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Fecal microbiota transplantation:whole grain highland barley improves glucose metabolism by changing gut microbiota

Food Science and Human Wellness 2024年第4期13卷 2014-2024页

作者： xin ren Fulong Zhang Min Zhang Yuan Fang Zenglong Chen Meili Huan Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Grain Industry Highland Barley Deep Processing Technology Innovation CenterBeijing Technology and Business UniversityBeijing 100048China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China COFCO Nutrition and Health Research Institute Beijing 102209China

Highland barley(HB)is a high-altitude cereal with rich nutritional components and potential health *** clarify its hypoglycemic effect and mechanism,we investigated the effect of whole grain HB and fecal microbiota transplantation(FMT)on glucose metabolism and gut microbiota in high-fat diet and streptozotocin(HFD/STZ)-induced diabetic *** results showed that HB(40%)significantly decreased fasting blood glucose and the area under the glucose tolerance curve,significantly increased insulin secretion and improved insulin resistance in HFD/STZ-induced diabetic mice(P<0.05).Inflammatory factors and blood lipid indices were also significantly alleviated after 12 weeks of 40%HB intervention(P<0.05).Additionally,beneficial bacteria,such as Bifidobacterium and Akkermansia,were significantly enriched in the gut of diabetic mice after whole grain HB ***,the results of further FMT experiments verified that the fecal microbiota after the 40%HB intervention not only significantly increased the relative abundance of Bifidobacterium and Akkermansia but also effectively improved glucose metabolism and alleviated the inflammatory state in HFD/STZ-induced diabetic ***,our study confirmed the bridge role of gut microbiota in improving glucose metabolism of whole grain HB,which could promote the development of precision nutrition.

关键词： Highland barley Diabetes Glucose metabolism Gut microbiota Fecal bacteria transplantation

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Rotating Massive Strangeon Stars and X-Ray Plateau of Short GRBs

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Research in Astronomy and Astrophysics 2024年第3期24卷 47-57页

作者： Xi-Yan Yang Xiao-Yu Lai Wei-Wei Tan ren-xin Xu School of Physics and Optoelectronic Engineering Yangtze UniversityJingzhou 434023China Research Center for Astronomy Hubei University of EducationWuhan 4300205China Key Laboratory of Quark and Lepton Physics Central China Normal UniversityMinistry of EducationWuhan 430079China School of Physics Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

Strangeon stars,which are proposed to describe the nature of pulsar-like compact stars,have passed various observational *** maximum mass of a non-rotating strangeon star could be high,which implies that the remnants of binary strangeon star mergers could even be long-lived massive strangeon *** study rigidly rotating strangeon stars in the slowly rotating approximation,using the Lennard-Jones model for the equation of *** can significantly increase the maximum mass of strangeon stars with unchanged baryon numbers,enlarging the mass-range of long-lived strangeon *** spin-down after merger,the decrease of radius of the remnant will lead to the release of gravitational *** into account the efficiency of converting the gravitational energy luminosity to the observed X-ray luminosity,we find that the gravitational energy could provide an alternative energy source for the plateau emission of X-ray *** fitting results of X-ray plateau emission of some short gamma-ray bursts suggest that the magnetic dipole field strength of the remnants can be much smaller than that of expected when the plateau emission is powered only by spin-down luminosity of magnetars.

关键词： dense matter-(stars) pulsars general-(stars) gamma-ray burst general

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High-Performance and Large-Area Inverted Perovskite Solar Cells Based on NiO_(x) Films Enabled with A Novel Microstructure-Control Technology

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Energy & Environmental Materials 2024年第1期7卷 153-159页

作者： Guibin Shen xin Li Yuqin Zou Hongye Dong Dongping Zhu Yanglin Jiang xin ren Ng Fen Lin Peter Müller-Buschbaum Cheng Mu Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of ChemistryRenmin University of ChinaBeijing 100872China Solar Energy Research Institute of Singapore(SERIS) National University of SingaporeSingapore 117574Singapore Physik-Department Lehrstuhl für Funktionelle MaterialienTechnische Universität MünchenJames-Franck-Straße 185748Garching Germany Heinz Maier-Leibnitz Zentrum(MLZ) Technische Universität MünchenLichtenbergstr.185748Garching Germany

The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite *** this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination *** synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite ***,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.

关键词： interfacial contact inverted and large-area perovskite solar cells photovoltaic materials porous NiO_(x)films renewable energy

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Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

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Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min Song xin Jin Zhong Luo Shu-Gen Liu Shao-Bo Liu xing-Zhi Ma Zhi-Wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-xin ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan Basin The Member Deng-2 Marginal microbial mound-bank complex Depositional model Exploration implications

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The AMPK and AKT/GSK3β pathways are involved in recombinant proteins fibroblast growth factor 1(rFGF1 and rFGF1a) improving glycolipid metabolism in rainbow trout(Oncorhynchus mykiss) fed a high carbohydrate diet

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Animal Nutrition 2024年第2期17卷 11-24页

作者： Huixia Yu Shuo Geng Shuai Li Yingwei Wang xin ren Debin Zhong Haolin Mo Mingxing Yao Jiajia Yu Yang Li Lixin Wang College of Animal Science and Technology Northwest A&F University Meixian Aquaculture Farm of Shitouhe Reservoir Administration

Fibroblast growth factor 1(FGF1) regulates vertebrate cell growth, proliferation and differentiation, and energy metabolism. In this study, we cloned rainbow trout(Oncorhynchus mykiss) fgf1 and fgf1a, prepared their recombinant proteins(rFGF1 and rFGF1a), and described the molecular mechanisms by which they improve glycolipid metabolism in carnivorous fish. A 31-d feeding trial was conducted to investigate whether they could enhance glycolipid metabolism in rainbow trout on high-carbohydrate diets(HCD). A total of 720 rainbow trout(8.9 ± 0.5 g) were equally divided into 4 groups: the chow diet(CD) group injected with PBS, the HCD group injected with PBS, the HCD group injected with rFGF1(400 ng/g body weight), and the HCD group injected with rFGF1a(400 ng/g body weight). The results showed that short-term HCD had a significant positive effect on the specific growth rate(SGR) of rainbow trout(P < 0.05). However, it led to an increase in crude fat, serum triglyceride(TG) and glucose content, as well as serum glutamic pyruvic transaminase(GPT) and glutamic oxalacetic transaminase(GOT) contents(P < 0.05), suggesting a negative health effect of HCD. Nevertheless, rFGF1 and rFGF1a showed beneficial therapeutic effects. They significantly reduced the crude fat content of the liver, serum TG, GOT, and GPT contents caused by HCD(P < 0.05). The upregulation in atgl, hsl, and acc2 m RNAs implied the promotion of TG catabolism. Moreover, rFGF1 and rFGF1a contributed to promoting lipolysis by activating the AMPK pathway and reducing lipid accumulation in the liver caused by HCD. In addition,the rFGF1 and r FGF1a-treated groups significantly reduced serum glucose levels and elevated hepatic glycogen content under HCD, and increased glucose uptake by hepatocytes. We observed a decrease in mRNA levels for pepck, g6pase, and pygl, along with an increase in mRNA levels for gys, glut2, and gk in the liver. Furthermore, these proteins regulated hepatic gluconeogenesis and glycogen synt

关键词： Rainbow trout Recombinant proteins Fibroblast growth factor 1 Glycogen synthesis Lipid deposition

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Self-assembled monolayers(SAMs)in inverted perovskite solar cells and their tandem photovoltaics application

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Interdisciplinary Materials 2024年第2期3卷 203-244页

作者： Zijun Yi xin Li Yuchen Xiong Guibin Shen Wenguang Zhang Yihuai Huang Qinghui Jiang xin ren Ng Yubo Luo Jianghui Zheng Wei Lin Leong Fan Fu Tongle Bu Junyou Yang State Key Laboratory of Material Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhanChina China‐Eu Institute for Clean and renewable Energy Huazhong University of Science and TechnologyWuhanChina School of Electrical and Electronic Engineering Nanyang Technological UniversitySingaporeSingapore Department of Chemistry National University of SingaporeSingaporeSingapore School of Physics The University of SydneySydneyNew South WalesAustralia Laboratory for Thin Films and Photovoltaics Empa‐Swiss Federal Laboratories for Materials Science and TechnologyDübendorfSwitzerland State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhanChina

Self-assembled monolayers(SAMs)employed in inverted perovskite solar cells(PSCs)have achieved groundbreaking progress in device efficiency and stability for both single-junction and tandem configurations,owing to their distinctive and versatile ability to manipulate chemical and physical interface *** this regard,we present a comprehensive review of recent research advancements concerning SAMs in inverted perovskite singlejunction and tandem solar cells,where the prevailing challenges and future development prospects in the applications of SAMs are *** thoroughly examine the mechanistic roles of diverse SAMs in energy-level regulation,interface modification,defect passivation,and charge *** is achieved by understanding how interfacial molecular interactions can be finely tuned to mitigate charge recombination losses in inverted *** this comprehensive review,we aim to provide valuable insights and references for further investigation and utilization of SAMs in inverted perovskite single‐junction and tandem solar cells.

关键词： inverted perovskite solar cells power conversion efficiency self-assembled monolayers tandem

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海绵城市建设项目施工及运维规程的编制思考

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中国给水排水 2024年第12期40卷 49-56页

作者：蔡志文杨晨任心欣深圳市城市规划设计研究院股份有限公司广东深圳518028

针对施工精细程度不够、技术人员难以理解运维要点和操作性差以及质量评价体系缺失等问题,深圳市组织编制了《深圳市海绵城市建设项目施工、运行维护技术规程》(DB 4403/T 25—2019)。结合规程的总体构思、主要特点以及实践效果,重点介... 详细信息

针对施工精细程度不够、技术人员难以理解运维要点和操作性差以及质量评价体系缺失等问题,深圳市组织编制了《深圳市海绵城市建设项目施工、运行维护技术规程》(DB 4403/T 25—2019)。结合规程的总体构思、主要特点以及实践效果,重点介绍了海绵城市建设项目的施工及运行维护责任主体、施工运维质量评价及风险管控体系、项目层级的运行维护管理要求。该规程弥补了海绵城市建设在施工以及运行维护领域中的标准缺失,其实施进一步提高了政府牵头落实、多方主体参与的海绵城市建设落地效果,有利于海绵城市从高质量规划到高质量建成项目的转变。

关键词：海绵城市技术规程运行维护评价体系风险管控体系

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农村人居环境与经济协调发展的时空演化及障碍因素研究

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生态经济 2024年第7期40卷 184-195页

作者：陈弘任鑫湖南农业大学公共管理与法学学院湖南长沙410128

农村人居环境与经济协调发展是构筑宜居宜业和美乡村的关键问题。论文基于耦合协调度、空间自相关与障碍度等模型,分析2013—2021年我国省域农村人居环境与经济协调发展的时空演化规律及障碍因素。研究表明:(1)农村人居环境与经济发展... 详细信息

农村人居环境与经济协调发展是构筑宜居宜业和美乡村的关键问题。论文基于耦合协调度、空间自相关与障碍度等模型,分析2013—2021年我国省域农村人居环境与经济协调发展的时空演化规律及障碍因素。研究表明:(1)农村人居环境与经济发展水平整体呈同步上升的相对发展关系,但省域间差异明显。(2)农村人居环境与经济耦合协调发展在时序上呈现从“勉强协调”迈向“初级协调”的两阶段上升规律,且空间均衡格局逐渐显现,空间关联具有东部H-H集聚和西部L-L集聚特征。(3)农村人居环境与经济耦合协调发展的障碍度由高至低为:基础设施、居住条件、公共服务、经济规模、生态环境、生活水平、生产条件、产业结构,且不同农村地区的障碍因素具有各自的比较优劣势。应从人居环境与经济协调发展的要素长效投入、时空均衡联动与障碍度优劣比较方面精准施策。

关键词：农村人居环境农村经济耦合协调发展时空演化障碍因素

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考虑模糊多目标优化的风电场无功电压分区控制

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动力工程学报 2024年第1期44卷 99-108页

作者：王玮杨健任国瑞任鑫王华华北电力大学控制与计算机工程学院北京102206 中国华能集团清洁能源技术研究院有限公司北京102209

为提升双馈风电场的无功功率补偿和电压稳定能力,提出了一种考虑模糊多目标优化的风电场无功电压分区控制方法。基于有功功率数据对风电场进行分区降维,并计算获得了各分区的无功优化限值;定义了分区无功裕度指标用以描述风电场电压运... 详细信息

为提升双馈风电场的无功功率补偿和电压稳定能力,提出了一种考虑模糊多目标优化的风电场无功电压分区控制方法。基于有功功率数据对风电场进行分区降维,并计算获得了各分区的无功优化限值;定义了分区无功裕度指标用以描述风电场电压运行的安全裕度,综合考虑运行安全性和稳定性,建立了风电场无功电压的模糊多目标优化模型;提出了一种可大范围全局快速寻优的自适应遗传禁忌算法,通过重新定义交叉与变异概率提升了寻优的全局时效性,通过引入禁忌算法改善了寻优准确性。最后,以某双馈风电场为例进行了仿真验证。结果表明:所提方法能够为风电场预留充足的无功裕度,显著降低系统内部的电压波动。

关键词：风电场无功电压分区控制多目标自适应遗传禁忌算法

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Omics-imaging signature-based nomogram to predict the progression-free survival of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization

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World Journal of Clinical Cases 2024年第18期12卷 3340-3350页

作者： Qing-Long Guan Hai-Xiao Zhang Jun-Peng Gu Geng-Fei Cao Wei-xin ren Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous regionChina Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Enhanced magnetic resonance imaging(MRI)is widely used in the diagnosis,treatment and prognosis of hepatocellular carcinoma(HCC),but it can not effectively reflect the heterogeneity within the tumor and evaluate the effect after *** imaging analysis of voxel changes can effectively reflect the internal heterogeneity of the tumor and evaluate the progression-free survival(PFS).AIM To predict the PFS of patients with HCC before operation by building a model with enhanced MRI *** Delineate the regions of interest(ROI)in arterial phase,portal venous phase and delayed phase of enhanced *** extracting the combinatorial features of ROI,the features are fused to obtain deep learning radiomics(DLR)_***'s test was used to evaluate the diagnostic performance of different typological features.K-M analysis was applied to assess PFS in different risk groups,and the discriminative ability of the model was evaluated using the *** Tumor diameter and diolame were independent factors influencing the prognosis of ***'s test revealed multi-phase combined radiomic features had significantly greater area under the curve values than did those of the individual phases(Prences were observed between the multi-phase and individual phases feature sets(P<0.05).K-M survival analysis revealed a median survival time of high risk group and low risk group was 12.8 and 14.2 months,respectively,and the predicted probabilities of 6 months,1 year and 2 years were 92%,60%,40%and 98%,90%,73%,*** C-index was 0.764,indicating relatively good consistency between the predicted and observed *** and DLR have higher predictive value for 2-year PFS in *** Based on the multi-temporal characteristics of enhanced MRI and the constructed Nomograph,it provides a new strategy for predicting the PFS of transarterial chemoembolization treatment of HCC.

关键词： Magnetic resonance imaging Radiomics Deep learning Progression-free survival Transcatheter arterial chemoembolization Hepatocellular carcinoma

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