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p21活化激酶4致癌机制及与消化系统恶性肿瘤发生发展的关系

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山东医药 2024年第20期64卷 98-102页

作者： ali Muhammad 胡继成周明艳祝哲潘宜鹏徐剑海南医科大学第二附属医院肝移植科海口570311 海南医科大学第二附属医院临床医学研究所

p21活化激酶4(PAK4)是一种丝氨酸/苏氨酸蛋白激酶,在多种消化系统肿瘤中过表达,是肿瘤细胞信号转导的关键因子之一。PAK4过表达与肿瘤细胞的增殖、迁移、侵袭、免疫逃逸及耐药性有关。在消化系统肿瘤中,PAK4可通过影响细胞周期、细胞凋... 详细信息

p21活化激酶4(PAK4)是一种丝氨酸/苏氨酸蛋白激酶,在多种消化系统肿瘤中过表达,是肿瘤细胞信号转导的关键因子之一。PAK4过表达与肿瘤细胞的增殖、迁移、侵袭、免疫逃逸及耐药性有关。在消化系统肿瘤中,PAK4可通过影响细胞周期、细胞凋亡及细胞骨架重塑等生物学过程,促进肿瘤的恶性行为。多项研究表明,PAK4抑制剂显示出抑制肿瘤增殖和转移的潜力,在联合化疗中具有较好的应用前景。

关键词： p21活化激酶4 PAK4抑制剂消化系统肿瘤

Evaluating Neural Dialogue Systems Using Deep Learning and Conversation History

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Journal on Artificial Intelligence 2022年第3期4卷 155-165页

作者： Inshirah ali AlMutairi ali Mustafa Qamar Department of Computer Science College of ComputerQassim UniversityBuraydahSaudi Arabia

Neural talk models play a leading role in the growing popular building of conversational managers.A commonplace criticism of those systems is that they seldom understand or use the conversation data *** development of profound concentration on innovations has increased the use of neural models for a discussion *** recent years,deep learning(DL)models have achieved significant success in various tasks,and many dialogue systems are also employing DL *** primary issues involved in the generation of the dialogue system are acquiring perspectives into instinctual linguistics,comprehension provision,and conversation *** this paper,we mainly focus on DL-based dialogue *** issue to be overcome under this publication would be dialogue supervision,which will determine how the framework responds to recognizing the needs of the *** dataset utilized in this research is extracted from *** models implemented in this research are the seq2seq model,transformers,and GPT while using word embedding and *** results obtained after implementation depicted that all three models produced accurate *** the modern revolutionized world,the demand for a dialogue system is more than ***,it is essential to take the necessary steps to build effective dialogue systems.

关键词： Seq2Seq CNN dialogue systems NLP RNN transformer GPT

New approaches for diagnosis of dry eye disease

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1618-1628页

作者： Abdelrahman MElhusseiny ali AKhalil Reem HEl Sheikh Mohammad ABakr MohamedGaber Eissa Yasmine MEl Sayed Department of Ophthalmology Kasr Al Ainy School ofmedicineCairo UniversityDokki12611Egypt Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900NW17StreetMiamiFL33136USA Faculty of Medicine American University of BeirutBeirut2341Lebanon

We reviewed the literature for different diagnostic approaches for dry eye disease(DED) including the most recent advances, contradictions and promising diagnostic tools and technique. We performed a broad literature search for articles discussing different methods for diagnosis of DED including assessment of tear osmolarity, tear film stability, ocular biomarkers and others. Articles indexed in PubMed and google scholar were included. With the growing cosmetic industry, environmental pollution, and booming of digital screens, DED is becoming more prevalent. Its multifactorial etiology renders the diagnosis challenging and invites the emergence of new diagnostic tools and tests. Diagnostic tools can be classified, based on the parameter they measure, into tear film osmolarity, functional visual acuity, tear volume, tear turnover, tear film stability, tear film composition, ocular biomarkers and others. Although numerous methods exist, the most accurate diagnosis can be reached through combining the results of more than one test. Many reported tests have shown potential as diagnostic/screening tools, however, require more research to prove their diagnostic power, alone or in combination. Future research should focus on identifying and measuring parameters that are the most specific to DED diagnosis.

关键词： dry eye disease tear film stability tear osmolarity ocular biomarkers

Malaria stratification in a malarious area,a field exercise

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 807-811页

作者： Vatandoost Hassan Akbarzadeh Kamran Hanafi- Bojd Ahniad ali Mashayekhi Minoo Saffari Mohammad Malik Elfatih M Kenyi Luka Abakar John Baptist Busaq alikhan Esmailpour Mohammad Hassen Abuelgasim Oshaghi Mohamad ali Department of Medical Entomology & Vector Control School of Public Health & National Institute of Health ResearchTehran University of Medical Sciences Kerman University of Medical Sciences PHC and Preventive Medicine Ministry of Health Baghlan province Urmieh University of Medical Sciences Northern State Ministry of Health Malaria Control Programme

Objective:To conducted a spatial analysis for stratification of priority malaria control areas in Kahnuj County,as part of field ***:Information of Health Centers of Kahnuj County has been used for stratification retrospectively.A knowledge,attitudes and practices(KAP) study was arranged to provide preliminary information about the knowledge,attitude and practice related to malaria in the ***:Numbers of malaria cases has been decreased in year *** were five important vectors of malaria in this region including:Anopheles stephensi (***),Anopheles dthali(***).Anopheles superpictus(***),Anophels culicifacies(***),and Anopheles Jluviatilis(***),but majority of malaria cases in this county was related to Plasmodium vivax(***).Educational levels of community were 38% ,20% ,10% and 32% for illiterate,primary,secondary and university levels,respectively. KAP study revealed that about 37% of people have got malaria at least once and only 27% of people knew that mosquito is the vector of ***:Malaria in Kahnuj represents a real *** occurs in city *** can be suspected for the first peak of malaria cases in late spring in Kahnuj *** has a relatively high density in autumn while two malaria cases due to *** were reported in *** on KAP study,the knowledge of respondents seems good but the attitude and practice is *** to the data such as API,main malaria vector,transmission rate,and foreign migrants,the Kahnuj County has been spatially divided into three strata based on various *** authorities should implement all the interventions based on stratification.

关键词： Malaria Kahnuj Stratification Iran

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漫长的夏天和希望改变现状的呼声

世界知识 2009年第18期 6-6页

作者： ali Ahmad Jalali 王世达

过去七年，由于美军未能彻底消灭塔利班，国际捐赠方支持阿富汗重建的资金严重不足、使用效率低下，加上不少北约国家为在阿军事行动设定种种限制等因素，国际社会痛失稳定阿富汗局势的最好时机。8月20日，阿富汗举行总统大选，该国局... 详细信息

过去七年，由于美军未能彻底消灭塔利班，国际捐赠方支持阿富汗重建的资金严重不足、使用效率低下，加上不少北约国家为在阿军事行动设定种种限制等因素，国际社会痛失稳定阿富汗局势的最好时机。8月20日，阿富汗举行总统大选，该国局势正面临重大转折。新任总统必须团结不同民族、部落的民众，

关键词：现状夏天国际社会总统大选阿富汗军事行动北约国家塔利班

Extracting body surface dimensions from top-view images of pigs

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 182-191页

作者： Mingzhou Lu Tomas Norton ali Youssef Nemanja Radojkovic Alberto Peña Fernández Daniel Berckmans College of Engineering/Jiangsu Province Engineering Lab for Modern Facility Agriculture Technology&Equipment Nanjing Agricultural UniversityNanjing 210031China M3-BIORES-Measure Model&Manage BioresponsesKU LeuvenKasteelpark Arenberg 30B-3001 LeuvenBelgium

Continuous live weight and carcass traits estimation are important for the pig production and breeding *** is widely known that top-view images of a pig’s body(excluding its head and neck)reveal surface dimension parameters,which are correlated with live weight and carcass ***,because a pig is not constrained when an image is captured,the body does not always have a straight *** creates a big challenge when extracting the body surface dimension parameters,and consequently the live weight and carcass traits estimation has a high level of *** primary goal of this study is to propose an algorithm to automatically extract pig body surface dimension parameters,with a better accuracy,from top-view pig ***,the backbone line of a pig was ***,lengths of line segments perpendicular to the backbone line were calculated,and then feature points on the pig’s contour line were extracted based on the lengths variation of the perpendicular line ***,the head and neck of the pig were removed from the pig’s contour by an ***,four length and one area parameters were *** proposed algorithm was implemented in Matlab®(R2012b)and applied to 126 depth images of *** the results of the manual labeling tool as the gold standard,the length and area parameters could be obtained by the proposed algorithm with an accuracy of 97.71%(SE=1.64%)and 97.06%(SE=1.82%),*** parameters can be used to improve pig live weight and carcass traits estimation accuracy in the future work.

关键词： body surface dimension image analysis skeleton triangulated network ellipse fitting

Severe Acute Malnutrition among Hospitalized Children, Aden, Yemen

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Open Journal of Epidemiology 2016年第2期6卷 121-127页

作者： Mohammed ali Badi Iman ali Ba-Saddik Pediatric Department Faculty of Medicine and Health Sciences University of Aden Aden Yemen

Objective: Severe acute malnutrition (SAM) is one of the most common causes of morbidity and mortality among children under 5 years of age worldwide. The aim of this study was to find out the prevalence of SAM among hospitalized children at Al-Wahda teaching hospital in Aden, Yemen. Methods: This descriptive cross-sectional hospital based study was conducted on 622 hospitalized children (336 males and 286 females) below 6 years of age during 2012-2013. SAM was defined as a very low weight for height (below-3 Z scores of the median WHO growth standards). Results: SAM was diagnosed in 622 children with prevalence rate of 5.2% from total 11,941 admissions during 24 months period. A higher proportion of patients were marasmus 586 (94.2%) and only 36 (5.8%) were kwashiorkor. Marasmus was common in rbidities with SAM were gastroenteritis 442 (71.1%) and 103 pneumonia (16.6%) with a total cure of 492 (79.1%) patients. Conclusion: This high prevalence of SAM among males who were <5 years of age with high risk of gastroenteritis and pneumonia added weight to the urgent need to improve the nutritional status of children.

关键词： Severe Acute Malnutrition Marasmus Kwashiorkor

食管测压和pH监测:胃肠病专家所坚持的公开准则

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 44-45页

作者： ali M.A. Lacy B.E. 郑世成 Division of Gastroenterology and Hepatology Dartmouth-Hitchcock-Medical Center 1 Medical Center Drive Lebanon NH 03756 United States Dr.

Goals: To determine whether gastroenterologists use esophageal manometry (EM) and esophageal pH recording (pHR) in accordance with published guidelines. Study: Questionnaires were mailed to 900 randomly selected gastroenterologists nationwide. Each questionnaire requested demographic information and contained 11 case scenario-based questions, followed by a choice of management options. Results: A total of 275 completed questionnaires (30.6% )were returned. 63.6% and 64.4% of respondents were aware of published guidelines regarding the use of EM and pHR, respectively. The majority of respondents ordered EM appropriately: 1) to confirm a suspected diagnosis of achalasia (97.1% ); 2) to establish a diagnosis of connective tissue disease (89.7% ); 3) as part of the preoperative evaluation for anti-reflux surgery (74.6% ); and 4) to ensure the proper placement of pH probes (69.4% ). EM was rarely ordered for the initial workup of noncardiac chest pain. The majority of responding gastroenterologists would order pHR for the evaluation of: 1) endoscopy-negative patients being considered for anti-reflux surgery (79.1% ); 2) patients with recurrent GERD symptoms after anti-reflux surgery (62.5% ); 3) endoscopy-negative patients with GERD symptoms refractory to proton pump inhibitor (PPI) therapy; and 4) patients with extraesophageal manifestations of GERD that are refractory to PPI therapy (88.7% ). Conclusions: The majority of gastroenterologists in our study order EM and pHR in accordance with published guidelines. However, EM appears to be used less than expected for preoperative evaluation before anti-reflux surgery and for ensuring the proper placement of pH probes. In addition, the use of pHR to evaluate persistent GERD symptoms after anti-reflux surgery was less than anticipated.

关键词：食管测压 pH监测胃肠病失弛缓症抗反流手术内镜检查结缔组织病胸痛应用情景阴性患者

Coordination of Synergetic Excitation Controller and SVC Damping Controller Using Particle Swarm Optimization

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Journal of Energy and Power Engineering 2012年第8期6卷 1292-1300页

作者： Taoridi Ademoye ali Feliachi ali Karimi Advanced Power & Electric Research Center West Virginia University Morgantown WV 26506-6109 USA Open Systems International (OSI) 4101 Arrowhead Drive Medina MN 55340-9457 USA

This paper addresses the enhancement of power system stability by simultaneous tuning of synergetic excitation damping controller and SVC （static var compensator）-based damping controllers. Each machine or generator is considered as a subsystem and its interaction with the remaining part of the system, the SVC inclusive, is modeled as a quadratic function of the active power delivered by the generator. Stable manifold is constructed for each excitation controller and based on that, an effective damping controller is derived. A lead-lag compensator is employed as a supplementary controller for the SVC. PSO （particle swarm optimization） algorithm is effectively utilized to simultaneously tune the parameters for the excitation damping controller（s） and the SVC supplementary controller. The coordination of the controllers effectively dampens the power angle oscillation and regulates the generator terminal voltage when a fault occurs. Simulation results are obtained by using the PAT （power analysis toolbox） for a SMIB （single machine infinite bus） system and a two area power system.

关键词： Synergetic control SVC based damping controllers particle swarm optimization.