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Methylprednisolone improves microcirculation in streptozotocin-induced diabetic rats after myocardial ischemia/reperfusion

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Chinese Medical Journal 2011年第6期124卷 923-929页

作者： HU Zhi-cheng CHEN Yun-dai ren yi-hong Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100085 China

Background Methylprednisolone has been demonstrated to decrease inflammation, and it may protect organs from ischemia/reperfusion （I/R） injury. This study aimed to investigate the effects of methylprednisolone on diabetic myocardial I/R *** Forty adult male Sprague-Dawley （SD） rats were randomized into five groups （n=8 in each group） including a sham operation （sham） group, I/R group, diabetic sham operation （DMS） group, diabetic I/R （DM-I/R） group and methylprednisolone intervention （MP＋DM-I/R） group. The diabetic model was produced by injection of streptozotocin （STZ）. Body weight and blood glucose levels were determined after diabetes was established. Twelve weeks after induction of diabetes, a segmental I/R of the heart was induced by occluding the left anterior descending artery for one hour and then three hours of reperfusion in the I/R, DM-I/R and MP＋DM-I/R groups. Blood pressure and electrocardiogram were continuously recorded during the procedure. IL-1β, IL-6 and TNF-α were measured at certain time points during the surgery. After reperfusion, a microcirculation scan was performed; myocardial biomarkers and tissue structure were utilized to evaluate the reperfusion damage. Intercellular adhesion molecule （ICAM）-1 and NF-κBp65 expression were quantified by immunohistological staining. Total Toil-like receptor 4 （TLR4） and nuclear NF-κBp65 protein were determined by Western *** Twelve weeks after diabetes was established, blood glucose levels were elevated and body weights were lower in diabetic rats. After reperfusion, infarction size was increased, myocardial biomarkers and inflammatory cytokines levels were elevated. Microcirculation perfusion was significantly reduced in the DM-I/R group compared with the I/R group, however it was improved in the MP＋DM-I/R group. The expression of NF-κBp65 and ICAM-1 were increased in the DM-I/R group and decreased in the MP＋DM-I/R group, Compared with the non-diabetic I/R group, TLR4 and NF-κBp65

关键词： diabetes mellitus myocardial ischemia/reperfusion microcirculation methylprednisolone

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Identification and immune analysis of antimicrobial peptides from the cigarette beetle(Lasioderma serricorne)

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Insect Science 2024年第4期31卷 1121-1134页

作者： Yue Zhang yi Yan Guy Smagghe hong Yang ren-huai Dai Wen-jia Yang Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

Antimicrobial peptides(AMPs)in insects are endogenous peptides that are effector components of the innate defense system of the *** may serve as antimicrobial agents because of their small molecular weight and broad-spectrum antimicrobial *** this study,we performed transcriptome analysis of cigarette beetle(Lasioderma serricorne)larvae,parasitized by the ectoparasitic wasp,Anisopteromalus *** AMP genes were significantly upregulated following *** parasitism,postulating the hypothesis that the parasitization enhanced the host's resistance against pathogenic microorganisms through the regulation of host AMP ***,3 AMP genes(LsDef1,LsDef2,and LsCole)were significantly upregulated and we studied their immune function in *** challenge and functional analysis showed that LsCole was responsible for the immune response against Gram-negative and Gram-positive bacteria,while LsDef1 and LsDef2 were involved in insect defense against Gram-positive *** recombinant LsCole exhibited antimicrobial activities against the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus ***2 showed an antibacterial effect against *** and LsDef2 exhibited antibiofilm activity against *** 2 AMPs disrupted cell membranes and caused leakage of *** cell *** results indicated that the 3 AMPs in *** are involved in the innate immunity of this pest *** AMPs may have potential as antimicrobial agents for bacterial infection ***,data are discussed in relation to new control strategies with greater biosafety against pest insects with use of microbial biocontrol agents in combination with RNA interference against the insect's defensive AMP genes.

关键词： antimicrobial activity antimicrobial peptides innate immune response Lasioderma serricorne RNA interference

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Omeprazole affects clopidogrel efficacy but not ischemic events in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention

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Chinese Medical Journal 2011年第6期124卷 856-861页

作者： ren yi-hong ZHAO Ming CHEN Yun-dai CHEN Lian LIU hong-bin WANG Yu SUN Zhi-jun CHEN Jin-song HUANG Ting-ting GUO Yu-song XIE Yong-jin WANG Chun-ya Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China Department of Emergency Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Omeprazole, usually used in the antiplatelet therapy during percutaneous coronary intervention （PCI） in acute coronary syndrome （ACS）, has been reported to increase ischemic events in retrospective studies. However, other clinical trials gave paradoxical results. The aim of this study was to assess the effects of omeprazole on clopidogrel efficacy and clinical *** All patients （n=172） received aspirin （loading dose 300 mg and maintenance dose 100 mg/d） and clopidogrel （loading dose 600 mg and maintenance dose 75 mg/d） during the therapy. They were randomized to receive omeprazole （20 mg/d） or placebo for 30 days. Residual platelet activities in the adenosine 5＇-diphosphate （ADP） pathway were detected on the fifth day after PCI with thrombelastography （TEG）-mapping. The clinical events were recorded after one *** According to the five levels of platelet activities, the frequency distributions of the inhibition rates were significantly different （P=0.0062）. However, no significant change was seen in the distribution among the highest or the lowest inhibiting levels （〉95% and 〈30% inhibition rate）. And there were no significant differences （P 〉0.05） in events incidence, while gastra-intesternal bleeding decreased in co-administration of *** Omeprazole significantly blunts clopidogreal efficacy while not exacerbates ischimic events in ACS undergoing PCI. Omeprazaole even can decrease gastra-intestinal bleeding in those patients.

关键词： omeprazaole clopidogrel platelet activation thrombelastography mapping acute coronary syndrome

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Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1821-1832页

作者： Xu ren Yong-Ping Qu Chun-Lan Zhu Xiao-hong Xu hong Jiang yi-Xia Lu hong-Peng Xue Digestive Disease Hospital of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Digestive Endoscopy Center of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Second Department of Gastroenterology Digestive Disease Hospital of Heilongjiang Provincial Hospitaland Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Department of Pathology Heilongjiang Provincial HospitalHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous *** reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and *** have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since *** To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of *** Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were ***-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with *** primary outcome was its feasibility,indicated by technical *** secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and *** Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were ***-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,*** cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type *** five patients achieved technical success of *** patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN h

关键词： Intraductal papillary neoplasm of the bile duct Percutaneous transhepatic cholangioscopy Biliary polypectomy Feasibility Efficacy

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Normalized Solution for p-Kirchhoff Equation with a L2-supercritical Growth

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 414-429页

作者： Zhi-min ren Yong-yi LAN School of Sciences Jimei UniversityXiamen 361005China

In this paper,we investigate the following p-Kirchhoff equation{∫R^(N)|u|^(2)dx=ρ,(a+b)∫RN(|Δu}^(p)+|u|^(p))dx)(-Δpu+|u|^(p-2u)=|u|^(s-2)u+μu,x∈R^(N),where a>0,b≥0,p>0 are constants,constants,p*=N-P/Np is the ... 详细信息

关键词： p-Kirchhoff equation normalized solution mountain-pass lemma

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Quality assessment of friction-stir-welded aluminum alloy welds via three-dimensional force signals

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Advances in Manufacturing 2024年第1期12卷 61-75页

作者： Ji-hong Dong yi-Ming Huang Jia-Lei Zhu Wei Guan Xu-Kai ren Huan-Wei Yu Lei Cui Beijing Institute of Petrochemical Technology Beijing102617People’s Republic of China Beijing Academy of Safety Engineering and Technology Beijing102617People’s Republic of China AVIC Manufacturing Technology Institute Beijing100024People’s Republic of China Tianjin Key Laboratory of Advanced Joining Technology School of Materials Science and EngineeringTianjin UniversityTianjin300350People’s Republic of China Shaoxing Special Equipment Testing Institute Shaoxing Key Laboratory of Special Equipment Intelligent Testing and EvaluationShaoxing312071ZhejiangPeople’s Republic of China

An online detection technology must be developed for realizing the real-time control of friction stir *** this study,the three-dimensional force exerted on a material during friction stir welding was collected synchronously and the relationship between the forces and welding quality was *** results indicated that the fluctuation period of the traverse force was equal to that of the lateral force during the stable welding *** phase difference between two horizontal forces wasπ/*** values of the horizontal forces increased with welding speed,whereas their amplitudes remained the *** proposed force model showed that the traverse and lateral forces conformed to an elliptical curve,and this result was consistent with the behavior of the measured *** variational mode decomposition was used to process the plunge *** intrinsic mode function that represented the real fluctuation in the plunge force varied at the same frequency as the spindle rotational *** tunnel defects occurred,the fluctuation period features were consistent with those obtained during normal welding,whereas the ratio parameter defined in this study increased significantly.

关键词： Friction stir welding(FSW) Three-dimensional force model Variational mode decomposition Tunnel defect

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Evaluation of triple anti-platelet therapy by modified thrombelastography in patients with acute coronary syndrome

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Chinese Medical Journal 2008年第9期121卷 850-852页

作者： ren yi-hong YANG Ting-shu WANG Yu GAI Lu-yue LIU hong-bin CHEN Lian WANG hong-ye WANG Chun-ya XU Xiu-li JIN Jing XIN You-hong LI Rong-bin LI Hai-yan LIN Lin LIU Chun-xue Department of Cardiology General Hospital of the Chinese People's Liberation Army Beijing 100083 China

Most cases of acute coronary syndrome （ACS） involve coronary atherosclerosis and plaque rupture, as well as subsequent thrombosis. The initial thrombotic events leading to red thrombus formation are platelet adherence and aggregation. Platelets play a very important role during the establishment and progression of a thrombosis in a coronary artery. Therefore, in recent years guidelines have been developed in an effort to strengthen antiplatelet therapy in ACS, but unfortunately the methods to evaluate platelet activity and the strength of platelet inhibition are lacking.

关键词： platelet modified thrombelastography acute coronary syndrome

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Thrombosis and morphology of plaque rupture using optical coherence tomography

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Chinese Medical Journal 2013年第6期126卷 1092-1095页

作者： GUO Jun CHEN Yun-dai TIAN Feng LIU hong-bin CHEN Lian SUN Zhi-jun ren yi-hong JIN Qin-hua LIU Chang-fu HAN Bao-shi GAI Lu-yue YANG Ting-shu Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Thrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT） to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups （with or without thrombus） and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded. Results The fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus （（57.00＋17.00） Bm vs. （96.00＋48.00） Bm; P=0.0076）. Conclusions Plaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque.

关键词： optical coherence tomography thrombosis plaque rupture

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Optical coherence tomography assessment of edge dissections after drug-eluting stent implantation in coronary artery

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Chinese Medical Journal 2012年第6期125卷 1047-1050页

Background Edge dissections after coronary stent implantation are associated with increased short-term risk of major adverse cardiovascular events. The incidence and outcome of edge dissections after coronary stent implantation were reportedly different using different imaging techniques. We used optical coherence tomography （OCT） to assess the incidence, morphological findings and related factors of edge dissections after drug-eluting stent （DES） implantation. Methods Totally 42 patients with 43 de novo lesions in 43 native arteries undergoing DES implantation with OCT imaging were enrolled in this study. Results Nine edge dissections were detected in 43 arteries after DES implantation. There were four morphological patterns of stent edge dissections indentified in this study：（1） superficial intimal tears （n=3）, （2） subintimal dissections （n=4）, （3） split of media （n=1）, （4） disruption of the fibrotic cap of plaque （n=1）. Stent edge expansion and stent expansion were both higher in the group with dissections than those in the group without dissections （1.682±0.425 vs. 1.229±0.285, P=0.0290; 1.507±0.445 vs. 1.174±0.265, P=0.0072）. Conclusions The incidence of stent edge dissections detected by OCT was 21%. Stent edge dissection is related with stent edge expansion and stent expansion.

关键词： optical coherence tomography stent dissections

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Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies

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Regenerative Biomaterials 2024年第2期3卷 1-16页

作者： Xiaoqian hong Geer Tian Yang Zhu Tanchen ren Department of Cardiology of the Second Affliated Hospital and State Key Laboratory of Transvascular Implantation Devices Cardiovascular Key Laboratory of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310o09China Binjiang Institute of Zhejiang University Hangzhou 310053China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Metal ions participate in many metabolic processes in the human body,and their homeostasis is crucial for *** cardiovascular diseases(CVDs),the equilibriums of metal ions are frequently interrupted,which are related to a variety of disturbances of physiological processes leading to abnormal cardiac *** supplement of metal ions has the potential to work as therapeutic strategies for the treatment of *** with other therapeutic drugs,metal ions possess broad availability,good stability and safety and diverse drug delivery *** delivery strategies of metal ions are important to exert their ther-apeutic effects and reduce the potential toxic side effects for cardiovascular applications,which are also receiving increasing *** local delivery strategies for metal ions based on various biomaterials are constantly being *** this review,we comprehensively summarized the positive roles of metal ions in the treatment of cVDs from three aspects:protecting cells from oxidative stress,inducing angiogenesis,and adjusting the functions of ion *** addition,we introduced the transferability of metal ions in vascular reconstruction and cardiac tissue repair,as well as the currently available engineered strategies for the precise delivery of metal ions,such as integrated with nanoparticles,hydrogels and scaffolds.

关键词： metal ions cardiovascular disease tissue engineering oxidative stress angiogenesis ion channel

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