检索结果-南通市图书馆

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Ion-acoustic waves at the night side of Titan's ionosphere:higher-order approximation

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2020年第5期72卷 70-77页

作者： s M Ahmed E r Hassib U M Abdelsalam r E Tolba W M Moslem Department of Mathematics Faculty of ScienceSuez UniversitySuezEgypt Department of Mathematics Faculty of ScienceFayoum UniversityFayoumEgypt Department of Mathematics Rustaq College of EducationOman Centre for Theoretical Physics The British University in Egypt(BUE)El-Shorouk CityCairoEgypt Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt

Nonlinear solitary waves are investigated for a plasma system at the night side of Titan's *** plasma model consists of three positive ions,namely C2H5^+,HCNH^+,and C3H5^+,as well as Maxwellian *** basic set of fluid equations is reduced to a Korteweg de-Vries(KdV)equation and linear inhomogeneous higher order KdV(LIHO-KdV)*** solitary wave solutions of both equations are obtained using a renormalization *** solitary waves'existence region and the wave profile are investigated,and their dependences on the plasma parameters at the night side of Titan's ionosphere are *** solitary waves'phase velocities are subsonic or supersonic,and the propagating pulses are usually *** effect of higher-order corrections on the perturbation theory is *** is found that the higher-order contribution makes the amplitude slightly taller,which is suitable for describing the solitary waves when the amplitude augments.

关键词： plasmas ion-acoustic waves planets and satellites:atmospheres

serological surveillance for sArs-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic

在线全文

学校读者我要写书评

暂无评论

World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda r Conde sofia L Costa regina C s sant’Anna Isa M F Antunes Mônica C Carneiro Fabio s ronzei Julia C scaffo Felipe r Pinheiro Lialyz s Andre Helvecio C Povoa Valéria T Baltar Fabíola Giordani Eduarda s Hemerly Gisele C Alexandre Karla C de Paula Márcio Watanabe Antonio Claudio L da Nóbrega Jackeline Christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de sáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BACKGrOUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(sArs-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for sArs-CoV-2 antibodies could indicate the immunoreactive profile during the COVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-sArs-CoV-2 antibodies in individuals within a university setting during the COVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-rJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of COVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(Or)=1.16,95%CI:1.02-1.31](Ps who had been in contact with a COVID-19-positive case(Or=3.49,95%CI:2.34-5.37)(Pse who had received the COVID-19 vaccine(Or=2.33,95%CI:1.61-3.35)(Psocial isolation(Or=0.59,95%CI:0.41-0.84)(Psho

关键词： serological surveillance sArs-CoV-2 antibodies COVID-19 serological rapid test risk factors for COVID-19

regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer s.Atasoy Deniz Atasoy rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(rGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel rGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of rGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by rGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by rGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these rGs6-expressing ***,rGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying rGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(rGs6)

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv sam s.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University school of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnsO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

sYNTHEsIs OF OrGANO sOLUBLE ArOMATIC POLY(AMIDE-IMIDE)s BAsED ON 2-(5-(3,5-DINITrOPHENYL)-1,3,4-OXADIAZOLE-2-YL)PYrIDINE IN AN IONIC LIQUID

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer science 2011年第6期29卷 699-711页

作者： Y.Mansoori s.shah sanaei s.V.Atghia M.r.Zamanloo Gh.Imanzadeh Department of Applied Chemistry Faculty of ScienceUniversity of Mohaghegh ArdabiliArdabil 56199-11367Iran

In this work, the syntheses of new thermally stable poly（amide-imide）s with pendant 2-pyridyl-l,3,4-oxadiazole units in n-butyl methyl imidazolium bromide as reaction media have been reported. A new dicarboxylic acid has been derived from the reaction of diamine, 2-（5-（3,5-diaminophenyl）-1,3,4-oxadiazole-2-yl）pyridine （POBD）, and trimellitic acid anhydride. Polymers were prepared from the reaction of the diimide-diacid （DIDA） and different aromatic diamines in butyl methyl imidazolium bromide, [bmim] [Br], in the presence of triphenyl phosphite （TPP） as condensing agent without needing any extra components. The prepared poly（amide-imide）s were characterized by FTIr, elemental analysis, and through the synthesis of a model compound. The prepared polymers were soluble in polar and aprotic solvents, such as DMF, DMsO, NMP and DMAc. The inherent viscosity of the polymer solutions was in the range of 0.52-1.33 dL/g measured in concentrated H2sO4 at a concentration of 0.125 g/dL at （25 ± 0.5）℃. The results are compared with the results obtained from common direct polycondensation with NMP as solvent. Polymers obtained in ionic liquid showed higher inherent viscosity than that of polymers obtained via classical method in NMP. Thermal properties of the polymers were studied with DsC and TGA methods.

关键词： Poly(amide-imide) Ionic liquid Polycondensation 1,3,4-Oxadiazole

Impact of Zika virus non-structural protein mutations on hippocampal damage

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Heterogeneity of mature oligodendrocytes in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.r.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne stratton G.r.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by robertson and río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus rNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Influence of the Cd/s Molar ratio on the Optical and structural Properties of Nanocrystalline Cds Thin Films

在线全文

学校读者我要写书评

暂无评论

Journal of Materials science & Technology 2010年第3期26卷 193-199页

作者： M.Thambidurai N.Murugan N.Muthukumarasamy s.Agilan s.Vasantha r.Balasundaraprabhu3 Department of Physics Coimbatore Institute of Technology Department of Mechanical Engineering Coimbatore Institute of Technology Department of Physics PSG College of Technology

Nanocrystalline Cds thin films have been deposited using precursors with different thiourea concentrationonto glass substrates by sol-gel spin coating *** crystalline nature of the films has been observedto be strongly dependent on thiourea concentration and annealing *** Cds films are found tobe nanocrystalline in nature with hexagonal *** grain size is found to be in the range of 7.6 to11.5 nm depending on the thiourea concentration and annealing *** high resolution transmissionelectron microscopy （HrTEM） results of the Cds films prepared using cadmium to thiourea molar ratio of0.3：0.3 indicate the formation of nanocrystalline Cds with grain size of 5 *** transform infrared （FTIr）analysis shows the absorption bands corresponding to Cd and *** optical study carried out to determinethe band gap of the nanostructured Cds thin films shows a strong blue *** band gap energy has beenobserved to lie in the range of 3.97 to 3.62 eV following closely the quantum confinement dependence ofenergy on crystallite *** dependence of band gap of the Cds films on the annealing temperature andthiourea concentration has also been *** photoluminescence （PL） spectra display two main emissionpeaks corresponding to the blue and green emissions of Cds.

关键词： sol-gel Cds quantum dots High resolution transmission electronmicroscopy (HrTEM)