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Peripheral BDNF Regulates Somatosensory–Sympathetic Coupling in Brachial Plexus Avulsion-Induced Neuropathic Pain

Neuroscience Bulletin 2023年第12期39卷 1789-1806页

作者： Hang Xian Huan guo Yuan-Ying Liu Jian-Lei Zhang Wen-Chao Hu Ming-jun Yu Rui Zhao Rou-Gang Xie Hang Zhang Rui Cong Department of Orthopedics Xijing HospitalThe Air Force Medical UniversityXi’an710032China Pain and Related Diseases Research Laboratory Medical College of Shantou UniversityShantou515041China School of Life Science and Research Center for Resource Peptide Drugs Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological ResourcesYanan UniversityYanan716000China Department of Neurobiology School of Basic MedicineThe Air Force Medical UniversityXi’an710032China The Sixth Regiment School of Basic MedicineThe Air Force Medical UniversityXi’an710032China The Tenth Squadron of the Third Regiment School of Basic MedicineThe Air Force Medical UniversityXi’an710032China

Brachial plexus avulsion(BPA)is a combined injury involving the central and peripheral nervous *** with BPA often experience severe neuropathic pain(NP)in the affected *** is insensitive to the existing treatments,which makes it a challenge to researchers and *** evidence shows that a BPA-induced pain state is often accompanied by sympathetic nervous dysfunction,which suggests that the excitation state of the sympathetic nervous system is correlated with the existence of ***,the mechanism of how somatosensory neural crosstalk with the sympathetic nerve at the peripheral level remains *** this study,through using a novel BPA C7 root avulsion mouse model,we found that the expression of BDNF and its receptor TrκB in the DRGs of the BPA mice increased,and the markers of sympathetic nervous system activity includingα1 andα2 adrenergic receptors(α1-AR andα2-AR)also increased after *** phenomenon of superexcitation of the sympathetic nervous system,including hypothermia and edema of the affected extremity,was also observed in BPA mice by using CatWalk gait analysis,an infrared thermometer,and an edema *** knockdown of BDNF in DRGs not only reversed the mechanical allodynia but also alleviated the hypothermia and edema of the affected extremity in BPA ***,intraperitoneal injection of adrenergic receptor inhibitors decreased neuronal excitability in patch clamp recording and reversed the mechanical allodynia of BPA *** another branch experiment,we also found the elevated expression of BDNF,TrκB,TH,α1-AR,andα2-AR in DRG tissues from BPA patients compared with normal human DRGs through western blot and *** results revealed that peripheral BDNF is a key molecule in the regulation of somatosensory-sympathetic coupling in BPA-induced *** study also opens a novel analgesic target(BDNF)in the treatment of this pain with fewer complications,which has great potential for clinica

关键词： Brachial plexus avulsion Neuropathic pain Sympathetic nervous system Brain-derived neurotrophic factor Peripheral sensitization Mechanical allodynia

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Wideband switchable dual-functional terahertz polarization converter based on vanadium dioxide-assisted metasurface

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Chinese Physics B 2022年第1期31卷 324-331页

作者： De-Xian Yan Qin-Yin Feng Zi-Wei Yuan Miao Meng Xiang-jun Li guo-Hua Qiu Ji-Ning Li Key Laboratory of Electromagnetic Wave Information Technology and Metrology of Zhejiang Province College of Information EngineeringChina Jiliang UniversityHangzhou 310018China Center for THz Research China Jiliang UniversityHangzhou 310018China College of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300072China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China

The terahertz technology has attracted considerable attention because of its potential applications in various ***,the research of functional devices,including polarization converters,remains a major demand for practical *** this work,a reflective dual-functional terahertz metadevice is presented,which combines two different polarization conversions through using a switchable *** functions can be achieved because of the insulator-to-metal transition of vanadium dioxide(VO_(2)).At room temperature,the metadevice can be regarded as a linear-to-linear polarization convertor containing a gold circular split-ring resonator(CSRR),first polyimide(PI)spacer,continuous VO_(2) film,second PI spacer,and gold *** converter possesses a polarization conversion ratio higher than 0.9 and a bandwidth ratio of 81%in a range from 0.912 THz to 2.146 *** the temperature is above the insulator-to-metal transition temperature(approximately 68℃)and VO_(2) becomes a metal,the metasurface transforms into a wideband linear-to-circular polarization converter composed of the gold CSRR,first PI layer,and continuous VO_(2) *** ellipticity is close to-1,while the axis ratio is lower than 3 dB in a range of 1.07 THz-1.67 *** metadevice also achieves a large angle tolerance and large manufacturing tolerance.

关键词： metasurface polarization conversion vanadium dioxide dual-functional

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Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 329-339页

作者： Pan guo Nan Li Lili Fan jun Lu Boying Liu Bing Zhang Yumei Wu Zhidong Liu Jiawei Li Jiaxin Pi Dongli Qi Tianjin State Key Laboratory of Modern Chinese Medicine The Institute of Traditional Chinese MedicineTianjinUniversity of Traditional Chinese MedicineNo.88Yuquan RoadTianjin300193China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Tianjin University ofTraditional Chinese MedicineNo.88Yuquan RoadTianjin300193China School of Pharmaceutical Science and Technology Tianjin UniversityTianjin300193China

Labrasol, as a non-ionic surfactant, can enhance the permeation and absorption of drugs, and is extensively used in topical, transdermal, and oral pharmaceutical preparations as an emulsifier and absorption enhancer. Recent studies in our laboratory have indicated that labrasol has a strong absorption enhancing effect on different types of drugs in vitro and in vivo. This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Western blot, and immunohistochemical staining. The results indicated that labrasol obviously enhance the transcorneal permeability of fluorescein sodium, and the enhancement was realized by interacting with and down-regulating the associated proteins, such as Factin, claudin-1 and β-catenin, which were contributed to cell-cell connections, respectively.

关键词： Enhanced corneal permeation Tight junctions associated proteins Labrasol Ussing chamber Western blot Immunohistochemistry

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RLV末端能量管理段轨迹在线规划与制导

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宇航学报 2015年第2期36卷 151-157页

作者：周敏周军郭建国西北工业大学精确制导与控制研究所西安710072

针对可重复使用飞行器(RLV)末端能量管理段利用数值优化算法在线规划轨迹的实时性无法保证,工程应用性差的问题,在末端能量管理段的航向调整段(HAC)轨迹前增加直线预测捕获段(PASL),并在该阶段提前完成末端区域能量管理(TAEM)段轨迹的... 详细信息

针对可重复使用飞行器(RLV)末端能量管理段利用数值优化算法在线规划轨迹的实时性无法保证,工程应用性差的问题,在末端能量管理段的航向调整段(HAC)轨迹前增加直线预测捕获段(PASL),并在该阶段提前完成末端区域能量管理(TAEM)段轨迹的在线规划,从而降低工程中对轨迹在线规划方法实时性的高要求。首先,通过求解零气动角下的质点运动方程解析解,得到直线预测捕获段结束点的飞行状态预测值作为TAEM段轨迹的初始点状态。然后,在线求解以航向调整段进入点飞行器航向角偏差最小为目标函数,以动压、过载和速度滚转角限制为约束的非线性规划问题,得到航向调整螺旋线中心的最优位置。最后,设计了以规划轨迹确定的标称气动角指令为前馈,以跟踪偏差的比例+微分律生成指令(PD)为反馈的TAEM段制导律。算例仿真校验了本文基于弹道预测的末端能量管理方法的有效性。

关键词：可重复使用飞行器末端能量管理弹道预测轨迹在线规划实时性

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Balloon dilatation for treatment of hepatic venous outflow obstruction following pediatric liver transplantation

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World Journal of Gastroenterology 2017年第46期23卷 8227-8234页

作者： Zhi-Yuan Zhang Long Jin Guang Chen Tian-Hao Su Zhi-jun Zhu Li-Ying Sun Zhen-Chang Wang guo-Wen Xiao Department of Interventional Radiology Beijing Friendship HospitalCapital Medical University Department of Transplantation Surgery Beijing Friendship HospitalCapital Medical University Department of Radiology Beijing Friendship HospitalCapital Medical University

AIM To assess the efficacy and safety of balloon dilatation for the treatment of hepatic venous outflow obstruction(HVOO) following pediatric liver *** A total of 246 pediatric patients underwent liver transplantation at our hospital between june 2013 and September 2016. Among these patients, five were ultimately diagnosed with HVOO. Seven procedures(two patients underwent two balloon dilatation procedures) were included in this analysis. The demographic data,types of donor and liver transplant, interventional examination and therapeutic outcomes of these five children were analyzed. The median interval time between pediatric liver transplantation and balloon dilatation procedures was 9.8 mo(range: 1-32).RESULTS Five children with HVOO were successfully treated by balloon angioplasty without stent placement, with seven procedures performed for six stenotic lesions. All children underwent successful percutaneous intervention. Among these five patients, four were treated by single balloon angioplasty, and these patients did not develop recurrent stenosis. In seven episodes of balloon angioplasty across the stenosis, the pressure gradient was 12.0 ± 8.8 mm Hg before balloon dilatation and 1.1 ± 1.5 mm Hg after the procedures, which revealed a statistically significant reduction(P < 0.05). The overall technical success rate among these seven procedures was 100%(7/7), and clinical success was achieved in all five patients(100%). The patients were followed for 4-33 mo(median: 15 mo). No significant procedural complications or procedurerelated deaths *** Balloon dilatation is an effective and safe therapeutic option for HVOO in children undergoing pediatric liver transplantation. Venous angioplasty is also recommended in cases with recurrent HVOO.

关键词： Hepatic venous outflow obstruction Pediatric liver transplantation Percutaneous transluminal balloon dilatation Pressure gradient Recurrent

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A High-Performance and Flexible Chemical Structure&Data Search Engine Built on CouchDB&ElasticSearch

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Chinese Journal of Chemical Physics 2018年第3期31卷 341-349,368页

作者： Ren-zhi Li Bo-jie Li guo-zhen Zhang jun Jiang Yi Luo Hefei National Laboratory for Physical Sciences at the Microscale School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefei 230026China

Computer-assisted chemical structure searching plays a critical role for efficient structure screening in cheminformatics. We designed a high-performance chemical structure & data search engine called DCAIKU, built on CouchDB and ElasticSearch engines. DCAIKU converts the chemical structure similarity search problem into a general text search problem to utilize off-the-shelf full-text search engines. DCAIKU also supports flexible document structures and heterogeneous datasets with the help of schema-less document database. Our evaluations show that DCAIKU can handle both keyword search and structural search against millions of records with both high accuracy and low latency. We expect that DCAIKU will lay the foundation towards large-scale and cost-effective structural search in materials science and chemistry research.

关键词： Search engine Cheminformatics Structural search Schema-less databases

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Effect of Phosphorus Fertilization to P Uptake and Dry Matter Accumulation in Soybean with Different P Efficiencies

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Journal of Integrative Agriculture 2014年第2期13卷 326-334页

作者： AO Xue guo Xiao-hong ZHU Qian ZHANG Hui-jun WANG Hai-ying MA Zhao-hui HAN Xiao-ri ZHAO Ming-hui XIE Fu-ti College of Agronomy Shenyang Agricultural University College of Land and Environment Shenyang Agricultural University

Phosphorus （P） is an essential element for plant growth and yield. Improving phosphorus use efficiency of crops could potentially reduce the application of chemical fertilizer and alleviate environmental damage. Soybean （Glycine max （L.） Merr.） is sensitive to phosphorus （P） in the whole life history. Soybean cultivars with different P efficiencies were used to study P uptake and dry matter accumulation under different P levels. Under low P conditions, the P contents of leaf in high P efficiency cultivars were greater than those in low P efficiency cultivars at the branching stage. The P accumulation in stems of high P efficiency cultivars and in leaves of low P efficiency cultivars increased with increasing P concentration at the branching stage. At the late podding stage, the P accumulation of seeds in high and low P efficiency cultivars were 22.5 and 26.0%, respectively; and at the mature stage were 69.8 and 74.2%, respectively. In average, the P accumulation in whole plants and each organ was improved by 24.4% in high P efficiency cultivars compared to low P efficiency cultivars. The biomass between high and low P efficiency cultivars were the same under extended P condition, while a significant difference was observed at late pod filling stage. At the pod setting stage, the biomass of high P efficiency cultivars were significant greater （17.4%） than those of low P efficiency cultivars under high P condition. Meanwhile, under optimum growth conditions, there was little difference ofbiomass between the two types of cultivars, however, the P agronomic efficiency and P harvest index were significant higher in high P efficiency cultivars than those in low P efficiency cultivars.

关键词： Glycine max (L.) Merr. soybean phosphorus use efficiency

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Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma

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Bioactive Materials 2021年第12期6卷 4707-4716页

作者： Yuxun Ding Xiaohui Xiao Lingli Zeng Qiuping Shang Wei Jiang Sha Xiong Xiaohui Duan jun Shen Ruibing Wang Jinshan guo Yue Pan Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineDepartment of RadiologyMedical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou510120China Longgang E.N.T.Hospital&Shenzhen Key Laboratory of E.N.T. Institute of E.N.T.ShenzhenGuangdong518116China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Department of Histology and Embryology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China

Despite extensive use of radiotherapy in nasopharyngeal carcinoma(NPC)treatment because of its high radiosensitivity,there have been huge challenges in further improving therapeutic effect,meanwhile obviously reducing radiation *** this end,synergistic chemoradiotherapy has emerged as a potential strategy for highly effective NPC ***,we developed RGD-targeted platinum-based nanoparticles(RGD-PtNPs,denoted as RPNs)to achieve targeted chemoradiotherapy for *** nanoparticles consist of an RGD-conjugated shell and a cis-platinum(CDDP)crosslinking *** advantage of RGD,the RPNs may effectively accumulate in tumor,penetrate into tumor tissues and be taken by cancer cells,giving rise to a high delivery efficiency of *** they are fully enriched in tumor sites,the CDDP loaded RPNs can act as radiotherapy sensitizer and chemotherapy *** means of X-ray-promoted tumor cell uptake of nanoparticle and CDDP-induced cell cycle arrest in radiation-sensitive G2/M phases,RPNs may offer remarkable therapeutic outcome in the synergistic chemoradiotherapy for NPC.

关键词： Nasopharyngeal carcinoma(NPC) Chemoradiotherapy Polymeric nanoparticles Precise treatment

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Serum lipid profiles： novel biomarkers predicting advanced prostate cancer in patients receiving radical prostatectomy

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Asian Journal of Andrology 2015年第2期17卷 239-244,I0008页

作者： Gui-Ming Zhang Xiao-Jian Qin Hai-Liang Zhang Wen-jun Xiao Yao Zhu Cheng-Yuan Gu Bo Dai guo-Hai Shi Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Shanghai Medical College Fudan University Shanghai China.

This study aimed to evaluate the role of serum lipid profiles as novel biomarkers in predicting pathological characteristics of prostate cancer （PCa）. We retrospectively analyzed 322 consecutive patients with clinically localized PCa receiving radical prostatectomy （RP） and extended pelvic lymphadenectomy. Unconditional logistic regression was used to estimate the prostatectomy Gleason score （pGS）, pathological stage and lymph node involvement （LNI） in RP specimens. Preoperative prostate-specific antigen （PSA） levels, biopsy GS （bGS）, and preoperative tumor, node, metastasis staging were used as basic variables to predict postoperative pathological characteristics. Preoperative serum lipid profiles were introduced as potential predictors. A receiver operating characteristic （ROC） curve was used to determine predictive efficacy. Significant differences in pathological characteristics were observed among patients with normal and abnormal total cholesterol （TC）, triglyceride （TG）, and low-density lipoprotein （LDL） levels, with the exception of pGS in the TG group. Multivariable regression analysis revealed that the odds ratio for high levels of TC for LNI compared with normal TC levels was 6.386 （95% confidence interval [Cl] 1.510-27.010）, 3.270 （95% CI. 1.470-7.278） for high levels of TG for pT3-4 disease, and 2.670 （95% Ch 1.134-6.287） for high levels of LDL for pGS. The area under the ROC curve of the models with dyslipidemia was larger than that in models without dyslipidemia, in predicting pathological characteristics. Abnormal TC, TG, and LDL levels are significantly associated with postoperative pathological status in PCa patients. Together with preoperative PSA levels, bGS, and clinical stage, dyslipidemia is more accurate in predicting pathological characteristics.

关键词： biological markers dyslipidemias lipids pathology prostatic neoplasms

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Ultrasensitive biosensors based on long-range surface plasmon polariton and dielectric waveguide modes

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Photonics Research 2016年第6期4卷 262-266页

作者： Leiming Wu jun guo Hailin Xu Xiaoyu Dai Yuanjiang Xiang SZU-NUS Collaborative Innovation Center for Optoelectronic Science & Technology Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University College of Physics and Energy Shenzhen University

An ultrasensitive biosensor based on hybrid structure and composed of long-range surface plasmon polariton(LRSPP) and dielectric planar waveguide(PWG) modes is proposed. Both PWG and LRSPP modes have strong resonances to form strong coupling between the two modes, and the two modes can couple to enhance sensitivity of sensors. In the hybrid structure, PWG is composed of cytop–Si–cytop multilayers and the LRSPP configuration is composed of cytop–metal–sensing medium multilayer slabs. The highest imaging sensitivities of 2264 and3619 RIU-1were realized in the proposed sensors based on Au and Al-monolayer graphene, respectively, which are nearly 1.2 and 1.9 times larger than the 1910 RIU-1sensitivity of the conventional LRSPR sensor(LRSPP sensor). Moreover, it is demonstrated that the PWG-coupled LRSPP biosensor is applicable to the sensing medium,with refractive index in the vicinity of 1.34.

关键词： RIU Ultrasensitive biosensors based on long-range surface plasmon polariton and dielectric waveguide modes

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