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Anemarsaponin B mitigates acute pancreatitis damage in mice through apoptosis reduction and MAPK pathway modulation

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BIOCELL 2024年第5期48卷 745-758页

作者： yi HU ZhongYANG ren ZHENGZhong ZHAO YONGJIA HUANG WANTING HUANG JIE LIU LING DING Gastroenterology Department Chongqing University Jiangjin HospitalJiangjin Central Hosptial of ChongqingChongqingChina Surgical Department Chongqing Jiangjin District Hospital of Chinese MedicineChongqingChina Pharmacy Department Chongqing University Jiangjin HospitalJiangjin Central Hosptial of ChongqingChongqingChina

Background:Acute pancreatitis(AP),known for its rapid onset and significant incidence and mortality rates,presents a clinical challenge due to the limited availability of effective treatments and preventive *** B(ASB)has emerged as a potential therapeutic agent,demonstrating capabilities in reducing immune inflammation,positioning it as a promising candidate for AP ***:We investigated the effects of ASB on AP in mice,induced by caerulein and lipopolysaccharide(LPS).Peripheral blood samples were collected 24 h post-induction with caerulein to assess of key biomarkers including lipase,amylase,TNF-α,IL-1β,IL-6,SOD,and GSH-Px.A range of techniques such as immunohistochemistry staining,immunofluorescence staining,Western blotting,and quantitative Polymerase Chain Reaction(q-PCR),were employed to measure the expression of critical ***,pancreas samples from the mice were harvested for microbiome and metabolome sequencing,with the data analyzed to understand the impact of ASB on ***:Our study revealed that,compared to the sham group,the AP group exhibited significantly higher serum levels of lipase,amylase,and cytokines,while levels of SOD and GSH Px were notably *** with ASB led to a substantial decrease in the levels of lipase,amylase,and cytokines,and an increase in SOD and GSH-Px levels.q-PCR analysis of pancreatic histiocytes corroborated these serum *** and Eosin(H&E)staining indicated significant alterations in the pathological changes in the pancreas,lungs,and small intestine of the AP model due to *** assays demonstrated that ASB alleviated the apoptosis of pancreatic histiocytes in the AP *** Blot and histological analyses showed that ASB reduced the phosphorylation of TAK,p38,JNK,and ERK proteins,as well as the levels of TRAF6 protein in the AP ***,metabolomic and gut microbiota analysis identified 27 differential metabolites and 34 diffe

关键词： Anemarsaponin B Acute pancreatitis Cytokines MAPK TRAF6 Gut flora

Cemented vertebra and adjacent vertebra refractured in a chronic kidney disease-mineral and bone disorder patient: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1804-1809页

作者： Ti-Dong Zhang Shuai Cao Hui-Yong ren Yu-Min Li yi-Ming Yuan Department of Orthopedics Civil Aviation General HospitalBeijing 100123China

BACKGROUND Although percutaneous vertebral augmentation(PVA)is a commonly used procedure for treating vertebral compression fracture(VCF),the risk of vertebral refracture should be *** kidney disease-mineral and bone disorder(CKD-MBD)is a systemic disease of mineral and bone *** is associated with an increased risk of *** studies have reported the use of PVA in patients with *** herein report a rare case wherein the cemented vertebra and the adjacent vertebra refractured simultaneously in a CKD-MBD patient after *** SUMMARY A 74-year-old man suffered from low back pain after taking a fall about 3 wk *** to physical examination,imaging and laboratory findings,diagnoses of T12 VCF,CKD-MBD,and chronic kidney disease stage 5 were *** then received percutaneous vertebroplasty at T12 *** weeks later,he presented with T12 and L1 vertebral refractures caused by lumbar *** again,he was given PVA which was optimized for the refractured *** the short-term postoperative effect was satisfactory,he reported chronic low back pain again at the 3-month *** It is necessary that patients with CKD-MBD who have received PVA are aware of the adverse effects of *** may increase the risk of vertebral ***,the PVA surgical technique needs to be optimized according to the condition of the *** medium-and long-term effects of PVA remain uncertain in patients with CKD-MBD.

关键词： Chronic kidney disease-mineral and bone disorder Percutaneous vertebral augmentation Vertebral compression fracture Vertebral refracture Cemented vertebra Adjacent vertebra Case report

Progress in modeling and control of probe-and-drogue autonomous aerial refueling

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Chinese Journal of Aeronautics 2024年第5期37卷 6-26,I0001页

作者： Jinrui ren Quan QUAN School of Automation Xi’an University of Posts&TelecommunicationsXi'an 710072China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

By refueling aircraft while they are in flight,aerial refueling is an efficient technique to extend their endurance and *** Aerial Refueling(AAR)is anticipated to be used to complete aerial refueling for unmanned *** are three aerial refueling methods:the Probe-and-Drogue Refueling(PDR)refueling method,the flying-boom refueling method,and the boom-drogue-adapter refueling *** paper considers the PDR approach,the most challenging of the three,because the flexible hose-drogue assembly has fast dynamics and is susceptible to various kinds of winds,which makes the probe docking with the drogue *** is divided into four phases,namely the rendezvous phase,joining phase,refueling phase,and reform phase,with the refueling phase being the most *** controller design faces the greatest challenge during the docking control of the refueling phase since it calls for a high level of safety,precision,and *** a result,the modeling and control issues encountered during the refueling phase are typical and *** fundamental idea of AAR is presented in the paper first,after which the characteristics and requirements of AAR are *** progress in modeling and control techniques for the AAR’s refueling phase is then systematically ***,potential future work for high safety,precision,and efficiency requirements is examined and suggested.

关键词： Aerial refueling Probe-and-drogue refueling Docking Flight controlsystems Unmanned Aerial Vehicles

Tb^(3+)-nucleic acid probe-based label-free and rapid detection of mercury pollution in food

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Food Science and Human Wellness 2024年第2期13卷 993-998页

作者： Xuhan Xia Chenxi Zhou Yulin Zhu yi Dong Qiang He Mohammad Rizwan Khan Yuanlong Chi Rosa Busquets Ruijie Deng Yao ren College of Biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610065China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia School of Life Sciences Pharmacy and ChemistryKingston University LondonKingston Upon Thames KT12EEUK

Mercury is a threatening pollutant in food,herein,we developed a Tb^(3+)-nucleic acid probe-based label-free assay for mix-and-read,rapid detection of mercury *** assay utilized the feature of light-up fluorescence of terbium ions(Tb^(3+))via binding with single-strand *** ion,Hg^(2+)induced thymine(T)-rich DNA strand to form a double-strand structure(T-Hg^(2+)-T),thus leading to fluorescence *** on the principle,Hg^(2+)can be quantified based on the fluorescence of Tb^(3+),the limit of detection was 0.0689μmol/L and the linear range was 0.1-6.0μmol/*** to the specificity of T-Hg^(2+)-T artificial base pair,the assay could distinguish Hg^(2+)from other metal *** recovery rate was ranged in 98.71%-101.34%for detecting mercury pollution in three food *** assay is low-cost,separation-free and mix-to-read,thus was a competitive tool for detection of mercury pollution to ensure food safety.

关键词： Mercury pollution Food safety Nucleic acid probe Label-free Terbium

Protective mechanism of quercetin in alleviating sepsis-related acute respiratory distress syndrome based on network pharmacology and in vitro experiments

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World Journal of Emergency Medicine 2024年第2期15卷 111-120页

作者： Weichao Ding Wei Zhang Juan Chen Mengmeng Wang yi ren Jing Feng Xiaoqin Han Xiaohang Ji Shinan Nie Zhaorui Sun Department of Emergency Medicine Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Department of Emergency Medicine Jinling Clinical Medical College of Nanjing University of Chinese MedicineNanjing 210002China Department of Emergency Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002China Department of Emergency Medicine Xuzhou Municipal Hospital Affiliated to Xuzhou Medical UniversityXuzhou 221000China

BACKGROUND:Sepsis-related acute respiratory distress syndrome(ARDS)has a high mortality rate,and no effective treatment is available *** is a natural plant product with many pharmacological activities,such as antioxidative,anti-apoptotic,and anti-inflammatory *** study aimed to elucidate the protective mechanism of quercetin against sepsis-related ***:In this study,network pharmacology and in vitro experiments were used to investigate the underlying mechanisms of quercetin against sepsis-related *** targets and signaling pathways of quercetin against sepsis-related ARDS were screened and were verified by in vitro ***:A total of 4,230 targets of quercetin,360 disease targets of sepsis-related ARDS,and 211 intersection targets were obtained via database *** the 211 intersection targets,interleukin-6(IL-6),tumor necrosis factor(TNF),albumin(ALB),AKT serine/threonine kinase 1(AKT1),and interleukin-1β(IL-1β)were identified as the core targets.A Gene Ontology(GO)enrichment analysis revealed 894 genes involved in the inflammatory response,apoptosis regulation,and response to *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis identified 106 *** eliminating and generalizing,the hypoxia-inducible factor-1(HIF-1),TNF,nuclear factor-κB(NF-κB),and nucleotide-binding and oligomerization domain(NOD)-like receptor signaling pathways were *** docking revealed that quercetin had good binding activity with the core ***,quercetin blocked the HIF-1,TNF,NF-κB,and NODlike receptor signaling pathways in lipopolysaccharide(LPS)-induced murine alveolar macrophage(MH-S)*** also suppressed the inflammatory response,oxidative reactions,and cell ***:Quercetin ameliorates sepsis-related ARDS by binding to its core targets and blocking the HIF-1,TNF,NF-κB,and NOD-like receptor signaling pathways to reduce inflammation,cell apoptosis,and oxidative

关键词： Quercetin Sepsis-related acute respiratory distress syndrome Network pharmacology

High-performance sodium storage for cobalt phosphide composite array electrodes

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Rare Metals 2024年第8期43卷 3724-3734页

作者： Man Zhang Xiao-Xu Liu Tian-yi Ji Yang Li Da-Wei Sheng Shao-Dong Li Pei-Pei ren Ze-Xiang Shen School of Material Science and Engineering Shaanxi University of Science and TechnologyXi'an 710021China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore

Transition metal phosphides hold great potential as sodium-ion batteries anode materials owing to their high theoretical capacity and modest ***,volume changes and low intrinsic conductivity seriously largely hinder the further development of metal phosphide *** design of phosphide anode materials with reasonable structure is conducive to solving the problems of volume expansion and slow reaction kinetics during the *** this work,a composite material integrating zeolite imidazolate backbone(ZIF) and carbon materials was synthesized by the original growth ***,by the oxidation-phosphating process,CoP nanoarray composites riveted to carbon fiber(CoP@CF) were *** the CoP@CF,CoP nanoparticles are uniformly distributed on ZIF-derived carbon,reducing agglomeration and volume change during *** also provides a highly conductive network for the active material,improving the electrode ***,when evaluated as an anode for sodium-ion batteries,CoP@CF electrode displays enhanced reversible capacity(262 mAh·g^(-1) at 0.1 A·g^(-1)after 100 cycles),which is much better than that of pure CF electrode(57 mAh·g^(-1) at 0.1 A·g^(-1) after 100 cycles)prepared without the addition of *** rate performance of CoP@CF electrode is also superior to that of pure CF electrode at various current densities from 0.05 to1 A·g^(-1).The sodium storage behavior of CoP@CF was revealed by ex-situ X-ray photoelectron spectroscopy,X-ray diffraction,and synchrotron radiation absorption *** method provides a reference for the design and synthesis of anode materials in sodium-ion batteries.

关键词： Cobalt phosphide Array structure Freestanding anodes Sodium-ion batteries

Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

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Rare Metals 2024年第9期43卷 4286-4301页

作者： Li Song Xiao-hong Zhong Fang-Lin Wang Zhi-Hui Huang Zhe hong Yun-Fang Gao Hai-Dong Wang Jian-Wei ren Sheng-Jie Peng Lei Li College of Biological Chemical Sciences and EngineeringJiaxing University College of Chemical Engineering Zhejiang University of Technology College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Research and Development Department Jiangxi Ganfeng Li Energy Technology Co.Ltd. Department of Mechanical Engineering Science University of Johannesburg

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***, the carbon nanotubes（CNTs） coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH（denoted as SN-Ni Co-LDH） nanosheets array are grown on Ni Co foam（NCF） substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation costs. Benefiting from the S–N co-doping and low-crystallinity of Ni Co-LDH, the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g-1(4.94 C·cm-2) at 5 m A·cm-2. Furthermore, the fabricated asymmetry supercapacitor（ASC） achieves an extraordinary energy density of 77 Wh·kg-1(0.617 m Wh·cm-2) at a power density of 438 W·kg-1(3.5 m W·cm-2) and outstanding stability(91% capacity retention after 5000 cycles at20 m A·cm-2). Impressively, the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman spectra. Therefore,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance, and also provides guidance for the rational design of the smart electrodes.

关键词： Carbon nanotubes Convenient synthesis NiCo-LDH Sulfur and nitrogen co-doped Supercapacitor

High-precision X-ray polarimeter based on channel-cut crystals

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Nuclear Science and Techniques 2024年第3期35卷 30-39页

作者： Shang-Yu Si Zhong-Liang Li Wen-hong Jia Lian Xue hong-Xin Luo Jian-Cai Xu Bai-Fei Shen Lin-Gang Zhang Liang-Liang Ji Yu-Xin Leng ren-Zhong Tai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China

We report on using synthetic silicon for a high-precision X-ray polarimeter comprising a polarizer and an analyzer,each based on a monolithic channel-cut crystal used at multiple Brewster reflections with a Bragg angle very close to 45°.Experiments were performed at the BL09B bending magnet beamline of the Shanghai Synchrotron Radiation Facility using a Si(800)crystal at an X-ray energy of 12.914 keV.A polarization purity of 8.4×10^(-9)was *** result is encouraging,as the measured polarization purity is the best-reported value for the bending magnet ***,this is the firstly systematic study on the hard X-ray polarimeter in China,which is crucial for exploring new physics,such as verifying vacuum birefringence.

关键词： X-ray polarimeter Vacuum birefringence Synchrotron radiation Channel-cut crystal

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： Zhong yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin ren Wen-xuan LIANG Wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms