then used along with machine learning models to classify them as legitimate or *** use a large anonymized dataset(call detailed records)from a large telecommunication provider containing more than 1 billion records collected over 10 *** have conducted extensive evaluation demonstrating that the proposed approach achieves high accuracy and detection rate whilst minimizing the error ***,the proposed features when used collectively achieve a true-positive rate of around 97%with a false-positive rate of less than 0.01%.

关键词： social network analysis reputation unwanted calls robo-callers telephone network Spam Over Internet Technology(SPIT)

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Optimization Algorithms of PERT/CPM Network Diagrams in Linear Diophantine Fuzzy Environment

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1095-1118页

作者： Mani Parimala Karthikeyan Prakash Ashraf Al-Quran Muhammad riaz Saeid Jafari Department of Mathematics Bannari Amman Institute of TechnologySathyamangalamTamil Nadu638401India Basic Sciences Department Preparatory Year DeanshipKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Mathematics University of the PunjabLahorePakistan College of Vestsjaelland South Herrestraede 11Slagelse4200Denmark

The idea of linear Diophantine fuzzy set(LDFS)theory with its control parameters is a strong model for machine learning and optimization under *** activity times in the critical path method(CPM)representation procedures approach are initially static,but in the Project Evaluation and Review Technique(PERT)approach,they are *** study proposes a novel way of project review and assessment methodology for a project network in a linear Diophantine fuzzy(LDF)*** LDF expected task time,LDF variance,LDF critical path,and LDF total expected time for determining the project network are all computed using LDF numbers as the time of each activity in the project *** primary premise of the LDF-PERT approach is to address ambiguities in project network activity timesmore simply than other approaches such as conventional PERT,Fuzzy PERT,and so *** LDF-PERT is an efficient approach to analyzing symmetries in fuzzy control systems to seek an optimal *** also present a new approach for locating LDF-CPM in a project network with uncertain and erroneous activity *** the available resources and activity times are imprecise and unpredictable,this strategy can help decision-makers make better judgments in a project.A comparison analysis of the proposed technique with the existing techniques has also been *** suggested techniques are demonstrated with two suitable numerical examples.

关键词： Linear Diophantine fuzzy graphs project management PERT CPM linear Diophantine fuzzy numbers score function accuracy function

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Customizable multifunctional metasurface absorber based on bidirectional deep neural networks covering the quasi-entire terahertz band

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Chinese Optics Letters 2024年第6期22卷 182-190页

作者： Zhipeng Ding Wei Su Lipeng’an Ye Yuanhang Zhou Wenlong Li riaz Ali Bin Tang Hongbing Yao College of Mechanics and Engineering Science Hohai UniversityNanjing 211100China School of Microelectronics and Control Engineering Changzhou UniversityChangzhou 213164China

In this work, we propose a novel approach that combines a bidirectional deep neural network(BDNN) with a multifunctional metasurface absorber(MMA) for inverse design, which can effectively address the challenge of on-demand customization for absorbers. The inverse design of absorption peak frequencies can be achieved from 0.5 to 10 terahertz(THz), covering the quasi-entire THz band. Based on this, the BDNN is extended to broadband absorption, and the inverse design yields an MMA at the desired frequency. This work provides a broadly applicable approach to the custom design of multifunctional devices that can facilitate the evaluation and design of metasurfaces in electromagnetic absorption.

关键词： terahertz inverse design bidirectional deep neural network metasurface

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Elevating Image Steganography:A Fusion of MSB Matching and LSB Substitution for Enhanced Concealment Capabilities

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Computers, Materials & Continua 2024年第5期79卷 2923-2943页

作者： Muhammad Zaman Ali Omer riaz Hafiz Muhammad Hasnain Waqas Sharif Tenvir Ali Gyu Sang Choi Department of Information Technology The Islamia University of BahawalpurBahawalpur63100Pakistan Department of Computer Science The Islamia University of BahawalpurBahawalpur63100Pakistan School of Computer Science and Engineering Yeungnam UniversityGyeongbuk38541Korea

In today’s rapidly evolving landscape of communication technologies,ensuring the secure delivery of sensitive data has become an essential *** overcome these difficulties,different steganography and data encryption methods have been proposed by researchers to secure *** of the proposed steganography techniques achieve higher embedding capacities without compromising visual imperceptibility using LSB *** this work,we have an approach that utilizes a combinationofMost SignificantBit(MSB)matching andLeast Significant Bit(LSB)*** proposed algorithm divides confidential messages into pairs of bits and connects them with the MSBs of individual pixels using pair matching,enabling the storage of 6 bits in one pixel by modifying a maximum of three *** proposed technique is evaluated using embedding capacity and Peak Signal-to-Noise Ratio(PSNR)score,we compared our work with the Zakariya scheme the results showed a significant increase in data concealment *** achieved results of ourwork showthat our algorithmdemonstrates an improvement in hiding capacity from11%to 22%for different data samples while maintaining a minimumPeak Signal-to-Noise Ratio(PSNR)of 37 *** findings highlight the effectiveness and trustworthiness of the proposed algorithm in securing the communication process and maintaining visual integrity.

关键词： Steganography most significant bit(MSB) least significant bit(LSB) peak signal-to-noise ratio(PSNR)

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Dynamical study of varicella-zoster virus model in sense of Mittag-Leffler kernel

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International Journal of Biomathematics 2024年第3期17卷 153-183页

作者： Qura Tul Ain Aziz Khan Thabet Abdeljawad J.F.Gomez-Aguilar Saleem riaz Department of Mathematics Guizhou University GuiyangGuizhou 550025P.R.China Department of Mathematics and Sciences Prince Sultan University P.O.Bor 66833 11586 RiyadhSaudi Arabia Department of Medical Research China Medical University Taichung 40402Taiwan CONACyT-Tecnologico Nacional de Mécico/CENIDET Interior Internado Palmira S/N Col.Palmira C.P.62490CuernavacaMorelosMécico IConsejo Academico Universidad Virtual CNCIMonterreyMécico School of Automation Northwestern Polytechnical University 170072 Xian P.R.China

The primary varicella-zoster virus(VzV)infection that causes chickenpox(also known as varicella),spreads quickly among people and,in severe circumstances,can cause to fever and *** this paper,the Mittag-Leffler fractional operator is used to examine the mathematical representation of the *** fractional-order differential equations are created in terms of the disease's dynamical analysis such as S:Susceptible,V:Vaccinated,E:Exposed,I:Infectious and R:*** derive the existence criterion,positive solution,Hyers-Ulam stability,and boundedness of results in order to examine the suggested fractional-order model's ***,some numerical examples for the VzV model of various fractional orders are shown with the aid of the generalized Adams-Bashforth-Moulton approach to show the viability of the obtained results.

关键词： Varicella-zoster virus model Hyers-Ulam stability ABC fractional operator Schauder fix point theory numerical analysis

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Multi-Elemental Chemostratigraphy,Sequence Development,Depositional History,and Environmental Importance of Early Eocene Red Beds(Kuldana Formation)in NW Himalayas,Pakistan

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Journal of Earth Science 2024年第2期35卷 349-375页

作者： Amir Shahzad George Kontakiotis Thierry Adatte Khawaja Shoaib Ahmed Muhammad Tayyib riaz Hammad Tariq Janjuhah Evangelia Besiou Institute of Geology University of Azad Jammu and KashmirMuzaffarabad13100Pakistan Department of Historical Geology-Paleontology Faculty of Geology and GeoenvironmentSchool of Earth SciencesNational and Kapodistrian University of AthensPanepistimiopolisZografou15784Greece Institute of Earth Sciences(ISTE) University of LausanneLausanneCH-1015Switzerland Department of Geology Shaheed Benazir Bhutto UniversitySheringalPeshawar18050Pakistan

The Eocene Kuldana Formation(KF)in the Yadgar area of Pakistan,comprises a diverse range of sedimentary facies,including variegated red beds of shales,mudstones,and sandstones,as well as interbedded limestone and *** this study,we conducted an integrated micropaleontological,sedimentological,mineralogical,and geochemical investigation to determine the depositional setting,biochronology,provenance,and paleoclimate of the *** study identified six lithofacies and six microfacies,which indicate a variety of environments ranging from floodplains and channels to the margins and shallow marine *** nannofossil biostratigraphy places the KF in the Early Eocene,more precisely the NP10 zone(Ypresian),and the fossil zone of benthic foraminifera classifies the study section as the Shallow Benthic Zone SBZ-8(Middle Ilerdian 2).In terms of petrography,the KF sandstone was classified as litharenite and feldspathic litharenite,while the QtFL diagram suggests a recycled *** proxies indicate an oxidizing environment,a high-to-low regular sedimentation rate,moderate-to-intense chemical weathering in the source region,and a warm-humid to dry climate during the deposition of ***,the findings suggest that the deposition of KF marks the end of Neo-Tethys due to the Early Eocene Indian–Kohistan collision and that the uplifting of the Himalayas provided the source for the deposition of KF in the foreland *** study provides new insights into the depositional environment,biochronology,provenance,and paleoclimate of KF,and highlights the potential for red beds as reliable indicators of oxygenation levels in proximity to mineral deposits.

关键词： sedimentary microfacies Paleocene–Eocene thermal maximum stratigraphic correlations paleoenvironmental reconstruction nannofossils paleontology

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UNet Based onMulti-Object Segmentation and Convolution Neural Network for Object Recognition

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Computers, Materials & Continua 2024年第7期80卷 1563-1580页

作者： Nouf Abdullah Almujally Bisma riaz Chughtai Naif Al Mudawi Abdulwahab Alazeb Asaad Algarni Hamdan A.Alzahrani Jeongmin Park Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science Air UniversityIslamabad44000Pakistan Department of Computer Science College of Computer Science and Information SystemNajran UniversityNajran55461Saudi Arabia Department of Computer Sciences Faculty of Computing and Information TechnologyNorthern Border UniversityRafha91911Saudi Arabia Information Technology Department College of Computing and InformaticsSaudi Electronic UniversityRiyadh13316Saudi Arabia Department of Computer Engineering Korea Polytechnic UniversitySiheung-siGyeonggi-do237Republic of Korea

The recent advancements in vision technology have had a significant impact on our ability to identify multiple objects and understand complex *** technologies,such as augmented reality-driven scene integration,robotic navigation,autonomous driving,and guided tour systems,heavily rely on this type of scene *** paper presents a novel segmentation approach based on the UNet network model,aimed at recognizing multiple objects within an *** methodology begins with the acquisition and preprocessing of the image,followed by segmentation using the fine-tuned UNet ***,we use an annotation tool to accurately label the segmented *** labeling,significant features are extracted from these segmented objects,encompassing KAZE(Accelerated Segmentation and Extraction)features,energy-based edge detection,frequency-based,and blob *** the classification stage,a convolution neural network(CNN)is *** comprehensive methodology demonstrates a robust framework for achieving accurate and efficient recognition of multiple objects in *** experimental results,which include complex object datasets like MSRC-v2 and PASCAL-VOC12,have been *** analyzing the experimental results,it was found that the PASCAL-VOC12 dataset achieved an accuracy rate of 95%,while the MSRC-v2 dataset achieved an accuracy of 89%.The evaluation performed on these diverse datasets highlights a notably impressive level of performance.

关键词： UNet segmentation blob fourier transform convolution neural network

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Morpho-anatomical adaptations of dominantly grown wild Datura inoxia to wastewater resource:Productivity and ecological issues

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Geoscience Frontiers 2024年第3期15卷 248-258页

作者： Taimoor Hassan Farooq Shagufta Jabeen Awais Shakoor Muhammad Saleem Arif Nadia Siddique Khuram Shahzad Muhammad Umair riaz Yong Li Bangor College China a Joint Unit of Bangor University and Central South University of Forestry and TechnologyChangsha 410004HunanChina Department of Botany The Islamia University of BahawalpurBahawalpur 63100Pakistan Hawkesbury Institute for the Environment Western Sydney UniversityPenrithNSW 2751Australia Department of Environmental Sciences Government College University FaisalabadFaisalabad 38000Pakistan Department of Forestry Rangeand Wildlife ManagementThe Islamia University of BahawalpurBahawalpur 63100Pakistan Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China National Engineering Laboratory for Applied Technology of Forestry and Ecology in South China Central South University of Forestry and TechnologyChangsha 410004HunanChina

With the increasing global water scarcity,wastewater irrigation has become widespread,but it can have detrimental ecological *** wastewater contains valuable nutrients for plants,improper treatment or the use of untreated wastewater in irrigation can negatively impact soil fertility and plant *** study is divided into two parts:firstly,a phytosociological survey was conducted to identify plant species with the highest importance value index(IVI)in the vicinity of wastewaterirrigated ***,a comparative morpho-anatomical analysis was carried out to investigate the morpho-anatomical adaptations of the species with the highest IVI under wastewater irrigation compared to normal water *** results of the phytosociological survey revealed the presence of 51 plant species in the vicinity of the wastewater-irrigated areas,with varying relative densities and *** inoxia exhibited the highest IVI(28.79),followed by Xanthium strumarium(24.34),while Lippia nodiflora showed the lowest IVI(1.86).The morphological growth of *** was superior under normal water irrigation,but the average root length was greater under wastewater *** cell anatomy,cell thickness and cell area characteristics in the dermal,ground,and vascular tissues of the stem and root tended to be greater under wastewater ***,the opposite trend was observed in leaf anatomical analysis,possibly due to the combined effect of wastewater and climatic *** and root xylem thickness were greater under wastewater irrigation,whereas phloem thickness was higher under normal water *** number of vascular bundles in the stem,root,and leaf was higher under wastewater treatment compared to normal water irrigation,but their arrangement was circular in the latter and scattered under wastewater *** inoxia demonstrated strong adaptive potential under wastewater irrigation,as indicated by its highest relative d

关键词： Water pollution Phytosociology Structural growth Phytoremediation Agricultural irrigation Ecological concerns

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