检索结果-南通市图书馆

Inhibition of KLF7-Targeting Micro RNA 146b Promotes Sciatic Nerve Regeneration

Neuroscience Bulletin 2018年第3期34卷 419-437页

作者： Wen-Yuan Li Wei-Ting Zhang Yong-Xia Cheng yan-Cui Liu Feng-Guo Zhai Ping Sun Hui-Ting Li Ling-xiao Deng xiao-Feng Zhu Ying Wang Department of Anatomy Mudanjiang College of Medicine The Affiliated Hongqi Hospital Mudanjiang College of Medicine Department of Pathology Mudanjiang College of Medicine Department of Pharmacy Mudanjiang College of Medicine Spinal Cord and Brain Injury Research Group Stark Neuro-sciences Research Institute Indiana University School of Medicine

A previous study has indicated that Krüppel-like factor 7（KLF7）, a transcription factor that stimulates Schwann cell（SC） proliferation and axonal regeneration after peripheral nerve injury, is a promising therapeutic transcription factor in nerve injury. We aimed to identify whether inhibition of micro RNA-146 b（mi R-146 b）affected SC proliferation, migration, and myelinated axon regeneration following sciatic nerve injury by regulating its direct target KLF7. SCs were transfected with mi RNA lentivirus, mi RNA inhibitor lentivirus, or KLF7 si RNA lentivirus in vitro. The expression of mi R146 b and KLF7,as well as SC proliferation and migration, were subsequently evaluated. In vivo, an acellular nerve allograft（ANA） followed by injection of GFP control vector or a lentiviral vector encoding an mi R-146 b inhibitor was used to assess the repair potential in a model of sciatic nerve gap. mi R-146 b directly targeted KLF7 by binding to the 30-UTR, suppressing KLF7. Up-regulation of mi R-146 b and KLF7 knockdown significantly reduced the proliferation and migration of SCs, whereas silencing mi R-146 b resulted in increased proliferation and migration. KLF7 protein was localized in SCs in which mi R-146 b was expressed in ***, 4 weeks after the ANA, anti-mi R-146 b increased KLF7 and its target gene nerve growth factor cascade, promoting axonal outgrowth. Closer analysis revealed improved nerve conduction and sciatic function index score, and enhanced expression of neurofilaments, P0（anti-peripheral myelin）, and myelinated axon regeneration. Our findings provide new insight into the regulation of KLF7 by mi R-146 b during peripheral nerve regeneration and suggest a potential therapeutic strategy for peripheral nerve injury.

关键词： miR-146b KLF7 Schwann cells Sciatic nerve injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vapour-phase O-methylation of Catechol with Methanol on Ti-containing Phosphate Catalysts

引用

Chemical Research in Chinese Universities 2006年第4期22卷 533-536页

作者： ZHU xiao-mei LI Xue-mei LIU Gang ZOU Xiu-jing WANG yan-li JIA Ming-jun ZHANG Wen-xiang College of Chemistry Jilin University Changchun 130021 P. R. China Shanghai Huayi Acrylic Acid Co. Ltd. Shanghai 200137 P. R. China

Ti-containing phosphate（ Ti-P-O ） catalysts with different molar ratios of P to Ti （0--2. 0 ） were synthesized and characterized by XRD, N2-adsorption/desorption, IR and temperature-programmed desorption （TPD） methods. The catalytic properties of Ti-P-O samples in the vapor-phase O-methylation of catechol with methanol were also studied. The catechol conversion increases with the increase of the molar ratio of P to Ti in a range of 0-0. 33, while a further increase in the P content leads to a decrease of the catalytic activity. Meanwhile, the selectivities of the catalysts to the main product（guaiacol） increase gradually with the increase of the molar ratio of P to Ti. The presence of relatively strong Lewis acidic and/or basic sites in the P-free catalyst should be responsible for the formation of C-alkylation products. The weak acid-base characteristics of the catalysts are favourable for the mono-O-methylation of catechol. In comparison with the Lewis acidic sites, the Bronsted acidic sites on the catalysts are more active for the title reaction.

关键词： Phosphates Acid-base catalysis Guaiacol Catechol O-Methylation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonlinear Transmission Property of the Excited State Proton Transfer Molecule 7-Hydroxyquinoline

引用

Chinese Physics Letters 2000年第11期17卷 809-811页

作者： xiao Dong ZHANG Gui-Lan WANG Hai-yan TANG Guo-Qing CHEN Wen-Ju Institute of Modern Optics Nankai UniversityTianjin 300071 Key Laboratory of Opto-electronics Information Technical ScienceEducation Ministry of China

Nonlinear transmission property of 7-hydroxyquinoline with excited state proton transfer effect was investigated at 355 and 532nm using picosecond laser *** experiment result shows that the transmissivity of 7-hydroxyquinoline is nonlinear at 355nm but it is linear at *** nonlinear transmissivity of 7-hydroxyquinoline originates from the larger nonlinearity of anion and cation formed in excited state proton transfer ***,7-hydroxyquinoline might be used as ultrafast optical amplitude limit material.

关键词： material. process. Nonlinear

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High sampling-rate measurement of turbulence velocity fluctuations in Mach 1.8 Laval jet using interferometric Rayleigh scattering

引用

Chinese Physics B 2017年第2期26卷 341-344页

作者： Li Chen Fu-Rong yang Tie Su Wei-Yi Bao Bo yan Shuang Chen ren-Bing Li China Aerodynamics Research and Development Center Mianyang 621000 China

Interferometric Rayleigh scattering diagnostic technique for the time-resolved measurement of flow velocity is studied. Theoretically, this systematic velocity-measured accuracy can reach up to 1.23 m/s. Measurement accuracy is then evaluated by comparing with hot wire anemometry results. Moreover, the distributions of velocity and turbulence intensity in a supersonic free jet from a Laval nozzle with a Mach number of 1.8 are also obtained quantitatively. The sampling rate in this measurement is determined to be approximately 10 k Hz.

关键词： Fabry–Pérot interferometer Rayleigh scattering time-resolved velocity measurement turbulence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced wear resistance,antibacterial performance,and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro

引用

Bio-Design and Manufacturing 2024年第5期7卷 670-686页

作者： Qingge Wang Jia Liu Hong Wu Jingbo Liu Yaojia ren Luxin Liang Xinxin yan Ian Baker Shifeng Liu V.V.Uglov Chengliang yang Liqiang Wang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Affiliated Hospital of Youjiang Medical University for Nationalities Guangxi Key Laboratory for Preclinical and Translational Research on Bone and Joint Degenerative DiseasesGuangxi Zhuang Autonomous Region Engineering Research Center for Biomaterials in Bone and Joint Degenerative DiseasesGuangxi Key Laboratory for Biomedical Material ResearchBaise 533000China Department of Orthopedics The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Orthopedics Renmin HospitalWuhan UniversityWuhan 430060China Thayer School of Engineering Dartmouth CollegeHanoverNH 03755-8000USA School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Belarusian State University 220030 MinskBelarus State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection *** meet these requirements,the low-elastic-modulus alloy—Ti–35Nb–2Ta–3Zr—was used as the substrate,and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO_(2)nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-coating *** effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO_(3))and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the tribocorrosion,corrosion,and early in vitro osteogenic behaviors of the nanotubes were *** tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube ***-HA showed great wear resistance with a wear rate of(1.26±0.06)×10^(−3)mm^(3)/(N·m)due to adhesive and ***-CaSiO_(3)showed enhanced cell adhesion,proliferation,and alkaline phosphatase *** coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of≥89.5%against Escherichia *** findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.

关键词： βTi alloy Surface modification Wear resistance Corrosion resistance Osteogenic behavior Antibacterial activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

THE DGW-I FURNACE A MATERIALS PROCESSING FACILITY IN "SZ-2" SPACECRAFT

引用

空间科学学报 2002年第Z1期22卷 154-158页

作者： WANG Jinchang LIU yan AI Fei YU Qiang ren Juanxi TAN xiaochen CEI Weixing Shanghai Institute of Ceramics The Chinese Academy of SciencesShanghai 200050P.R.China Center for Space Science and Applied Research The Chinese Academy of SciencesP.R.China Lanzhou Institute of Physics The Chinese Academy of Space TechnologyP.R.China

The DGW-I is a new material processing facility developed in China,which was firstly carried into orbit in November 1999 by the SZ-1 spacecraft and then in January 2001 carried by SZ-2 into space again,and successfull... 详细信息

关键词： Microgravity Space material science Material processing facility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Complementation analyses of Sinorhizobium meliloti nifA mutant with different originated nifA genes

引用

Chinese Science Bulletin 2006年第22期51卷 2748-2754页

作者： YAO Zhenhua TIAN Zhexian DAI xiaomi BECKER Anke LI Jian yan Haiqin xiao yan ZHU Jiabi YU Guanqiao RUVERG Silvia WANG Yiping ZOU Huasong National Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China National Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University B eijing 100871 China Lehrstuhl für Genetik Universitat Bielefeld Postfach 100131D-33615 33501 Bielefeld Germany Graduate School of the Chinese Academy of Sciences Beijing 100039China

推断的一个以前的工作 Enterobacter 下水道的 nifA 基因没恢复 Sinorhizobium meliloti nifA 的共生显型变异。在现在的学习， Bra-dyrhizobium 的 twonifA 基因日本嗯并且 Mesorhizobium huakuii 也没恢复 S 的共生显型。meliloti ni... 详细信息

推断的一个以前的工作 Enterobacter 下水道的 nifA 基因没恢复 Sinorhizobium meliloti nifA 的共生显型变异。在现在的学习， Bra-dyrhizobium 的 twonifA 基因日本嗯并且 Mesorhizobium huakuii 也没恢复 S 的共生显型。meliloti nifA 异种。在微数组试验的整个 genomic， 238 基因被发现是在 S 以后表示的差别。meliloti nifA 组成地在它的 nifAmutant 被表示了。相反，当表示 *** 时，仅仅 20， 7 和 9 基因改变了他们的 transcriptional 层次， M。在 Sm nifA 异种的 huakuii 和 Enterobacter 下水道 nifA 基因独立。这些基因包括房子保留，精力和中央中间代谢被分类进几官能基，运输系统和共生。有趣地， nifHoperons，显示出的高表示面对任何一个 B 铺平的基因。japonium 或 M。huakuii NifA，它被随后的紫胶 Z 熔化实验证实。

关键词： NifA 基因表达微阵列生物化学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced thermoelectric performance of Cu_(2)SnSe_(3) via synergistic effects of Cd-doping and CuGaTe_(2) alloying

引用

Rare Metals 2022年第10期41卷 3466-3474页

作者： Yi-Jing Fan Kun-Ling Peng Yu-Ling Huang Hui-Jun Liao Zheng-Yong Huang Jian Li yan-Ci yan Hao-Shuang Gu Bin Zhang Yong-Ming Hu Xu Lu xiao-Yuan Zhou Faculty of Physics and Electronic Sciences Hubei Key Laboratory of Ferro and Piezoelectric Materials and DevicesHubei UniversityWuhan430062China College of Physics Chongqing UniversityChongqing400044China State Key Laboratory of Power Transmission Equipment and System Security and New Technology Chongqing UniversityChongqing400044China School of Science Chongqing University of Posts and TelecommunicationsChongqing400065China Analytical and Testing Center Chongqing UniversityChongqing400044China

In this work,we show significantly enhanced thermoelectric performance in Cu_(2) SnSe_(3) via a synergistic effect of Cd-doping and CuGaTe_(2) alloying in the temperature range of 300-823 *** the electron and phonon transport properties can be simultaneously regulated by Cd doping at Sn site,leading to a higher quality ***,a maximum figure of merit(zT) value of ~0.68 was obtained for Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3) sample at823 K,which is about four times higher than that of the pristine sample(zT=0.18 at 773 K).Furthermore,Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3) was alloyed with CuGaTe_(2) to reduce the lattice thermal conductivity in the high-temperature ***,a further enhanced zT value(0.77,823 K) was achieved in the(Cu_(2) Sn_(0.93)Cd_(0.07)Se_(3))_(0.94)(CuGaTe_(2))_(0.06) sample,with a high average zT(zT_(ave)) value of0.30 between 300 and 823 *** results demonstrate that Cd-doping combined with CuGaTe2 alloying could be an effective method to enhance zT values of Cu_(2) SnSe_(3) based compounds.

关键词： Cu_(2)SnSe_(3) Synergistic optimization Alloying Quality factor Thermoelectric

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of magnetic resonance imaging in liver metastases

引用

World Journal of Gastroenterology 2024年第1期30卷 112-114页

作者： Xing-Liang Huang xiao-Dong Wang Zhao-Miao Gong yan-Feng Zheng Jing-Xin Mao Department of Science and Education Dianjiang People's Hospital of ChongqingChongqing 408399China Department of Science and Industry Chongqing Medical and Pharmaceutical CollegeChongqing 400030China

This letter to the editor is a commentary on a study titled"Liver metastases:The role of magnetic resonance imaging."Exploring a noninvasive imaging evaluation system for the biological behavior of hepatocellular carcinoma(HCC)is the key to achieving precise diagnosis and treatment and improving *** review summarizes the role of magnetic resonance imaging in the detection and evaluation of liver metastases,describes its main imaging features,and focuses on the added value of the latest imaging tools(such as T1 weighted in phase imaging,T1 weighted out of phase imaging;diffusion-weighted imaging,T2 weighted imaging).In this study,I investigated the necessity and benefits of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid for HCC diagnostic testing and prognostic evaluation.

关键词： Liver metastases Magnetic resonance imaging Liver-specific contrast agents Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Hepatocellular carcinoma Hepatobiliary contrast agents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combining prognostic value of serum carbohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenocarcinoma

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 798-809页

作者： Dong-Qin Xia Yong Zhou Shuang yang Fang-Fei Li Li-Ya Tian yan-Hua Li Hai-yan Xu Cai-Zhi xiao Wei Wang Oncology Treatment Center of Traditional Chinese Medicine Chongqing University Cancer HospitalChongqing 400030China Department of Oncology Chongqing Weisiteng Biotech Translational Research InstituteChongqing 430039China Chongqing Key Laboratory on Big Data for Bio Intelligence Chongqing University of Posts and TelecommunicationsChongqing 430065China

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a common cancer with increasing morbidity and mortality due to changes of social *** To evaluate the significance of serum carbohydrate antigen 19-9(CA19-9)and tumor size changes pre-and post-neoadjuvant therapy(NAT).METHODS This retrospective study was conducted at the Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer *** study specifically assessed CA19-9 levels and tumor size before and after *** A total of 156 patients who completed NAT and subsequently underwent tumor resection were included in this *** average age was 65.4±10.6 years and 72(46.2%)patients were *** survival analysis,we defined the post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level as the CA19-9 ratio(CR).The patients were divided into three groups:CR0.5 and*** regard to tumor size measured by both computed tomography and magnetic resonance imaging,we defined the post-NAT tumor size/pre-NAT tumor size as the tumor size ratio(TR).The patients were then divided into three groups:TR0.5 and*** on these groups divided according to CR and TR,we performed both overall survival(OS)and disease-free survival(DFS)***-rank tests showed that both OS and DFS were significantly different among the groups according to CR and TR(P<0.05).CR and TR after NAT were associated with increased odds of achieving a complete or near-complete pathologic ***,CR(hazard ratio:1.721,95%CI:1.373-3.762;P=0.006),and TR(hazard ratio:1.435,95%CI:1.275-4.363;P=0.014)were identified as independent factors associated with *** This study demonstrated that post-NAT serum CA19-9 level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with OS in patients with PDAC who received NAT and subsequent surgical resection.

关键词： Pancreatic ductal adenocarcinoma Carbohydrate antigen 19-9 Tumor size Pathologic response Biomarkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：