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Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibiton of acylcarnitine in rats

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Chinese Journal of Natural Medicines 2021年第2期19卷 120-133页

作者： ren Huan-Huan NIU Zheng guo rui FU Min LI Hai-Ru ZHANG Xuan-Yu YAO Li Department of Medicinal Chemistry and Natural Medicine Chemistry Department of PharmacognosyCollege of PharmacyHarbin Medical UniversityHarbin 150081China State-Province Key Laboratory of Biomedicine-Pharmaceutics of China Harbin Medical UniversityHarbin 150081China Key Laboratory of Systems Biomedicine(Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China Department of Ultrasound The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China

Pulmonary arterial hypertension(PAH)is a devastating pulmonary circulation disease lacking high-efficiency *** present study aims to decipher the therapeutic mechanism of Rhodiola crenulata,a well-known traditional chinese medicine with cardiopulmonary protection capacity,on PAH by exploiting functional *** rat model with PAH was successfully established for first,following Rhodiola crenulata water extract(RCE)treatment,then analysis of chemical constituents of RCE was performed,additional morphologic,hemodynamic,echocardiographic measurements were examined,further targeted lipidomics assay was performed to identify differential lipidomes,at last accordingly mechanism assay was done by combining qRT-PCR,Western blot and *** lipidomes were identified and characterized to differentiate the rats with PAH from healthy controls,mostly assigned to acylcarnitines,phosphatidylcholines,sphingomyelin associated with the PAH ***,RCE administration reversed high level of decadienyl-L-carnitine by the modulation of metabolic enzyme CPT1A in mRNA and protein level in serum and lung in the rats with ***,RCE was observed to reduce autophagy,confirmed by significantly inhibited PPARγ,LC3B,ATG7 and upregulated p62,and inactivated LKB1-AMPK signal ***,we accurately identified the constituents in RCE,and delineated the therapeutic mechansim that RCE ameliorated PAH through inhibition of fatty acid oxidation and ***,RCE might be a potential therapeutic medicine with multi-targets characteristics to prevent the progression of *** novel findings pave a critical foundation for the use of RCE in the treatment of PAH.

关键词： Pulmonary arterial hypertension Rhodiola crenulata Target lipidomics Fatty acid oxidation Autophagy

Is Yang-Mills theory unitary in fractional spacetime dimensions?

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 59-64页

作者： Qingjun Jin Ke ren Gang Yang rui Yu Graduate School of China Academy of Engineering Physics Beijing 100193China School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China International Centre for Theoretical Physics Asia-Pacific Hangzhou 310024China School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China Beijing Computational Science Research Center Beijing 100193China

We present concrete evidence that Yang-Mills theory exhibits non-unitarity in non-integer spacetime *** violation of unitarity stems from evanescent operators that,while vanishing in four dimensions,are non-zero in general d *** demonstrate that these evanescent operators lead to the emergence of both negative-norm states and complex anomalous dimensions.

关键词： gauge field theories field theories in dimensions other than four renormalization

A Reducing Iteration Orthogonal Matching Pursuit Algorithm for Compressive Sensing

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Tsinghua Science and Technology 2016年第1期21卷 71-79页

作者： rui Wang Jinglei Zhang Suli ren Qingjuan Li School of Computer and Communication Engineering University of Science and Technology Beijing School of Computer and Control Engineering University of Chinese Academy of Sciences

In recent years, Compressed Sensing（CS） has been a hot research topic. It has a wide range of applications, such as image processing and speech signal processing owing to its characteristic of removing redundant information by reducing the sampling rate. The disadvantage of CS is that the number of iterations in a greedy algorithm such as Orthogonal Matching Pursuit（OMP） is fixed, thus limiting reconstruction ***, in this study, we present a novel Reducing Iteration Orthogonal Matching Pursuit（RIOMP） algorithm that calculates the correlation of the residual value and measurement matrix to reduce the number of *** conditions for successful signal reconstruction are derived on the basis of detailed mathematical *** compared with the OMP algorithm, the RIOMP algorithm has a smaller reconstruction error. Moreover, the proposed algorithm can accurately reconstruct signals in a shorter running time.

关键词： compressed sensing signal processing wireless sensor networks

Development characteristics and failure modes of reactivated ancient landslides in the Sichuan–Tibet transportation corridor,China

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Journal of Mountain Science 2023年第12期20卷 3596-3613页

作者： WU rui-an ZHANG Yong-shuang guo Chang-bao ren San-shao YAO Xin LIU Xiao-yi YANG Zhi-hua DU guo-liang Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China China University of Geosciences Beijing 100083China China Aero Geophysical Survey and Remote Sensing Center for Natural Resources Beijing 100083China School of Urban Geology and Engineering Hebei GEO UniversityShijiazhuang 050031China

The risk of reactivated ancient landslides in the Sichuan–Tibet transportation corridor in China is significantly increasing,primarily driven by the intensification of engineering activities and the increased frequency of extreme weather *** escalation has resulted in a considerable number of fatalities and extensive damage to critical engineering ***,the factors contributing to the reactivation and modes of destruction of ancient landslides remain ***,it is imperative to systematically analyze the developmental characteristics and failure modes of reactivated ancient landslides to effectively mitigate disaster *** on a combination of data collection,remote sensing interpretation,and field investigations,we delineated the developmental attributes of typical ancient landslides within the study *** attributes encompass morphological and topographic aspects,material composition,and spatial structure of ancient ***,we identified the key triggers for the reactivation of ancient landslides,including water infiltration,reservoir hydrodynamics,slope erosion,and excavation,by analyzing representative cases in the study *** of ancient landslides is sometimes the result of the cumulative effects of multiple predisposing ***,our investigations revealed that the reactivation of these ancient landslides primarily led to local ***,over extended periods of dynamic action,the entire zone may experience gradual *** categorized the reactivation modes of ancient landslides into three distinct types based on the reactivation sequences:progressive retreat,backward thrusting,and forward pulling–backward *** study is of great significance for us to identify ancient landslides,deepen our understanding of the failure modes and risks of reactivated ancient landslides on the eastern margin of the Tibetan Plateau,and formulate effective disaster prevention and m

关键词： Ancient landslide Reactivation characteristic Triggering factor Failure mode Sichuan-Tibet transportation corridor Eastern Tibetan Plateau

Analytical method for the mechanical response of buried pipeline under the action of strike-slip faulting

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Underground Space 2022年第2期7卷 268-277页

作者： Zhiping Hu Xiang ren Qiyao Wang rui Wang rui Pan School of Civil Engineering Chang’an UniversityXi’an 710061China Institute of Underground Structure and Engineering Chang’an UniversityXi’an 710061China

Buried pipelines are commonly damaged when laid across strike-slip faults,always leading to some level of destruction with fault *** moment of the neutral axis of a pipe section was obtained by integration,and the equations for the bending moment and the bending strain on a pipeline’s section were presented here,based on a trilinear stress–strain *** calculation method for the lateral soil pressure and pipeline’s bending strain near the fault-crossing point was *** soil pressure was regarded as being related to lateral pipeline movement and,for accurate calculation,this part of the pipeline was divided into finite element *** iterative process for solving for pipe bending strain was derived,and the algorithm and program for calculating bending strain and the potential damage position of the pipeline’s sections was compiled based on Matlab *** with finite element method(FEM)results and the current standard method,in the situation of a pipeline being in tension under the action of a strike-slip fault(intersection anglerence value for the strain response analysis of tensile steel pipelines under strike-slip faulting.

关键词： Strike-slip fault Buried pipeline Analytical method Mechanical response

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CR尘肺高千伏摄影图像的质量管理与控制

实用预防医学 2009年第5期16卷 1485-1486页

作者：任瑞国仇正忠刘富英郑志华湖北省十堰市东风职业病防治所湖北十堰442001

目的探讨CR尘肺高千伏摄影图像的质量管理与控制。方法对2000张高千伏胸片按质量标准评价分析。重点分析三级片及废片产生的原因。结果CR高千伏胸片中一级片占76.6%,二级片占21.9%,三级片占1.2%,废片占0.3%。三级片及废片缺陷依序为画... 详细信息

目的探讨CR尘肺高千伏摄影图像的质量管理与控制。方法对2000张高千伏胸片按质量标准评价分析。重点分析三级片及废片产生的原因。结果CR高千伏胸片中一级片占76.6%,二级片占21.9%,三级片占1.2%,废片占0.3%。三级片及废片缺陷依序为画面、位置、伪影、锐利度、对比度。结论采用CR尘肺高千伏摄影,需要注意多个方面的质量管理与控制。

关键词： CR 尘肺高千伏质量管理

Computation of the stability derivatives via CFD and the sensitivity equations

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Acta Mechanica Sinica 2011年第2期27卷 179-188页

作者： guo-Dong Lei Yu-Xin ren Department of Engineering Mechanics Tsinghua University 100084 Beijing China

The method to calculate the aerodynamic stability derivates of aircrafts by using the sensitivity equations is ex- tended to flows with shock waves in this paper. Using the newly developed second-order cell-centered finite volume scheme on the unstructured-grid, the unsteady Euler equations and sensitivity equations are solved simultaneously in a non-inertial frame of reference, so that the aerodynamic stability derivatives can be calculated for aircrafts with complex geometries. Based on the numerical results, behavior of the aerodynamic sensitivity parameters near the shock wave is discussed. Furthermore, the stability derivatives are analyzed for supersonic and hypersonic flows. The numerical results of the stability derivatives are found in good agree- ment with theoretical results for supersonic flows, and variations of the aerodynamic force and moment predicted by the stability derivatives are very close to those obtained by CFD simulation for both supersonic and hypersonic flows.

关键词： Aerodynamic stability derivatives Non-inertial frame of reference unstructured-grid Finite volume scheme Sensitivity equations

Minimum-Cost Forest for Uncertain Multicast with Delay Constraints

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Tsinghua Science and Technology 2019年第2期24卷 147-159页

作者： Bangbang ren Geyao Cheng Deke guo College of Systems Engineering National University of Denfense Technology

The use of multicast transmission can efficiently reduce the consumption of network resources by jointly serving multiple destinations with a single source node. Currently, many multicast applications impose the constraint wherein multicast flows must be processed by a series of Virtual Network Functions(VNFs) before reaching their destinations. Given a multicast transmission, there are usually multiple server nodes, each of which is able to host all the required VNFs. Thus, the multicast flow should be initially steered to one or a few selected server nodes that act as pseudo sources, and the destinations will then retrieve new flow from any of these pseudo *** this paper, we model this kind of multicast as an uncertain multicast with multiple pseudo sources, whose routing structure is usually a forest consisting of multiple isolated trees. We then characterize and construct the Delay-guaranteed Minimum Cost Forest(D-MCF) such that each path from the source to the destination satisfies the end-to-end delay constraint. To tackle this NP-hard problem, we design two efficient methods, the Partition Algorithm(PA) and the Combination Algorithm(CA), to approximate the optimal solution. Theoretical analyses and evaluations indicate that these two methods can generate the desired routing forest for any multicast ***, the PA method achieves a better balance between performance and time consumption than the CA method. The evaluation results show that PA-(Ω+20) can reduce total cost by 49:02% while consuming 12:59% more time, thus significantly outperforming the CA-(Ω+20) method.

关键词： uncertain multicast network function virtualization delay guaranteed

Design of a prediction system based on the dynamical feed-forward neural network

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Science China(Information Sciences) 2023年第1期66卷 43-59页

作者： Xiaoxiang guo Weimin HAN Jingli ren Henan Academy of Big Data Zhengzhou University Department of Mathematics University of Iowa

Analysis and prediction of time series play a significant role in scientific fields of meteorology,epidemiology, and economy. Efficient and accurate prediction of signals can give an early detection of abnormal variations, provide guidance on preparing a timely response and avoid presumably adverse *** this paper, a prediction system is designed based on the dynamical feed-forward neural network. The trajectory information in the reconstructed phase space, which is topologically equivalent to the dynamical evolution of the system, is applied to establish the prediction model. Moreover, an integer constrained particle swarm optimization algorithm is employed to select the optimal time delay, which is the parameter of our system. Simulation results for applications on the Lorenz system, stock market index, and influenza data indicate that our proposed method can produce efficient and reliable predictions.

关键词： prediction system phase space reconstruction topological equivalence dynamical feed-forward neural network integer constrained particle swarm optimization algorithm