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Reconstructing the post-LGM deglacial history of Hollingsworth Glacier on Ricker Hills,Transantarctic Mountains,Antarctica

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Journal of Mountain Science 2022年第5期19卷 1217-1230页

作者： rhee hyun-hee SEONG Yeong-Bae WOO Ju-Sun Oh Changhwan YU Byung-Yong Division of Glacial Environment Research Korea Polar Research InstituteIncheon 21990Republic of Korea Department of Geography Education Korea UniversitySeoul 02841Republic of Korea School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Republic of Korea Department of Earth and Environmental Science Chungbuk National UniversityCheongju 28644Republic of Korea AMS laboratory Korea Institute of Science and TechnologySeoul 02792Republic of Korea

The Transantarctic Mountains are an important corridor between the East Antarctic Ice Sheet and the Western Ross Sea,where most current ice streams and outlet glaciers *** investigated Ricker Hills,the largest exposed mountainous region between Southern Victoria Land and Terra Nova Bay,and dated the glacial landforms using in-situ cosmogenic-nuclide 10 Be surface exposure dating to reconstruct the paleo-glacial *** surface of the Hollingsworth glacier lowered since the middle of Marine Isotope Stage(MIS)2(22.1 ka);therefore,the Last Glacial Maximum(LGM)occurred before that ***,geomorphic,and climatic records constrained the glacial surface slope to be between 5.4°and 6.8°.The ice was 270-320 m thicker at the LGM(MIS 2)than presently but did not override the top surface of the Benson ***,previous glacial periods such as the local LGM(MIS 4)or Penultimate Glacial Maximum(MIS 6)maintained thicker ice than the LGM(MIS 2).The Ross Ice Shelf opening during the mid-Holocene(~6 ka)caused the rapid collapse of the terminal outlet glaciers and supplied notable snow accumulation upstream,which stagnated *** greatest lowering and retreat occurred during the late Holocene(2.3~0.8 ka),when elephant seal colonies thrived in the Ross Embayment.

关键词： East Antarctic Ice Sheet Last Glacial Maximum Deglaciation Holocene Cosmogenic nuclide exposure dating Glacier reconstruction

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-hee Park Su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety Division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

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Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO KYUNG PARK MINSUK KWON MINAE AN JUNG YONG HONG JOON OH PARK SUNG hee LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

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Clinical course of subepithelial lesions detected on upper gastrointestinal endoscopy

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World Journal of Gastroenterology 2010年第4期16卷 439-444页

作者： Yeun Jung Lim hee Jung Son Jong-Soo Lee Young Hye Byun hyun Joo Suh Pool Lyul rhee Jae J Kim Jong Chul rhee Center for Health Promotion Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine50Irwon-dongGangnam-guSeoul 135-710South Korea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine50Irwon-dongGangnam-guSeoul 135-710South Korea

AIM:To evaluate the natural history of subepithelial ***:We reviewed the medical records of 104 159 patients who underwent upper gastrointestinal endoscopy at the Center for Health Promotion of Samsung Medical Center between 1996 and *** lesions were detected in 795 patients(0.76%);252 patients were followed using upper gastrointestinal endoscopy for 82.5 ± 29.2 mo(range,12-160 mo;median,84 mo;1st quartile,60 mo;3rd quartile,105 mo).The median interval of follow-up endoscopy was 12 mo(range,6-105 mo;1st quartile,12 mo;3rd quartile,24 mo).RESULTS:The mean patient age was 53 years(range,22-80 years),and the male-to-female ratio was 2.36:1(177/75).The lesion size at initial measurement averaged 8.9 mm(range,2-25 mm;median,8 mm;1st quartile,5 mm;3rd quartile,10 mm).Of the 252 lesions,244(96.8%) were unchanged and 8(3.2%) were significantly increased in size(from 12.9 ± 6.0 to 21.2 ± 12.2 mm) after a mean interval of 59.1 ± 27.5 mo(range,12-86 mo).Surgical resection of lesions was performed when the lesions were ≥ 3 cm in *** lesions were diagnosed as gastrointestinal stromal tumors with an intermediate or high risk of malignancy and one lesion was classified as a ***:Most small subepithelial lesions do not change as shown by endoscopic examination,and regular follow-up with endoscopy may be considered in small,subepithelial lesions,especially lesions < 1 cm in size.

关键词： Subepithelial tumor Ultrasonography Gastrointestinal diseases Gastrointestinal endoscopy Time factors

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Unexpected anterograde amnesia associated with Buscopan used as a predmedication for endocscopy

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World Journal of Gastroenterology 2007年第28期13卷 3895-3896页

作者： Hyuk Lee hee Jung Son Poong-Lyul rhee Jae J Kim Jong Chul rhee Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710Korea Departments of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710Korea Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710Korea

It has been known that peripheral adverse event is caused by peripheral antimuscarinic action, from hyoscine butylbromide (Buscopan; Boehringer Ingelheim, Germany) used as a premedication for endoscopy. However, symptoms or signs associated with the central nervous system are rarely reported in the field of anesthesiology and peripartum labor. This central anticholinergic syndrome is likely caused by blockade of muscarinic cholinergic receptors in the central nervous system. There is no report on Buscopan-induced central anticholinergic syndrome in endoscopy room so far. Three middle-aged females unexpectedly suffered from anterograde amnesia after intramuscular injection of hyoscine butylbromide as an antispasmodic premedication for endoscopy at our endoscopy unit in the Health Promotion Center.

关键词： Endoscopy Hyoscine butylbromide Central anticholinergic syndrome Amnesia

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Transcriptomic Responses of Garlic(Allium sativum L.)to Heat and Drought Stresses

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 3077-3090页

作者： Seung hee Eom Tae Kyung hyun Department of Industrial Plant Science and Technology Chungbuk National UniversityCheongju28644Korea

Heat and drought are prominent abiotic stressors that limit crop productivity and yield,particularly concerning climate change;therefore,understanding the molecular mechanisms underlying plant stress responses is crucial for stress-tolerant crop *** study conducted a transcriptomic analysis to elucidate how garlic(Allium sativum L.)responds to drought and heat stress *** libraries were generated to identify differentially expressed genes(DEGs)induced by drought and heat *** classification and clustering analysis of DEGs revealed stress-specific gene expression ***,cell wall-related genes were implicated in the drought response,whereas heat stress was associated with heat stress transcription factors and heat shock *** results provide essential information for future studies on stress tolerances in garlic.

关键词： Differentially expressed gene drought heat garlic transcriptome

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Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

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Chinese Journal of Integrative Medicine 2022年第9期28卷 802-808页

作者： Bo-Ra Jeon Muhammad Irfan Seung Eun Lee Jeong Hoon Lee Man hee rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal Science(NIHHS)Eumseong27709Republic of Korea

Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella ***:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow *** blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt ***:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases.

关键词： antiplatelet ethnomedicine integrinα_(Ⅱb)β_(3) mitogen-activated protein kinase Rumex acetosella L.

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Comparison of scoring systems in predicting the severity of acute pancreatitis

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World Journal of Gastroenterology 2015年第8期21卷 2387-2394页

作者： Joon hyun Cho Tae Nyeun Kim hyun hee Chung Kook hyun Kim Division of Gastroenterology and Hepatology Department of Internal Medicine Yeungnam University College of Medicine

AIM:To investigate the prognostic usefulness of several existing scoring systems in predicting the severity of acute pancreatitis(AP).METHODS:We retrospectively analyzed the prospectively collected clinical database from consecutive patients with AP in our institution between January 2011 and December ***,Acute Physiology and Chronic Health Evaluation(APACHE)-Ⅱ,and bedside index for severity in acute pancreatitis(BISAP)scores,and computed tomography severity index(CTSI)of all patients were *** C-reactive protein(CRP)levels were measured at admission(CRPi)and after 24h(CRP24).Severe AP was defined as persistent organ failure for more than 48 *** predictive accuracy of each scoring system was measured by the area under the receiver-operating curve(AUC).RESULTS:Of 161 patients,21(13%)were classified as severe AP,and 3(1.9%)*** significant cutoff values for prediction of severe AP were Ranson≥3,BISAP≥2,APACHE-Ⅱ≥8,CTSI≥3,and CRP24≥*** for Ranson,BISAP,APACHE-Ⅱ,CTSI,and CRP24 in predicting severe AP were 0.69(95%CI:0.62-0.76),0.74(95%CI:0.66-0.80),0.78(95%CI:0.70-0.84),0.69(95%CI:0.61-0.76),and0.68(95%CI:0.57-0.78),***-Ⅱdemonstrated the highest accuracy for prediction of severe AP,however,no statistically significant pairwise differences were observed between APACHE-Ⅱand the other scoring systems,including ***:Various scoring systems showed similar predictive accuracy for severity of *** models are needed in order to achieve further improvement of prognostic accuracy.

关键词： Severity Scoring systems Predictors Acute pancreat

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Endoscopic cyanoacrylate injection for the treatment of gastric varices in children

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World Journal of Gastroenterology 2015年第9期21卷 2719-2724页

作者： Seak hee Oh Seung Jin Kim Kang Won rhee Kyung Mo Kim Department of Pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoul 138-736South Korea

AIM:To evaluate the efficacy and safety of N-butyl-2-cyanoacrylate in treating acute bleeding of gastric varices in ***:The retrospective study included 21 children with 47 episodes of active gastric variceal bleeding who were treated by endoscopic injection of N-butyl-2-cyanoacrylate at Asan Medical Center Children's Hospital between August 2004 and December *** reduce the risk of embolism,each injection consisted of 0.1-0.5 mL of 0.5 mL N-butyl-2-cyanoacrylate diluted with 0.5 or 0.8 mL *** primary outcome was incidence of hemostasis after variceal obliteration and the secondary outcome was complication of the ***:The 21 patients experienced 47 episodes of active gastric variceal bleeding,including rebleeding,for which they received a total of 52 cyanoacrylate *** 42 bleeding episodes,hemostasis was achieved after one injection and following five bleeding episodes it was achieved after two *** mean volume of each single aliquot of cyanoacrylate injected was 0.3 ± 0.1 mL(range:0.1-0.5 m L).Injection achieved hemostasis in 45 of 47(95.7%) episodes of acute gastric variceal *** patients(52.4%) developed rebleeding events,with the mean duration of hemostasis being 11.1 ± 11.6 mo(range:1.0-39.2 mo).No treatment-related complications such as distal embolism were noted with the exception of abdominal pain in one patient(4.8%).Among four mortalities,one patient died of variceal ***:Endoscopic variceal obliteration using a small volume of aliquots with repeated cyanoacrylate injection was an effective and safe option for the treatment of gastric varices in children.

关键词： Cyanoacrylate Gastric varix Children Endoscopic va

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