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Understanding Differences in Event Attribution Results Arising from Modeling Strategy

Journal of Meteorological Research 2022年第1期36卷 49-60页

作者： Wenxia ZHANG liwen ren Tianjun ZHOU State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 University of Chinese Academy of Sciences Beijing 100049

While there is high confidence that human activities have increased the likelihood and severity of hot extreme events over many parts of the world,there is notable spread in quantitative estimates of anthropogenic influence even on a single *** better understand the uncertainty of attribution results,here we compare different event attribution methods using the 2015 July-August record-breaking heat event in northwestern China as a case *** address the anthropogenic influence on the likelihood of the extreme event,we employ attribution runs with two modeling strategies—atmosphere-only and coupled simulations—with different *** atmosphere-only attribution runs,given the observed sea surface boundary conditions and external forcings in 2015,it is estimated that anthropogenic forcing has increased the likelihood of hot extremes such as that observed in 2015 in the target region,by approximately 27 and 12 times in MIROC5 and HadGEM3-A-N216,*** Coupled Model Intercomparison Project phase 5(CMIP5)fully coupled attribution runs,given the external forcing at the 1961-2015 level and regardless of sea surface boundary conditions,there is a 21-fold increase in the likelihood of similar heat events due to anthropogenic *** differences in quantitative attribution results can arise from modeling strategies,which are tightly linked to different conditioning in ***,different ocean boundary conditions,external forcings,and air-sea coupling processes contribute to different attribution results between the two modeling *** each modeling strategy,model uncertainty affects quantitative attribution *** comparison of different attribution methods provides a better understanding of the uncertainty of attribution results,which is useful in synthesizing and interpreting attribution results.

关键词： event attribution anthropogenic influence uncertainty modeling strategy

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Impact of 1.5°C and 2.0°C global warming on aircraft takeoff performance in China

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Science Bulletin 2018年第11期63卷 700-707页

作者： Tianjun Zhou liwen ren Haiwen Liu Jingwen Lu LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Department of Aviation Meteorology Civil Aviation University of ChinaTianjin 300300China

Associated with global warming, climate extremes such as extreme temperature will significantly increase. Understanding how climate change will impact the airflights is important to the planning of future flight operations. In this study, the impacts of 1.5 and 2 degree's global warming on the aircraft takeoff performance in China are investigated using a unique climate projection data from an international collaboration project named HAPPI. It is found that the mean summer daily maximum temperature, which is a major factor that affects the flight through changing the aircraft's takeoff weight, will increase significantly with magnitude less than 1.5℃ over most parts of China except for the Tibetan Plateau. The half a degree additional global warming will lead to higher extreme temperature in the arid and semi-arid western China, the Tibetan Plateau and the northeastern China, while the change in eastern China is weak. Five airports including Beijing, Shanghai, Kunming, Lasa and Urumqi will see ～1.0°-2.0℃(1.4°-3.0℃) higher daily maximum temperature under 1.5℃(2.0℃) scenario. The half-degree additional warming will lead to a shift toward higher extreme temperature in these five sites. For both1.5° and 2.0℃ scenarios, the number of weight-restriction days will increase significantly at 3 airports including Beijing, Shanghai, and Lasa. Urumqi will witness an increase of weight-restriction days only in 2.0℃ future.

关键词： Extreme temperature 1.5 and 2 degree's global warming Airflight Weight-restriction days

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Dust Acoustic Wave in Dusty Plasmas With Streaming Ions Under Ultraviolet Irradiation

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空间科学学报 2012年第2期32卷 191-196页

作者： ren liwen WANG Chi State Key Laboratory of Space Weather Center for Space Science and Applied ResearchChinese Academy of SciencesBeijing 100190

The reductive perturbation method is applied to investigate the dust acoustic soliton in dusty plasmas with streaming ions under ultraviolet irradiation theoretically and *** self-consistent dust charge variation is taken into *** is shown that the ultraviolet irradiation can significantly lower the magnitude of the dust negative charge,and ion streaming velocity firstly raise the magnitude of the dust negative charge and then lower *** the growth of(Ultraviolet) UV photo flux or ion streaming velocity,the phase velocity and width of the solitary waves decrease, whereas its amplitude increases.

关键词： Dusty plasma Solitary wave Ultraviolet irradiation Streaming ion

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Recent Development and Preliminary Results of Chinese Meridian Project

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空间科学学报 2013年第1期33卷 1-5页

作者： WANG Chi ren liwen State Key Laboratory of Space Weather Center for Space Science and Applied ResearchChinese Academy of Sciences

The Meridian Project is a ground-based network program to monitor solar-terrestrial space environment,which consists of a chain of 15 ground-based observatories located roughly along 120°E longitude and 30°N *** Meridian project started in 2008,and its construction was completed by *** integration and test phase of the Meridian Project conducted in 2011 demonstrated its observation capabilities as *** project will be in full operation in 2012. This report gives an overview of the recent development and preliminary results of the Meridian Project since 2010.

关键词： Meridian Project Space weather Ground-based

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3-O-Acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma

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Acta Pharmaceutica Sinica B 2020年第2期10卷 301-312页

作者： Wan Li liwen ren Xiangjin Zheng Jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Glioblastoma is the most common and aggressive primary tumor in the central nervous system,accounting for 12%-15%of all brain tumors.3-O-Acetyl-11-keto-β-boswellic acid(AKBA),one of the most active ingredients of gum resin from Boswellia carteri Birdw.,was reported to inhibit the growth of glioblastoma cells and subcutaneous ***,whether AKBA has antitumor effects on orthotopic glioblastoma and the underlying mechanisms are still *** orthotopic mouse model was used to evaluate the anti-glioblastoma effects of *** effects of AKBA on tumor growth were evaluated using *** effects on the alteration of metabolic landscape were detected by *** underlying mechanisms of autophagy reducing by AKBA treatment were determined by immunoblotting and immunofluorescence,*** electron microscope was used to check morphology of cells treated by *** results showed that AKBA(100 mg/kg)significantly inhibited the growth of orthotopic U87-MG *** from MALDI-MSI showed that AKBA improved the metabolic profile of mice with glioblastoma,while immunoblot assays revealed that AKBA suppressed the expression of ATG5,p62,LC3 B,p-ERK/ERK,and P53,and increased the ratio of p-mTOR/*** together,these results suggested that the antitumor effects of AKBA were related to the normalization of aberrant metabolism in the glioblastoma and the inhibition of *** could be a promising chemotherapy drug for glioblastoma.

关键词： Glioblastoma AKBA MALDI-MSI Phospholipids Autophagy

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Scientific challenges and instrumentation for the International Meridian Circle Program

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Science China Earth Sciences 2021年第12期64卷 2090-2097页

作者： William LIU Michel BLANC Chi WANG Eric DONAVAN John FOSTER Mark LERTER Hermann OPGENOOTYH liwen ren National Space Science Centre Chinese Academy of SciencesBeijing100190China University of Toulouse Toulouse31400France University of Calgary CalgaryT2N 1N4Canada MIT Haystack Observatory CambridgeMA01886USA University of Leicester LeicesterLE17RHUK University of Umeå UmeåSE-90187Sweden

Earth’s ecosystems and human activities are threatened by a broad spectrum of hazards of major importance for the safety of ground infrastructures,space systems and space flight:solar activity,earthquakes,atmospheric and climatic disturbances,changes in the geomagnetic field,fluctuations of the global electric *** and understanding these major hazards to better predict and mitigate their effects is one of the greatest scientific and operational challenges of the 21st *** diverse,these hazards share one feature in common:they all leave their characteristic imprints on a critical layer of the Earth’s environment:its ionosphere,middle and upper atmosphere(IMUA).The objective of the International Meridian Circle Program(IMCP),a major international program led by the Chines Academy of Sciences(CAS),is to deploy,integrate and operate a global network of research and monitoring instruments to use the IMUA as a screen on which to detect these *** this article,we first show that the geometry required for the IMCP global observation system leads to a deployment of instruments in priority along the 120°E-60°W great meridian circle,which will cover in an optimal way both the dominant geographic and geomagnetic latitude variations,possibly complemented by a second Great Circle along the 30°E-150°W meridians to capture longitude ***,starting from the Chinese Meridian Project(CMP)network and using it as a template,we give a preliminary and promising description of the instruments to be integrated and deployed along the 120°E-60°W great circle running across China,Australia and the Americas.

关键词： International Meridian Circle Program Ionosphere Middle-upper atmosphere Space weather Chinese Meridian Project

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MELK is an oncogenic kinase essential for metastasis,mitotic progression,and programmed death in lung carcinoma

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Signal Transduction and Targeted Therapy 2021年第1期6卷 83-94页

作者： Qin Tang Wan Li Xiangjin Zheng liwen ren Jinyi Liu Sha Li Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines BeijingChina Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical College100050 BeijingChina

Lung cancer is the fastest growth rate of morbidity and mortality in nearly a decade,and remains difficult to ***,the molecular mechanisms underlying its development are still *** this study,bioinformatics analysis showed that MELK was highly expressed in lung cancer and negatively correlated to the survival of lung adenocarcinoma(LUAD).Immunohistochemistry analysis of LUAD patient tissues revealed there were a high level of MELK expression in *** of MELK expression inhibits the migration and invasion of LUAD cells,which may be mediated by Twist1,Slug,MMP7,and *** of MELK promoted the growth of LUAD cells in medium,3D Matrigel,and nude *** of MELK by OTSSP167 arrested cycle of LUAD cells at G2/M phase via PLK1-CDC25C-CDK1 pathway,and triggered apoptosis-mediated ***,these data indicate that MELK is critical for metastasis,mitotic progression,and programmed death of LUAD and may be a promising therapeutic target for LUAD.

关键词： metastasis PLK1 lung

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Tumorigenic bacteria in colorectal cancer:mechanisms and treatments

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Cancer Biology & Medicine 2022年第2期19卷 147-162页

作者： Sha Li Jinyi Liu Xiangjin Zheng liwen ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Beijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

Colorectal cancer(CRC)is the third most common and the second most fatal *** recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of *** bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella *** been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal *** bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,*** toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from *** bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 ***,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy *** with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different *** this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial *** bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced *** bacteria may be useful as biomarkers or therapeutic targets for CRC.

关键词： Colorectal cancer microbiota tumorigenic mechanism genotoxicity cancer pathways tumor immunity

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Author correction to‘3-O-Acetyl-11-keto-bboswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma’[Acta Pharm Sin B 10(2020)301-312]

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3783-3784页

作者： Wan Li liwen ren Xiangjin Zheng Jinyi Liu Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China

The authors apologize for two inadvertent mistakes in Fig.5:the image of immunofluorescence of LC3B in the Vehicle group(Fig.5c)and the image of transmission electron microscope in the AKBA 10 mmol/L group(Fig.5f)were provided *** corrected Fig.5 is shown *** original data of these figures have been provided to the Editorial Office,and the corresponding authors or the Editorial Office can be contacted for original data access.

关键词： correction Office image

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Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3465-3480页

作者： Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu liwen ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du The State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Key Laboratory of Drug Target Research and Drug Screen Institute of Materia MedicaChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100050China Department of Pharmacology Capital Medical UniversityBeijing 100069China

Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for *** of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of ***,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying ***33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 *** also arrested the cell cycle at G2/M phase and induced mitochondria-dependent *** gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the ***33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR ***,SW33 appears to be a promising drug for treating GBM effectively and safely.

关键词： SW33 GBM G2/M phase Apoptosis Autophagy mTOR Anti-inflammation Safety

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