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Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

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Protein & Cell 2010年第5期1卷 491-500页

作者： Yang Wu Zhiyong Lou Yi Miao Yue Yu hui Dong Wei Peng Mark Bartlam Xuemei Li Zihe rao National Laboratory of Macromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Structural Biology Laboratory Tsinghua UniversityBeijing 100084China College of Life Sciences and Tianjin State Laboratory of Protein Science Nankai UniversityTianjin 300071China

Enterovirus 71(EV71),one of the major causative agents for hand-foot-and-mouth disease(HFMD),has caused more than 100 deaths among Chinese children since March *** EV71 genome encodes an RNAdependent RNA polymerase(RdRp),denoted 3D^(pol),which is central for viral genome replication and is a key target for the discovery of specific antiviral *** we report the crystal structures of EV71 RdRp(3D^(pol))and in complex with substrate guanosine-5'-triphosphate and analog 5-bromouridine-5'-triphosphate best to 2.4Å*** structure of EV71 RdRp(3D^(pol))has a wider open thumb domain compared with the most closely related crystal structure of poliovirus *** the EV71 RdRp(3D^(pol))complex with GTP or Br-UTP bounded shows two distinct movements of the polymerase by substrate or analogue *** model of the complex with the template:primer derived by superimposition with foot-and-mouth disease virus(FMDV)3D/RNA complex reveals the likely recognition and binding of template:primer RNA by the *** results together provide a molecular basis for EV71 RNA replication and reveal a potential target for anti-EV71 drug discovery.

关键词： enterovirus 71 RNA-dependent RNA polymerase crystal structure drug target

PROTACs:great opportunities for academia and industry (an update from 2020 to 2021)

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2181-2244页

作者： ming He Chaoguo Cao Zhihao Ni Yongbo Liu Peilu Song Shuang Hao Yuna He Xiuyun Sun Yu rao Ministry of Education(MOE)Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua University100084 BeijingP.R.China Tsinghua-Peking Center for Life Sciences 100084 BeijingP.R.China School of Pharmaceutical Sciences Zhengzhou University450001 ZhengzhouChina

PROteolysis TArgeting Chimeras(PROTACs)technology is a new protein-degradation strategy that has emerged in recent *** uses bifunctional small molecules to induce the ubiquitination and degradation of target proteins through the ubiquitin–proteasome *** can not only be used as potential clinical treatments for diseases such as cancer,immune disorders,viral infections,and neurodegenerative diseases,but also provide unique chemical knockdown tools for biological research in a catalytic,reversible,and rapid *** 2019,our group published a review article“PROTACs:great opportunities for academia and industry”in the journal,summarizing the representative compounds of PROTACs reported before the end of *** the past 2 years,the entire field of protein degradation has experienced rapid development,including not only a large increase in the number of research papers on protein-degradation technology but also a rapid increase in the number of small-molecule degraders that have entered the clinical and will enter the clinical *** addition to PROTAC and molecular glue technology,other new degradation technologies are also developing *** this article,we mainly summarize and review the representative PROTACs of related targets published in 2020–2021 to present to researchers the exciting developments in the field of protein *** problems that need to be solved in this field will also be briefly introduced.

关键词： diseases clinical journal

Vibrational Spectra of Distorted Structure Molecules by Using Lie Algebraic Techniques： an Application to Copper and Magnesium Octaethyl Porphyrin

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Chinese Physics Letters 2010年第10期27卷 80-83页

作者： Srinivasa rao Karumuri School of Sciences and Humanities Sri Viveka Institute of Technology (SVIT) Madalavari Gudem Nunna Krihna District-521212 India

Using a U （2） algebraic model the fundamental stretching vibrations of copper octaethyl porphyrin and magnesium octaethyl porphyrin are calculated for 24 vibrational bands. The locality parameter ξ confirms the highly local behavior of the stretching modes of these porphyrin molecules. The model Hamiltonian so constructed appears to describe the vibrational energy levels accurately.

关键词： VIBRATIONAL spectra NUCLEAR structure LIE algebras COPPER compounds PORPHYRINS MOLECULAR models

密植对不同年代大豆品种群体光合生产和产量形成的影响

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作物学报 2025年第1期51卷 161-173页

作者：丁树启程彤王弼琨于德彬饶德民孟凡钢赵胤凯王晓慧张伟吉林省农业科学院(中国农业科技东北创新中心)大豆研究所吉林长春130033 吉林农业大学农学院吉林长春130118

密植是挖掘优良大豆品种生产潜力的有效途径,但对于育种时间跨度长达百年的大豆品种而言,其对密植的响应差异仍不清楚。为明晰密植对不同年代大豆品种群体光合生产和产量形成的影响,以1930s-2020s育成的50个大豆品种为试验材料,探究了... 详细信息

密植是挖掘优良大豆品种生产潜力的有效途径,但对于育种时间跨度长达百年的大豆品种而言,其对密植的响应差异仍不清楚。为明晰密植对不同年代大豆品种群体光合生产和产量形成的影响,以1930s-2020s育成的50个大豆品种为试验材料,探究了不同年代大豆品种(1930s-1940s、1950s-1960s、1970s-1980s、1990s-2000s和2010s-2020s)在不同密度水平(常规密度200,000株hm^(–2)和高密度300,000株hm^(–2))下叶面积指数(LAI)、叶面积指数增长率(LGR)、光合势(LAD)、干物质积累、作物生长率(CGR)、下部叶片衰老和产量的响应差异。结果表明,随着育成年代的推进,大豆群体光合生产能力和产量均逐渐提升。与老品种(1930s-1940s,1950s-1960s和1970s-1980s)相比,新品种(1990s-2000s和2010s-2020s)在高密度下表现出更好的生长状态。新品种在高密度下的叶面积指数(LAI)增幅更大,盛荚期(R4)的LAI的增幅依次为17.79%和23.06%,盛荚-鼓粒期(R4-R6)的LAI衰减更缓慢,LAD增幅更大。在R6期,新品种在高密度下的干物质积累增幅更大,依次为25.28%和28.96%,其CGR也显著增加(P <0.05),依次为21.66%和25.38%;此外,新品种在高密度下下部叶片黄叶节位上移量和叶片SPAD值的降幅较小,表现出较强的抗衰老特性。在产量方面,新品种在高密度下单位面积粒数和荚数增幅较大,百粒重降幅较小,产量显著(P <0.05)提升,其产量增幅依次为4.49%和5.04%。综上,生育初期,新品种在高密度下表现出较强的“源”增加能力,其叶源值高且稳定,光能截获量大,干物质积累多,促进籽粒“库”快速发育;而生育后期,其叶面积指数衰减速度较慢,群体光合能力强,籽粒灌浆充分,因而显著提高单位面积粒数和荚数,从而弥补百粒重的微降,实现大豆产量显著提升。

关键词：大豆密植不同年代光合生产产量

Correlation between thrombopoietin and inflammatory factors,platelet indices,and thrombosis in patients with sepsis:A retrospective study

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World Journal of Clinical Cases 2022年第13期10卷 4072-4083页

作者： Wan-Hua Xu Li-Chan Mo Mao-Hua Shi hui rao Xiao-Yong Zhan Mo Yang Department of Hematology Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Emergency Medicine The First People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Rheumatology and Immunology The First People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pediatrics Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Thrombopoietin(TPO)is a primary regulator of thrombopoiesis in physiological ***,in combination with its specific cytokine receptor c-Mpl,drives platelet production by inducing the proliferation and differentiation of ***,the role of TPO in sepsis is not well *** elevated levels of TPO are often accompanied by a decrease of platelet count(PLT)in systemic infected conditions,which is contrary to the view that TPO promotes platelet production under physiological *** addition,whether TPO mediates organ damage in sepsis remains *** To explore the relationships between TPO and inflammatory factors,platelet indices,and thrombotic indicators in *** A total of 90 patients with sepsis diagnosed and treated at the emergency medicine department of The First People’s Hospital of Foshan between January 2020 and March 2021 were enrolled in this *** addition,110 patients without sepsis who came to the emergency medicine department were included as *** and laboratory parameters including age,gender,TPO,blood cell count in peripheral blood,platelet indices,inflammatory factors such as high-sensitivity Creactive protein(hs-CRP),interleukin(IL)-21,and IL-6,organ damage indicators,and thrombotic indicators were collected and analyzed by using various statistical *** The results showed that the TPO levels were higher in the sepsis group than in controls[86.45(30.55,193.1)vs 12.45(0.64,46.09)pg/mL,P<0.001],but PLT was lower(P<0.001).Multivariable analysis showed that white blood cell count(WBC)[odds ratio(OR)=1.32;95%confidence interval(CI):1.01-1.722;P=0.044],TPO(OR=1.02;95%CI:1.01-1.04;P=0.009),IL-21(OR=1.02;95%CI:1.00-1.03;P=0.019),troponin I(OR=55.20;95%CI:5.69-535.90;P=0.001),and prothrombin time(PT)(OR=2.24;95%CI:1.10-4.55;P=0.027)were independent risk factors associated with *** levels were positively correlated with IL-21,IL-6,hs-CRP,creatinine,D-dimer,P

关键词： Sepsis Thrombopoietin Interleukin-21 Platelets Thrombosis

Nonlinear behavior of the population dynamics of three-level systems in the presence of single photon absorption

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Chinese Physics B 2019年第2期28卷 272-276页

作者： Allam Srinivasa rao Photonic Sciences Laboratory Physical Research Laboratory

We numerically investigate the population dynamics in a single photon resonant three-level cascade and non-cascade energy level molecules at 532-nm wavelength. The time-dependent population in the energy levels in the presence of 100 ps(pico-second) and 100 ns(nano-second) laser pulses is described in the form of rate equations. We provide a brief idea of how the optical energy transfer takes place in the light-matter interaction and we also discuss the absorption as a function of pulse width and repetition rate. We also plot the z-scan transmittance curve as a function of number of excitation pulses participating in the absorption.

关键词： nano-second laser pico-second laser nonlinear absorption z-scan

Characteristics and outcome of impacted button batteries among young children less than 7 years of age in China:a retrospective analysis of 116 cases

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World Journal of Pediatrics 2018年第6期14卷 570-575页

作者： Tao Huang Wen-Qing Li Zhong-Fang Xia Jun Li Kai-Cheng rao En-ming Xu Department of ENT Wuhan Children’s Hospital(Wuhan Maternal and Child Health Care Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Medicine Wuhan Children’s Hospital(Wuhan Maternal and Child Health Care Hospital)Tongji Medical CollegeHuazhong University of Science and T echnologyNo.100 Jiangan DistrictWuhan 430016China

Background Ingestion of button batteries occurs in about ten persons per one million persons each year, with most of them children, and one in every 1000 battery ingestions leads to serious injuries. This study aimed to describe the clinical features and outcome of ingestion or inhalation of button batteries in children spanning a decade from January, 2006 to December, 2016 at a tertiary care hospital. Methods We reviewed the clinical records of children who sought treatment for inhaled or ingested button batteries at our hospital during the study period. Data on gender, age, time from ingestion to treatment, site of impaction, imaging findings, and outcomes were retrieved and analyzed. Results We identified 116 pediatric cases of ingestion or inhalation of button batteries. Their mean age was 26 months. The time from ingestion or inhalation of button batteries to treatment was 0.5 hours to 2 weeks. Ninety-seven (83.6%) button batteries were located in the nasal cavity, 13 (11.2%) in the gastrointestinal (GI) tract including 6 in the esophagus, and 7 in the stomach and lower GI tract, and 6 (5.2%) in the auditory tract. Twenty-one (21.6%) children with nasal button batteries had preoperative septal perforations and one (1.0%) had postoperative septal perforation. One child with esophageal button battery developed esophageal stricture and one died of sudden cardiac arrest perioperatively. One child had auditory dam-ages in the right tympanic membrane and ossicles. Conclusions Inhalation or ingestion may occur in the nasal cavities, the esophagus and GI tract and the auditory tract. Prompt diagnosis and treatment are required for a satisfactory outcome and ingested or inhaled button batteries require different treatment protocols.

关键词： Button battery Ingestion Inhalation Foreign body Children Nasal cavities Esophagus Auditory tract Removal

Magnetoresistance Behavior of La_((2-x))/3Bi_(x/3)Ca_(l/3)MnO_(3) (x = 0.4)

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Chinese Physics Letters 1997年第6期14卷 453-456页

作者： TANG Wei-hua LIANG Jing-kui LIANG Chang-lin SUN Ji-rong rao Guang-hui Institute of Physics&Center for Condensed Matter Physics Chinese Academy of SciencesBeijing 100080 International Center for Materials Physics Chinese Academy of SciencesShenyang 110015 Department of Physics Beijing Normal UniversityBeijing 100875

The magnetoresistance(MR)behavior of La_((2-x)/3)Bi_(x/3)Ca_(l/3)MnO_(3)(x=0.4)compound was *** compound exhibits complex magnetic transitions,i.e.,paramagnetic-canted ferromagnetic-ferromagnetic-spin glass *** temperature dependence of resistivity of the compound indicates a semiconducting behavior,and no semiconductor-metal transition was associated with these magnetic *** magnetoresistance ratio exhibits a critical maximum corresponding to the canted ferromagnetic transition.A MR ratio as large as 86%was observed at 85 *** temperature dependence of MR ratio is well described by the relation of(ρo-ρH)/ρo=A(M/M_(s))^(2).

关键词： transition. resistance ferromagnetic

Representation of classifier distributions in terms of hypergeometric functions

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China Particuology 2007年第4期5卷 274-283页

作者： B.Venkoba rao Engineering and Industrial Services Tata Consultancy Services Ltd.1 Mangaldas RoadPune 411001India

This paper derives alternative analytical expressions for classifier product distributions in terms of Gauss hypergeometric function, 2F1, by considering feed distribution defined in terms of Gates-Gaudin-Schumann function and efficiency curve defined in terms of a logistic function. It is shown that classifier distributions under dispersed conditions of classification pivot at a common size and the distributions are difference similar. The paper also addresses an inverse problem of classifier distributions wherein the feed distribution and efficiency curve are identified from the measured product distributions without needing to know the solid flow split of particles to any of the product streams.

关键词： Classifier Efficiency curve Inverse problem