检索结果-南通市图书馆

Enhancing diaphragmatic defect repair and regeneration:How biomaterials leading the way to progress?

BMEMat(BioMedical Engineering Materials) 2024年第3期2卷 92-107页

作者： Mojtaba Farahani Przemysław Gnatowski Raziyeh Najafloo Tina Navaei Edyta Piłat Justyna Kucińska-Lipka Mohammad reza Saeb Masoud Mozafari Institute of Biomedical Engineering Department of Pharmacology and PhysiologyFaculty of MedicineUniversity of MontrealMontrealCanada Research Center Centre Hospitalier Universitaire Sainte-JustineMontrealCanada Department of Polymer Technology Faculty of ChemistryGdańsk University of TechnologyGdańskPoland Faculty of Sustainable Design Engineering University of Prince Edward IslandCharlottetownCanada Department of Pharmaceutical Chemistry Medical University of GdańskGdańskPoland Research Unit of Medical Imaging Physics and TechnologyFaculty of MedicineUniversity of OuluOuluFinland

Physicians encounter significant challenges in dealing with large diaphragmatic defects in both pediatric and adult *** hernias,such as Morgagni,Bochdalek,and Hiatus hernias,can result in congenital lesions that are often undiagnosed until the appearance of symptoms(bleeding,anemia,and acid reflux).Therefore,substantial potential exists for developing tissue-engineered constructs as novel therapeutic options in *** research indicates promising mid-term performance for both natural and synthetic ***,studies exploring their application in diaphragm regeneration are limited and remain in the early research ***,further investigation is required to address the constraints in human tissue supply for clinical *** article comprehensively reviews the role of biomaterials in diaphragmatic tissue repair and *** emphasizes biomaterials,including biomimetic polymers used in technological *** summary will enable researchers to critically assess the capability of existing natural biomaterials as essential tissueengineered patches for clinical use.

关键词： biomaterials diaphragm diaphragmatic defects hernia scaffolds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Serendipity in Recommender Systems:A Systematic Literature Review

引用

Journal of Computer Science & Technology 2021年第2期36卷 375-396页

作者： reza Jafari Ziarani reza Ravanmehr Department of Computer Engineering Central Tehran BranchIslamic Azad UniversityTehran ***Iran

A recommender system is employed to accurately recommend items,which are expected to attract the user's *** over-emphasis on the accuracy of the recommendations can cause information over-specialization and make recommendations boring and even *** and diversity are two partly useful solutions to these ***,novel and diverse recommendations cannot merely ensure that users are attracted since such recommendations may not be relevant to the user's ***,it is necessary to consider other criteria,such as unexpectedness and *** is a criterion for making appealing and useful *** usefulness of serendipitous recommendations is the main superiority of this criterion over novelty and *** bulk of studies of recommender systems have focused on serendipity in recent ***,a systematic literature review is conducted in this paper on previous studies of serendipity-oriented recommender ***,this paper focuses on the contextual convergence of serendipity definitions,datasets,serendipitous recommendation methods,and their evaluation ***,the trends and existing potentials of the serendipity-oriented recommender systems are discussed for future *** results of the systematic literature review present that the quality and the quantity of articles in the serendipity-oriented recommender systems are progressing.

关键词： systematic literature review recommender system serendipity evaluation metric evaluation method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacokinetic Comparison and Bioequivalence Evaluation of Two 20-mg Vonoprazan Fumarate Tablets in Bangladeshi Healthy Male Subjects

引用

Journal of Biosciences and Medicines 2024年第8期12卷 230-243页

作者： Md. Alimur reza Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana Md. Ashraful Islam Nafisa Ahamed Arifa Akram Novus Clinical Research Services Ltd. Dhaka Bangladesh Medical College for Women & Hospital Dhaka Bangladesh National Institute of Laboratory Medicine & Referral Centre (NILMRC) Dhaka Bangladesh

Background: Vonoprazan fumarate, a novel potassium-competitive acid blocker, outperforms traditional proton pump inhibitors in acid suppression and can be effectively combined with antibiotics to eradicate Helicobacter pylori. Objective: The study aimed to determine if two Vonoprazan formulations—Vonoprazan Fumarate 20 mg Tablet of Beximco Pharmaceuticals Limited, Bangladesh (test product) and Takecab 20 mg Tablet of Takeda Pharmaceutical Company Limited, Japan (reference product)—met FDA’s bioequivalence requirements by comparing their pharmacokinetic characteristics in healthy Bangladeshi adults. Methods: This was a single-center, randomized, open-label, two-period, two-sequence, laboratory-blind, double-crossover experiment. After 10 hours of fasting, 18 subjects were randomly assigned to receive a single oral dose of either formulation. During each treatment period, blood samples were collected at specific times (pre-dose and up to 48 hours post-dose) to measure plasma Vonoprazan levels using liquid chromatography-tandem mass spectrometry. A non-compartmental model was used to calculate pharmacokinetic parameters using the plasma drug concentration-time profile. A statistical comparison of the pharmacokinetic parameters of the two formulations of the test and reference product was conducted using SAS® statistical software to assess the bioequivalence. Primary pharmacokinetic parameters (Cmax, AUC0-t, and AUC0-∞) and secondary parameters (Tmax, T1/2, Kel, and AUC extrapolation) were calculated for both drug formulations. If the confidence intervals for the natural log-transformed Cmax, AUC0-t, and AUC0-∞ values fell between 80% and 125%, the drug products would be considered bioequivalent. Result: The geometric mean ratio of Vonoprazan between the test and reference groups was found to be 109.04% (99.47% - 119.53%), 101.37% (95.58% - 107.50%), and 101.24% (95.43% - 107.41%), with 90% confidence intervals (CIs) for the Cmax, AUC0–t, and AUC0–∞, and these outcomes

关键词： Bioequivalence Vonoprazan Pharmacokinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cooperative Neuro Adaptive Control of Leader Following Uncertain Multi-Agent Systems with Unknown Hysteresis and Dead-Zone

引用

Journal of Systems Science & Complexity 2020年第2期33卷 312-332页

作者： SHAHNAZI reza Department of Electrical Engineering Faculty of EngineeringUniversity of GuilanRasht ***Iran

In this paper,a cooperative adaptive control of leader-following uncertain nonlinear multiagent systems is *** communication network is weighted undirected graph with fixed *** uncertain nonlinear model for each agent is a higher-order integrator with unknown nonlinear functions,unknown disturbances and unknown input ***,the gains of input actuators are unknown nonlinear functions with unknown *** most common behaviors of input actuators in practical applications are hysteresis and *** this paper,backlash-like hysteresis and dead-zone are used to model the input *** universal approximation theorem proved for neural networks,the unknown nonlinear functions are *** unknown weights of neural networks are derived by proposing appropriate adaptive *** cope with modeling errors and disturbances an adaptive robust structure is *** Lyapunov synthesis approach not only all the adaptive laws are derived but also it is proved that the closed-loop network is cooperatively semi-globally uniformly ultimately bounded(CSUUB).In order to investigate the effectiveness of the proposed method,it is applied to agents modeled with highly nonlinear mathematical equations and inverted *** results demonstrate the effectiveness and applicability of the proposed method in dealing with both numerical and practical multi-agent systems.

关键词： Adaptive neural network backlash-like hysteresis dead-zone leader-following multi-agent systems weighted undirected graph

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of molecular imaging in prognosis,diagnosis,and treatment of gastrointestinal cancers:An update on new therapeutic methods

引用

World Journal of Methodology 2024年第4期14卷 43-60页

作者： Mobina Fathi Hayder Jasim Taher Sabah Jassim Al-Rubiae Shirin Yaghoobpoor Ashkan Bahrami reza Eshraghi Hossein Sadri Mahsa Asadi Anar Ali Gholamrezanezhad Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Radiology Hilla University CollegeBabylon 00964Iraq Faculty of Medicine Kashan University of Medical SciencesKashan ***Iran Department of Radiology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033United States

One of the leading causes of cancer-related death is gastrointestinal cancer,which has a significant morbidity and mortality *** preoperative risk assessment is essential for directing patient care,its biological behavior cannot be accurately predicted by conventional imaging *** pathophysiological information in anatomical imaging that cannot be visually identified can now be converted into high-dimensional quantitative image features thanks to the developing discipline of molecular *** order to enable molecular tissue profile in vivo,molecular imaging has most recently been utilized to phenotype the expression of single receptors and targets of biological *** is expected that molecular imaging will become increasingly important in the near future,driven by the expanding range of biological therapies for *** this live molecular fingerprinting,molecular imaging can be utilized to drive expression-tailored customized *** technical aspects of molecular imaging are first briefly discussed in this review,followed by an examination of the most recent research on the diagnosis,prognosis,and potential future clinical methods of molecular imaging for GI tract malignancies.

关键词： Molecular imaging Personalized medicine Gastrointestinal cancers Positron emission tomography-computed tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nullors, and Nullor Circuits; There Applications in Symbolic Circuit Analysis and Design

引用

Applied Mathematics（应用数学） 2024年第1期

作者： reza Hashemian

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

引用

World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： Amir Human Hoveidaei reza Niakan Seyed Hossein Hosseini-Asl Abijith Annasamudram Janet D Conway International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all *** membership characteristics,however,are poorly *** study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United *** To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching *** This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical *** reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled *** and ethnicity were evaluated visually utilizing retrieved *** Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were *** members per state and capita determined geographic *** Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice *** The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)*** with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(P=0.002).Most orthopedic surgeons(88.12%,)practiced in academic *** those professionals who occupied leadership positions,14%were women,while 86%were ***,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic *** per capita rate across the United States was 0.30 LLRS orthopedic

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

引用

Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui Md.Muzahid Ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Exponential B-spline collocation method for numerical solution of the generalized regularized long wave equation

引用

Chinese Physics B 2015年第5期24卷 177-190页

作者： reza Mohammadi Department of Mathematics University of Neyshabur

The aim of the present paper is to present a numerical algorithm for the time-dependent generalized regularized long wave equation with boundary conditions. We semi-discretize the continuous problem by means of the Crank-Nicolson finite difference method in the temporal direction and exponential B-spline collocation method in the spatial direction. The method is shown to be unconditionally stable. It is shown that the method is convergent with an order of θ（k2 ＋ h2）. Our scheme leads to a tri-diagonal nonlinear system. This new method has lower computational cost in comparison to the Sinc-collocation method. Finally, numerical examples demonstrate the stability and accuracy of this method.

关键词： solitary waves GRLW equation exponential B-spline collocation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced empirical models for predicting the drift capacity of less ductile RC columns with flexural,shear,or axial failure modes

引用

Frontiers of Structural and Civil Engineering 2019年第5期13卷 1251-1270页

作者： Mohammad reza AZADI KAKAVAND reza ALLAHVIRDIZADEH Unit of Strength of Materials and Structural Analysis Institute of Basic Sciences in Engineering SciencesUniversity of InnsbruckInnsbruck 6020Austria ISISE Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal

Capacity of components subjected to earthquake actions is still a widely interesting research topic. Hence, developing precise tools for predicting drift capacities of reinforced concrete (RC) columns is of great interest. RC columns are not only frequently constructed, but also their composite behavior makes the capacity prediction a task faced with many uncertainties. In the current article, novel empirical approaches are presented for predicting flexural, shear and axial failure modes in RC columns. To this aim, an extensive experimental database was created by collecting outcomes of previously conducted experimental tests since 1964, which are available in the literature. It serves as the basis for deriving the equations for predicting the drift capacity of RC columns by different regression analyses (both linear with different orders and nonlinear). Furthermore, fragility curves are determined for comparing the obtained results with the experimental results and with previously proposed models, like the ones of ASCE/SEI41-13. It is demonstrated that the proposed equations predict drift capacities, which are in better agreement with experimental results than those computed by previously published models. In addition, the reliability of the proposed equations is higher from a probabilistic point of view.

关键词： flexural-shear-axial failure drift capacity reinforced concrete columns statistical analysis fragility curves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：