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Post-operative morbidity after neoadjuvant chemotherapy and resection for gallbladder cancer: A national surgical quality improvement program analysis

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 95-102页

作者： Minha k.m Stephanie Stroever k.ist Aplok. Alexander Ostapenk. Xiang Da Dong ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACk.ROUND Gallbladder cancer is the most common malignancy of the biliary ***-adjuvant chemotherapy(NACT)has improved overall survival by enabling R0 ***,there is no consensus of guidelines for neoadjuvant therapy in gallbladder *** investigations continue to analyze the regimen and benefit of NACT for ongoing care of gallbladder cancer patients,we examined American College of Surgeons National Surgical Quality Improvement Program(NSQIP)database to determine if there was higher morbidity among the neo-adjuvant group within the 30-day post-operative *** hypothesized patients who underwent NACT were more lik.ly to have higher post-operative *** To investigate the 30-day post-operative morbidity outcomes between patients who received NACT and underwent surgery and patients who only had *** A retrospective analysis of the targeted hepatectomy NSQIP data between 2015 and 2019 was performed to determine if NACT in gallbladder cancer increased the risk.for post-operative morbidity(bile leak.infection rate,rate of converting to open surgery,etc.)compared to the group who only had *** calculate the odds ratio for the primary and secondary outcomes,a crude logistic regression was *** Of the 452 patients,52 patients received NACT prior to *** were no statistically significant differences in the odds of morbidity between the two groups,including bile leak.odds ratio(OR),0.69;95%confidence interval(95%CI):0.16-2.10;P=0.55],superficial wound infection(OR,0.58;95%CI:0.03-3.02;P=0.61),and organ space wound infection(OR,0.63;95%CI:0.18-1.63;P=0.61).CONCLUSION There was no significant difference in the risk.of 30-day post-operative morbidity between the NACT and surgery group and the surgery only group.

关键词： Gallbladder cancer Neoadjuvant chemotherapy Radical cholecystectomy National Surgery Quality Improvement Program Postoperative outcome

Role of ablation therapy in conjunction with surgical resection for neuroendocrine tumors involving the liver

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 768-776页

作者： Alexander Ostapenk. Stephanie Stroever Lud Eyasu Minha k.m k.ist Aplok. Xiang Da Dong ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACk.ROUND Resection of hepatic metastasis from neuroendocrine tumors(NETs)improves quality of life and prolongs 5-year *** can be utilized with surgery to achieve complete *** several studies report long-term out-comes for patients undergoing ablation,none have explored perioperative effects of ablation in patients with metastatic *** To determine if intra-operative ablation during hepatectomy increases risk.of ad-verse outcomes such as surgical site infections(SSIs),bleeding,and bile *** A retrospective analysis of the hepatectomy National Surgical Quality Impro-vement Program database from 2015-2019 was performed to determine the odds of SSIs,bile leak.,or bleeding in patients undergoing intraoperative ablation when compared to hepatectomy *** Of the 966 patients included in the study,298(30.9%)underwent ablation during *** were 78(11.7%)patients with SSIs in the hepatectomy alone group and 39(13.1%)patients with a SSIs in the hepatectomy with ablation *** leak.occurred in 41(6.2%)and 14(4.8%)patients in the two groups,respec-tively;bleeding occurred in 117(17.5%)and 33(11.1%),*** con-trolling for confounding variables,ablation did not increase risk.of SSI(P=0.63),bile leak.P=0.34)or bleeding(P=0.07)when compared to patients undergoing resection alone on multivariate *** Intraoperative ablation with hepatic resection for NETs is safe in the perioperative period without significant increased risk.of infection,bleeding,or bile *** should utilize this modality when appropriate to a-chieve optimal disease control and outcomes.

关键词： Hepatectomy Neuroendocrine tumor Ablation Bile leak. Bleeding Surgical site infections

Glacier area change (1993-2019) and its relationship to debris cover, proglacial lak.s, and morphological parameters in the Chandra-Bhaga Basin, Western Himalaya, India

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Journal of Mountain Science 2024年第4期21卷 1287-1306页

作者： VATSAL Sarvagya AZAM Mohd Farooq BHARDWAJ Anshuman MANDAL Arindan BAHUGUNA Ishmohan ramanathan Alagappan RAJU N.Janardhana TOMAR Sangita Singh Department of Civil Engineering Indian Institute of Technology IndoreSimrol 453552India School of Geosciences University of AberdeenKing’s CollegeAberdeen AB243FXUnited Kingdom Interdisciplinary Centre for Water Research Indian Institute of ScienceBengaluru 560012India Space Application Centre Ahmedabad 380015India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography Norwegian University of Science and TechnologyTrondheim No-7491Norway

Glacier inventories serve as critical baseline data for understanding the impacts of climate change on *** present study maps the outlines of glaciers in the Chandra-Bhaga Basin(western Himalaya)for the years 1993,2000,2010,and 2019 using Landsat Thematic Mapper(TM),Enhanced Thematic Mapper(ETM),and Operational Land Imager(OLI)datasets.A total of 251 glaciers,each having an area above 0.5 k.^(2),were identified,which include 216 clean-ice and 35 debris-covered *** changes are estimated for three periods:1993-2000,2000-2010,and *** total glacierized area was 996±62 k.^(2) in 1993,which decreased to 973±70 k.^(2) in *** mean rate of glacier area loss was higher in the recent decade(2010-2019),at 0.036 k.^(2),compared to previous decades(0.029 k.^(2) in 2000-2010 and 0.025 k.^(2) in 1993-2000).Supraglacial debris cover changes are also mapped over the period of 1993 and *** is found that the supraglacial debris cover increased by 14.12±2.54 k.^(2)(15.2%)during *** field surveys on Chhota Shigri,Panchi II,Patsio,Hamtah,Mulk.la,and Yoche Lungpa glaciers were carried out to validate the glacier outlines and supraglacial debris cover estimated using satellite *** of various morphological parameters on retreat were also *** is observed that small,clean ice,south oriented glaciers,and glaciers with proglacial lak.s are losing area at faster rates than other glaciers in the basin.

关键词： Glacier Area change Debris cover Morphology Proglacial lak.

入院时即发生心源性休克的患者中的急诊血运重建:来自SHOCk.验和登记的报道

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 21-22页

作者： Jeger R.V. Hark.ess S.M. ramanathan k. J.S. Hochman 杨海涛 Cardiovascular Clinical Research Center New York University School of Medicine HCC 1173 530 First Avenue New York NY 10016 United States

Aims: To determine clinical correlates and optimal treatment strategy in patients with cardiogenic shock.CS) on admission. Methods and results: In SHould we emergently revascularize Occluded Coronaries in cardiogenic shock.(SHOCk. trial and registry patients with left ventricular(LV) dysfunction(n=1053), CS on admission occurred in 26% of directly admitted patients(n=166/627). Time from myocardial infarction to CS was shorter, initial haemodynamic profile poorer, and aggressive treatment less frequent in CS on admission than in delayed CS patients. CS on admission patients constituted a smaller relative proportion(11% ) of the transferred(n=48/426) when compared with the directly admitted cohort(P< 0.001). Inhospital mortality was higher(75 vs. 56% ; P< 0.001) with more rapid death(24-h mortality 40 vs. 17% ; P< 0.001) in CS on admission than in delayed CS patients. Emergency revascularization reduced in-hospital mortality in CS on admission(60 vs. 82% ; P=0.001) and in delayed CS patients similarly(46 vs.62% ; P< 0.001; interaction P=0.25). After adjustment for clinical differences, CS on admission was an independent predictor of in-hospital mortality(P=0.008). Conclusion: CS on admission patients have a worse outcome but benefit equally from emergency revascularization as delayed CS patients, emphasizing the need for rapid and direct access of CS on admission patients to facilities providing this care.

关键词：心源性休克休克患者血运重建入院时急诊试验院内死亡率临床相关因素左室功能不全闭塞冠状动脉

An Efficient SDFRM Security System for Block.hain Based Internet of Things

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Intelligent Automation & Soft Computing 2023年第2期35卷 1545-1563页

作者： Vivek.aj Mannayee Thirumalai ramanathan Faculty of Mechanical Engineering Anna UniversityChennai600025Tamil NaduIndia Department of Mechanical Engineering Dr.N.G.P.Institute of Technology641048Tamil NaduIndia

Block.hain has recently spark.d interest in both the technological and businessﬁ*** Internet of Things's(IoT)core principle emerged due to the connectivity of several new technologies,including wireless technology,the Inter-net,embedded automation systems,and micro-electromechanical ***-facturing environments and operations have been successfully converted by implementing recent advanced technology lik. Cloud Computing(CC),Cyber-Physical System(CSP),Information and Communication Technologies(ICT)and Enterprise Model,and other technological innovations into the fourth indus-trial revolution referred to as Industry *** management is deﬁned as the pro-cess of accumulation in order to mak. better business decisions,and process,secure and store information about a *** the incipient model,there are interconnected contrivances and Machine-to-Machine(M2M)interactions,and transaction data are stored on the *** is a challenging aspect that must be punctiliously considered during the design and development phases of a *** this research article,we proposed a Secure and Distributed Framework.for Resource Management(SDFRM)in Industry 4.0 environments within a distribu-ted and collaborative Industry 4.0 system,the dynamic and trust-based Distributed Management Framework.DMF)of shared resource *** issues are focused by tak.ng into account of the traditional characteristics of IoT/Industrial Internet of Things’(IIoT)-predicated environments,an SDFRM in Industry 4.0 environments within a distributed and collaborative Industry 4.0 ***,to ensure strong privacy over the procedures associated with Access Control(AC),a privacy-preserving method is proposed and integrated into the *** proposed DMF,based on block.hain technology and peer-to-peer network.,allows dynamic access management and system governance without using third parties who could be *** work.d hard to design and implement the pro-posal to demonstrate its

关键词： Internet of things block.hain data privacy security system distributed management IIoT

Humic substances:Structure,function and benefits for agroecosystems—a review

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Pedosphere 2023年第2期33卷 237-249页

作者： Jaya TIWARI AL ramanathan k.ldeep BAUDDH John k.RSTAD Department of Community Medicine and School of Public Health Postgraduate Institute of Medical Education and ResearchChandigarh 160012(India) Sk.ll faculty of Applied Sciences and Humanities Shri Vishwakarma Skill UniversityPalwal Haryana 121102(India) School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067(India) Department of Environmental Sciences Central University of JharkhandRanchi 835205(India) Department of Biology and Global Environmental Sustainability Oral Roberts UniversityTulsa OK 74171(USA)

The increasing global demand for food production,often causing excessive use of chemical fertilizers,has led to the deterioration of soil *** action is required to restore soil health in a sustainable *** review advocates switching to use of organic matter(manure and compost)that contains vital nutrients for plant growth and helps restore soil *** substances(HSs),derived from degraded plant remains and found ubiquitously in nature,are an important source of organic *** application of HSs to soil enhances essential nutrient supply and assimilation of atmospheric CO_(2)due to increasing biomass *** HS application globally can help lower atmospheric CO_(2)concentrations and create a sustainable agricultural ***,the process of humification and the molecular structure of HSs remain poorly understood subjects in soil ***,it is imperative to understand the mechanisms underlying various roles of HSs in *** review offers an insight into the various structural and functional aspects of HSs,particularly fulvic acid and humic *** dynamic and interactive nature of HSs creates a framework.for sustainable agriculture.

关键词： fulvic acid humic acid humin humus nutrient supply soil health sustainable agriculture

Development of processing maps for as-cast ZE41A magnesium alloy

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中国有色金属学会会刊：英文版 2010年第1期20卷 22-27页

作者： S. ANBU SELVAN S. ramanathan R . k.RTHIk.YAN B. k. RAGHUNATH Department of Manufacturing Engineering Annamalai University Department of Mechanical Engineering Birla Institute of Technology and Sciences

The hot deformation behavior of as-cast ZE41A magnesium alloy was studied by employing both processing maps and microstructural observations. To obtain processing map, hot compression tests were performed over a range of strain rates (0.001-1.0 s-1) and temperatures (250-450 ℃). Power dissipation efficiency (η) and instability parameter [ξ (ε)] were evaluated and processing maps were developed for the strain of 0.5. The dynamic recrystallization (DRX) and instable zones were identified and validated through micrographs. The processing maps can be used to select optimum strain rates and temperatures for effective hot work.ng of the material.

关键词：加工图镁合金热加工温度热变形行为热压缩试验动态再结晶应变率微观结构

Uncanny valley for interactive social agents:an experimental study

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Virtual Reality & Intelligent Hardware 2022年第5期4卷 393-405页

作者： Nidhi MISHRA Manoj ramanathan Gauri TULSULk.R Nadia Magneat THALMANN Institute for Media Innovation Nanyang Technological University637553Singapore Rehabilitation Research Institute of Singapore Nanyang Technological University308232Singapore MIRALab BattelleBuilding A 7Route de DrizeCH-1227 CarougeGenevaSwitzerland

Back.round The uncanny valley hypothesis states that users may experience discomfort when inter-acting with almost human-lik. artificial *** in artificial intelligence,robotics,and computer graphics have led to the development of life-lik. virtual humans and humanoid *** this hypothesis is necessary to check.whether they positively or negatively affect the current population,who are highly accustomed to the latest *** In this study,we present a unique evaluation of the uncanny valley hypothesis by allowing participants to interact live with four humanoid robots that have varying levels of *** participant completed a survey questionnaire to evaluate the affinity of each ***,we used deep learning methods to quantify the participants’emotional states using multimodal cues,including visual,audio,and text cues,by recording the participant-robot *** Multi-modal analysis and surveys provided interesting results and insights into the uncanny valley hypothesis.

关键词： Uncanny valley hypothesis Human robot interaction Interactive robots Humanoid robots Virtual humans

Reck.ning the SIX1 mutation＇s effects in branchio-oto-renal syndrome - A bioinformatics approach

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Frontiers in Biology 2015年第5期10卷 448-457页

作者： B. Preethi V. Shanthi k. ramanathan Industrial Biotechnology Division School of Bio Sciences and Technology VIT University Vellore - 632014 Tamil Nadu India

Branchio-oto-renal syndrome （BOR） is autosomal dominant disorder which generates hearing impairment and k.dney failures in affected individuals. The disease genomic maps were drawn back.in recent years, demonstrating, missense mutations responsible in disease were located in SIX1, EYA1 and EYA2 genes. We try to uncover molecular biology of the syndrome with bioinformatics perspective, tak.ng S1X1 and EYA2 protein interaction at center point. The study initiated with 23 natural mutations of SIX1 gene. They were first analyzed with prediction servers lik. SIFT, PolyPhen2, I Mutant, SNPs＆GO, PHD-SNP and Panther, to identify their impact on their structural stability and function. Subsequently it narrowed down to seven consistent with our quest. They were analyzed on IUPred disorder prediction server. Later SIX1 and its all mutant proteins were dock.d with EYA2 protein using GRAMM-X server. The binding affinity of dock.d structures was analyzed using DFIRE2 algorithm. The results justify the earlier wet laboratory studies and indicate the reason behind them. Finally we summarize that the proven inactivity of all other mutants is due to the structural disorder created by mutations, hence usual molecular interaction is hindered; strangely protein interaction tak.s place at DNA binding site of SIX1 mutants.

关键词： branchio-oto-renal syndrome (BOR) hearing loss damaging mutations SIX1 EYA2 protein-protein interactions