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Immunogenic potential and protective efficacy of formalin inactivated circulating Indian strain of West nile virus

Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 946-951页

作者： Pritom Chowdhury siraj Ahmed Khan rashmee Topno Prafulla Dutta r.n.s.yadav Jagadish Mahanta regional Medical research Centre ICMR(NE Region)DibrugarhAssamIndia Centre for studies in Biotechnology Dibrugarh UniversityDibrugarh-786004AssamIndia

Objective:To assess the best suitable condition for virus *** to study the immunogenic potential and protective efficacy of a circulating West nile virus(WnV) strain in ***:Bulk preparation of circulating WnV:WnIrGC07(GeneBank ID:HQ246154).was undertaken in a bioreaclor using *** Inactivation was done in three different conditions:22 ℃.4 ℃ and room *** virus preparations were evaluated for antigenicity by ELIsA and toxicity by cell proliferation *** efficacy was done in-viro on swiss albino mice against standard Indian WnV and Japanese encephalitis virus(JKV)*** and cell mediated immune response was evaluated in mice sera by ELIsA and neutralization ***:Inactivation at 22 ℃ was found to be more suitable in terms of less toxicity and high *** same was selected to study the immune response and efficacy in *** induced neutralizing antibody titre of 1:625 and high EgG *** vivo experiment showed 100% protective efficacy against WnV and 20.8% cross protective efficacy against *** assessment of cellular immunity through immunized mice revealed augmentation of high levels of pro-inflammatory cytokines and moderate levels of anti—cytokines indicating a mixed balance of Th1 and Th2 ***:Findings suggest that formalin inactivated Indian WnV strain has a good immunogenic *** is the first study on assessment of immunogenic potential of a lineage 5 strain of *** study reveals that it would be a promising and effective candidate for vaccine studies which warrants further evaluation.

关键词： West nile virus Assam Immunization Efficacy neutralizing antibody Cytokine

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Medicinal Effects, Phytochemistry,Pharmacology of Euphorbia prostrata and Promising MolecularMechanisms

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Chinese Journal of Integrative Medicine 2024年第2期30卷 181-192页

作者： nirmala Kumari yadav rakesh yadav Department of Pharmacy Banasthali VidyapithBanasthali(304022)RajasthanIndia Department of Pharmaceutical sciences Indira Gandhi UniversityMeerpurRewari(122502)HaryanaIndia national Forensic sciences University Tripura CampusAgartala(799001)TripuraIndia

Euphorbiaceae is a large family of dicotyledonous angiosperms with diverse genera including Euphorbia prostrata(***).Current research has provided scientific evidence for traditional uses of *** against diverse pathological conditions such as anti-hemorrhoidal,anti-inflammatory,analgesic,wound healing,antioxidant,antibacterial,leishmanicidal,antitumor activity,and so *** phytochemical screening has revealed the presence of glycosides,phytosterols,flavonoids,polyphenols,tannins,and anthraquinones with chemical structures elucidation of their respective *** uniqueness of such multifactorial compounds present in this species endorses it as the potent therapeutic or prophylactic choice for several fatal *** ethnomedical applications served as a significant citation for pharmacology,the molecular mechanism has not been reviewed *** present paper provides a comprehensive review of research outcomes,pharmacology,toxicology,and molecular signaling of phytochemicals of *** species as a reference for relevant *** study of bioactive compounds in crude extracts and fractions,the demonstration of primary mechanisms of pharmacology,along with the addition of toxicity,and clinical trials,should be conceded in *** review underlines the *** species that can be a promising phytomedicine since we are committed to excavating more intensely into their pharmacological role.

关键词： Euphorbia prostrata Euphorbiaceae phytochemicals ethnomedical applications toxicology molecularmechanism

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Identification of earthquake induced structural damage based on synchroextracting transform

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 475-487页

作者： roshan Kumar Gaurav Kumar Wei Zhao Arvind r yadav Gang Yu Jayendra Kumar Evans Amponsah Department of Electronic and Information Technology Miami College of Henan UniversityHenan 475004China Alliance University Alliance College of Engineering and DesignBanglore 562106India Department of Electronics and Comm Parul UniversityVadodra 391760India school of Electrical Engineering University of JinanJinan 250022China Department of Electronics and Comm NIT JamshedpurJamshedpur 831014India Department of Civil engineering Kwame Nkrumah University of Science and TechnologyKumasi 10959Ghana

several popular time-frequency techniques,including the Wigner-Ville distribution,smoothed pseudo-Wigner-Ville distribution,wavelet transform,synchrosqueezing transform,Hilbert-Huang transform,and Gabor-Wigner transform,are investigated to determine how well they can identify damage to *** this work,a synchroextracting transform(sET)based on the short-time Fourier transform is proposed for estimating post-earthquake structural *** performance of sET for artificially generated signals and actual earthquake signals is examined with existing *** other tested techniques,sET improves frequency resolution to a great extent by lowering the influence of smearing along the time-frequency ***,interpretation and readability with the proposed method are improved,and small changes in the time-varying frequency characteristics of the damaged buildings are easily detected through the sET method.

关键词： cross-term damage detection earthquake signal synchroextracting transform time-frequency

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Traffic Engineering and Quality of service in Hybrid software Defined networks

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China Communications 2024年第2期21卷 96-121页

作者： samiullah Mehraban rajesh Kumar yadav IOT Lab Department of Computer Science&EngineeringDelhi Technological UniversityDelhi 110042India

For Future networks, many research projects have proposed different architectures around the globe;software Defined network(sDn) architectures, through separating Data and Control Layers, offer a crucial structure for it. With a worldwide view and centralized Control, the sDn network provides flexible and reliable network management that improves network throughput and increases link utilization. In addition, it supports an innovative flow scheduling system to help advance Traffic Engineering(TE). For Medium and large-scale networks migrating directly from a legacy network to an sDn network seems more complicated & even impossible, as there are High potential challenges, including technical, financial, security, shortage of standards, and quality of service degradation challenges. These challenges cause the birth and pave the ground for Hybrid sDn networks, where sDn devices coexist with traditional network devices. This study explores a Hybrid sDn network’s Traffic Engineering and Quality of services Issues. Quality of service is described by network characteristics such as latency, jitter, loss, bandwidth,and network link utilization, using industry standards and mechanisms in a Hybrid sDn network. We have organized the related studies in a way that the Quality of service may gain the most benefit from the concept of Hybrid sDn networks using different algorithms and mechanisms: Deep reinforcement Learning(DrL), Heuristic algorithm, K path partition algorithm, Genetic algorithm, sOTE algorithm, rOAr method, and routing Optimization with different optimization mechanisms that help to ensure high-quality performance in a Hybrid sDn network.

关键词： DrL hsDn QoE Qos sDn TE

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The circuitry landscape of perovskite solar cells:An in-depth analysis

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Journal of Energy Chemistry 2024年第7期94卷 393-413页

作者： siddhi Vinayak Pandey Daniel Prochowicz Apurba Mahapatra saravanan Pandiaraj Abdullah n.Alodhayb seckin Akin Pankaj yadav Department of solar Energy School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of self-Development skills King Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Metallurgical and Materials Engineering Necmettin Erbakan University42060 KonyaTurkey Department of Physics School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

The extensive research and development in perovskite solar cells (PsCs) have rekindled the hopes of converting solar energy into *** elusive understanding of underlying mechanisms is required for the development of efficient *** the years,Impedance spectroscopy (Is) characterization,along with complementary techniques,has proven to be an effective way to understand and analyze the charge transport and recombination at interface and bulk of *** Is of PsCs have been analyzed,interpreted,and improvised continuously,revealing intricate details about the ***,there is a lack of centralized source of these details,which make it tougher to account for the generalized approach to understand the device *** present work is focused on compiling the research done on various PsC device architectures via Is to construct a comprehensive foundation of information on impedance plots,equivalent circuits,and associated processes.

关键词： Impedance spectroscopy Perovskite solar cells Equivalent Circuits

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Laparoscopic right radical hemicolectomy: Central vascular ligation and complete mesocolon excision vs D3 lymphadenectomy - How I do it?

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1521-1526页

作者： Kaushal yadav Department of surgical Oncology Max HospitalGurugram 122001HaryanaIndia

In colon cancer surgery,ensuring the complete removal of the primary tumor and draining lymph nodes is *** drainage in the colon follows the vascular supply,typically progressing from pericolic to paraaortic lymph *** nCCn guidelines recommend the removal of 10-12 lymph nodes for ade-quate oncological resection,achieving complete oncological resection involves more than just meeting these numerical *** techniques have been developed and studied over time to attain optimal oncological outcomes.A key technique central to this goal is identifying the ileocolic vessels at their origin from the superior mesenteric *** excision of the visceral and parietal mesocolon ensures the intact removal of the specimen,while D3 lymphade-nectomy targets all draining regional lymph *** these principles emphasize different aspects,they ultimately converge to achieve the same goal of complete oncological *** article aims to simplify the surgical steps that align with the principle of central vascular ligation and mesocolon mobilization while ensuring adequate D3 dissection.

关键词： Carcinoma caecum Carcinoma ascending colon right hemicolectomy Extended right hemicolectomy Central vascular ligation Complete mesocolon excision D3 lymphadenectomy Laparoscopic right hemicolectomy Minimally invasive hemico-lectomy

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CuO–TiO_(2) based self-powered broad band photodetector

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nano Materials science 2024年第3期6卷 345-354页

作者： Chiranjib Ghosh Arka Dey Iman Biswas rajeev Kumar Gupta Vikram singh yadav Ashish yadav neha yadav Hongyu Zheng Mohamed Henini Aniruddha Mondal Department of Physics National Institute of Technology DurgapurWest BengalIndia Department of Physics University of Petroleum&Energy Studies DehradunUttarakhandIndia Babasaheb Bhimrao Ambedkar University Lucknow226031India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China school of Physics and Astronomy University of NottinghamNottinghamNG72RDUnited Kingdom

An efficient room-temperature self-powered,broadband(300 nm–1100 nm)photodetector based on a CuO–TiO_(2)/TiO_(2)/p-si(100)heterostructure is *** CuO–TiO_(2)nanocomposites were grown in a two-zone horizontal tube furnace on a 40 nm TiO_(2)thin film deposited on a p-type si(100)*** CuO–TiO_(2)/TiO_(2)/p-si(100)devices exhibited excellent rectification characteristics under dark and individual photoillumination *** devices showed remarkable photo-response under broadband(300–1100 nm)light illumination at zero bias voltage,indicating the achievement of highly sensitive self-powered photodetectors at visible and near-infrared light *** maximum response of the devices is observed at 300 nm for an illumination power of 10 *** response and recovery times were calculated as 86 ms and 78 ms,***,under a small bias,the devices showed a prompt binary response by altering the current from positive to negative under illumination *** main reason behind this binary response is the low turn-on voltage and photovoltaic characteristics of the *** illumination conditions,the generation of photocurrent is due to the separation of photogenerated electron-hole pairs within the built-in electric field at the CuO–TiO_(2)/TiO_(2)*** characteristics make the CuO–TiO_(2)/TiO_(2)broadband photodetectors suitable for applications that require high response speeds and self-sufficient functionality.

关键词： self-powered CuO–TiO_(2) nanocomposite Broadband photodetector Two-zone horizontal tube furnace responsivity

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Gas hydrate saturation from nGHP 02 LWD data in the Mahanadi Basin

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Energy Geoscience 2024年第2期5卷 279-289页

作者： Uma shankar Pradeep Kumar yadav sneha Devi Udham singh yadav Department of Geophysics Institute of ScienceBHUVaranasi221005India Oil and natural Gas Corporation Ltd. Gas Hydrate Research&Technology Centre(GHRTC)Panvel410221Navi MumbaiIndia

During the Indian national Gas Hydrate Program(nGHP)Expedition 02,Logging-while-drilling(LWD)logs were acquired at three sites(nGHP-02-11,nGHP-02-12,and nGHP-02-13)across the Mahanadi Basin in area *** applied rock physics theory to available sonic velocity logs to know the distribution of gas hydrate at site nGHP-02-11 and *** physics modeling using sonic velocity at well location shows that gas hydrate is distributed mainly within the depth intervals of 150-265 m and 100 -215 mbsf at site nGHP-02-11 and nGHP-02-13,respectively,with an average saturation of about 4%of the pore space and the maximum concentration of about 40%of the pore space at 250 m depth at site nGHP-02-11,and at site nGHP-02-13 an average saturation of about 2%of the pore space and the maximum concentration of about 20%of the pore space at 246 m depth,as gas hydrate is distributed mainly within 100-246 mbsf at this *** of gas hydrate estimated from the electrical resistivity method using density derived porosity and electrical resistivity logs from Archie's empirical formula shows high saturation compared to that from the sonic ***,estimates of hydrate saturation based on sonic P-wave velocity may differ significantly from that based on resistivity,because gas and hydrate have higher resistivity than conductive pore fluid and sonic P-wave velocity shows strong effect on gas hydrate as a small amount of gas reduces the velocity significantly while increasing velocity due to the presence of *** site nGHP-02-11,gas hydrate saturation is in the range of 15%e30%,in two zones between 150-180 and 245-265 *** nGHP-02-012 shows a gas hydrate saturation of 20%e30%in the zone between 100 and 207 *** nGHP-02-13 shows a gas hydrate saturation up to 30%in the zone between 215 and 246 *** observations from rock physics modeling and Archie’s approximation show the gas hydrate concentrations are relatively low(re space)at the sites of the

关键词： Mahanadi Basin Gas hydrate sonic log Effective medium modeling Electrical resistivity log Archie’s analysis Gas hydrate saturation

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Genetic variability and trait association analysis in linseed(Linum usitatissimum L.)for yield and related traits

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Oil Crop science 2024年第3期9卷 151-159页

作者： sandeep Kumar yadav neha singh Hemant Kumar yadav CsIr-national Botanical research Institute Rana Pratap MargLucknow226001UPIndia Academy of scientific and Innovative research(AcsIr) Ghaziabad201002India state Planning Commission LucknowUPIndia

Diversity information mining about a crop for different attributes is an essential step for effective breeding *** present investigation evaluates the quantum of genetic variability and determines the relationship among the important agro-economic traits based on two years of phenotypic data of 210 accessions of *** traits,capsule weight per plant,capsule per plant,husk weight per plant,and seed weight per plant exhibited comparatively higher genetic coefficient of variation(GCV)and phenotypic coefficient of variation(PCV).In contrast,oil content and seed per capsule exhibited a lower *** high magnitude of broad sense heritability was observed for all traits except seeds per capsule and husk weight per *** trait,capsules per plant,plant height,and days to 50%flowering showed high genetic advance coupled with high *** cluster analysis grouped 210 accessions into six distinct *** of 210,144(68.57%)accessions were grouped into three clusters(I,II,and III),in which cluster-III was the largest,containing 64 accessions followed by cluster II and *** highest inter-cluster distance was observed between clusters-I and V(127.85),while the lowest was between clusters-II and IV(27.09).The positive correlation of capsule weight per plant with the seed weight per plant and a negative correlation with the days to 50%flowering indicates that high yielding linseed varieties with early flowering/maturity could be developed through direct and indirect ***,seed yield and oil content could be enhanced together as indicated by ghe positive association among these two important *** this study,high yielding accessions with moderate to high oil content such as GP36,GP31,GP14,GP54,GP26,GP24,GP34,GP21,GP37 and GP27 and early flowering(less than 70 days)accessions such as GP2,GP26,GP27,CG33,CG44,CG42,CG132,and CG31 identified as potential genetic materials that could be exploited for developing early matu

关键词： Linseed Genetic variability Heritability Genetic advance PCA Dendrogram

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Automated Time Based Multi-Criteria Bug Triage Approach:Developer Working Efficiency and social network Based Developer recommendation

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Journal of shanghai Jiaotong university(science) 2024年第3期29卷 566-578页

作者： yadav Asmita sInGH Kumar sandeep Krishna Engineering College Ghaziabad 201007India JIIT Noida 201309India

In software development projects,bugs are common *** report bugs in open source *** is a need to develop high quality developer prediction model that considers developer work satisfaction,keep within limited development cost,and improve bug resolution *** address and resolve bug report as soon as possible is the main focus of triager when a new bug is ***,developer work efficiency is an important factor in *** address these issues,a proposed approach recommends a set of developers that could potentially share their knowledge with each other to fix new bug *** proposed approach is called developer working efficiency and social network based developer recommendation(Dwesn).It is a composite model that builds developers'profile by using developer average bug fixing time,work efficiency to fix variety of bugs,as well as the developer's social interactions with other developers.A similarity measure is applied between new bug and bugs in corpus to extract the list of capable developers from the *** proposed approach only selects those developers who are active and less loaded with *** developer with the highest profile score is assigned the *** evaluated our approach on the subset of five large open-source projects including Mozilla,netbeans,Eclipse,Firefox and OpenOffice,and compared it with the *** results demonstrate that combination of developers'efficiency with their average bug fixing time and interactions in their social network gives good accuracy and efficiently reduces bug tossing *** approach shows an improvement in prediction accuracy,precision,recall,F-score and reduced bug tossing length up to 93.89%,93.12%,93.46%,93.27%and 93.25%,*** proposed approach achieved a 93%hit ratio and 93.34%mean reciprocal rank,indicating that our proposed triager is able to efficiently assign bugs to correct developers.

关键词： open-source repository bug report bug assignment tossing length bug triager developer social network developer recommendation

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