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Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through Ar-MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert r.wang Andrew M.Baschnagel Zijian Ni Sean r.Brennan Hypatia K.Newton Darya Buehler Christina Kendziorski randall J.Kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(Ar)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While Ar regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and rNA knockdown of Ar identified a bZIP transcription factor MAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

GO/MgO/Mg interface mediated strengthening and electromagnetic interference shielding in AZ31 composite

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Journal of Magnesium and Alloys 2023年第10期11卷 3800-3814页

作者： Z.Y.Xu C.F.Fang C.J.Li r.wang X.P.Zhang J.Tan Y.M.wang Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian 116023China

More requirements of electromagnetic interference(EMI) shielding performance are put forward for lightweight structural materials due to the development of aerospace and 5G communications. Herein, graphene oxide(GO) decorated with SnO_(2) coating is introduced as reinforcement into AZ31 Mg alloy. During the smelting process, the MgO layer is in situ gernerated at interface between GO and the molten Mg alloy matrix by consuming SnO_(2). In the solid state, such kind of interface structure can improve the GO-Mg interface bonding intensity,also significantly generate stacking faults. The AZ31 composite reinfoced by trace modified GO(0.1 wt%) exhibits high ultimate strength and almost the same elongation with AZ31 alloy. Compared with AZ31 alloy, the yield strength and ultimate tensile strength of composite are increased by 33.5% and 23.7%, respectively. Meanwhile, the multi-level electromagnetic reflection from the multi-layer structure of GO and the interface polarization caused by the MgO mid-layer can significantly improve EMI shielding performance. The appropriate interface design strategy achieves the effect of “two birds with one stone”.

关键词： Metal-matrix composites Mechanical properties EMI shielding Microstructures

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An r.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.r.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.r.Hou C.Y.Hu H.M.Hu K.Hu r.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.r.Li r.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.r.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.r.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng r.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.rademacker C.F.redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive r&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector r&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Laser additive manufacturing of strong and ductile Al-12Si alloy under static magnetic field

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Journal of Materials Science & Technology 2023年第32期163卷 101-112页

作者： r.wang J.wang L.M.Lei S.Yu T.Hu S.S.Shuai S.Z.Xu Z.H.Cao X.P.Li C.Y.Chen Z.M.ren State Key Laboratory of Advanced Special Steels School of Materials Science and EngineeringShanghai UniversityShanghai 200444China AECC Commercial Aircraft Engine Co. Ltd.Shanghai 201108China School of Mechanical and Manufacturing Engineering The University of New South Wales(UNSW Sydney)Sydney NSW 2052Australia

rapid cooling and solidification during laser additive manufacturing(LAM)can produce ultra-fine microstructure with higher ***,the non-uniform cell/grain structure can easily result in early stress concentration and fracture during deformation,which remains a major challenge for the LAM *** Al-12Si as the model alloy,we employed the external static magnetic field(SMF)to modulate the laser powder bed fusion process(L-PBF),demonstrating a uniform microstructure with a refined cell *** mechanical properties show that the SMF can produce a combination of high tensile strength of 451.4±0.5 MPa and large uniform elongation of 10.4%±0.79%,which are superior to those of previously-reported Al-Si alloys with post-treatment or element *** mechanism analysis based on multi-scale simulation reveals the determining role of SMF in rapid solidification,and this method is applicable to the microstructure control of other metallic materials during LAM.

关键词： Laser powder bed fusion Magnetic field Al alloys Grain refinement Strengthening mechanism

Progress and perspective of interface design in garnet electrolyte-based all-solid-state batteries

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Carbon Energy 2021年第3期3卷 385-409页

作者： Junrun Feng Zhonghui Gao Lin Sheng Zhangxiang Hao Feng r.wang Department of Chemical Engineering University College LondonLondonUK Institute of New Energy for Vehicles School of Materials Science and EngineeringTongji UniversityShanghaiChina

Inorganic solid-state electrolytes(SSEs)are nonflammable alternatives to the commercial liquid-phase *** enables the use of lithium(Li)metal as an anode,providing high-energy density and improved stability by avoiding unwanted liquid-phase chemical *** the different types of SSEs,the garnet-type electrolytes witness a rapid development and are considered as one of the top candidates to pair with Li metal due to their high ionic conductivity,thermal,and electrochemical ***,the large resistances at the interface between garnet-type electrolytes and cathode/anode are the major bottlenecks for delivering desirable electrochemical performances of all-solid-state batteries(SSBs).The electrolyte/anode interface also suffers from metallic dendrite formation,leading to rapid performance *** is a fundamental material challenge due to the poor contact and wettability between garnet-type electrolytes with electrode ***,we summarize and analyze the recent contributions in mitigating such materials challenges at the *** used to address these challenges are divided into different categories with regard to their working *** one hand,progress has been made in the anode/garnet interface,such as the successful application of Li-alloy anode and different artificial interlayers,significantly improving interfacial *** the other hand,the desired cathode/garnet interface is still hard to reach due to the complex chemical and physical structure at the *** common methods used are nanostructured cathode host and sintering additives for increasing the contact *** the basis of this information,we present our views on the remaining challenges and future research of electrode/garnet *** review not only motivates the need for further understanding of the fundamentals,stability,and modifications of the garnet/electrode interfaces but also provides guidelines for the future de

关键词： all-solid-state batteries garnet electrolytes garnet/electrode interface solid-solid interface

一种新的基于MrI的深度学习网络联合注意力机制预测IDH突变星形细胞瘤CDKN2A/B纯合缺失状态

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国际医学放射学杂志 2024年第2期 250-250页

作者： L.Q.Zhang r.wang J.N.Gao Y.Tang X.Y.Xu Y.B.Kan 束宏敏

摘要目的建立一种基于MrI的高精度深度学习方法，用于预测异柠檬酸脱氢酶（IDH）突变星形细胞瘤中细胞周期蛋白依赖性激酶抑制剂2A/B(CDKN2A/B)纯合缺失状

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TEMPErATUrE DEPENDENCE OF VISCOSITY OF Al-Si ALLOY MELTS

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Acta Metallurgica Sinica(English Letters) 2005年第2期18卷 159-163页

作者： H.r.Geng r.wang Z.X.Yang J.H.Chen C.J.Sun Y.wang SchoolofMaterialsScienceandEngineering JinanUniversityJinan250022China SchoolofMaterialsScienceandEngineering ShandongUniversityJinan250061China

The relationship between the viscosity and temperature of Al-Si alloy melts was investigated. The viscosity of three different types of Al-Si alloy melts was measured. It was showed that the relationship between the viscosity and temperature of hypoeutectic Al-5%Si and eutectic Al- 12.5%Si alloy melts is approximately exponential except for some special zones, but that of the hypereutectic melt is different. The paper discussed the correlation of the viscosity and atomic density, which is thought that the viscosity corresponds to the atomic density to some extent.

关键词： Al-Si alloy melt viscosity liquid metal atomic density

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Intervening in cellular carcinogenesis resulting from exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-blpyridine](PhIP)

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Intervening in cellular carcinogenesis resulting from exposu...

由超拍电子伏特加速器产生的超高能伽马射线气泡

第三届中国兽医临床大会

作者： Hwa-Chain r.wang DVM MSPhd Professor of Molecular Oncology Anticancer Molecular Oncology LaboratoryDepartment of Biomedical and Diagnostic SciencesCollege of Veterinary MedicineThe University of TennesseeKnoxvilleTennessee37996USA

Human breast cancer is the most common type of cancer and the seeond leading cause of cancer deaths among women in northem America and Europe.

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li ruo-Yu Liu ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic ray research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster