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发芽糙米特征营养、食味品质提升及功能性评价研究进展

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食品科学 2025年第1期46卷 284-292页

作者：任传英洪滨张珊袁迪冯俊然山珊张竞一管立军李波黄文功卢淑雯黑龙江省农业科学院食品加工研究所黑龙江省食品加工重点实验室黑龙江省全谷物营养食品工程技术研究中心黑龙江哈尔滨150086 黑龙江省农业科学院农产品质量安全研究所黑龙江哈尔滨150086

发芽糙米作为一种全谷物,保留了完整的皮层和胚,集中了大部分营养素和功能性活性物质,但由于皮层纤维结构致密,蒸饭过程中阻碍了吸水速率、吸水量和淀粉糊化,与大米相比,其蒸煮性和食用品质较差,且难以同煮同熟,因此一直以来未被广大消... 详细信息

发芽糙米作为一种全谷物,保留了完整的皮层和胚,集中了大部分营养素和功能性活性物质,但由于皮层纤维结构致密,蒸饭过程中阻碍了吸水速率、吸水量和淀粉糊化,与大米相比,其蒸煮性和食用品质较差,且难以同煮同熟,因此一直以来未被广大消费者接受。本文综述糙米发芽的生理代谢反应及发芽过程中营养成分、活性成分和食味品质的变化,总结发芽糙米胁迫富集γ-氨基丁酸(γ-aminobutyric acid,GABA)技术和发芽糙米的功能特性研究现状。糙米发芽过程中,多种生物活性物质在酶促反应下富集,尤其是特征成分GABA含量显著提升。多种逆境胁迫均可通过改变Ca^(2+)、H^(+)或底物水平促进GABA富集,一些预处理技术可进一步提升发芽糙米的食味品质。GABA与其他营养成分和活性成分发挥协同作用,赋予发芽糙米抗高血脂、抗高血糖、保护心脏、改善睡眠、抗炎和抗氧化等一系列功效与作用。

关键词：发芽糙米特征营养食味品质功能性

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Improving the energy release characteristics of PTFE/Al by doping magnesium hydride

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Defence Technology（防务技术） 2022年第2期18卷 219-228页

作者： Jia-xiang Wu Qiang Liu bin feng Qin yin Yu-chun Li Shuang-zhang Wu Zhong-shen Yu Jun-yi huang xin-xin ren College of Field Engineering Army Engineering University of PLANanjing210007China China huayin Ordnance Test Center Huayin714200China 31104 Troop of PLA Nanjing210001China

Magnesium hydride(MgH2)was doped into PTFE/Al to improve the energy release characteristics of the material system and strive for better application in military *** types of PTFE/Al/MgH2 reactive materials with different MgH2 content were prepared by molding sintering *** dynamic mechanical properties of the materials were studied by performing split-Hopkinson pressure bar(SHPB)tests and scanning electron microscope *** thermal behavior,reaction energy,reaction process and reaction mechanism were systematically investigated by conducting thermogravimetry-differential scanning calorimetry tests,oxygen bomb calorimeter measurements,Xray diffraction and SHPB *** results show that MgH2 particles less than 10%content contribute to heightening the dynamic mechanical properties of PTFE/Al *** product Mg generated by decomposition of MgH2 can not only react with gas phase C2F4þbut also undergo a Grignard-type reaction with condensed *** reaction energy and ignition threshold of PTFE/Al/MgH2 reactive materials enhance monotonously as MgH2 content *** the increase of MgH2 content from 0%to 20%,the reaction time is prolonged as well as the reaction intensity is enhanced dramatically arising from the massive water vapour produced by the reaction between O2 and *** gaseous products generated can form a high pressure shortly after the reaction,which helps to elevate the damage effect of the PTFE/Al system.

关键词： PTFE/Al/MgH_(2) Mechanical properties Thermal behavior Reaction energy Ignition threshold

High-performance phosphate supported on HZSM-5 catalyst for dehydration of glycerol to acrolein

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1031-1040页

作者： feng zhang xin ren He huang Jun huang Medak Sudhakar Licheng Liu Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences

The purpose of this study is to increase acrolein yield and capability of coking resistance in the reaction of glycerol dehydration to acrolein by assembling metal phosphate supported on HZSM-5 catalyst. The as-prepared catalysts were characterized by XRD, SEM, EDS, BET, NH_3-TPD, CO_2-TPD and Py-IR techniques. It was found that metal phosphate species were incorporated into the porous structure of HZSM-5 zeolites, thus influencing the surface and textural physico-chemical properties of the supporters. The alkaline-treated HZSM-5 catalyst promoted the dispersion of phosphate species on the carriers. Moreover, the amount of strong acidity was tremendously improved by adding the different metal hydrophosphates and the catalysts show high catalytic activity. In this present work, the Sn1/4 H_2PO_4/HZSM-5 catalyst exhibited good performance in the catalytic activity and coking resistant ability, which resulted in a high acrolein yield of 83% initially and acrolein yield of 68% after 30 h. The acidity, especially the ratio of strong to weak acid, plays an important role in promoting acrolein yield and stability simultaneously.

关键词： JHZSM-5 Metal hydrophosphate Glycerol dehydration Coking resistance

Germinated brown rice relieves hyperlipidemia by alleviating gut microbiota dysbiosis

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Journal of Integrative Agriculture 2023年第3期22卷 945-957页

作者： ren Chuan-ying zhang shan HONG bin GUAN Li-jun huang Wen-gong feng Jun-ran SHA Di-xin YUAN Di LI Bo JI Ni-na LIU Wei LU Shu-wen Food Processing Research Institute Heilongjiang Academy of Agricultural SciencesHarbin 150086P.R.China Heilongjiang Province Key Laboratory of Food Processing Harbin 150086P.R.China Safety and Quality Institute of Agricultural Products Heilongjiang Academy of Agricultural SciencesHarbin 150086P.R.China Soybean Research Institute Heilongjiang Academy of Agricultural SciencesHarbin 150086P.R.China The Second Affiliated Hospital Harbin Medical UniversityHarbin 150086P.R.China

Hyperlipidemia is a frequent metabolic disorder that is closely associated with diet. It is believed that brown rice, containing the outer bran layer and germ, is beneficial for the remission of hyperlipidemia. This study established a rat model of hyperlipidemia by feeding a high-fat diet. The hypolipidemic potential of germinated brown rice(Gbrown) and germinated black rice(a germinated black-pigmented brown rice, Gblack) were explored in the model rats, mainly in the aspects of blood lipids, lipases, apolipoproteins, and inflammation. The gut microbiota in hyperlipidemic rats receiving diverse dietary interventions was determined by 16S rDNA sequencing. The results showed that the intervention of Gbrown/Gblack alleviated the hyperlipidemia in rats, evidenced by decreased TC, TG, LDL-C, and apolipoprotein B, and increased HDL-C, HL, LPL, LCAT, and apolipoprotein A1. Gbrown/Gblack also weakened the inflammation in hyperlipidemia rats, evidenced by decreased TNF-α, IL-6, and ET-1. In addition, 16S rDNA sequencing revealed that the diet of Gbrown/Gblack elevated the abundance and diversity of gut microbiota in hyperlipidemia rats. At the phylum level, Gbrown/Gblack decreased Firmicutes, increased Bacteroidetes, and decreased the F/B ratio in hyperlipidemia rats. At the genus level, Gbrown/Gblack decreased Streptococcus and increased Ruminococcus and Allobaculum in hyperlipidemia rats. Some differential microbial genera relating to lipid metabolism were also determined, such as the Lachnospira and Ruminococcus in the Gblack group, and the Phascolarctobacterium, Dorea, Turicibacter, and Escherichia-Shigella in the Gbrown group. Notably, the beneficial effect of Gblack was stronger than Gbrown. To sum up, the dietary interventions of Gbrown/Gblack contributed to the remission of hyperlipidemia by alleviating the dysbiosis of gut microbiota.

关键词： hyperlipidemia germination brown rice black rice gut microbiota

Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection:A single-center retrospective observational study in China

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 358-364页

作者： Yue ying Rui-Dong Li Jing-Wen Ai yi-Min Zhu Xian Zhou yi-yi Qian xin-Chang Chen Xu-Yang Wang Hao-Cheng zhang Yang Li shan-shan Weng yi-Qi Yu yi-feng Tao Yu-Xian huang Zheng-xin Wang Wen-Hong zhang Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Background:Infections still represent the main factors influencing morbidity and mortality following liver *** study aimed to evaluate the incidence and risk factors for infection and survival after liver ***:We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our *** manifestations and results of pathogen detection test were used to define *** analyzed the prevalence,risk factors and prognosis of patients with ***:The median follow-up was 214 days;the incidence of infection after liver transplantation was 46.7%(n=98)which included pneumonia(43.4%),biliary tract infection(21.9%),peritonitis(21.4%)and bloodstream infection(7.6%).Among the pathogens in pneumonia,the most frequently isolated was Acinetobacter baumanii(23.5%)and Klebsiella pneumoniae(21.2%).Model for end-stage liver disease(MELD)score(OR=1.083,95%CI:1.045–1.123;Pduration of drainage tube(OR=1.040,95%CI:1.007–1.074;P=0.017)were independent risk factors for posttransplant ***-cause mortality was 11.0%(n=23).The prognostic factors for postoperative infection in liver recipients were prior-transplant infection,especially pneumonia within 2 weeks before ***-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection(65.2%vs.90.0%;hazard ratio:4.480;Prenal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients.

关键词： Infection Liver transplantation Risk factors MELD score

基于灰色预测的模糊免疫PID控制器在板厚控制系统中的应用

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钢铁 2010年第11期45卷 62-67页

作者：任新意杜凤山黄华贵张尚斌燕山大学机械工程学院机械系河北秦皇岛066004 亚稳材料制备技术与科学国家重点实验室河北秦皇岛066004

针对冷连轧板厚控制系统中存在非线性、时变和时滞等缺点,提出了一种基于灰色预测的模糊免疫PID控制策略。该控制策略借鉴生物免疫系统中的调节作用和模糊推理逻辑可逼近非线性函数的特性,将模糊控制和免疫反馈机理与传统PID控制相结合... 详细信息

针对冷连轧板厚控制系统中存在非线性、时变和时滞等缺点,提出了一种基于灰色预测的模糊免疫PID控制策略。该控制策略借鉴生物免疫系统中的调节作用和模糊推理逻辑可逼近非线性函数的特性,将模糊控制和免疫反馈机理与传统PID控制相结合。同时将灰色预测在线应用,用其预测结果代替被控对象的测量值,与给定输入的偏差及偏差变化率作为模糊控制器的输入来调整PID控制器的参数。仿真及现场试验结果表明,该控制策略具有超调量小,调整时间短,抗干扰能力和鲁棒性强等优点,控制效果优于传统控制方法。

关键词：自适应控制灰色预测模糊免疫PID 时滞板厚控制系统

Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

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Biomedical and Environmental Sciences 2020年第1期33卷 37-47页

作者： XU Lu YU Shu Qing GAO Le huang yi WU shan shan YANG Jun SUN yi xin YANG Zhi Rong CHAI San Bao zhang Yuan JI Li Nong SUN feng ZHAN Si Yan Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Mathematics and Statistics University of Maryland Baltimore CountyBaltimore MD 21250MarylandUSA National Clinical Research Center of Digestive Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China The Primary Care Unit School of Clinical MedicineUniversity of CambridgeCambridge CB21TNUK Department of Endocrinology and Metabolism Peking University International HospitalBeijing 102206China Department of Clinical Epidemiology and Biostatistics McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing 100044China

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary *** Databases including Medline,Embase,the Cochrane Library,and ***(***)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried *** risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of *** analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also *** A total of 292 trials were included in this *** with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and *** with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),*** GLP-1 RAs were more effective than DPP-4 Is in lowering the three ***,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

关键词： Body mass index Body weight Diabetes mellitus Dipeptidyl-peptidase IV inhibitors Glucagon-like peptide-1 receptor agonists Network meta-analysis Waist circumference

Amelioration of ligamentum flavum hypertrophy using umbilical cord mesenchymal stromal cell-derived extracellular vesicles

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Bioactive Materials 2023年第1期19卷 139-154页

作者： Cheng Ma xin Qi yi-Fan Wei Zhi Li He-Long zhang He Li feng-Lei Yu Ya-Nan Pu Yong-Can huang Yong-xin ren Department of Orthopaedics The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu210029China Department of Pathogen Biology and Immunology Nanjing Medical UniversityNanjingJiangsu210029China Department of Orthopaedics Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu210024China Outpatient&Emergency Management Department The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036China

Ligamentum flavum(LF)hypertrophy(LFH)has been recognised as one of the key contributors to lumbar spinal ***,no effective methods are available to ameliorate this *** this study,human umbilical cord mesenchymal stromal cell-derived extracellular vesicles(hUCMSC-EVs)were introduced for the first time as promising vehicles for drug delivery to treat *** downregulation of miR-146a-5p and miR-221-3p expressions in human LF tissues negatively correlated with increased LF *** hUCMSC-EVs enriched with these two miRNAs significantly suppressed LFH in vivo and notably ameliorated the progression of transforming growth factorβ1(TGF-β1)-induced fibrosis in vitro after delivering these two miRNAs to mouse LF *** results further demonstrated that miR-146a-5p and miR-221-3p directly bonded to the 3′-UTR regions of SMAD4 mRNA,thereby inhibiting the TGF-β/SMAD4 signalling ***,this translational study determined the effectiveness of a hUCMSC-EVs-based approach for the treatment of LFH and revealed the critical target of miR-146a-5p and *** findings provide new insights into promising therapeutics using a hUCMSC-EVs-based delivery system for patients with lumbar spinal stenosis.

关键词： Ligamentum flavum hypertrophy Fibrosis Umbilical cord mesenchymal stromal cells Extracellular vesicle miR-146a-5p miR-221-3p

SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： Xiujuan du Yuhua Yan Juehua Yu Tailin Zhu Chu-Chung huang Lingli zhang xingyue shan ren Li Yuan Dai Hui LV Xiao-Yong zhang Jianfeng feng Wei-Guang Li Qiang Luo Fei Li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathways revealed that Sh2b1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed