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Myelopathy as a Presentation of Cervical Spine Metastasis: A Case Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 64-71页

作者： Ramin Shayan-Moghadam Mosayeb Soleymani Hassan Zolghadr Mohammad Hossein Nabian Saeed reza Mehrpour Department of Orthopedic and Trauma Surgery Shariati Hospital Tehran University of Medical Sciences Tehran Iran Center for Orthopedic Trans-Deciplinary Applied Research Tehran University of Medical Sciences Tehran Iran

Cervical myelopathy is a consequence of spinal cord compression in the cervical spine. Degenerative cervical spondylosis, osteophytes, discosteophyte complex, degenerative spondylolisthesis and hypertrophy of ligamentum flavum are the main etiologies of cervical myelopathy. Metastasis to cervical spine could be a rare cause of cervical myelopathy. The present study is a case report;presented a 36-year-old male with severe pain in cervical region, gait disability and impairment in sensory and motor function of upper left extremity. The patient had a history of thyroidectomy and cervical lymph node dissection due to follicular thyroid carcinoma (FTC) with improper follow-ups. He was diagnosed with metastatic cervical myelopathy and underwent surgical treatment. Cervical myelopathy due to metastasis is a rare condition and only few cases have been reported so far. So myelopathies can be a complication of metastatic cancers, and it should be considered by health professionals.

关键词： Myelopathy Metastasis Thyroid Cancer

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白内障手术候选者的眼部生物特征参数分析

国际眼科杂志 2024年第8期24卷 1186-1193页

作者： Zahra Sarlak Masoud Khorrami-Nejad Hamed Ghasemi Ali Nouraeinejad reza Yousefi 伊朗德黑兰医科大学Farabi眼科医院转化眼科研究中心 *** 伊朗德黑兰医科大学康复学院视光系 ***

目的:分析白内障手术候选人的眼部生物特征参数。方法:横断面研究。纳入2017-01/2021-09就诊于伊朗德黑兰Farabi眼科医院的4607例白内障患者(4607眼)。使用IOLMaster 700评估眼轴(AL)、角膜曲率(Kf、Ks、Km)、前房深度(ACD)。根据AL分为... 详细信息

目的:分析白内障手术候选人的眼部生物特征参数。方法:横断面研究。纳入2017-01/2021-09就诊于伊朗德黑兰Farabi眼科医院的4607例白内障患者(4607眼)。使用IOLMaster 700评估眼轴(AL)、角膜曲率(Kf、Ks、Km)、前房深度(ACD)。根据AL分为22 mm25 mm组,根据ACD分为3.00 mm3.60 mm组。结果:患者平均年龄60.3±14.1(8-95)岁,女2243例(48.69%),男2364例(51.31%)。AL、ACD和平均角膜曲率范围分别为23.1-23.4 mm、3.1-3.2 mm和44.50-45.00 D。AL>25 mm组ACD平均值显著高于22 mm≤AL≤25 mm组和22 mm3.60 mm组的平均AL显著高于3.00 mm25 mm组的Kf、Ks、Km均值显著高于ACD>3.60 mm组和22 mm

关键词：白内障眼轴前房深度角膜曲率

Extreme exposure of fluoride and arsenic contamination in shallow coastal aquifers of the Ganges delta,transboundary of the Indo-Bangladesh region

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Geoscience Frontiers 2024年第1期15卷 286-303页

作者： Dipankar Ruidas Subodh Chandra Pal Tanmoy Biswas Asish Saha Abu reza Md.Towfiqul Islam Department of Geography The University of BurdwanPurba BardhamanWest Bengal 713104India Department of Disaster Management Begum Rokeya UniversityRangpur 5400Bangladesh Department of Development Studies Daffodil International UniversityDhaka 1216Bangladesh

Globally,shallow aquifer groundwater(GW)has been severely affected in recent decades for both geogenic and anthropogenic *** hydro-geochemical characteristics of the GW change inconsistently with the addition of unwanted inorganic trace elements into the GW aquifer of the Indo-Bangladesh delta region(IBDR),such as arsenic(As)along with fluoride(F-)*** GW can have a negative impact on drinking water supplies and agricultural *** pollution can have serious adverse effects on the environment and human ***,the GW quality of this region is deteriorating progressively,and human health threatening by various life-threatening ***,the current study concentrated on the GW quality evaluation and prediction of possible health issues in the IBDR due to elevated contamination of As along with F-within GW aquifers by considering sixteen *** survey-based statistical methods such as entropy quality index(EWQI)combined with health risk index(HRI)was implemented for evaluating the As and F-sensitivity with the help of correlation testing and principal component *** study's outcome explains that a substantial portion of the IBDR has been vastly experiencing inferior GW quality,environmental issues,and health-related problems in dry and wet seasons,correspondingly for As and *** diagram verified the suitability of water that almost 55%of GW across the study area’s aquifers are unfit for drinking as well as cultivation of *** analysis and the Monte Carlo simulation method were also applied to assess the contaminant's concentration level and probable health risk *** present study concludes that the elevated exposure of As and F-pollution has to be monitored regularly and prevent unwanted GW contamination through implementing sustainable approaches and policies to fulfil the sustainable development goal 6(SDG-6)till 2030,ensuring the most basic human right of clean,safe,and hy

关键词： Indo-Bangladesh delta Entropy quality index Health risk index Monte Carlo simulation SDG-6

Clinical implications of single cell sequencing for bladder cancer

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Oncology Research 2024年第4期32卷 597-605页

作者： reza YADOLLAHVANDMIANDOAB MEHRSA JALALIZADEH FRANCIELE APARECIDA VECHIA DIONATO KEINI BUOSI PATRÍCIA A.F.LEME LUCIANA S.B.DAL COL CRISTIANE F.GIACOMELLI ALEX DIAS ASSIS NASIM BASHIRICHELKASARI LEONARDO OLIVEIRA REIS UroScience School of Medical SciencesUniversity of CampinasUNICAMPCampinasSao Paulo13083-872Brazil ImmunOncology Pontifical Catholic University of CampinasPUC-CampinasCampinasSao Paulo13087-571Brazil

Bladder cancer(BC)is the 10th most common cancer worldwide,with about 0.5 million reported new cases and about 0.2 million deaths per *** this scoping review,we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA *** searched PubMed,CENTRAL,Embase,and supplemented with manual searches through the Scopus,and Web of Science for published studies until February *** included original studies that used at least one single-cell technology to study bladder ***-one publications were included in the ***-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition *** studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine *** remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell ***-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer *** nascent tool can advance the early diagnosis,prognosis judgment,and targeted therapy of bladder cancer.

关键词： Bladder cancer Urothelial carcinoma Transitional cell carcinoma Single-cell sequencing Tumor heterogeneity Immunotherapy Scoping review Tumor microenvironment

MyoRing植入术治疗圆锥角膜的疗效观察

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国际眼科杂志 2024年第4期24卷 500-507页

作者： Masoud Khorrami-Nejad Rawshan Jumaah Farshid Karimi Khosrow Jadidi Mobina Farahani reza Yousefi 伊朗德黑兰医科大学康复学院 *** 伊朗马什哈德医科大学眼视光系 *** 伊朗德黑兰Bina眼科医院研究中心眼科 *** 伊朗哈马丹Hamedan医科大学 ***

目的:比较MyoRing植入前后圆锥角膜(KCN)患者角膜前后表面散光和全屈光散光。方法:历史队列研究。比较植入360度全环植入物(MyoRing)的KCN患者的术前和术后全屈光、角膜前后表面散光,术后3、6、9、12 mo连续随访四次。结果:共纳入KCN患... 详细信息

目的:比较MyoRing植入前后圆锥角膜(KCN)患者角膜前后表面散光和全屈光散光。方法:历史队列研究。比较植入360度全环植入物(MyoRing)的KCN患者的术前和术后全屈光、角膜前后表面散光,术后3、6、9、12 mo连续随访四次。结果:共纳入KCN患者79例85眼,其中男43例,女36例,平均年龄29±7.41(17-48)岁。随访期间,全屈光散光、角膜前后表面散光呈减少趋势。MyoRing植入后12 mo,总屈光散光测量值显著下降2.09 D (4.27±3.15 vs2.18±1.63 D,P<0.001)。此外,术后测量显示,角膜前表面和后表面散光分别改善约3.20 D和0.59 D[6.40±1.90 vs 3.20±1.75 D(P<0.001)和1.30±0.55 vs 0.71±0.35(P<0.001)]结论:MyoRing植入可显著改善散光参数,包括全屈光散光以及角膜前后表面散光。

关键词：圆锥角膜角膜基质环植入术 MyoRing 角膜地形图总散光角膜散光

Evaluating for unrecognized deficits in perimetry associated with functional upper eyelid malposition

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Advances in Ophthalmology Practice and Research 2024年第1期4卷 39-44页

作者： Linyan Wang Davin C.Ashraf Michael Deiner Oluwatobi O.Idowu Seanna R.Grob Bryan J.Winn M reza Vagefi Robert C.Kersten Department of Ophthalmology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Ophthalmology University of CaliforniaSan FranciscoUSA Department of Ophthalmology Oregon Health and Science UniversityPortlandUSA Department of Ophthalmology Tufts Medical CenterBostonUSA Department of Ophthalmology University of UtahSalt Lake CityUtahUSA

Objective:To investigate whether functional upper eyelid malposition is associated with unrecognized deficits in automated perimetry among glaucoma patients by examining patients undergoing eyelid surgery who had not been identified as requiring eyelid taping during glaucoma field ***:In this retrospective pre-post study,an automated database search followed by manual chart review was used to identify eligible patients from January 2012 to March *** patients had reliable visual field testing within two years before and after functional upper blepharoplasty or ptosis repair and no comorbid ocular *** part of routine practice,glaucoma visual field technicians taped patients with pupil-obstructing eyelid malposition;taped examinations were excluded from *** and demographic characteristics,mean deviation,and pattern standard deviation were evaluated within a two year period before and after eyelid ***:The final analysis included 60 eyes of 38 *** in visual field parameters after eyelid surgery did not reach statistical significance in crude or adjusted *** patients with ptosis,the margin reflex distance-1 was not associated with change in mean deviation after surgery(Pearson R2=0.0061;P=0.700).Five of 17 eyes excluded from analysis due to unreliable pre-operative visual fields demonstrated substantial improvement after ***:Functional upper eyelid malposition does not appear to cause spurious visual field abnormalities among glaucoma patients with reliable visual fields who were determined not to require eyelid taping at the time of their visual *** visual fields could be a sign of eyelid interference in this population.

关键词： Visual field Ptosis Dermatochalasis Glaucoma Perimetry Visually significant

添加不同量促腐熟菌剂对木屑和黄浆水堆肥的影响

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甘肃农业大学学报 2024年第2期59卷 117-126页

作者：杨娜马亚兰顾欣 Eftekhari Ali reza 李思琦李雪雪宁夏大学农学院宁夏银川750021

【目的】以木屑和黄浆水为原料,探讨促腐熟菌剂不同添加量对堆肥进程的影响。【方法】采用好氧发酵罐堆肥试验,设置不加促腐熟菌剂(T_(0))、加促腐熟菌剂质量分数0.1%(T_(1))、0.3%(T_(2))、0.9%(T_(3))共4个处理,以堆肥温度、pH值、种... 详细信息

【目的】以木屑和黄浆水为原料,探讨促腐熟菌剂不同添加量对堆肥进程的影响。【方法】采用好氧发酵罐堆肥试验,设置不加促腐熟菌剂(T_(0))、加促腐熟菌剂质量分数0.1%(T_(1))、0.3%(T_(2))、0.9%(T_(3))共4个处理,以堆肥温度、pH值、种子发芽指数、养分质量分数作为评价指标。采用主成分分析,研究促腐熟菌剂添加量对物料发酵进程和腐熟度的影响,明确最佳添加量。【结果】与T_(0)比较,添加促腐熟菌剂处理提前2 d进入高温期。发酵结束后,各处理的堆肥p H值介于7.46~7.74。添加不同质量分数的促腐熟菌剂可以不同程度地降低堆肥物料的碳、氮损失。与T_(0)相比,T_(1)、T_(2)、T_(3)氮损失分别降低9.41%、14.12%和4.71%,碳损失分别降低3.06%、7.97%和5.89%,其中T_(2)的氮、碳损失最低,分别为75.26%和7.82%。添加促腐熟菌剂的堆肥腐熟度比T_(0)提高3.64%~9.09%,T_(2)最先达到腐熟。【结论】综上所述,在木屑和黄浆水堆肥中添加质量分数0.3%的促腐熟菌剂,能显著促进物料腐熟,有利于降低氮、碳损失,提高堆肥质量,为木屑和黄浆水的肥料化利用提供了依据。

关键词：木屑促腐熟菌剂黄浆水堆肥发酵

ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea Fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

Pharmacokinetics and Bioequivalence of Dienogest in Healthy Bangladeshi Female Volunteers: An Open-Label, Single-Dose, Randomized, Two-Way Crossover Study

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 779-789页

作者： Nusrat Mahmud Nafisa Ahamed Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana Arifa Akram Md. Alimur reza BIRDEM General Hospital Dhaka Bangladesh Medical College for Women & Hospital Dhaka Bangladesh Novus Clinical Research Services Ltd. Dhaka Bangladesh National Institute of Laboratory Medicine & Referral Centre (NILMRC) Dhaka Bangladesh

Background: Dienogest is a potential treatment for pelvic pain associated with endometriosis, a condition of significant concern in gynaecology. The current study was conducted as a crossover-randomized bioequivalence assessment of two oral Dienogest 2 mg formulations, aiming to provide valuable insights for healthcare professionals and researchers in this field. Objective: The primary aim of this research was to evaluate and compare the pharmacokinetic characteristics of Dienogest 2 mg tablets. Dinogest (Dienogest 2 mg) tablets, manufactured by Nuvista Pharma Limited in Bangladesh, and Visanne (Dienogest 2 mg) tablets, manufactured by Bayer Pharma in Germany, were the test and reference formulations, respectively. Materials and Method: The study was an open-label, balanced, randomized, two treatments, two sequences, two periods, two-way crossover, laboratory blind, single oral dose bioequivalence study conducted in healthy adult females under fasting conditions. The study was carried out on 13 healthy, non-pregnant female subjects, and all the subjects completed both study periods with a 15-day washout in between. Randomization was used to assign the test and reference formulations to the subjects. Following each oral administration, a series of blood samples were obtained at different time intervals from pre-dose to 72 hours post-dose and analyzed for Dienogest concentrations using a validated bio-analytical method. A standard non-compartmental model was used to analyze the pharmacokinetic parameters. The primary pharmacokinetic parameters were peak plasma drug concentration (Cmax), the area under the plasma concentration-time curve from time zero to time t (AUC0–t), and AUC from t = 0 to infinity (AUC0–∞). The other PK parameters included time to reach Cmax (Tmax), terminal elimination rate constant (Kel), and half-life (t1/2). Result: The ratios and 90% CI for the geometric mean test/re

关键词： Dienogest Bioequivalence Study Endometriosis Novus CRSL