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Marine red yeast supplementation improves laying performance by regulating small intestinal homeostasis in aging chickens

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Animal Nutrition 2024年第3期18卷 177-190页

作者： Yudian Zhao Sujin Si Yangguang ren Xing Wu Zihao Zhang Yixiang Tian Jing Li Yijie Li meng Hou Xueyang yao Zhaoheng Xu Ruirui Jiang Xiangtao Kang Yujie Gong Qiang Li Yadong Tian College of Animal Science and Technology Henan Agricultural UniversityZhengzhou 450046China Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources Zhengzhou 450046China Henan College of Animal Husbandry and Economics Zhengzhou 450046China College of Animal Science and Veterinary Medicine Henan Institute of Science and TechnologyXinxiang 453003China AB Vista Marlborough SN84ANUK

Recent studies have shown that age-related aging evolution is accompanied by imbalances in intestinal *** red yeast(MRY)is a functional probiotic that has been shown to have antioxidant,immune and other ***,we chose 900 healthy Hy-Line Brown hens at 433 d old as the research subjects and evaluated the correlation between intestinal health,laying performance,and egg quality in aged hens through the supplementation of *** laying hens were assigned into 5 groups and received diet supplementation with 0%,0.5%,1.0%,1.5%,and 2%MRY for 12 *** results showed that MRY supplementation increased egg production rate,average egg weight,and egg quality,and decreased feed conversion ratio and daily feed intake(P<0.05).The MRY supplement improved antioxidant indicators such as superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),stimulated villus height,and increased the villus height to crypt depth ratio(V/C ratio)in the intestine(P<0.05).It also regulated the expression of intestinal inflammatory factors(transforming growth factor-β[TGF-β],interleukin[IL]-1β,IL-8,tumor necrosis factor-α[TNF-α])while increasing serum immunoglobulin G(IgG)levels(P<0.05).Furthermore,MRY supplementation upregulated the mRNA expression of tight junction proteins(occludin and zonula occludens-1[ZO-1]),anti-apoptotic gene(Bcl-2),and autophagy-related proteins(beclin-1 and light chain 3I[LC3I])in the intestine(P<0.05).The MRY supplement also led to an increase in the concentration of short-chain fatty acids in the cecum,and the relative abundance of the phylum Bacteroidetes,and genera Bacteroides and Rikenellaceae_RC9_gut_*** LEfSe analysis revealed an enrichment of Sutterella and Akkermansia *** conclusion,the results of this experiment indicated that the additional supplementation of MRY can improve the production performance of laying hens and may contribute to the restoration and balance of intestinal homeostasis,which sup

关键词： Marine red yeast Laying hen Senescence Intestinal homeostasis

Evolution of the porous structure for phosphoric acid etching carbon as cathodes in Li–O_(2) batteries:Pyrolysis temperature-induced characteristics changes

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Carbon Energy 2024年第1期6卷 172-181页

作者： Feiyang Yang Ying yao Yunkai Xu Cong Wang Meiling Wang Jingjie ren Cunzhong Zhang Feng Wu Jun Lu Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Beijing Institute of Technology Chongqing Innovation Center ChongqingChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina

Although biomass-derived carbon(biochar)has been widely used in the energy field,the relation between the carbonization condition and the physical/chemical property of the product remains ***,we revealed the carbonization condition's effect on the morphology,surface property,and electrochemical performance of the obtained *** open slit pore structure with shower-puff-like nanoparticles can be obtained by finely tuning the carbonization temperature,and its unique pore structure and surface properties enable the Li–O_(2) battery with cycling longevity(221 cycles with 99.8%Coulombic efficiency at 0.2 mA cm^(−2) and controlled discharge–charge depths of 500 mAh g^(−1))and high capacity(16,334 mAh g^(−1) at 0.02 mA cm^(−2)).This work provides a greater understanding of the mechanism of the biochar carbonization procedure under various pyrolysis conditions,paving the way for future study of energy storage devices.

关键词： biomass Li-O_(2) battery oxygen catalysts porous carbon temperature parameters

Study on TCM intervention of NF-κB signal pathway in the treatment of bronchial asthma

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Journal of Hainan Medical University 2022年第21期28卷 68-72页

作者： LAI Hai-yan YI Wei DENG Kun LONG Juan ren meng-yao QIAO Yun ZHOU Bei LI Wei-wei The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530299China Graduate School of Guangxi University of Chinese Medicine Nanning 530000China College of Acupuncture-Moxibustion and Tuina Guangxi University of Chinese MedicineNanning 530299China College of Pharmacy Guangxi University of Chinese MedicineNanning 530299China

Bronchial asthma(asthma for short)is a common chronic respiratory disease inchildren,which has adverse effects on children's physical and mental *** factorκB(NF-κB)signaling pathway is an important transcription factor in airway inflammation,and plays an important role in airway inflammation and airway remodeling in *** studies have found that traditional Chinese medicine has positive effects in the treatment of ***,this paper aims to review the literatures on the treatment of asthma through traditional Chinese medicine compound and single herbs and extracts by regulating the NF-κB signaling pathway for nearly a *** is found that traditional Chinese medicine can inhibit airway inflammation,relieve airway smooth muscle spasm and reduce airway resistance through the regulation of NF-κB signaling pathway,so as to play a key role in the treatment of asthma,and provide a scientific basis for the treatment of asthma with traditional Chinese medicine.

关键词： Bronchial asthma NF-κB Traditional Chinese medicine Research overview

Combining systemic inflammatory response index and albumin fibrinogen ratio to predict early serious complications and prognosis after resectable gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 732-749页

作者： Jing-yao ren Da Wang Li-Hui Zhu Shuo Liu Miao Yu Hui Cai School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui Autonomous RegionChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina The First Clinical Medical School Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Gastric cancer has a high incidence and fatality rate,and surgery is the preferred course of ***,patient survival rates are still low,and the incidence of major postoperative complications cannot be *** systemic inflammatory response,nutritional level,and coagulation status are key factors affecting the postoperative recovery and prognosis of gastric cancer *** systemic inflammatory response index(SIRI)and the albumin fibrinogen ratio(AFR)are two valuable comprehensive indicators of the severity and prognosis of systemic inflammation in various medical *** To assess the clinical importance and prognostic significance of the SIRI scores and the AFR on early postoperative outcomes in patients undergoing radical gastric cancer *** We conducted a retrospective analysis of the clinicopathological characteristics and relevant laboratory indices of 568 gastric cancer patients from January 2018 to December *** calculated and compared two indicators of inflammation and then examined the diagnostic ability of combined SIRI and AFR values for serious early postoperative *** scored the patients and categorized them into three groups based on their SIRI and AFR *** analysis was used to compare the three groups of patients the prognostic value of various preoperative SIRI-AFR scores for 5-year overall survival(OS)and disease-free survival(DFS).RESULTS SIRI-AFR scores were an independent risk factor for prognosis[OS:P=0.004;hazards ratio(HR)=3.134;DFS:P<0.001;HR=3.543]and had the highest diagnostic power(area under the curve:0.779;95%confidence interval:0.737-0.820)for early serious complications in patients with gastric *** tumor-node-metastasis stage(P=0.001),perioperative transfusion(P=0.044),positive carcinoembryonic antigen(P=0.014)findings,and major postoperative complications(P=0.011)were factors associated with *** Preoperative SIRI and AFR values were s

关键词： Inflammation Albumin fibrinogen ratio Gastric cancer Complications Prognosis

Multiple valence states of Fe boosting SERS activity of Fe_(3)O_(4) nanoparticles and enabling effective SERS-MRI bimodal cancer imaging

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Fundamental Research 2024年第4期4卷 858-867页

作者： Jie Lin Xuehua Ma Anran Li Ozioma Udochukwu Akakuru Chunshu Pan meng He Chenyang yao Wenzhi ren Yanying Li Dinghu Zhang Yi Cao Tianxiang Chen Aiguo Wu Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science Key Laboratory of Magnetic Materials and DevicesZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo315201China School of Engineering Medicine Key Laboratory of Big Data-Based Precision Medicine(Beihang University)Ministry of Industry and Information TechnologyBeihang UniversityBeijing100191China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Bejing 100049China

Developing novel nanoparticle-based bioprobes utilized in clinical settings with imaging resolutions ranging from cell to tissue levels is a major challenge for tumor diagnosis and ***,an optimized strategy for designing a Fe_(3)O_(4)-based bioprobe for dual-modal cancer imaging based on surface-enhanced Raman scattering(SERS)and magnetic resonance imaging(MRI)is *** SERS activity of ultrasmall Fe_(3)O_(4) nanoparticles(NPs)was discovered,and a 5×10^(-9)M limit of detection for crystal violet molecules was successfully *** high-efficiency interfacial photon-induced charge transfer in Fe_(3)O_(4) NPs was promoted by multiple electronic energy levels ascribed to the multiple valence states of Fe,which was observed using ultraviolet-visible diffuse reflectance *** functional theory calculations were utilized to reveal that the narrow band gap and high electron density of states of ultrasmall Fe_(3)O_(4) NPs significantly boosted the vibronic coupling resonances in the SERS system upon *** subtypes of cancer cells were accurately recognized via high-resolution SERS imaging in vitro using the prepared Feg Og-based bioprobe with high sensitivity and good ***,Fe_(3)O_(4)-based bioprobes simultaneously exhibited T,-weighted MRI contrast enhancement with an active targeting capability for tumors in *** the best of our knowledge,this is the first report on the use of pure semiconductor-based SERS-MRI dual-modal nanoprobes in tumor imaging in vivo and in vitro,which has been previously realized only using semiconductor-metal complex *** non-metallic materials with SERS-MRI dual-modal imaging established in this report are a promising cancer diagnostic platform,which not only showed excellent performance in early tumor diagnosis but also possesses great potential for image-guided tumor treatment.

关键词： Fe_(3)O_(4)NPs SERS-MRI dual-modal nanoprobes PICT Multiple valence states Cancer diagnosis

Fusarium mycotoxins:The major food contaminants

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mLife 2024年第2期3卷 176-206页

作者： Zheng Qu Xianfeng ren Zhaolin Du Jie Hou Ye Li Yanpo yao Yi An Agro‐Environmental Protection Institute Ministry of Agriculture and Rural AffairsTianjinChina Institute of Quality Standard and Testing Technology for Agro‐Products Shandong Academy of Agricultural SciencesJinanChina

Mycotoxins,which are secondary metabolites produced by toxicogenic fungi,are natural food toxins that cause acute and chronic adverse reactions in humans and *** genus Fusarium is one of three major genera of mycotoxin‐producing ***,fumonisins,and zearalenone are the major Fusarium mycotoxins that occur *** mycotoxins have the potential to infiltrate the human food chain via contamination during crop production and food processing,eventually threatening human *** occurrence and development of Fusarium mycotoxin contamination will change with climate change,especially with variations in temperature,precipitation,and carbon dioxide *** address these challenges,researchers have built a series of effective models to forecast the occurrence of Fusarium mycotoxins and provide guidance for crop *** mycotoxins frequently exist in food products at extremely low levels,thus necessitating the development of highly sensitive and reliable detection *** successful detection methods have been developed to meet the requirements of various situations,and an increasing number of methods are moving toward highthroughput *** Fusarium mycotoxins cannot be completely eliminated,numerous agronomic,chemical,physical,and biological methods can lower Fusarium mycotoxin contamination to safe levels during the preharvest and postharvest *** theoretical innovations and technological advances have the potential to facilitate the development of comprehensive strategies for effectively managing Fusarium mycotoxin contamination in the future.

关键词： climate change Fusarium mycotoxin management strategy mycotoxin detection

A Selective‑Response Hypersensitive Bio‑Inspired Strain Sensor Enabled by Hysteresis Effect and Parallel Through‑Slits Structures

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Nano-Micro Letters 2024年第2期16卷 139-153页

作者： Qun Wang Zhongwen yao Changchao Zhang Honglie Song Hanliang Ding Bo Li Shichao Niu Xinguan Huang Chuanhai Chen Zhiwu Han Luquan ren Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China Liaoning Academy of Materials LiaoningShenyang 110167People’s Republic of China Key Laboratory of CNC Equipment Reliability(Ministry of Education) Jilin UniversityChangchunJilin 130022People’s Republic of China

Flexible strain sensors are promising in sensing minuscule mechanical signals,and thereby widely used in various advanced ***,the effective integration of hypersensitivity and highly selective response into one flexible strain sensor remains a huge ***,inspired by the hysteresis strategy of the scorpion slit receptor,a bio-inspired flexible strain sensor(BFSS)with parallel through-slit arrays is designed and ***,BFSS consists of conductive monolayer graphene and viscoelastic styrene–isoprene–styrene block *** the synergistic effect of the bio-inspired slit structures and flexible viscoelastic materials,BFSS can achieve both hypersensitivity and highly selective frequency ***,the BFSS exhibits a high gage factor of 657.36,and a precise identification of vibration frequencies at a resolution of 0.2 Hz through undergoing different morphological changes to high-frequency vibration and low-frequency ***,the BFSS possesses a wide frequency detection range(103 Hz)and stable durability(1000 cycles).It can sense and recognize vibration signals with different characteristics,including the frequency,amplitude,and *** work,which turns the hysteresis effect into a"treasure,"can provide new design ideas for sensors for potential applications including human–computer interaction and health monitoring of mechanical equipment.

关键词： Bio-inspired strain sensors Hysteresis effect Hypersensitivity Selective frequency response Health monitoring applications

Tb^(3+)-nucleic acid probe-based label-free and rapid detection of mercury pollution in food

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Food Science and Human Wellness 2024年第2期13卷 993-998页

作者： Xuhan Xia Chenxi Zhou Yulin Zhu Yi Dong Qiang He Mohammad Rizwan Khan Yuanlong Chi Rosa Busquets Ruijie Deng yao ren College of Biomass Science and Engineering Healthy Food Evaluation Research CenterSichuan UniversityChengdu 610065China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia School of Life Sciences Pharmacy and ChemistryKingston University LondonKingston Upon Thames KT12EEUK

Mercury is a threatening pollutant in food,herein,we developed a Tb^(3+)-nucleic acid probe-based label-free assay for mix-and-read,rapid detection of mercury *** assay utilized the feature of light-up fluorescence of terbium ions(Tb^(3+))via binding with single-strand *** ion,Hg^(2+)induced thymine(T)-rich DNA strand to form a double-strand structure(T-Hg^(2+)-T),thus leading to fluorescence *** on the principle,Hg^(2+)can be quantified based on the fluorescence of Tb^(3+),the limit of detection was 0.0689μmol/L and the linear range was 0.1-6.0μmol/*** to the specificity of T-Hg^(2+)-T artificial base pair,the assay could distinguish Hg^(2+)from other metal *** recovery rate was ranged in 98.71%-101.34%for detecting mercury pollution in three food *** assay is low-cost,separation-free and mix-to-read,thus was a competitive tool for detection of mercury pollution to ensure food safety.

关键词： Mercury pollution Food safety Nucleic acid probe Label-free Terbium

Beyond ribosomal function:RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3931-3948页

作者： Wenkang Fu Yanyan Lin Mingzhen Bai Jia yao Chongfei Huang Long Gao Ningning Mi Haidong Ma Liang Tian Ping Yue Yong Zhang Jinduo zhang Yanxian ren Liyun Ding Lunzhi Dai Joseph WLeung Jinqiu Yuan Wenhua Zhang Wenbo meng The First School of Clinical Medicne Lanzhou UniversityLanzhou 730030China Department of General Surgery the First Hospital of Lanzhou UniversityLanzhou 730030China Key Laboratory of Biotherapy and Regenerative Medicine of Gansu Province the First Hospital of Lanzhou UniversityLanzhou 730000China School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China National Clinical Research Center for Geriatrics and Department of General Practice State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Division of Gastroenterology UC Davis Medical Center and Sacramento VA Medical CenterSacramentoCA 95817USA Clinical Research Center Big Data Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China School of Life Sciences Lanzhou UniversityLanzhou 730000China

Cholangiocarcinoma(CCA)is a bile duct malignancy with a dismal *** study systematically investigated the role of the ribosomal protein S6(RPS6)gene,which is dependent in *** found that RPS6 upregulation in CCA tissues was correlated with a poor *** investigations have shown that alterations in RPS6 expression,both gain-and loss-of function could affect the proliferation of CCA *** xenograft tumor models,RPS6 overexpression enhances tumorigenicity,whereas RPS6 silencing reduces *** analysis using RNA-seq and proteomics elucidated downstream signaling pathways of RPS6 depletion by affecting the cell cycle,especially DNA *** followed by mass spectrometry has identified numerous spliceosome complex proteins associated with *** profiling revealed that RPS6 affects numerous alternative splicing(AS)events,and combined with RNA immunoprecipitation sequencing,revealed that minichromosome maintenance complex component 7(MCM7)binds to RPS6,which regulates its AS and increases oncogenic activity in *** RPS6 with vivo phosphorodiamidate morpholino oligomer(V-PMO)significantly inhibited the growth of CCA cells,patient-derived organoids,and subcutaneous xenograft *** together,the data demonstrate that RPS6 is an oncogenic regulator in CCA and that RPS6-V-PMO could be repositioned as a promising strategy for treating CCA.

关键词： Cholangiocarcinoma Ribosomal protein S6 Alternative splicing p53 Minichromosome maintenance complex component 7 Vivo morpholino Patient-derived organoids