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Anticancer Activity of Diosgenin and Its Molecular Mechanism

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Chinese Journal of Integrative Medicine 2023年第8期29卷 738-749页

作者： ren qun-li WANG Qian ZHANG Xin-qun WANG Miao HU Huan TANG Jun-jie YANG Xiong-tong RAN Ying-hui liU Huan-huan SONG Zhi-xing liU Jian-guo li Xiao-lan Special Key Laboratory of Microbial Resources and Drug Development of Guizhou Higher Education Institution Zunyi Medical UniversityZunyiGuizhou Province(563000)China School of Stomatology Zunyi Medical UniversityZunyiGuizhou Province(563000)China Institute of life Sciences Zunyi Medical UniversityZunyiGuizhou Province(563000)China Zheng'an County People's Hospital ZunyiGuizhou Province(563000)China School of Basic Medicine Zunyi Medical UniversityZunyiGuizhou Province(563000)China

Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea, and Rhizoma polgonati, has shown high potential and interest in the treatment of various cancers, such as oral squamous cell carcinoma, laryngeal cancer, esophageal cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, prostate cancer, glioma, and leukemia. This article aims to provide an overview of the in vivo, in vitro,and clinical studies reporting the diosgenin’s anticancer effects. Preclinical studies have shown promising effects of diosgenin on inhibiting tumor cell proliferation and growth, promoting apoptosis, inducing differentiation and autophagy, inhibiting tumor cell metastasis and invasion, blocking cell cycle, regulating immunity and improving gut microbiome. Clinical investigations have revealed clinical dosage and safety property of diosgenin. Furthermore, in order to improve the biological activity and bioavailability of diosgenin, this review focuses on the development of diosgenin nano drug carriers, combined drugs and the diosgenin derivatives. However, further designed trials are needed to unravel the diosgenin’s deficiencies in clinical application.

关键词： diosgenin steroidal sapogenin anticancer molecular mechanism biological activity

Antioxidant Effect of Selenium-containing Glutathione S-Transferase in Rat Cardiomyocytes

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Chemical Research in Chinese Universities 2012年第3期28卷 454-458页

作者： YIN li HAN Xiao YU Yang GUO Xiao ren li-qun FANG Jing-qi liU Zhi-yi YAN Gang-lin WEI Jing-yan College of Pharmaceutical Science Jilin UniversityChangchun 130021P.R.China Key Laboratory of Molecular Enzymology and Engineering Ministry of EducationCollege of Life ScienceJilin UniversityChangchun 130012P.R.China

As one of the most important antioxidant enzymes, glutathione peroxidase（GPX） protects cells and tissues from oxidative damage, and plays an important role in cardiovascular and cerebrovascular injuries induced by oxida- tive stress. The antioxidant effect of selenium-containing glutathione S-transferase（Se-GST）, a mimic of GPX was investigated on rat cardiomyocytes. To explore the protection function of Se-GST in hydrogen peroxide（H202） chal- lenged rat cardiomyocytes, we examined malondialdehyde（MDA）, lactate dehydrogenase（LDH）, superoxide dismu- tase（SOD） and cell apoptosis. The results demonstrate exposure of rat cardiomyocytes to H202 for 6 and 12 h induced the significant increases of MDA, LDH and apoptosis rate of cardiomyocytes, but pretreatment of rat cardiomyocytes with Se-GST at 0.0005 or 0.001 unit/mL prevents oxidative stress induced by H202 with the decreases of cell apopto- sis. All the results hint Se-GST has antioxidant activity for oxidative stress challenged rat cardiomyocvtes.

关键词： Selenium-containing glutathione S-transferase(Se-GST) Cell apoptosis Cardiac myocyte Oxidative stress

Effect of Sodium Ferulate on Myocardial Ischemia Fibrosis Induced by Isoproterenol

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Chemical Research in Chinese Universities 2009年第5期25卷 699-704页

作者： GAO Hai-cheng SUN Bo YU Xiao-yan GAO Hai-mei SHI Yan MIAO Chun-sheng li Xiang-jun LUO Ping ZOU Ying-gang WEI Hai-feng ZHAO Juan ren li-qun School of Pharmacy Jilin University Changchun 130021 P. R. China The Second Clinical Hospital of Jilin University Changchun 130041 P. R. China

We examined whether the powerful sodium ferulate（SF） could improve myocardial ischemia fibrosis degree and gain the information of myocardial energy metabolism via experimental model of myocardial ischemia fibrosis. The model of myocardial ischemia fibrosis was made for the wistar rats induced with 15 mg/kg isoproterenol（Iso） subcutaneous injection. In experiment l, Iso effective model drug of myocardial ischemia fibrosis at present was administrated to the rats with myocardial ischemia fibrosis and 2, 4, 6, 12, 24, 48 and 72 h, 7 and 21 d later, the changes of adenosine content in rat myocardial tissue and hydroxyproline in blood serum were compared. In experiment 2, SF was administrated to the rats with myocardial ischemia fibrosis and 21 d later, the effect of SF on benazepril as reference drug curing myocardial ischemia fibrosis was evaluated by measuring the changes of adenosine in rat myocardial tissue and hydroxyproline content in blood serum. In the model group, there was a remarkable increase in hydroxyproline content and a decrease in adenosine content of myocardial tissue in experiment 1; there was a remarkable decrease in hydroxyproline in blood serum and a increase in adenosine content in myocardial tissue, which were recovered gradually to control in experiment 2（P〈0.05）. The results of experiment 1 show that with the increasing of pathological change degree, the rat adenosine content reduced gradually and arrived at the lowest value three weeks later（P〈0.05）; the hydroxyproline content was obviously higher compared with that of control group（P〈0.05）. The results of experiment 2 show that rat adenosine content in myocardial tissue and hydroxyproline content in blood serum were recovered gradually to normal level after injection SF. The effect of SF against myocardial ischemia fibrosis in preventive group is better than that of improving the myocardial ischemia fibrosis drug. Meanwhile, hinting HPLC is a good method to measure the adenosine content.

关键词： Energy metabolism Hydroxyproline Myocardial fibrosis HPLC

Clinical features of renal artery stenosis in elderly patients

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Chinese Medical Journal 2007年第4期120卷 345-347页

作者： TANG Ri-ning liU Bi-cheng ren li-qun WANG Yan-li MA Gen-shan Institute of Nephrology Zhong Da Hospital Southeast University Nanjing 210009 China Department of Cardiology Zhong Da Hospital Southeast University Nanjing 210009 China

Together with an increasingly aging world population there is also an increasing prevalence of atherosclerosis. renal artery stenosis （RAS） is one of the systemic manifestations of atherosclerosis. Its incidence is about 15%-35%. RAS accounts for 5%-27% of all patients with end-stage renal disease （ESRD）. Patients with renal dysfunction resulting from RAS are at risk of death from cardiovascular disease and ESRD.

关键词： renal artery obstruction angiography aged

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气管血管球瘤一例

中华病理学杂志 2005年第2期34卷 124-125页

作者：任立群吕宁中国协和医科大学中国医学科学院肿瘤医院病理科 100021

患者男,29岁.间断性咳嗽2年,症状加重伴气短2个月,于2003年12月25日入院.术前CT示:隆突上方、气管下段可见不规则形肿物.支气管镜检查:气管下段可见葡萄状肿物突向腔内.手术行气管节段切除、端端吻合术。

关键词：气管肿物血管球瘤气短端端吻合术腔内入院间断性行气

老年综合评估干预对良性前列腺增生患者抑郁和焦虑情绪的影响

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中华老年医学杂志 2011年第11期30卷 921-923页

作者：李洁邹继红任利群中南大学附属中大医院老年病科南京210009

目的探讨老年综合评估（CGA）干预对良性前列腺增生症（BPH）患者抑郁、焦虑情绪的影响。方法2009年6月至2010年6月我院老年科门诊90例BPH患者（≥65岁）随机分成对照组（45例）及CGA干预组（45例），对照组采用常规治疗及对症处理，干... 详细信息

目的探讨老年综合评估（CGA）干预对良性前列腺增生症（BPH）患者抑郁、焦虑情绪的影响。方法2009年6月至2010年6月我院老年科门诊90例BPH患者（≥65岁）随机分成对照组（45例）及CGA干预组（45例），对照组采用常规治疗及对症处理，干预组首先采用CGA，在此基础上拟定综合治疗方案，指导会诊，并给予治疗及对症处理。治疗前及随访6个月后门诊进行国际前列腺症状评分（IPSS）、生活质量评分（QOLS）、抑郁自评量表（SDS）、焦虑自评量表（SAS）评估，并分别进行两组治疗前后对比分析，以评价CGA对BPH患者生活质量及抑郁、焦虑情绪的影响。结果对照组治疗后BPH患者的IPSS、QOLS、SDS和sAs评分均明显减少（t=11．0，5．84，7．08和9．68，均P〈0．01），CGA干预组治疗后BPH患者的IPSS、QOLS、SDS和SAS评分均明显减少（t=14．0，10．4，9．16和6．1，均P〈0．01）。随访6个月后CGA干预组BPH患者的IPSS、QOLS、SDS和SAS评分明显低于同期对照组（t=4．25，5．55，3．45和2．88，P〈0．01）。结论老年综合评估可以明显改善良性前列腺增生患者的生活质量及抑郁、焦虑情绪。

关键词：前列腺增生综合预防生活质量抑郁焦虑

罗格列酮对糖基化终产物诱导鼠心肌成纤维细胞氧化应激和胶原代谢影响的研究

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中国糖尿病杂志 2015年第9期23卷 849-852页

作者：李洁刘乃丰任利群东南大学附属中大医院老年科南京210009 东南大学心血管病研究所

目的观察AGE诱导心肌成纤维细胞对氧化应激(OS)和胶原蛋白Ⅰ、Ⅲ合成分泌的影响及罗格列酮(RGZ)的干预作用。方法不同浓度AGE与心肌成纤维细胞孵育,予RGZ干预48h,收集培养上清液,分别应用超氧化物歧化酶(SOD)、丙二醛(MDA)试剂盒检测SO... 详细信息

目的观察AGE诱导心肌成纤维细胞对氧化应激(OS)和胶原蛋白Ⅰ、Ⅲ合成分泌的影响及罗格列酮(RGZ)的干预作用。方法不同浓度AGE与心肌成纤维细胞孵育,予RGZ干预48h,收集培养上清液,分别应用超氧化物歧化酶(SOD)、丙二醛(MDA)试剂盒检测SOD活性和MDA含量,采用EliSA检测胶原蛋白Ⅰ、Ⅲ含量。结果 RGZ与200mg/L AGE共同孵育心肌成纤维细胞48h,随RGZ浓度增高(0.1、1、10μmol/L),心肌成纤维细胞培养上清液中SOD活性逐渐增高[(21.564±1.614),(22.323±1.260),(23.661±1.562)vs(19.320±0.896)nU/ml,P<0.05或P<0.01];与200mg/L AGE组比较,MDA含量逐渐降低[(1.325±0.048),(1.279±0.032),(1.229±0.045)vs(1.629±0.043)nmol/ml,P<0.01];与200mg/L AGE组比较,胶原蛋白Ⅰ和胶原蛋白Ⅲ含量均呈递减趋势[(79.17±3.25),(60.42±3.58),(42.71±5.11)vs(85.54±2.28)ng/ml,P<0.01;(37.52±3.43),(27.09±4.75),(20.81±3.26)vs(40.75±2.70)ng/ml,P<0.01]。结论 AGE诱导心肌成纤维细胞OS,增加胶原蛋白Ⅰ、Ⅲ合成分泌;RGZ能抑制AGE诱导的心肌成纤维细胞OS,抑制AGE诱导的胶原蛋白Ⅰ、Ⅲ合成分泌,对糖尿病心肌纤维化的防治有重要意义。

关键词：罗格列酮糖基化终产物心肌成纤维细胞胶原蛋白氧化应激

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含铁尘泥金属化球团的合理渣系

钢铁研究学报 2017年第5期29卷 357-363页

作者：毛瑞任立群杜屏王飞江苏省(沙钢)钢铁研究院江苏张家港215625

基于转底炉工艺,结合FeO-SiO_2-CaO三元相图,对金属化球团的渣系进行理论分析,同时开展模拟实验,研究了含铁尘泥金属化球团合理渣系结构。结果表明,对于含铁尘泥球团,当二元碱度为0.37~0.67时,渣系熔点小于1 150℃,球团在较低的还原温... 详细信息

基于转底炉工艺,结合FeO-SiO_2-CaO三元相图,对金属化球团的渣系进行理论分析,同时开展模拟实验,研究了含铁尘泥金属化球团合理渣系结构。结果表明,对于含铁尘泥球团,当二元碱度为0.37~0.67时,渣系熔点小于1 150℃,球团在较低的还原温度下即可形成液相;随着渣系碱度的逐渐降低,含铁尘泥金属化球团的抗压强度呈现先增大后降低的趋势,当球团碱度为0.61时,抗压强度达到最大;金属化球团的强度与反应温度呈正相关性,反应温度的提高可大幅提高球团的强度。当球团二元碱度为0.85时,反应温度由1190℃提高至1220℃,球团的抗压强度可提高近100%。但随着球团碱度逐渐降低,不同温度条件下球团抗压强度的差异逐渐减小。

关键词：含铁尘泥转底炉资源化利用金属化球团

Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(li and Jia,2023).

关键词： death specialized barrier