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Journal of Energy Chemistry 2015年第3期24卷 309-314页

作者： Andrey O Drachuk Vladimir P Melnikov nadezhda S Molokitina Anatoliy N Nesterov Lev S Podenko Aleksey M Reshetnikov Andrey Yu Manakov Institute of Earth Cryosphere SB RAS625026Malygin str.86TyumenRussian Federation Tyumen State Oil and Gas University 625000Volodarsky str.38TyumenRussian Federation Nikolaev Institute of Inorganic Chemistry SB RAS630090Lavrentiev av.3NovosibirskRussian Federation

The results on a dissociation behavior of propane hydrates prepared from ＂dry water＂ and contained unreacted residual water in the form of ice inclusions or supercooled liquid water（water solution of gas） were presented for temperatures below 273 *** temperature ramping or pressure release method was used for the dissociation of propane hydrate *** was found that the mechanism of gas hydrate dissociation at temperatures below 273 K depended on the phase state of unreacted water in the hydrate *** hydrates dissociated into ice and gas if the ice inclusions were in the hydrate *** samples of propane hydrates with inclusions of unreacted supercooled water only（without ice inclusions） dissociated into supercooled water and gas below the pressure of the supercooled water-hydrate-gas metastable equilibrium.

关键词： gas hydrates dry water supercooled liquid water ice hydrate dissociation

Pro-inflammatory cytokines levels in tears and dry eye disease in Parkinson’s disease

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Annals of Eye Science 2023年第4期8卷 36-47页

作者： Azyadeh Camacho-Ordonez Atzin Robles-Contreras Oscar Guerrero-Berger nadezhda Camacho-Ordonez Roberto Rodríguez-Rivas Laura Adalid-Peralta Amin Cervantes-Arriaga Mayela Rodríguez-Violante Anterior Segment Department Hospital Fundacion Nuestra Senora de la LuzPrivate Assistance InstitutionMexico CityMexico Neuroophthalmology Clinic National Institute of Neurology and NeurosurgeryMexico CityMexico Biomedical Research Center Hospital Fundacion Nuestra Senora de la LuzPrivate Assistance InstitutionMexico CityMexico Institute for Immunodeficiency Center for Chronic ImmunodeficiencyMedical CenterFaculty of MedicineAlbert-Ludwigs-University of FreiburgFreiburgGermany Department of Neuroimmunology National Institute of Neurology and NeurosurgeryMexico CityMexico Peripheral Unit for the Study of Neuroinflammation of the Institute of Biomedical Research National Institute of Neurology and NeurosurgeryMexico CityMexico Movement Disorder Clinic National Institute of Neurology and NeurosurgeryMexico CityMexico

Background:Neuroinflammation is an essential event in Parkinson’s disease(PD).Identifying affordable and less invasive biomarkers to make an early diagnosis and monitor therapeutic strategies should be a priority among *** study’s objective was to measure tear levels of cytokines in subjects with PD and their association with motor features and the presence of dry eye ***:A total of 16 subjects with PD and 16 age-and sex-matched controls were *** Disorders Society-Unified Parkinson’s Disease Rating Scale(MDS-UPDRS),Hoehn and Yahr(HY)stage scale,Montreal Cognitive Assessment(MoCA),tear break-up time(TBUT),blink rate(BR),Dry Eye Questionnaire 5(DEQ-5)were examined,and pro-inflammatory cytokines[interleukin(IL)-1β,IL-6,IL-8,IL-10,IL-12p70 and tumor necrosis factor-alpha(TNF-α)]were quantified in tears using the BD Cytometric Bead Array Human Inflammatory Cytokine ***:Higher tear TNF-αwere quantified in PD compared to controls(2.94±3.95 vs.0.33±0.49 pg/mL,P=0.008).According to DEQ-5,50.0%(n=8)of PD subjects and 12.5%(n=2)controls had dry eye disease(DED).No differences were found in cytokines concentrations between PD patients with DED compared to those without ***-8 was associated with the HY stage,TBUT,DEQ-5,and a better MoCA score.A higher BR correlated moderately with a lower HY stage(r=−0.645,P=0.007),and DED patients have lower BR in PD(12.14±2.54 vs.9.0±2.06 blinks/minute,P=0.031).Conclusions:PD patients have higher levels of TNF-αin tears than age-and sex-matched ***-8 in tears may be both involved in the severity of the disease and in the development of DED in *** addition,our findings suggest that as HY stage increases,indicating a more advanced stage,BR decreases,indicating greater motor ***,the presence of DED is associated with higher levels of bradykinesia in PD patients,suggesting a potential relationship between DED and motor impairment severity.

关键词： Tears pro-inflammatory cytokines dry eye disease(DED) Parkinson’s disease(PD)

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汉俄名词数量范畴对比研究

汉俄名词数量范畴对比研究

作者：娜佳（Gubarkova nadezhda）大连外国语大学

学位级别：硕士

数量范畴是人们对客观世界的属性进行认知的结果之一。客观存在的数量在语言中被赋予了具体的形式,形成了语言的数量范畴。数量范畴总是反映客观对象之间的数量关系。名词是词类的重要组成部分之一,没有名词,就不可能为事物、动物和人... 详细信息

数量范畴是人们对客观世界的属性进行认知的结果之一。客观存在的数量在语言中被赋予了具体的形式,形成了语言的数量范畴。数量范畴总是反映客观对象之间的数量关系。名词是词类的重要组成部分之一,没有名词,就不可能为事物、动物和人等命名。许多语言中的名词可以表达不同的语法范畴,当然也可以表达数量范畴。在不同的语言中,数量范畴的表达方式是不同的。例如,在俄语中,名词的数量范畴一是通过词法和句法手段来表达,如使用后缀和词尾等;二是由名词与其他词构成的短语来表达。在汉语中,名词的数量范畴是通过句法手段、词法手段以及语用手段来表达的。本文尝试研究、对比汉语与俄语中的名词数量范畴,概括两种语言中数量范畴的差异,并探究差异产生的原因。为了清晰地探究,我们采用了文献研究法、描写法和对比法等研究方法。本文主要内容包括以下三个部分:首先,我们分别探讨了汉语和俄语中名词数量范畴的表现形式。对汉语的名词和数量范畴的概念进行了界定,对汉语的名词进行了分类,概括描述了汉语名词数量范畴的表现。探究了俄语的名词数量范畴,并对其进行了分类。之后,对汉俄名词数量范畴的异同进行了对比分析。通过对比我们发现:汉语中的名词数量范畴是否存在,在语言学界仍有争议。所以对汉语名词数量范畴分类还没有统一的标准,学者们分出的类型也不太一致。而俄语中的名词数量范畴是一个成熟的概念,所以有普遍认可的分类标准和类型。俄语中,几乎每个名词都有复数或单数的形式。而在汉语中,名词本身在数量范畴方面是中性的。与俄语不同,汉语中的名词没有明显的单复数形态标记,但进入句子后,大多数名词都可以表达复数或单数的意义。这两种语言中,有一些名词如专有名词、集体名词、成对出现的事物的名词等在数量范畴上既有相同点,也存在差异。接下来,我们对汉俄名词数量范畴的表达手段进行了描写。我们发现汉语名词表达数量范畴的手段有句法手段、词法手段和语用手段。俄语表达名词数量范畴的手段有句法手段、词法手段,还有其他一些手段,如重音、异干互补等。我们也对汉俄名词数量范畴的表达手段的异同进行了概括和总结。最后,我们对汉俄名词数量范畴表现形式出现差异的原因进行了分析,并发现存在差异的主要原因是两种语言在文字系统、语言类型方面存在差异,两种语言的使用者的思维方式也有一定的差异。这些差异解释了两种语言中名词数量范畴和表达的特殊性。因此,我们具体从两种语言文字类型的差异、语言类型学上的差异以及民族思维的差异对汉俄名词数量范畴的影响进行了分析。在论文的结语部分,我们对本文内容进行概括和总结。本文的创新之处在于首次对汉语和俄语的名词数量范畴进行了对比研究,并分析了差异产生的原因。本文的研究不足之处是缺少汉语和俄语名词数量范畴研究的充足的资料,尤其是汉语名词数量范畴的研究资料较少,分析不够充分。由于文章篇幅有限,本文仅对汉俄名词数量范畴进行了初步的静态的描写,分析了汉俄名词数量范畴的异同与差异产生的原因,缺少语义功能角度的分析。这些问题都需要在接下来的工作中进行进一步的研究。笔者希望这项对比研究将鼓励研究者在未来更深入地探索这一课题。

关键词：数量范畴名词汉语俄语

Simulated Solar Microwave Radiation Blocks the Formation of Biofilms

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Natural Science 2015年第3期7卷 127-131页

作者： Yulia S. Shishkova Stanislav N. Darovskih nadezhda V. Vdovina nadezhda L. Pozdnyakova I. A. Komarova Elena V. Shishkova Evgenij V. Vodyanitskiy South Ural State Medical University Chelyabinsk Russia South Ural State University Chelyabinsk Russia

The article presents the results of the experimental study that was devoted to determining the blocking influence of the solar microwave radiation on the process of biofilm formation in Gram-positive and Gram-negative microorganisms. The microwave generator that allows simulating microwave “splashes” of the Sun in the frequency range (4.0 - 4.3 GHz) with the controlled intensity of radiation (from 50 μW/sm2 to 500 μW/sm2) was used for conducting this research. It is found out that the simulated solar radiation of the microwave range blocks the formation of the extracellular matrix by the opportunistic microorganisms. The results of this study confirm the hypothesis of the evolutionary nature of the leading role of the microwave radiation of the Sun in the life processes of organisms. The technology of the exposure on the microorganisms that was used in the experiment opens up the real prospects for reducing the persistent potential of microorganisms and improving the efficiency of the bacterial infections treatment.

关键词： Solar Microwave Radiation Microorganisms Biofilms Extracellular Matrix Persistence

A new can didate vaccine for human brucellosis based on influenza viral vectors:a preliminary investigation for the development of an immunization schedule in a guinea pig model

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Infectious Diseases of Poverty 2021年第1期10卷 56-65页

作者： Dina Bugybayeva Zhailaubay Kydyrbayev nadezhda Zinina Nurika Assanzhanova Bolat Yespembetov Yerken Kozhamkulov Kunsulu Zakarya Sholpan Ryskeldinova Kaissar Tabynov Research Institute for Biological Safety Problems 15 MomushulyGvardeyskiy 080409Kazakhstan Kazakh National Agrarian University 8 Abay AvenueAlmaty 050010Kazakhstan Research Institute of Cardiology and Internal Medicine 120 Aiteke biAlmaty 050000Kazakhstan.

Background:A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors(rIVV)subtypes H5N1 expressing Brucella outer membrane protein(Omp)16,L7/L12,Omp19or Cu-Zn SOD proteins has been *** paper presents the results of the study of protection of the vaccine using on guinea pigs,including various options of administering,dose and *** data of the novel vaccine candidate will contribute to its further movement into the preclinical stage ***:General states of guinea pigs was assessed based on behavior and dynamics of a guinea pig weight-gain *** effectiveness of the new anti-brucellosis vector vaccine was determined by studying its protective effect after conjunctival,intranasal and sublingual administration in doses 10^(5) EID50,10^(6) EID_(50) and 10^(7) EID_(50) during prime and boost vaccinations of animals,followed by challenge with a virulent strain of *** 16 M *** sake of comparison,the commercial ft melitensis Rev.1 vaccine was used as a *** protective properties of vaccines were assessed by quantitation of Brucella colonization in organs and tissues of infected animals and compared to the control ***:It was observed a gradual increase in body weight of guinea pigs after prime and booster immunization with the vacci ne using conjunctival,intra nasal and subli ngual routes of administration,as well as after using various doses of *** most optimal way of using the vaccine has been established:double intranasal immunization of guinea pigs at a dose of 10^(6) EID50, which provides 80%protection of guinea pigs from *** 16 M infection(P<0.05),which is comparable to the results of the effectiv en ess of the commercial *** Rev.1 vacci ***:We developed effective human vaccine candidate against brucellosis and developed its immunization protocol in guinea pig *** believe that because of these studies,the proposed

关键词： Human brucellosis Influenza viral vectors Vaccine candidate Protection Guinea pigs Immunization route Vaccination dose

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冻土水文地质学研究进展

南水北调与水利科技（中英文） 2022年第4期20卷 782-801页

作者：戴长雷于淼宋成杰 nadezhda Pavlova 尉意茹李梦玲黑龙江大学寒区地下水研究所哈尔滨150080 黑龙江大学水利电力学院哈尔滨150080 黑龙江大学中俄寒区水文和水利工程联合实验室哈尔滨150080 东北联邦大学地质勘探学院俄罗斯雅库茨克677000 俄罗斯科学院西伯利亚分院麦尔尼科夫冻土研究所俄罗斯雅库茨克677000

冻土水文地质学主要研究冻土区水分要素的时空分布和运动规律及其与冻土间的相互作用。在微观上,冻结温度、未冻水含量以及孔隙水压力等冻土层独有的水热参数决定了冻土的结构和物理力学性质,同时影响了冻土层的冻融过程。而宏观上,冻... 详细信息

冻土水文地质学主要研究冻土区水分要素的时空分布和运动规律及其与冻土间的相互作用。在微观上,冻结温度、未冻水含量以及孔隙水压力等冻土层独有的水热参数决定了冻土的结构和物理力学性质,同时影响了冻土层的冻融过程。而宏观上,冻土层的存在改变了常规的地表径流和水系模式,地下水的循环系统也由于冻土层的季节性冻融发生了根本变化,形成了冻土区独特的水文地质条件。从微观和宏观两种角度系统归纳与总结国内外冻土水文地质学研究进展,并分析包括地球物理技术、水化学、冻土水文模型在内的技术方法,同时对高寒区特有的地下水溢流冰、融雪入渗和冻土保墒现象的研究成果进行总结与分析。冻土水文的发展趋势应在积累研究数据和技术方法的基础上进一步探索产汇流过程机理,并建立更完善的冻土水文物理模型,定量分析冻土与水资源之间的相互作用。

关键词：冻土水文地质学产汇流地球物理技术水化学冻土水文模型

Kinetics and mechanisms of glucose absorption in the rat small intestine under physiological conditions

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Journal of Biophysical Chemistry 2012年第2期3卷 191-200页

作者： Andrei A. Gruzdkov Liudmila V. Gromova nadezhda M. Grefner Yan Yu. Komissarchik I. P. Pavlov Institute of Physiology RAS St. Petersburg Russia Institute of Cytology RAS St. Petersburg Russia

Previous studies have shown two components of glucose absorption in the small intestine: a secondary active transport through SGLT1, and unsaturated component, recently attributed mainly to the facilitated diffusion through GLUT2, but the relationship between these two components under physiological conditions remains controversial. In chronic experiments on nonanesthetized rats we investigated for the first time the kinetics of maltose hydrolysis and glucose absorption in the isolated loop of the small intestine in a wide range of maltose and glucose concentrations (25 ÷ 200 mmol/l glucose). The processes were simulated on mathematical models which took into account the current views about mechanisms of hydrolysis and transport of nutrients and geometric characteristics of the intestinal surface. The results of chronic experiments and mathematical simulation have shown that under the close to physiological conditions the glucose transport mediated by SGLT1 is the main mechanism of its absorption in comparison with the unsaturated component. This was demonstrated not only at low, but also at high substrate concentrations. We conclude that correct evaluation of the relative contribution of different mechanisms in glucose transport through the intestinal epithelium requires taking into account the geometric specificities of its surface.

关键词： Membrane Hydrolysis Glucose Transport SGLT1 GLUT2 Small Intestine Mathematical Modeling

Modern aspects of construction of information microwave therapy devices

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Natural Science 2013年第12期5卷 1230-1237页

作者： Stanislav N. Darovskih Evgenij P. Popechitelev nadezhda V. Vdovina Ivan V. Novikov Saint Petersburg Electrotechnical University “LETI” Saint Petersburg Russian South Ural State University Chelyabinsk Russian

This article is devoted to presenting modern aspects of building information microwave therapy devices. And it presents an analysis of the existing problems of the organism homeostasis control by means of electromagnetic radiation. The new principles of synthesis of operating influences are formulated. On the basis of the thermodynamic approach is justified as a leading role modeling the space microwave background to restore disturbed homeostasis of the organism. The general patterns of development of the pathological process and possible mechanisms of corrective action of natural electromagnetic background are described. The implementation of the approach offered by the authors to constructing device information physiotherapy allowed creating high-performance hardware and software means for the prevention and treatment of a wide range of human diseases.

关键词： Information Microwave Therapy Homeostasis Electromagnetic Pollution Relict Radiation Electromagnetic Radiation

Reparative histogenesis of skin: Reaction on the application of l-cysteine of argentum nitrate gel

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Open Journal of Regenerative Medicine 2012年第3期1卷 25-28页

作者： Margarita B. Petrova Natalya V. Pavlova Elena A. Kharitonova nadezhda V. Ilyashenko Department of Biology Tver State Medical Academy Tver Russia

The effect of L-cysteine of argentum nitrate gel on the wound process of experimental animals is investigated. The results show that the nanogel, being bacteriostatic, accelerates the course of inflammation phase resulting in fast cleansing of the wound surface and stimulation of the granulation tissue formation. The main cell elements of this tissue—fibroplasts are characterized by the state of functional excitation. The time of wound healing with the use of L-cysteine of argentum nitrate gel was reduced by three days, and the index of wound repair acceleration was about 20%.

关键词： L-Cysteine of Argentum Nitrate Gel Skin Healing Process Wound Repair Stimulation Fibroplasts

Do unemployment and payor category impact length of stay and hospital charges of spine fusion patients?

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Health 2012年第3期4卷 150-154页

作者： Mohammad Sami Walid nadezhda Zaytseva Aaron C. M. Barth Joe Sam Robinson Jr. Medical Center of Central Georgia Macon USA

Introduction: In this paper we investigate the possible connection between socioeconomic status as demarcated by employment and in-surance status and consumption of healthcare resources in spine surgery patients. Methods: The clinical records of 1599 spine surgery pa-tients counted from 2008-2009 were reviewed. The largest groups of patients belonged to MS-DRG 460 (N = 585) and to MS-DRG 473 (N = 700). These two MS-DRG patient groups were used as the study cohort representing patients who, by definition, did not have serious comor-bidities or complications. Results: Unemployed non-cervical patients tended to stay on average 1.8 days longer in hospital and had on average $5800 higher hospital charges. No major differ-ences were noted in length of stay and hospital cost between government and private insurance patients. However, self-pay non-cervical fusion patients had notable increases in length of stay and hospital cost, especially in the >39 and <60 age group with the difference in length of stay amounting to 5 days and in hospital charges to $10,000. Univariate analysis with DRG (460 or 473) as a covariate showed significant impact from employment status on length of stay (F = 4.259, P = 0.014) and less significant impact from payor category on hospital charges (F = 2.229, P = 0.064) in the economically-productive 40 -59 age group. Conclusions: In general, no increase in hospital resource consumption was noted except among self-pay patients, the same group seemingly least able to afford expensive healthcare.

关键词： Spine Fusion Hospital Charges Payor Category