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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

Neural regeneration research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel refai Gerald r.rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Analysis and Optimization of Operational and Pollutant Attributes of Diesel Engine with CNT-Infused Orange Peel Biodiesel-Diesel Blend Fuel

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Journal of Thermal Science 2024年第2期33卷 761-778页

作者： ranjeet rAI r.r.SAHOO Mechanical Engineering Department GLA UniversityMathura281406India Mechanical Engineering Department IIT(BHU)Varanasi221005India

The current study is performed to find sustainable solutions for the future of transportation and environmental *** conventional methods and experimental design table(L16 Orthogonal Array)techniques have been employed to examine and optimize a diesel-powered engine's operational and pollutant *** L16 Orthogonal Array is obtained through Taguchi's experimental design approach using Minitab 16 *** experimental design incorporated three control variables,namely engine speed,fuel type,and engine load,each with four *** operational parameters,namely brake thermal efficiency(BTE)and brake specific fuel consumption(BSFC),as well as the emission characteristics,including hydrocarbon(HC),carbon monoxide(CO),nitrogen oxide(NO),and smoke emissions,were acquired using the L16 orthogonal array(OA) and subsequently *** utilization of methodologies such as signal-to-noise(S/N) ratio and grey analysis was employed to determine the optimal operational state of the engine to achieve maximum performance while minimizing *** engine's ideal state of operation,in terms of BTE and BSFC,was determined to be at 75% engine load,1000 r/min engine speed,and using 10^(-4)(in vol) carbon nanotube incorporated 20% orange peel biodiesel(OPB20CNT100) blended fuel(A3-B1-C4).The study indicated that engine load significantly influenced BTE and BSFC,with 84.05% and 87.79% contribution factors,*** 25% engine load,1000 r/min,and OPB20CNT100 fuel(A1-B1-C4) CO,smoke,NO,and HC emissions were the *** load affects emissions the *** BSFC increased 3.10% and NO emissions 1.77%.BTE,CO,smoke,and HC emissions decreased by 1.9%,12.29%,47.05%,and 47.22%,respectively,at optimal operating conditions concerning diesel *** study shows that Taguchi-Grey's experimental design optimizes diesel engine operational and pollutant *** outcomes revealed that orange peel biodiesel infused with CNT can replace diesel fuel in a

关键词： Taguchi-Grey method OPB20CNT100 transesterification S/N ratio GrG HC CO and NO

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The effect of initial geometric imperfection on the nonlinear resonance of functionally graded carbon nanotube-reinforced composite rectangular plates

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Applied Mathematics and Mechanics(English Edition) 2018年第9期39卷 1219-1238页

作者： r.GHOLAMI r.ANSArI Department of Mechanical Engineering Lahijan Branch Islamic Azad University Department of Mechanical Engineering University of Guilan

The purpose of the present study is to examine the impact of initial geometric imperfection on the nonlinear dynamical characteristics of functionally graded carbon nanotube-reinforced composite(FG-CNTrC) rectangular plates under a harmonic excitation transverse load. The considered plate is assumed to be made of matrix and single-walled carbon nanotubes(SWCNTs). The rule of mixture is employed to calculate the effective material properties of the plate. Within the framework of the parabolic shear deformation plate theory with taking the influence of transverse shear deformation and rotary inertia into account, Hamilton’s principle is utilized to derive the geometrically nonlinear mathematical formulation including the governing equations and corresponding boundary conditions of initially imperfect FG-CNTrC plates. Afterwards, with the aid of an efficient multistep numerical solution methodology, the frequency-amplitude and forcing-amplitude curves of initially imperfect FG-CNTrC rectangular plates with various edge conditions are provided, demonstrating the influence of initial imperfection,geometrical parameters, and edge conditions. It is displayed that an increase in the initial geometric imperfection intensifies the softening-type behavior of system, while no softening behavior can be found in the frequency-amplitude curve of a perfect plate.

关键词： nonlinear dynamical characteristics imperfect functionally graded carbon nanotube-reinforced composite(FG-CNTrC) rectangular plate geometric imperfection sensitivity

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Moore-Gibson-Thompson theory for thermoelastic dielectrics

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Applied Mathematics and Mechanics(English Edition) 2021年第2期42卷 309-316页

作者： J.r.FErNANDEZ r.QUINTANILLA Department of Applied Mathematics I University of VigoCampus As Lagoas MarcosendeVigo 36310Spain Department of Mathematics Polytechnic University of CataloniaTerrassa 08222Spain

We consider the system of equations determining the linear thermoelastic deformations of dielectrics within the recently called Moore-Gibson-Thompson(MGT)***,we obtain the system of equations for such a ***,we consider the case of a rigid solid and show the existence and the exponential decay of ***,we consider the thermoelastic case and obtain the existence and the stability of the *** decay of solutions in the one-dimensional case is also recalled.

关键词： Moore-Gibson-Thompson(MGT)thermoelastic dielectrics existence semigroup exponential decay

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Dirichlet Process Gaussian Mixture Models:Choice of the Base Distribution

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Journal of Computer Science & Technology 2010年第4期25卷 653-664页

作者： Dilan Grür Carl Edward rasmussen Gatsby Computational Neuroscience Unit University College London Department of Engineering University of Cambridge Max Planck Institute for Biological Cybernetics.D-72076 Tubingen

In the Bayesian mixture modeling framework it is possible to infer the necessary number of components to model the data and therefore it is unnecessary to explicitly restrict the number of components. Nonparametric mixture models sidestep the problem of finding the ＂correct＂ number of mixture components by assuming infinitely many components. In this paper Dirichlet process mixture （DPM） models are cast as infinite mixture models and inference using Markov chain Monte Carlo is described. The specification of the priors on the model parameters is often guided by mathematical and practical convenience. The primary goal of this paper is to compare the choice of conjugate and non-conjugate base distributions on a particular class of DPM models which is widely used in applications, the Dirichlet process Gaussian mixture model （DPGMM）. We compare computational efficiency and modeling performance of DPGMM defined using a conjugate and a conditionally conjugate base distribution. We show that better density models can result from using a wider class of priors with no or only a modest increase in computational effort.

关键词： Bayesian nonparametrics Dirichlet processes Gaussian mixtures

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A higher-order porous thermoelastic problem with microtemperatures

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1911-1926页

作者： J.r.FErNáNDEZ r.QUINTANILLA Department of Applied Mathematics I University of VigoETSI de Telecomunicacion Campus As Lagoas Marcosende s/nVigo 36310Spain Department of Mathematics Polytechnical University of CatalunyaTerrassa 08222BarcelonaSpain

In this paper,we study a porous thermoelastic problem with microtemperatures assuming parabolic higher order in time derivatives for the thermal *** model is derived and written as a coupled linear ***,a uniqueness result is proved by using the logarithmic convexity method in the case that we do not assume that the mechanical energy is positive ***,the existence of the solution is obtained by introducing an energy function and applying the theory of linear semigroups.

关键词： higher order thermoelasticity microtemperature logarithmic convexity method existence and uniqueness

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Multidimensional images and aberrations in STEM

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Chinese Physics B 2024年第9期33卷 68-74页

作者： Eric r.Hoglund Andrew r.Lupini Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831United States

recent advances in scanning transmission electron microscopy(STEM)have led to increased development of multidimensional STEM imaging modalities and novel image reconstruction *** interest arises because the main electron lens in a modern transmission electron microscope usually has a diffraction-space information limit that is significantly better than the real-space resolution of the same *** state-of-affairs is sometimes shared by other scattering methods in modern physics and contributes to a broader excitement surrounding multidimensional techniques that scan a probe while recording diffraction-space images,such as ptychography and scanning nano-beam ***,the contrasting resolution in the two spaces raises the question as to what is limiting their effective ***,we examine this paradox by considering the effects of aberrations in both image and diffraction planes,and likewise separate the contributions of pre-and post-sample *** consideration provides insight into aberration-measurement techniques and might also indicate improvements for super-resolution techniques.

关键词： scanning transmission electron microscopy(STEM) aberrations

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Water and nutrient recovery from urine:A lead up trail using nano-structured In_(2)S_(3)photo electrodes

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Chinese Physics B 2021年第5期30卷 531-535页

作者： r Jayakrishnan T r Sreerev Adith Varma Department of Physics University of KeralaThiruvananthapuramKerala 695581India Photovoltaic research Laboratory Christian College Chenagnnur 689122India

Developments of economic systems are critical for bio-regenerative life support systems in manned space *** this work we report on the feasibility of using two direct sunlight powered processes sequentially for the recovery of water and nutrients from *** work presents experimental evidence on nutrient and water recovery achieved using the proto-type designed and *** report the design and testing of a solar still which would serve on the nutrient recovery *** cooled condensate from the solar still is fed into a solar powered electrolysis unit where nano-structured indium sulphide(In_(2)S_(3))thin films coated over fluorine doped tin oxide(SnO_(2):F)substrate serve as one of the working *** electrolysis takes place in the absence of an electrolyte which manifests as a technical achievement of our *** results show that the COD level in the recycled water is very *** In_(2)S_(3)photo-electrodes are stable without any physical damage after the process.

关键词： semiconductors water quality thin film structure and morphology electrolysis

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Characterization of water-in-crude oil emulsions in oil spill response

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Journal of Environmental Sciences 2003年第4期15卷 506-509页

作者： MATHEr r.r. FOTHErINGHAM A.F. YANG r.D. HeriotWattUniversityScottishBordersCampus HeriotWattUniversityScottishBordersCampusHeriotWattUniversityScottishBordersCampus GalashielsUKGalashielsUKGalashielsUK

The formation of water in crude oil emulsions occurs when crude oils are spilled into sea. The water in crude oil emulsions significantly change the properties of the spilled crude oils and in turn influence the choices made relating to oil spill countermeasures. The water in crude oil emulsions were characterized using various techniques in this study. The environmental scanning electron microscopy observation of water droplets in the emulsions is also presented. It is a powerful tool in emulsion observations.

关键词： oil spill water in oil emulsions oil spill response DSC ESEM

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Hidden Markov Model Approach for Software reliability Estimation with Logic Error

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International Journal of Automation and computing 2020年第2期17卷 305-320页

作者： r.Bharathi r.Selvarani Department of Computer Science PES UniversityBangalore 560100India research scholar Visvesvaraya Technological UniversityBelagavi 590018India Department of Computer Science Alliance UniversityBangalore 562106India

To ensure the safe operation of any software controlled critical systems,quality factors like reliability and safety are given utmost *** this paper,we have chosen to analyze the impact of logic error that is one of the contributors to the above *** view of this,we propose a novel framework based on a data driven approach known as software failure estimation with logic error(SFELE).Here,the probabilistic nature of software error is explored by observing the operation of a safety critical system by injecting logic *** occurrence of error,its propagations and transformations are analyzed from its inception to end of its execution cycle through the hidden Markov model(HMM)*** found that the proposed framework SFELE supports in labeling and quantifying the behavioral properties of selected errors in a safety critical system while traversing across its system components in addition to reliability estimation of the *** attempt at the design level can help the design engineers to improve their system quality in a costeffective manner.

关键词： Hidden Markov model(HMM) reliability logic error safety critical software failure

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