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Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li Bao Chuan-zhi Chen Chang-Zhen ren Ke-Yan Sun Hao Liu Shao-Hua Song zhi-ren Fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various ***,little is known about its effect on hepatic ischemia-reperfusion(I/R)*** study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying ***:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R *** alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver *** severity related to the inflammatory response and reactive oxygen species(ROS)production was also ***,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in ***:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and *** oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin *** addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in *** blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling ***:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

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Morphological Classification of Infrared Galaxies Based on WISE

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Research in Astronomy and Astrophysics 2024年第4期24卷 222-236页

作者： zhi-ren Pan Bo Qiu Cui-Xiang Liu A-Li Luo Xia Jiang Xiao-Yu Guo School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

This study introduces a novel convolutional neural network,the WISE Galaxy Classification Network(WGC),for classifying spiral and elliptical galaxies using Wide-field Infrared Survey Explorer(WISE)*** attains an accuracy of 89.03%,surpassing the combined use of K-means or SVM with the Color-Color method in more accurately identifying galaxy *** enhanced variant,WGC_mag,integrates magnitude parameters with image features,further boosting the accuracy to 89.89%.The research also delves into the criteria for galaxy classification,discovering that WGC primarily categorizes dust-rich images as elliptical galaxies,corresponding to their lower star formation rates,and classifies less dusty images as spiral *** paper explores the consistency and complementarity of WISE infrared images with SDSS optical images in galaxy morphology *** SDSS Galaxy Classification Network(SGC),trained on SDSS images,achieved an accuracy of 94.64%.The accuracy reached 99.30% when predictions from SGC and WGC were *** the complementarity of features in WISE and SDSS images,a novel variant of a classifier,namely the Multi-band Galaxy Morphology Integrated Classifier,has been *** classifier elevates the overall prediction accuracy to 95.39%.Lastly,the versatility of WGC was validated in other data *** the HyperLEDA data set,the distinction between elliptical galaxies and Sc,Scd and Sd spiral galaxies was most pronounced,achieving an accuracy of 90%,surpassing the classification results of the Galaxy Zoo 2 labeled WISE data *** research not only demonstrates the effectiveness of WISE images in galaxy morphology classification but also represents an attempt to integrate multi-band astronomical data to enhance understanding of galaxy structures and evolution.

关键词： methods:data analysis infrared:galaxies galaxies:spiral galaxies:elliptical and lenticular cD

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Risk stratification in gastric cancer lung metastasis: Utilizing an overall survival nomogram and comparing it with previous staging

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 357-381页

作者： zhi-ren Chen Mei-Fang Yang zhi-Yuan Xie Pei-An Wang Liang Zhang Ze-Hua Huang Yao Luo Department of Science and Education Xuzhou Medical UniversityXuzhou Clinical CollegeXuzhou 221000Jiangsu ProvinceChina Department of Neurology Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Neurology Clinical LaboratoryGastrointestinal SurgeryCentral Hospital of XuzhouCentral Hospital of XuzhouXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Central HospitalXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology Xuzhou Centre HospitalXuzhou 221000Jiangsu ProvinceChina Department of Public Health Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is prevalent and aggressive,especially when patients have distant lung metastases,which often places patients into advanced *** identifying prognostic variables for lung metastasis in GC patients,it may be po-ssible to construct a good prediction model for both overall survival(OS)and the cumulative incidence prediction(CIP)plot of the *** To investigate the predictors of GC with lung metastasis(GCLM)to produce nomograms for OS and generate CIP by using cancer-specific survival(CSS)*** Data from January 2000 to December 2020 involving 1652 patients with GCLM were obtained from the Surveillance,epidemiology,and end results program *** major observational endpoint was OS;hence,patients were se-parated into training and validation *** analysis determined va-rious *** and multivariate Cox analyses validated the independent predictive *** distinction and calibration were performed with the time-dependent area under the curve(AUC)and calibration *** evaluate the accuracy and clinical usefulness of the nomograms,decision curve analysis(DCA)was *** clinical utility of the novel prognostic model was compared to that of the 7th edition of the American Joint Committee on Cancer(AJCC)staging system by utilizing Net Reclassification Improvement(NRI)and Integrated Discrimination Improvement(IDI).Finally,the OS prognostic model and Cox-AJCC risk stratification model modified for the AJCC system were *** For the purpose of creating the OS nomogram,a CIP plot based on CSS was *** multivariate regression analysis identified eleven significant prognostic factors(P0),time-de-pendent ROC curve(training/v

关键词： Gastric cancer Lung metastasis Nomograms Surveillance Epidemiology Surveillance epidemiology and end results program database Overall survival Prognosis

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Self-assembly of differentiated dental pulp stem cells facilitates spheroid human dental organoid formation and prevascularization

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World Journal of Stem Cells 2024年第3期16卷 287-304页

作者： Fei Liu Jing Xiao Lei-Hui Chen Yu-Yue Pan Jun-Zhang Tian zhi-ren Zhang Xiao-Chun Bai School of Basic Medical Sciences Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Health Management Guangdong Second Provincial General HospitalGuangzhou 510317Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People’s Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Centre of Reproduction Development and AgingFaculty of Health SciencesUniversity of MacaoMacao 999078China Department of Stomatology Guangdong Second Provincial General HospitalGuangzhou 510317Guangdong ProvinceChina Zhuhai Institute of Translational Medicine Zhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000Guangdong ProvinceChina Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND The self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative *** cells can self-organise into microsized organ units,partially modelling tissue function and *** pulp organoids have been used to recapitulate the processes of tooth development and related ***,the lack of vasculature limits the utility of dental pulp *** To improve survival and aid in recovery after stem cell transplantation,we demonstrated the three-dimensional(3D)self-assembly of adult stem cell-human dental pulp stem cells(hDPSCs)and endothelial cells(ECs)into a novel type of spheroid-shaped dental pulp organoid in vitro under hypoxia and conditioned medium(CM).METHODS During culture,primary hDPSCs were induced to differentiate into ECs by exposing them to a hypoxic environment and *** hypoxic pretreated hDPSCs were then mixed with ECs at specific ratios and conditioned in a 3D environment to produce prevascularized dental pulp *** biological characteristics of the organoids were analysed,and the regulatory pathways associated with angiogenesis were *** The combination of these two agents resulted in prevascularized human dental pulp organoids(Vorganoids)that more closely resembled dental pulp tissue in terms of morphology and ***-cell RNA sequencing of dental pulp tissue and RNA sequencing of Vorganoids were integrated to analyse key regulatory pathways associated with *** biomarkers forkhead box protein O1 and fibroblast growth factor 2 were identified to be involved in the regulation of *** In this innovative study,we effectively established an in vitro model of Vorganoids and used it to elucidate new mechanisms of angiogenesis during regeneration,facilitating the development of clinical treatment strategies.

关键词： Human dental pulp stem cells Prevascularized organoids Integrated analyses Angiogenesis Forkhead box protein O1

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SMTLOC:基于多源频谱的SMT求解器缺陷定位

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软件学报 2024年第7期35卷 3314-3331页

作者：王笑爽周志德李晓晨江贺任志磊大连理工大学软件学院辽宁大连116024 高安全系统的软件开发与验证技术工业和信息化部重点实验室(南京航空航天大学) 江苏南京210016

SMT求解器作为重要的基础软件,其存在的缺陷可能会导致依赖于它的软件功能失效,甚至带来安全事故.然而,修复SMT求解器缺陷是一个十分耗时的任务,因为开发者需要花费大量的时间和精力来理解并找到缺陷的根本原因.虽然已有许多软件缺陷定... 详细信息

SMT求解器作为重要的基础软件,其存在的缺陷可能会导致依赖于它的软件功能失效,甚至带来安全事故.然而,修复SMT求解器缺陷是一个十分耗时的任务,因为开发者需要花费大量的时间和精力来理解并找到缺陷的根本原因.虽然已有许多软件缺陷定位方面的研究,但尚未有系统的工作研究如何自动定位SMT求解器缺陷.因此,提出一种基于多源频谱的SMT求解器缺陷定位方法SMTLOC.首先,对于给定的SMT求解器缺陷,SMTLOC提出一种枚举算法,用以对触发该缺陷的公式进行变异,从而生成一组不触发缺陷,但与触发缺陷的公式具有相似执行路径的证人公式.然后,SMTLOC根据证人公式的执行路径以及SMT求解器的源码信息,提出一种融合覆盖频谱和历史频谱的文件可疑度计算方法,从而定位可能存在缺陷的文件.为了验证SMTLOC的有效性,收集60个SMT求解器缺陷.实验结果表明,SMTLOC的缺陷定位效果明显优于传统的频谱缺陷定位方法,SMTLOC可以将46.67%的缺陷定位在TOP-5的文件内,定位效果提升了133.33%.

关键词： SMT求解器缺陷定位覆盖频谱历史频谱

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甘州区森林资源保护现状及发展对策

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林业科技情报 2024年第2期56卷 83-86页

作者：任志甘州区兔儿坝天然植被管护站甘肃张掖734000

森林资源是国民经济发展的基础之一。做好森林资源的保护是所有林业人所面临的课题之一。在本区内因地制宜地保护好森林资源。充分挖掘森林资源保护的潜力都是值得认真探讨的工作。本文从本区域的森林资源现状和保护存在的问题入手,分... 详细信息

森林资源是国民经济发展的基础之一。做好森林资源的保护是所有林业人所面临的课题之一。在本区内因地制宜地保护好森林资源。充分挖掘森林资源保护的潜力都是值得认真探讨的工作。本文从本区域的森林资源现状和保护存在的问题入手,分析从森林火灾防控,森林病虫害防治和防止森林破坏等方面。提出了促进本区域森林资源保护的对策和建议。

关键词：甘州区森林资源保护现状对策

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量子力学教学中的几个数学细节

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高师理科学刊 2024年第4期44卷 107-110页

作者：任智百色学院材料科学与工程学院广西百色533000

量子力学波动力学分支是建立在算符、本征值方程和算符代数的数学形式之上的.通过对三个教学情境:(1)算符x,p_(x)不可易的推导过程;(2)位置算符的特征波函数的推导过程;(3)力学算符的运动方程推导过程,所涉及数学细节的理解和解释,展现... 详细信息

量子力学波动力学分支是建立在算符、本征值方程和算符代数的数学形式之上的.通过对三个教学情境:(1)算符x,p_(x)不可易的推导过程;(2)位置算符的特征波函数的推导过程;(3)力学算符的运动方程推导过程,所涉及数学细节的理解和解释,展现了量子力学教学中数学概念的清晰、推导的逻辑严密性和对数学形式的多样性及其它们彼此之间转换的灵活性的熟练掌握对量子物理概念理解的重要性.

关键词：算符位置算符运动方程量子力学

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蕅益智旭《论语点睛》之心性思想

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宜春学院学报 2024年第7期46卷 22-27页

作者：贺志韧金陵科技学院马克思主义学院江苏南京211100

在《论语点睛》中,蕅益智旭提出了很多融通佛儒的心性思想,为三教合流作出了重要贡献。在本体论上,他提出了“心外无人”思想,认为心是最高级别的哲学范畴,是宇宙万物的产生根源;在方法论上,他提出了“观心”和“炼心”的理念,主张通过... 详细信息

在《论语点睛》中,蕅益智旭提出了很多融通佛儒的心性思想,为三教合流作出了重要贡献。在本体论上,他提出了“心外无人”思想,认为心是最高级别的哲学范畴,是宇宙万物的产生根源;在方法论上,他提出了“观心”和“炼心”的理念,主张通过“格物致知”“心不违仁”“约心以礼”和“随境炼心”等方式来修炼心性;在境界论上,他提出了“无知”“无我”的境界观,主张将心性修炼到消除知见,忘记自我的思想高度。这些思想都非常新颖和别出心裁,为融会贯通佛、儒二家理论,推动二家思想交流提供了诸多路径。

关键词：《论语点睛》蕅益智旭心性思想观心

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基于IMU和运动学的四足机器人对角支撑状态估计算法

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控制与决策 2024年第9期39卷 2894-2902页

作者：陈辉任志刚冯祖仁刘帅冷昊熹西安交通大学自动化科学与工程学院西安710049

对角支撑是四足机器人复杂动态以及线性行走必备的一种状态.然而,目前鲜有有效的状态估计算法,无法支撑相应控制策略.为此,提出一种融合惯性测量单元(inertial measurement unit, IMU)和运动学约束的状态估计算法.首先,针对对角支撑状... 详细信息

对角支撑是四足机器人复杂动态以及线性行走必备的一种状态.然而,目前鲜有有效的状态估计算法,无法支撑相应控制策略.为此,提出一种融合惯性测量单元(inertial measurement unit, IMU)和运动学约束的状态估计算法.首先,针对对角支撑状态下运动学模型欠约束带来的位姿估计难题,通过分解机身坐标系到参考坐标系的变换矩阵,简化运动学方程,并利用IMU提供的可信俯仰和横滚角测量值,推导获得其余4个位姿量的解析式;然后,进一步基于腿部微分运动学和IMU提供的俯仰和横滚角速率,结合位姿量的导数获得线速度和偏航角速率的解析式;最后,通过仿真分析验证所提出算法的有效性.实验结果表明:位姿估计值准确、无漂移,偏航角速率和线速度的均方根误差分别小于2 deg/s和9 mm/s,优于现有算法且满足实际控制需求.

关键词：状态估计四足机器人运动学欠约束惯性测量单元对角支撑

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高效低时延分级多PAN太赫兹无线网络MAC层优化协议

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小型微型计算机系统 2024年第8期45卷 1966-1971页

作者：刘洋任智古金东周逊重庆邮电大学通信与信息工程学院重庆400065 中国工程物理研究院激光聚变研究中心四川绵阳621900

针对现有分级多PAN太赫兹无线网络MAC(Medium Access Control)协议中存在的子网形成方案不合理以及私有CTA(Channel Time Allocation)与子网内实际负载不匹配等问题,提出了一种高效低时延的MAC层优化协议.该协议采用基于泛听的按需形成... 详细信息

针对现有分级多PAN太赫兹无线网络MAC(Medium Access Control)协议中存在的子网形成方案不合理以及私有CTA(Channel Time Allocation)与子网内实际负载不匹配等问题,提出了一种高效低时延的MAC层优化协议.该协议采用基于泛听的按需形成子网机制避免了子网分布不均匀以及因子网形成后没有节点加入而造成的私有CTA资源浪费的问题.在子网形成后,子微微网协调器(Piconet Coordinator,PNC)根据子网内实际负载情况自适应选择私有CTA时隙资源优化机制,让有数据传输需求的节点及时将数据发出.仿真结果表明,所提出的方案能有效地降低数据帧平均接入时延,提高吞吐量以及数据帧的传输成功率.

关键词：太赫兹分级多PAN 无线网络媒体访问控制协议低时延

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