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基于退化模型动态校准的设备剩余寿命预测方法

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航空学报 2023年第19期44卷 171-186页

作者：任超李慧琴李天梅张建勋司小胜火箭军工程大学智剑实验室西安710025

剩余寿命预测是实现随机退化设备健康管理的关键技术。统计数据驱动的方法作为剩余寿命预测领域的典型方法,一般采用随机模型建模设备性能退化变量演变规律,以概率分布的形式给出剩余寿命分布的表达式。然而,退化模型函数形式的选择本... 详细信息

剩余寿命预测是实现随机退化设备健康管理的关键技术。统计数据驱动的方法作为剩余寿命预测领域的典型方法,一般采用随机模型建模设备性能退化变量演变规律,以概率分布的形式给出剩余寿命分布的表达式。然而,退化模型函数形式的选择本身是一个难题,尤其在模型函数形式选择不当时仅通过更新模型参数难以有效实现退化模型的校准,进而影响剩余寿命预测的准确性。鉴于此,提出了一种基于退化模型动态校准的设备剩余寿命预测方法,该方法首先建立了基于非线性扩散过程的设备随机退化过程模型,利用设备的退化监测数据运用Bayesian方法对模型参数进行估计,据此对设备未来退化趋势进行预测;然后,利用退化趋势预测误差建立了模型误差的参数化模型对退化模型进行补偿以校准退化模型函数形式,同时对补偿后的退化模型参数采用Bayesian方法进行更新,由此实现了对设备退化模型函数形式和参数的同时动态校准;在此基础上,推导给出了退化模型动态校准下的设备剩余寿命分布。最后,通过数值仿真和锂电池数据验证了所提方法的实用性和有效性。

关键词：剩余寿命退化过程模型动态校准 Bayesian方法 AIC准则

Comparative analysis of microRNA profiles between wild and cultured Haemaphysalis longicornis(Acari,Ixodidae) ticks

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Comparative analysis of microRNA profiles between wild and c...

中国畜牧兽医学会兽医寄生虫学分会第一届青年科学家学术论坛

作者： Jin Luo Qiao-yun ren Wenge Liu Zegong Wu Yangchun Tan Xiaofei Qiu Xiaofeng Xu Hong Yin jianxun Luo Guangyuan Liu State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Science

Background:The Haemaphysalis longicornis(***) are of great public health and economic ***(miRNAs) are known with functions of gene regulations at post-transcriptional ***:We herein compared the miRNA profiles of *** wild strain(HLWS) and *** cultured strain(HLCS) by Solexa deep sequencing combined with bioinformatics analysis and stem-loop real-time PCR.A total 15.63 and 15.48 million raw reads were yielded in HLWS and HLCS,*** the data 1517 and 1327 known conserved miRNA were found and 342 miRNAs performed differentially expressed between the two *** prediction showed 36 candidates novel miRNAs were *** exposition the function of novel miRNAs,The Gene Ontology was performed that the target and function prediction revealed a significant set of targets which are related to salivary gland development,pathogen-host interaction and regulation of defense response to pathogen of the wild *** *** cellular component biogenesis,immune system process and response to stimulus etc have high percent in the two tick *** analysis revealed that the percentages of most predicted functions of the miRNA targets were similar,with some taxon specific or taxon enhanced functions,such as different target numbers,specific functions(auxiliary transport protein and electron carrier functions),***:This study provides novel findings showing that miRNA regulation affects the expression of immune genes,indicating a considerable influence of environment-induced stressful stimulation on immune *** in the living environments of ticks can lead to differences in miRNAs between ticks and provide a basis and a convenient means to screen for genes encoding immune factors in ticks.

关键词： MicroRNA(miRNA) Haemaphysalis longicornis Comparative analysis wild culture

Molecular phylogeny of Hypoderma *** cattle and yaks in China

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Molecular phylogeny of Hypoderma *** cattle and yaks in Chin...

中国奶业协会第26次繁殖学术年会暨国家肉牛牦牛/奶牛产业技术体系第3届全国牛病防治学术研讨会

作者： GUAN Guiquan YIN Hong LUO jianxun GAO Jinliang LIU Zhijie MA Miling DANG Zhisheng LIU Aihong ren Qiaoyun LI Wenhui Key Laboratory of Veterinary Parasitology of Gansu Province State Key Laboratory of Veterinary Etiological BiologyLanzhou Veterinary Research InstituteChinese Academy of Agricultural Science

The molecular characteristics of third instar larvae(L3)of Hypoderma,***,*** and *** collected from various regions in China,were analyzed using the most variable region of the ribosomal 18S rRNA and the mitochondrial cytochrome oxidase I(CO I)gene *** the experiments,these L3 were identified by the morphological characters and then the genomic DNA was *** gene sequences were amplified by polymerase chain reaction(PCR)using specific primer for 18S rRNA and COI gene,*** results showed that the 18S rRNA and CO I gene segments were roughly 1827bp and 1250bp in this study,*** phylogenetic trees were constructed and the percent divergences were also determined based on the 18S rRNA and CO I gene sequences of Hypoderma species collected from China and in *** results showed that the intraspecific variation of ***,*** and *** were less than 0.2%,and the interspecific differences between *** and ***,*** and *** and *** and *** were more than 1.6%,1.2%and 1.2%,respectively,based on the 18S rRNA gene *** the intraspecific variation of ***,*** and *** were less than 1.5%,0.9%and 1.2%,and the interspecific differences between *** and ***,*** and *** and *** and *** were more than 9.3%,9.9%and 6.7%,respectively,based on the CO I gene *** indicated that the target genes of not only COI but 18S rRNA could be used to differentiate the three species of Hypoderma,***,*** and *** results are coincident with morphological analysis,which offer evidence defining *** as a valid ***,*** was considered as that just infested the yaks in high mountainous regions of *** a sample *** L3 was collected from the cattle,which means *** also infested cattle not only yaks.

关键词： COI gene 18S rRNA gene Hypoderma Molecular characteristics

MicroRNA-1 Promotes the Development of and Prolongs Engorgement Time in Hyalomma anatolicum anatolicum(Acari:Ixodidae) Ticks

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MicroRNA-1 Promotes the Development of and Prolongs Engorgem...

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Jin Luo Qiaoyun ren Wenge Liu Xiaofei Qiu Gaofeng Zhang Yangchun Tan Runlai Cao Hong Yin jianxun Luo Xiangrui Li Guangyuan Liu

MicroRNAs act as mRNA posttranscriptional regulators,playing important roles in cell differentiation,transcriptional regulation,growth and *** this study,microRNA expression profiles of Hyalomma anatolicum anatolicum ticks at different developmental stages were detected by high-throughput sequencing and functionally *** total,2,585,169,1,252,678,1,558,217 and 1,155,283 unique reads were obtained from eggs,larvae,nymphs and adults,respectively,with 42,46,45 and 41 conserved microRNAs in these stages,*** eggs as a control,48,43 and 39 microRNAs were upregulated and 3,10 and 9 downregulated in larvae,nymphs and adults,***-1(miR-1) was expressed in high abundance throughout *** development,with an average of nearly one million transcripts,and it is highly conserved among tick *** real-time PCR(qPCR) showed that miR-1 expression gradually increased with tick development,reaching the highest level at *** tissue expression was detected,with significantly higher levels in the salivary glands and epidermis than in the *** assays showed no significant change in body weight or spawning time or amount between experimental and control groups,but there was a significant difference(prent developmental stages and tissues show different expression patterns,with a certain role in prolonging ***-1,together with other family members,regulates mRNA function and may be used as a molecular marker for species ori

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多次封接对金属-玻璃封接绝缘子性能的影响

中国材料进展 2015年第7期34卷 605-609页

作者：任利娜张建勋冯生鞠鹤西安交通大学材料科学与工程学院陕西西安710049 西北有色金属研究院西安泰金工业电化学技术有限公司陕西西安710016

玻璃与金属封接件以其优良的气密性、密封性能、机械强度等综合性能,广泛应用于军品及民品行业中。针对应用于锂亚电池领域的玻璃金属封接绝缘子生产过程中出现的残次品,玻璃封接界面中出现的气泡、漏洞、炸裂等缺陷,分组设计返烧封接试... 详细信息

玻璃与金属封接件以其优良的气密性、密封性能、机械强度等综合性能,广泛应用于军品及民品行业中。针对应用于锂亚电池领域的玻璃金属封接绝缘子生产过程中出现的残次品,玻璃封接界面中出现的气泡、漏洞、炸裂等缺陷,分组设计返烧封接试验,通过对多次返烧绝缘子的玻璃状态、封接气密性、抗拉强度、拉伸量、拉拔时间等综合因素的观察和测试,发现多次封接过程中,绝缘子气密性、抗拉强度表现出来的量变趋势与玻璃-金属封接界面表现出的质变状态高度一致:玻璃整体状态较好,绝缘子性能较好。试验结果表明:第一次封接后产品综合性能最高,随着封接次数的增多,玻璃状态、气密性、抗拉强度均有明显下降,产品一致性越来越差;且发现玻璃坯的质地密实、尺寸精准、返烧前对绝缘子进行酸洗表面处理等因素都能有效提高产品封接的综合性能,并通过反复试验确定了保证产品性能的最多返烧次数。

关键词：封接绝缘子气密性抗拉强度

Prevalence of Anaplasma phagocytophilum in ruminants,rodents and ticks in Gansu,northwestern China

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Prevalence of Anaplasma phagocytophilum in ruminants,rodents...

第四届全国牛病防制及产业发展大会

作者： Jifei Yang Zhijie Liu Guiquan Guan Qing Liu Youquan Li Ze Chen Miling Ma Aihong Liu Qiaoyun ren jianxun Luo Hong Yin State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Grazing Animal Diseases MOAKey Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences

The zoonotic rickettsial pathogen Anaplasma phagocytophilum has a broad geographic distribution and a high degree of biological and clinical *** determine the prevalence of *** in the Gannan Tibet Autonomous Prefecture,northwestern China,four species of ruminaints,rodents and ticks were examined for *** *** from *** was detected by nested PCR in blood samples from 21/49（42.9%）sheep,35/91（38.5%）goats,51/158（32.3%）yaks,7/20（35.0%）cattle-yaks,and in spleen samples from 2/12（16.7%）rodents,*** the positive samples,25/78（32.1%）were from males and 89/240（37.1%）from females,and no statistically significant difference was observed in the prevalence of *** between male and female animals（P＞0.05）.For samples from tick larvae and nymphs,105 pools were tested;1 was positive of 46 larval tick pools;7 was positive of 59 nymphal tick *** adult ticks,40/598（6.7%）female ticks and26/528（4.9%）male ticks were *** results add new information on the epidemiology of *** and indicate the tick-animal cycle of anaplasmosis in the *** our knowledge,this is the first report of *** infection in Gansu Province in northwestern China.

关键词： A.phagocytophilum ruminant rodent tick prevalence

激光线能量对TC17钛合金焊接接头组织和疲劳性能的影响

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稀有金属材料与工程 2024年第7期53卷 1836-1844页

作者：任利娜张群兵雷晓维齐亮杨家典张建勋西安交通大学金属材料强度国家重点实验室陕西西安710049 西部钛业有限责任公司陕西西安710201 西安航空学院材料工程学院陕西西安710077 西北工业大学物理科学与技术学院陕西西安710072 贵州航宇科技发展股份有限公司贵州贵阳550081

在不同的激光线能量条件下对TC17钛合金进行了焊接,采用光学显微镜、扫描电镜、透射电镜、拉伸和疲劳试验机对接头的宏观形貌、微观组织和力学性能进行了对比研究。结果表明:随着激光线能量的增加,焊缝宏观形貌由Y型转变为X型、焊缝中... 详细信息

在不同的激光线能量条件下对TC17钛合金进行了焊接,采用光学显微镜、扫描电镜、透射电镜、拉伸和疲劳试验机对接头的宏观形貌、微观组织和力学性能进行了对比研究。结果表明:随着激光线能量的增加,焊缝宏观形貌由Y型转变为X型、焊缝中气孔缺陷数量先增加后减少,气孔缺陷主要分布在焊缝的中下部。焊缝由柱状晶粒组成,柱状晶内部存在条形枝晶,枝晶间距随着线能量的增加而逐渐增大。热影响区由尺寸较小的等轴晶组成,随着激光线能量的增加,α相晶粒逐渐细化,而β相逐渐粗化。在拉伸和疲劳试验中,TC17激光焊接接头均断裂在焊缝。受焊缝内部枝晶尺寸的影响,抗拉伸强度随线能量的增加而降低。气孔是导致疲劳断裂的主要原因,气孔缺陷数量越少,则疲劳寿命越长。

关键词： TC17钛合金焊接接头激光线能量微观组织疲劳行为

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钛焊接阴极辊接头及母材均晶化研究

热加工工艺 2015年第17期44卷 32-35页

作者：任利娜张建勋鞠鹤西安交通大学材料科学与工程学院陕西西安710049 西北有色金属研究院西安泰金工业电化学技术有限公司陕西西安710016

阴极辊作为电解铜箔的核心设备,其关键技术是表面钛筒套的制造方法。"旋压"和"焊接"工艺是其目前主要的制造方法,但两者各有利弊。近年来,焊接成型工艺被认为是钛阴极辊的最终主流制造方式而受到前所未有的重视。本文针对钛焊接阴极辊... 详细信息

阴极辊作为电解铜箔的核心设备,其关键技术是表面钛筒套的制造方法。"旋压"和"焊接"工艺是其目前主要的制造方法,但两者各有利弊。近年来,焊接成型工艺被认为是钛阴极辊的最终主流制造方式而受到前所未有的重视。本文针对钛焊接阴极辊在生产及使用过程出现的"光斑"或"亮带"等问题,从制造阴极辊的基材、焊接区域及阴极辊整体后处理等三个方面进行试验和分析,提出有效解决方法,最终得到了晶粒度等级较为一致的焊接阴极辊表面组织形貌。

关键词：阴极辊晶粒细化旋压焊接晶粒度

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中国实验方剂学杂志 2022年第18期28卷 20-29页

作者：陈潇潇侯敏王攀任钧国刘建勋中国中医科学院西苑医院基础医学研究所中药药理北京市重点实验室北京100091

目的研究降糖消脂片(JTXZT)对代谢相关脂肪性肝病的改善作用,从生物钟相关基因昼夜运动输出周期(CLOCK)、脑和肌肉芳烃受体核转录因子样蛋白-1基因(BMAL1)、孤儿核激素受体α(REV-ERBα)、孤儿核激素受体β(REV-ERBβ)的角度研究降糖消... 详细信息

目的研究降糖消脂片(JTXZT)对代谢相关脂肪性肝病的改善作用,从生物钟相关基因昼夜运动输出周期(CLOCK)、脑和肌肉芳烃受体核转录因子样蛋白-1基因(BMAL1)、孤儿核激素受体α(REV-ERBα)、孤儿核激素受体β(REV-ERBβ)的角度研究降糖消脂片的作用机制。方法将50只雄性SPF级C57BL/6J小鼠随机分为正常组(10只)与模型组(40只),正常组饲喂正常饲料,模型组饲喂高脂饲料。4周后将模型组随机分为4组,每组10只,即模型组、降糖消脂片高、低剂量(12.5、6.25 g·kg^(-1))组、奥利司他组(70 mg·kg^(-1)),正常组和模型组小鼠灌胃等体积蒸馏水,连续灌胃8周;测定体质量,生化法检测血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)含量,酶联免疫吸附测定法(ELISA)检测血清游离脂肪酸(FFA)、瘦素的含量;苏木素-伊红(HE)染色观察小鼠肝组织和附睾脂肪病理变化、马松(Masson)染色观察肝纤维化程度、油红O染色观察脂质变化情况;蛋白免疫印迹法(Western blot)和免疫组化检测生物钟相关基因CLOCK、BMAL1、REV-ERBα、REV-ERBβ蛋白表达水平的变化。结果与正常组比较,模型组小鼠TG,TC,LDL-C,HDL-C,AST,ALT,FFA、瘦素含量明显升高(P<0.05,P<0.01),肝组织细胞出现明显气球样变性和灶性小泡性脂肪变,脂肪细胞显著增大,有炎细胞聚集灶及纤维组织的增生,固醇调节元件结合蛋白1(SREBP1)和过氧化物酶体增殖物激活受体γ(PPARγ)蛋白表达显著增加(P<0.01),而PPARα蛋白表达明显减少(P<0.05),CLOCK、BMAL1、REV-ERBα和REV-ERBβ蛋白表达明显减少(P<0.05,P<0.01)。与模型组比较,JTXZT-H组可明显下调小鼠TG,TC,LDL-C,HDL-C,AST,ALT,FFA、瘦素含量(P<0.05,P<0.01),JTXZT各组肝组织气球样变性程度及范围明显减轻,肝窦压迫明显减轻,炎细胞浸润及纤维组织增生不明显,SREBP1、PPARγ蛋白表达均明显减少(P<0.05,P<0.01),PPARα蛋白表达显著增加(P<0.01),CLOCK、BMAL1、REV-ERBα和REV-ERBβ蛋白表达明显增多(P<0.05,P<0.01)。结论JTXZT对高脂饮食引起的小鼠代谢相关脂肪性肝病具有显著的改善作用,可能通过上调CLOCK、BMAL1、REV-ERBα和REV-ERBβ蛋白的表达,来调控下游相关脂质代谢蛋白(SREBP1、PPARγ、PPARα)的表达,达到治疗代谢相关脂肪性肝病的作用。

关键词：代谢相关脂肪性肝病降糖消脂片生物钟相关基因

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