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Waist Circumference reference Values for Screening Cardiovascular risk Factors in Chinese Children and Adolescents

Biomedical and Environmental Sciences 2010年第1期23卷 21-31页

作者： GUAN-SHENG MA CHENG-YE JI JUN MA JIE MI r1ta yt sling FENG XIONG WEI-LI YAN XIAO-QI HU YAN-PING LI SONG-M1NG DU HONG-YUN FANG AND J1NG-XIONG JIANG National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing100050 China Institute of Child and Adolescent Health Peking gniversi07 Health Science Center Beijing100191 China Capital Institute of Pediatrics Beijing 100020 China Department of Paediatrics TheChinese University of Hong Kong Hong Kong Special Administrative Re'on China The Children's Hospital of Chongqing Medical University Chongqing 400014 China School of Public Health Xinjiang Medical University Wulumuqi 830011 Xinjiang China National Center for Women and Childre's Health Chinese Center for Disease Control and Prevention Beijing 100013 China

Objectives To explore the optimal threshold values of waist circumference （WC） for detecting cardiovascular （CV） risk factors among Chinese children and adolescents. Methods Association of WC with CV risk factors was studied among 65 898 children aged 7-18 years whose data were pooled from nine previous studies in China. CV risk factors in this study included hypertension （blood pressure above 95 percentile levels）, dyslipidemia （with one or more of the following three indexes： TG ≥ 1.7 mmol/L, TC ≥ 5.18 mmol/L, and HDL-C ≤ 1.04 mmol/L） and elevated glucose level （fasting plasma glucose ≥5.6 mmol/L）. receive-operating characteristic analysis （rOC） and logistic regression were employed to derive optimal age- and sex-specific waist circumference references for predicting CV risk factors. results A slight increasing trend of CV risk factors was observed starting from the 75th percentile of waist circumference in the study population, while a remarkable increasing trend occurred from the 90th percentile. The optimal waist circumference thresholds for predicting high blood pressures were at the 75th percentile for both boys and girls, which was at the 90th percentiles for detecting at least two of the above three CV risk factors. In comparison with children with waist circumference below the 75th percentile, the odds ratio of two CV risk factors doubled among children with waist circumference between the 75th and the 90th percentile, and increased by 6 times among children with waist circumference above the 90th percentile. The trend of high blood pressure increasing with waist circumference remained significant after having been stratified by BMI category. Conclusion The 75th and the 90th percentiles of WC are the optimal cut-off points for predicting an increased and a substantially increased risk of CV factors in Chinese children and adolescents, respectively.

关键词： Waist circumference Cardiovascular disease risk factor China

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