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Molecular Cloning and Characterization of cDNA Encoding Fibrinolytic Enzyme-3 from Earthworm Eisenia foetida

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Acta Biochimica et Biophysica Sinica 2004年第4期36卷 303-308页

作者： guo-Qing DONG, Xiao-Ling YUAN, Ya-jun SHAN, Zhen-Hu ZHAO, Jia-Pei CHEN, and Yu-Wen CONG* Department of Experimental Therapy of ARS, Beijing Institute of Radiation Medicine, Beijing 100850, China Department of Experimental Therapy of ARS Beijing Institute of Radiation MedicineBeijing 100850 China

The earthworm fibrinolytic enzyme-3 (EFE-3, GenBank accession No: AY438622), from the earthworm Eisenia foetida, is a component of earthworm fibrinolytic enzymes. In this study, cDNA encoding the EFE-3 was cloned by RT-PCR. The cDNA contained an open reading frame of 741 nucleotides, which encoded a deduced protein of 247 amino acid residues, including signal sequences. EFE-3 showed a high degree of homology to earthworm (Lumbricus rebullus) proteases F-III-1, F-III-2, and bovine trypsin. The recombinant EFE-3 was expressed in E. coli as inclusion bodies, and the gene encoding the native form of EFE-3 was expressed in COS-7 cells in the medium. Both the refolding product of inclusion bodies and the secreted protease could dissolve the artificial fibrin plate.

关键词： earthworm Eisenia foetida earthworm fibrinolytic enzyme cloning expression refolding

The predictive value of histological tumor regression grading (TRG) for therapeutic evaluation in locally advanced esophageal carcinoma treated with neoadjuvant chemotherapy

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Chinese Journal of Cancer 2012年第8期31卷 399-400,F0003页

作者： Kang guo Ling Cai Yu Zhang Jian-Fei Zhu Tie-Hua Rong Peng Lin Chong-Li Hao Wu-Ping Wang Zhe Li Lan-jun Zhang State Key Laboratory of Oncology in South China GuangzhouGuangdong 510060P.R.China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Medical Oncology Tengzhou Municipal HospitalTengzhouShandong 277500P.R.China Department of Thoracic Surgery Tangdu HospitalFourth Military Medical UniversityXi'anShaanxi 710000P.R.China Department of Thoracic Surgery The First Affiliated Hospital of Yanan UniversityYananShaanxi 716000P.R.China

Response criteria remain controversial in therapeutic evaluation for locally advanced esophageal carcinoma treated with neoadjuvant *** aimed to identify the predictive value of tumor regression grading(TRG) in tumor response and ***-two patients who underwent neoadjuvant chemotherapy followed by esophagectomy and radical 2-field lymphadenectomy between june 2007 and june 2011 were included in this *** tissue specimens were reassessed according to the TRG *** prognostic factors,including clinicopathologic factors,were *** curves were generated by using the Kaplan-Meier method and compared with the log-rank *** factors were determined with multivariate analysis by using the Cox regression *** results showed that of 52 cases,43(83%) were squamous cell carcinoma and 9(17%) were *** was correlated with pathologic T(P = 0.006) and N(P < 0.001) *** overall survival for the entire cohort was 33 *** 1-and 2-year overall survival rates were 71% and 44%,*** survival analysis results showed that favorable prognostic factors were histological subtype(P = 0.003),pathologic T category(P = 0.026),pathologic N category(P < 0.001),and TRG G0(P = 0.041).Multivariate analyses identified pathologic N category(P < 0.001) as a significant independent prognostic *** results indicate that histomorphologic TRG can be considered as an alternative option to predict the therapeutic efficacy and prognostic factor for patients with locally advanced esophageal carcinoma treated by neoadjuvant chemotherapy.

关键词：疗效评价食管癌预测值组织学化疗晚期治疗肿瘤

郭军教授论“肾精亏虚,精室血瘀”辨治男性不育症

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中国男科学杂志 2024年第4期38卷 107-111页

作者：王浩郭军张江伟黄辰黄建峰骆第铖孙向平中国中医科学院西苑医院男科北京100091 宁夏回族自治区中医医院暨中医研究院宁夏郭军岐黄学者传承工作室宁夏银川750021

男性不育症属中医“无子”“艰嗣”等范畴。本病病因病机趋于复杂化,与肾、精室等脏腑密切相关,多表现为肾虚精亏,精室失用。本文将“肾虚精亏,精室血瘀”作为男性不育症发生的核心病机,认为其本虚在肾,血瘀在精室。在此基础上,拟定了... 详细信息

男性不育症属中医“无子”“艰嗣”等范畴。本病病因病机趋于复杂化,与肾、精室等脏腑密切相关,多表现为肾虚精亏,精室失用。本文将“肾虚精亏,精室血瘀”作为男性不育症发生的核心病机,认为其本虚在肾,血瘀在精室。在此基础上,拟定了“补肾、活血”的治疗原则,从补肾填精、补肾益气、补肾滋阴、补肾助阳立法,兼顾畅达精室血脉,改善本病诸症。此外,在应用补肾活血法时,也可参考“脑-心-肾-精室”轴的辨治思路,促进周身气机的协调有序。

关键词：肾精亏虚精室血瘀不育男性

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异质语言观与方言音系研究

江海学刊 2009年第6期 200-204页

作者：郭骏南京晓庄学院人文学院

语言是一种异质的动态系统,而不是同质的静态系统。汉语方言音系研究应在异质语言观的指导下,引进社会语言学的研究理念和研究方法,抽样确定被调查人,有足够样本数,采用词表调查,理清方言音系与语音差异的关系,选择中年群体作为描写对象... 详细信息

语言是一种异质的动态系统,而不是同质的静态系统。汉语方言音系研究应在异质语言观的指导下,引进社会语言学的研究理念和研究方法,抽样确定被调查人,有足够样本数,采用词表调查,理清方言音系与语音差异的关系,选择中年群体作为描写对象,采用变异分析方法描写语音系统、分析其变异状况及演变规律。

关键词：同质有序异质有序语言观方言音系

Temperature-induced resistance transition behaviors of melamine sponge composites wrapped with different graphene oxide derivatives

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Journal of Materials Science & Technology 2021年第26期85卷 194-204页

作者： Cheng-Fei Cao Wen-jun Liu Hui Xu Ke-Xin Yu Li-Xiu Gong Bi-Fan guo Yu-Tong Li Xiao-Lan Feng Ling-Yu Lv Hong-Tao Pan Li Zhao Jia-Yun Li Jie-Feng Gao guo-Dong Zhang Long-Cheng Tang Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Temperature-re s ponsive resistance transition behaviors of the melamine sponges wrapped with different graphene oxide derivatives(***,wide-ribbon and sheet)were *** sponge composites coated by three types of GO derivatives were prepared by a simple dip-coating *** these composites show good mechanical flexibility and reliability(almost unchanged compressive stress at 70%strain after 100 cycles),high hydrophobicity(water contact angle>120°),excellent flame resistance(self-extinguishing)and structural stability even after burning,which was used to construct the resistance-based fire alarm/warning ***,the different resistance response behaviors of such sensors are strongly dependent on the GO size and network formed on the MF skeleton ***,at a fixed high temperature of~350℃,the three fire alarm sensors show different response time(to trigger the alarm light)of 6.3,8.4 and 11.1 s for nanoribbon,wide-ribbon and sheet at the same concentration,*** structural observation and chemical analysis demonstrated that the discrepancy of temperature-responsive resistance transition behaviors of various GO derivatives was strongly determined by their different thermal reduction degrees during the high-tempe rature or flame treating *** work offers a design and development for construction of smart fire alarm device for potential fire prevention and safety applications.

关键词： Graphene oxide derivatives Fire warning response Structure and morphology Thermal reduction Temperature-responsive resistance transition

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国内图书馆与MOOC相关问题研究综述

国家图书馆学刊 2018年第6期27卷 88-100页

作者：郭军铁道警察学院图书馆

采用文献计量法和主题分析法,从MOOC理念引入与图书馆MOOC实践经验介绍、MOOC环境下图书馆及图书馆员的角色定位、MOOC环境下的图书馆服务创新、MOOC环境下的信息素养教育、MOOC环境下的版权服务、MOOC平台技术支持与优化等6个方面,对... 详细信息

采用文献计量法和主题分析法,从MOOC理念引入与图书馆MOOC实践经验介绍、MOOC环境下图书馆及图书馆员的角色定位、MOOC环境下的图书馆服务创新、MOOC环境下的信息素养教育、MOOC环境下的版权服务、MOOC平台技术支持与优化等6个方面,对国内图书馆与MOOC相关问题的研究内容进行梳理。在对当前研究特点及存在的主要问题进行剖析的基础上,指出下一阶段该领域的研究应注重MOOC环境下的图书馆学基础理论研究,加强图书馆参与MOOC本土化的实证研究,立足馆藏资源和实体空间助力MOOC的推广与普及,协调推进高校图书馆和公共图书馆与MOOC相融合。

关键词：图书馆 MOOC 服务创新研究综述

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语言变项中不同变式的确认

南京社会科学 2008年第10期 133-141页

作者：郭骏南京晓庄学院人文学院副教授博士南京211171

本文针对社会语言学界关于语言变项中不同变式类型的确认问题研究之不足,以江苏溧水"街上话"语音变异为例,就新旧式的确认、过渡式的存在与确认问题进行实证性研究。提出构成语言变项的不同变式除旧式、新式外还存在着"过渡式"这一变式... 详细信息

本文针对社会语言学界关于语言变项中不同变式类型的确认问题研究之不足,以江苏溧水"街上话"语音变异为例,就新旧式的确认、过渡式的存在与确认问题进行实证性研究。提出构成语言变项的不同变式除旧式、新式外还存在着"过渡式"这一变式类型,并从整体音节和音节构成两个层面对"旧式、过渡式、新式"三种不同变式类型加以具体确认,充分证明在语言变异过程中在语言结构的不同层面中都存在着这三种不同变式类型。此研究无论对社会语言学研究还是对汉语方言学研究都有着积极的意义。

关键词：语言变异语言变项语言变式旧式过渡式新式

A virtual 3D interactive painting method for Chinese calligraphy and painting based on real-time force feedback technology

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Frontiers of Information Technology & Electronic Engineering 2017年第11期18卷 1843-1853页

作者： Chao guo Zeng-xuan HOU You-zhi SHI jun XU Dan-dan YU School of Mechanical Engineering Dalian University of Technology Dalian 116024 China

A novel 3D interactive painting method for Chinese calligraphy and painting based on force feedback technology is proposed. The relationship between the force exerted on the brush and the resulting brush deformation is analyzed and a spring-mass model is used to build a model of the 3D Chinese brush. The 2D brush footprint between the brush and the plane of the paper or object is calculated according to the deformation of the 3D brush when force is exerted on the 3D brush. Then the 3D brush footprint is obtained by projecting the 2D brush footprint onto the surface of the 3D object in real time, and a complete 3D brushstroke is obtained by superimposing 3D brush footprints along the painting direction. The proposed method has been suc- cessfully applied in a virtual 3D interactive drawing system based on force feedback technology. In this system, users can paint 3D brushstrokes in real time with a Phantom Desktop haptic device, which can effectively serve as a virtual reality interface to the simulated painting environment for users.

关键词： 3D brush model 3D brushstroke 3D interactive painting Real-time force feedback technology

Lattice Boltzmann modeling and simulation of compressible flows

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Frontiers in Biology 2012年第5期7卷 582-600页

作者： Ai-guo Xu Guang-Cai Zhang Yan-Biao Gan Feng Chen Xi-jun Yu National Key Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsP.O.Box 8009-26Beijing 100088China North China Institute of Aerospace Engineering Langfang 065000China School of Science Linyi UniversityLinyi 276005China

In this mini-review we summarize the progress of Lattice Boltzmann （LB） modeling and simulating compressible flows in our group in recent years. Main contents include （i） Single-Relaxation-Time （SRT） LB model supplemented by additional viscosity, （ii） Multiple-Relaxation-Time （MRT） LB model, and （iii） LB study on hydrodynamic instabilities. The former two belong to improvements of physical modeling and the third belongs to simulation or application. The SRT-LB model sup- plemented by additional viscosity keeps the original framework of Lattice Bhatnagar-Gross Krook （LBGK）. So, it is easier and more convenient for previous SRT-LB users. The MRT-LB is a com- pletely new framework for physical modeling. It significantly extends the range of LB applications. The cost is longer computational time. The developed SRT-LB and MRT-LB are complementary from the sides of convenience and applicability.

关键词： lattice Boltzmann modeling compressible flows shock waves hydrodynamic instability