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Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome

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Chinese Medical Journal 2019年第8期132卷 889-904页

作者： Zhe Wang Cong-Min xu yi-xuan Liu Xiao-Qi Wang Lu Zhang Mo Li shi-wei Zhu Zhong-jie Xie Pei-Hong Wang Li-Ping duan Huai-Qiu Zhu State Key Laboratory for Turbulence and Complex Systems and Department of Biomedical Engineering College of Engineering Peking University Beijing 100871 China Center for Quantitative Biology Peking University Beijing 100871 China Department of Gastroenterology Peking University Third Hospital Beijing 100191 China

Background:Irritable bowel syndrome(IBS)is reported associated with the alteration of gut microbial composition termed as ***,the pathogenic mechanism of IBS remains unclear,while the studies of Chinese individuals are *** study aimed to understand the concept of dysbiosis among patients with Chinese diarrhea-predominant IBS(IBS-D),as a degree of variance between the gut microbiomes of IBS-D population and that of a healthy ***:The patients with IBS-D were recruited(assessed according to the Rome III criteria,by IBS symptom severity score)from the Outpatient Department of Gastroenterology of Peking University Third Hosp让al,and volunteers as healthy controls(HCs)were enrolled,during *** 16S rRNA sequences were extracted from fecal *** database project resources,basic local alignment search tool,and SparCC software were used to obtain the phylotype composition of samples and the internal interactions of the microbial ***,the non-parametric test,Wilcoxon rank-sum test was carried out to find the statistical significance between HC and IBS-D *** the P values were adjusted to q values to decrease the error ***:The study characterized the gut microbiomes of Chinese patients with IBS-D,and demonstrated that the dysbiosis could be characterized as directed alteration of the microbiome composition leading to greater disparity between relative abundance of two phyla,Bacteroidetes(Z=4.77,q=1.59×10^-5)and Firmicutes(Z=-3.87,q=5.83×10^-4).Moreover,it indicated that the IBS symptom features were associated with the dysbiosis of whole gut microbiome,instead of one or several certain genera even they were *** genera,Bacteroides and Lachnospiracea incertae sedis,were identified as the core genera,meanwhile,the non-core genera contribute to a larger pan-microbiome of the gut ***,the dysbiosis in patients with IBS-D was associated with a reduction of network complexity of

关键词： Irritable bowel syndrome Gut microbiome Dysbiosis Microbial diversity Community network complexity

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Thirty cases of childhood vocal tic disorders treated with acupoint catgut embedding combined with auricular plaster therapy

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World Journal of Acupuncture-Moxibustion 2021年第1期31卷 55-58页

作者： Li-ning duan shi-yu SU yi-feng xu Min LI Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation Guangzhou University of Chinese MedicineGuangzhou 510405China

Objective:To observe the clinical effect of acupoint catgut embedding combined with auricular plaster therapy in the treatment of children with vocal tic ***:Catgut embedding was performed at the acupoints Bǎihuì(百会GV20),Shéntíng(神庭GV24),Dàzhuī(大椎GV14),Shēnzhù(身柱GV12),Fèishū(肺俞BL13),and Wèishū(胃俞BL21),and then auricular plaster sticking was applied to the acupoints Yānhòu(咽喉TG3),Fèi(肺CO14),Wèi(胃CO4),jiāogǎn(交感AH6 a),Pízhìxià(皮质下AT4).Results:After treatment,the Yale Global Tic Severity Scale(YGTSS)scores of the patients were significantly reduced(P<0.05),5 cases were clinically cured,8 cases remarkably effective,12 cases effective,5 cases ineffective,and the total effective rate was 83.33%.Conclusion:Acupoint catgut embedding combined with auricular plaster therapy for vocal tic disorders was effective,being worthy of clinical popularization.

关键词： Children’s vocal tic disorders Acupoint catgut embedding Auricular plaster therapy

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Global trends and hot topics in clinical applications of perovskite materials:a bibliometric analysis

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Biomaterials Translational 2023年第3期4卷 131-141页

作者： Tai-Long shi yi-Fan Zhang Meng-xuan Yao Chao Li Hai-Cheng Wang Chuan ren Jun-Sheng Bai xu Cui wei Chen Department of Orthopaedic Surgery Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Key Laboratory of Biomechanics of Hebei Province ShijiazhuangHebei ProvinceChina NHC Key Laboratory of Intelligent Orthopaedic Equipment ShijiazhuangHebei ProvinceChina Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

In recent years,perovskite has received increasing attention in the medical ***,there has been a lack of related bibliometric analysis in this research *** study aims to analyse the research status and hot topics of perovskite in the medical field from a bibliometric perspective and explore the research direction of *** study collected 1852 records of perovskite research in the medical field from 1983 to 2022 in the Web of Science(WOS)*** country,institution,journal,cited references,and keywords were analysed using CiteSpace,VOS viewer,and Bibliometrix *** number of articles related to perovskite research in the medical field has been increasing every *** and USA have published the most papers and are the main forces in this research *** University of London Imperial College of Science,Technology,and Medicine is the most active institution and has contributed the most *** Applied Materials&Interfaces is the most prolific journal in this field.“Medical electronic devices”,“X-rays”,and“piezoelectric materials”are the most researched directions of perovskite in the medical field.“Performance”,“perovskite”,and“solar cells”are the most frequently used keywords in this *** Materials is the most relevant and academically influential journal for perovskite *** perovskites have been a hot topic in this field in recent years and will be a future research trend.X-ray,electronic medical equipment,and medical stents are the main research directions.

关键词： bibliometrics bibliometrix CiteSpace perovskite R package

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An FPGA‑based trigger system for CshiNE

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Nuclear Science and Techniques 2022年第12期33卷 138-146页

作者： dong Guo Yu‑Hao Qin Sheng Xiao Zhi Qin yi‑jie Wang Fen‑Hai Guan Xin‑Yue Diao Bo‑Yuan Zhang Yao‑Peng Zhang Da‑wei Si shi‑wei xu Xiang‑Lun wei He‑Run Yang Peng Ma Tian‑Li Qiu Hai‑Chuan Zou Li‑Min duan Zhi‑Gang Xiao Department of Physics Tsinghua UniversityBeijing 100084China Institute of Modern Physics Chinese Academy of ScienceLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

A trigger system of the general function was designed using the commercial module of CAEN V2495 for heavy-ion nuclear reaction experiments at Fermi *** system was applied and verified on the compact spectrometer for heavy IoN experiment(CshiNE).Based on the field-programmable logic gate array technology of the command register access and remote computer control operation,trigger functions can be flexibly configured according to experimental physical *** the trigger system on CshiNE,we conducted a beam experiment at 25 MeV/u^(86)Kr+^(124)Sn on the Radioactive Ion Beam Line 1 in Lanzhou,*** online results demonstrated that the trigger system worked normally and *** system can be extended to other experiments as well.

关键词： CshiNE Trigger system FPGA Heavy ion experiment

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基于点着色的无线传感器网络频点分配算法

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传感技术学报 2009年第1期22卷 111-115页

作者：石为人易军许磊黄剑杨硕重庆大学自动化学院重庆400044

无线传感器网络的特点是节点数量多、网络规模大,运算能力有限。针对网络随着载荷增加,数据包碰撞概率增大的情况,提出一种频点分配算法FFD。该算法以点着色理论为基础,结合功率控制,采用分布控制方式,使不同分簇内部采用不同的频点通信... 详细信息

无线传感器网络的特点是节点数量多、网络规模大,运算能力有限。针对网络随着载荷增加,数据包碰撞概率增大的情况,提出一种频点分配算法FFD。该算法以点着色理论为基础,结合功率控制,采用分布控制方式,使不同分簇内部采用不同的频点通信,以避免簇间干扰,降低碰撞概率。在Zigbee 2.4G频段得到三种不同发射功率的频点分配实验结果,并验证了算法能够达到预期指标,同时开销相对较小。

关键词：无线传感器网络频点分配碰撞率分簇结构

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Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA Yan ZHU dong Shan CHEN ren Bo shi Nan Nan LIU Si Hong FAN yi Pin WU Gui hui YANG Pu Ye BAI jiang Feng CHEN Hong CHEN Li ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG jin HUANG Qiu Hua HUANG shao Zhen ji Liang jiN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA hui WANG jing wei SONG Fang Li SUN Sheng WANG dong Ting WANG Ming xuan WANG Xiao Yan WANG yin Zhen WANG Yu dong WU wei WU Lan Ping XIAO Yan Hua XIE Hai Jun xu Hong Ming xu Shou Fang xuE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan ying ZHENG Kai ZHOU ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-Cheng Xiao Qing-Cui Bu jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei jia Fang-Jun Lu Xiang Ma Lian Tao wei Zhang Li Chen Li-Ming Song Ti-Pei Li Yu-Peng xu xue-Lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen yi-Bao Chen Yu-Peng Chen wei Cui wei-wei Cui jing-Kang Deng Yong-wei dong Yuan-Yuan Du Min-xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-dong Gu Ju Guan Cheng-Cheng Guo Da-wei Han jia Huo Lu-Hua jiang wei-Chun jiang jing jin Yong-jie jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li wei Li Xian Li Xiao-Bo Li xu-Fang Li Yang-Guo Li Zheng-wei Li Xiao-Hua Liang jing-Yuan Liao Bai-Sheng Liu Guo-Qing Liu Hong-wei Liu Xiao-jing Liu yi-Nong Liu Bo Lu xue-Feng Lu Qi Luo Tao Luo Bin Meng yi Nang jian-yin Nie Ge Ou Na Sai ren-Cheng Shang Xin-ying Song Liang Sun ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang Ling-Jun Wang weng-Shuai Wang Yu-Sa Wang Xiang-Yang wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo Xiao shao-Lin Xiong He xu jia-wei Yang Sheng Yang Yan-ji Yang yi-Jung Yang Qi-Bin yi Qian-Qing yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang wen-Zhao Zhang yi Zhang yi-Fei Zhang Yong-jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao shi-jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou Yu-xuan Zhu ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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界面摩擦对Kevlar织物吸收冲击能量能力的影响

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玻璃钢／复合材料 2015年第9期 57-63页

作者：史春旭段一平任家骏太原理工大学机械工程学院太原030024

大量实验证明,在弹体对织物的冲击过程中,弹体与纱线之间和纱线与纱线之间的摩擦对织物吸收弹体冲击能量的能力具有显著的影响。已经证明在球型弹体对织物的冲击中,弹体与纱线之间和纱线与纱线之间的摩擦是影响织物吸能特性的重要因素,... 详细信息

大量实验证明,在弹体对织物的冲击过程中,弹体与纱线之间和纱线与纱线之间的摩擦对织物吸收弹体冲击能量的能力具有显著的影响。已经证明在球型弹体对织物的冲击中,弹体与纱线之间和纱线与纱线之间的摩擦是影响织物吸能特性的重要因素,但是在平头弹体对织物的冲击过程中,界面摩擦是如何影响织物吸收冲击能量这一问题还未被研究。本文建立了织物的多尺度三维有限元模型,利用LS-DYNA模拟了平头弹体对四边固定织物的冲击过程。结果表明冲击过程中纱线的动能和势能是主要吸能机制,通过摩擦消耗的能量不是主要的吸收能量的机制,但是摩擦能够间接影响织物的吸能特性,较小的摩擦有助于促进纱线之间的相互运动和作用,同时能够增加弹体和织物相互作用的时间,有助于提高织物吸收能量的能力;弹体与纱线之间的摩擦对织物吸能特性的影响很小,纱线与纱线之间的摩擦在冲击过程中对织物吸能特性的影响起主要作用。

关键词：冲击织物摩擦能量吸收

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Mo含量对高等级管线钢相变行为及组织和性能的影响

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金属热处理 2021年第5期46卷 1-8页

作者：段贺单以银杨柯史显波严伟任毅中国科学院金属研究所辽宁沈阳110016 中国科学技术大学材料科学与工程学院辽宁沈阳230000 海洋装备用金属材料及其应用国家重点实验室辽宁鞍山114009

通过调整一种高强韧管线钢中的Mo含量,研究Mo含量对动态相变规律的影响。在相同热机械控制轧制(TMCP)工艺下,比较Mo含量为0.2%和0.3%的两种钢的强度和韧性的差异,通过光学显微镜、EBSD、TEM等手段研究两种钢的复杂针状铁素体组织,并对... 详细信息

通过调整一种高强韧管线钢中的Mo含量,研究Mo含量对动态相变规律的影响。在相同热机械控制轧制(TMCP)工艺下,比较Mo含量为0.2%和0.3%的两种钢的强度和韧性的差异,通过光学显微镜、EBSD、TEM等手段研究两种钢的复杂针状铁素体组织,并对组织和性能间的关系进行分析。结果表明:提高Mo含量有利于组织细化和针状铁素体的形成,动态CCT曲线向右下方移动;在相同轧制工艺条件下,0.3%Mo钢具有更高的强度,Mo含量的增加有助于提高沉淀强化和细晶强化的作用,同时增加了贝氏体铁素体(BF)的体积分数和MA岛的尺寸及数密度,并进一步提高了强度;两种钢在大角度晶界比例相同时,0.3%Mo钢的冲击性能较差,MA岛的尺寸和数密度及形状的不规则程度是影响冲击性能的主要因素。

关键词：管线钢 Mo 动态CCT曲线显微组织贝氏体铁素体

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箱梁水化热温度场时效模式及时变应力场

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长安大学学报（自然科学版） 2008年第4期28卷 51-56页

作者：张岗任伟贺拴海许世展宋一凡长安大学公路学院陕西西安710064

针对目前混凝土箱梁0#块在施工控制过程中出现早期裂缝现象,综合考虑混凝土材料特性、混凝土早期抗拉强度、混凝土水化热和对流边界条件的时变效应以及浇注时间的滞后效应,基于三维非稳定温度场理论,给出混凝土水化热温度场时效分析模... 详细信息

针对目前混凝土箱梁0#块在施工控制过程中出现早期裂缝现象,综合考虑混凝土材料特性、混凝土早期抗拉强度、混凝土水化热和对流边界条件的时变效应以及浇注时间的滞后效应,基于三维非稳定温度场理论,给出混凝土水化热温度场时效分析模式。采用大型通用软件对混凝土箱梁0#块水化热温度场和应力场进行三维数值仿真,得到水化热温度场和应力场时程关系曲线,总结了温度场和应力场时变效应规律。数值仿真与实测数据对比结果表明,水化热温度场时效模式更能准确地模拟工程实际。

关键词：桥梁工程混凝土箱梁时效模式水化热温度场时变应力场有限元方法

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