检索结果-南通市图书馆

Mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural regeneration research 2024年第7期19卷 1401-1402页

作者： Jean-David M.Gothié Timothy E.kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第6期15卷 585-592页

作者： Katherine Esser James J Butler Mackenzie roof Nathaniel P Mercer Michael C Harrington Alan P Samsonov Andrew J rosenbaum John G kennedy Department of Orthopaedic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGrOUND Cheilectomy of the 1^(st)metatarsophalangeal joint(MTPJ)is one of the most common procedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the PubMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 patients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up of 37.9±16.5 *** distribution of patients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTPJ arthroscopy and debridement following *** intra-articular bone debris was observed in 100%of patients in 1 *** weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9±3.2 to a postoperative score of *** complication rate was 8.4%,the most common of which was persistent joint pain and ***-two failures(8.7%)were ***-three secondary procedures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was *** marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsophalangeal joint Cheilectomy Minimally invasive surgery

Targeting AMPKa1 Gene in PC3 Cells by Triphenylmethanol Derivatives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2024年第7期16卷 111-120页

作者： William Yaw Boadi Jamari Jemison kennedy Welbert Sanaa Dudley Tayalla Hizer ryan Beni Departments of Chemistry and Biology Tennessee State University Nashville USA

Epidemiological studies indicate that treatment with metformin, an AMP-activated protein kinase (AMPK) activator, reduces the incidence of cancers. Activation of AMPK has also been reported to oppose tumor progression in diverse types of cancers and offers promising cancer therapy. Furthermore, AMPK is a primary regulator of energy metabolism and has also been implicated in cell cycle progression, angiogenesis, cell transformation, migration, and cancer. We have recently synthesized novel flavonoids, namely, triphenylmethanol derivatives (TPMs), but the effectiveness of the TPMs on the activity of AMPK remains unclear. We hypothesized that the novel TPMs would inhibit cancer cell proliferation through the activation of AMPK isoforms in cells. The effects of TPMs on prostate cells (PC-3) were investigated. Cells were exposed to TPMs for either 12 or 24 hr. at the respective doses of 0, 25, 50 100, and 200 µM based on the cell viability studies by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) (MTT) assay. The results indicate that cells exposed to the respective doses of TPMs increased both phospho- and total-AMPKα1 in a dose- and time-dependent manner. The effects of the increases for the phospho- and total-AMPKα in cells were greater for the 24-hr than the 12-hr. incubation. Further studies are currently going on to elucidate the specificities of the said insults in increasing the phospho- and total-AMPKα activities and for the other respective isoforms.

关键词： Prodrugs AMP-Activated Protein Kinase Polyphenols Prostate Cancer Triphenylmethanol

Climate Trends and Their Impact on Sorghum Production in Marigat, Baringo County: A Historical Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Modern Hydrology 2024年第2期14卷 106-129页

作者： kennedy O. Okuku Japheth O. Onyando romulus O. Okwany Clement K. Kiptum Department of Agricultural Engineering Egerton University Nakuru Kenya School of Engineering University of Eldoret Eldoret Kenya

Climate is subject to fluctuations in the majority of the world, mainly caused by rainfall as well as temperature variations. Climate fluctuations in Kenya have resulted in the spread of desert-like conditions in the ASALs region, such as Marigat in Baringo County. As a county, Baringo experiences great variations in climate annually, as well as uncertainty in expected rains, thereby negatively impacting the production of crops such as sorghum. This study applied the rainfall anomaly index (rAI), standardised precipitation evapotranspiration index (SPEI), standard precipitation index (SPI), and Mann-Kendall (MK) statistical test for trends on historical climatic data in analysing both temperature and precipitation data over the period 1990 to 2022 to determine their trend, patterns and how they affect the production of sorghum crops. The machine learning method (r studio) with inputs was used to calculate the SPI, SPEI, rAI and MK trend test. The rainfall varied from below average to above average during the study period with no clear pattern in the rAI, SPEI and SPI values. The years 2020 and 2000 stood out as they had higher and lower rainfall than usual, respectively. The Marigat area generally experienced more rainfall during the high/long rainfall season (AMJJ). The MK trend test on average monthly rainfall, SOND, AMJJ, and annual precipitation confirmed a positive trend in precipitation. However, the short rainy season (SOND) was found to be the most variable period for rainfall, and there was a slight increase in daily average temperatures during this season.

关键词： Trends Precipitation Temperature rAI SPI SPEI and MK

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

多层次营销迷局

商业周刊（中文版） 2024年第8期 64-71页

作者： ALICE KANTOr MICHAEL kennedy(插图) 不详

IM Academy向年轻的投资者承诺可以让他们快速致富许多会员反而失望了,甚至失去一切当帕特里斯·雷查兹(Patrice rechards)走进鹿特丹的这个体育场时,流行歌曲响起,闪光灯令人眼花缭乱,她能感觉到身体里流尚着一股神明之力。她在阿姆斯... 详细信息

IM Academy向年轻的投资者承诺可以让他们快速致富许多会员反而失望了,甚至失去一切当帕特里斯·雷查兹(Patrice rechards)走进鹿特丹的这个体育场时,流行歌曲响起,闪光灯令人眼花缭乱,她能感觉到身体里流尚着一股神明之力。她在阿姆斯特丹的一个相对贫穷且笃信宗教的家庭长大,是苏里南和荷兰混血,她一直都知道自已有更高的目标。但是,直到她发现了IMAcademy,她才明白这个目标到底是什么。自三个月前加人这个金融教育平台以来,这位26岁的女孩已经学会了如何交易期权、加密货币、股票和外汇,所有这些都是为了追求致富一一很快,她将与其他人分享这些课程。去年春天,她和来自欧洲各地的其他1.5万名年轻的IM会员一起完成了朝圣之旅,在为期三天的会议上亲眼见到了他们的导师克里斯·特里(Chris Terry),他正是IM的首席执行官。

关键词：首席执行官阿姆斯特丹期权苏里南营销闪光灯多层次

NEW DEVELOPMENTS IN WrOUGHT 718-TYPE SUPErALLOYS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2005年第1期18卷 39-46页

作者： r.L. kennedy research & Development ATI Allvac 2020 Ashcraft Avenue Monroe North Carolina NC28111-5030 USA

research and development efforts are still very active on 718-type alloys although two major members of this widely used family, 718 and 625, were invented almost a half-century ago. Emphasis in this type of work at ATI Allvac is directed at improving existing alloys and developing new alloys to meet ever-increasing industrial demands. The improvement of existing alloys is exemplified by addition of minor elements P and B in alloy 718. The discovery of the beneficial effect of P and B in wrought alloy 718 led to development of a new, modified alloy, AllvacH 718 Err. A large effort has also been directed at studying the effects of major element modifications in 718-type alloys, and a new alloy, Allvacr 718PlusTM, has been developed. The new alloy has much better high temperature capability, especially thermal stability, approaching the level of Waspaloy but retains excellent processing characteristics, similar to alloy 718. Alloy 718PlusTM should be useful in any 718-type application requiring a higher working temperature. The properties and processing of this alloy are introduced in this paper.

关键词： 718 718 Er 718Plus Waspaloy Al-Ti effect

Knee Osteoarthritis Progression after Distal Femur Closing Wedge Osteotomy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Orthopedics 2024年第4期14卷 187-199页

作者： Ferdinand Nyankoué Mebouinz Khalifa Fall kennedy Muluem Justine raphaela Nyekel Moustapha Niane Alioune Badara Gueye Daniel Handy Eone Charles Valerie Kinkpé Department of Surgery and Specialties The Faculty of Medicine and Biomedical Sciences The University of Yaound&#233 I Yaound&#233 Cameroon Department of Orthopedic and Trauma Surgery Cheikh Anta Diop University of Dakar Dakar Senegal Department of Surgery and Specialties The Faculty of Medicine and Pharmaceuticals Sciences The University of Douala Douala Cameroon

Background: Despite the conservative treatment of tibio-femoral osteoarthritis through realignment osteotomies, the rate of total knee replacements following an osteotomy is increasing. The aim of this study was to identify the factors associated with the progression of knee osteoarthritis after a medial closing-wedge distal femoral osteotomy. Methods: Hospital-based observational study on 20 patients who underwent a medial closing-wedge distal femoral osteotomy evaluating the progression of osteoarthritis using the Kellgren and Laurence classification. The Wilcoxon test was used to compare the variation in the progressive stage of the Kellgren and Laurence classification of knee osteoarthritis preoperatively and at the final follow up. Univariate analysis made it possible to determine the factors associated with progression. The final significance threshold for statistical tests was set at 5% (p results: Overall, the mean follow-up of 46 months ± 6.6 months, with a mean age of 43 years (range: 27 - 69 years) and a female predominance (M: F = 3/7). The progression of tibiofemoral osteoarthritis following a medial closing-wedge distal femoral osteotomy is associated with valgus or varum malalignment been a moderate valgus (Or 6.2 [1.5 - 42.7] at 95% CI;p-value = 0.02), a correction of the mechanical deviation angle with a valgus alignment (Or 2.7 [0.9 - 8.3] at 95% CI), and loss of correction (Or 3.8 [1.3 - 11.6] at 95% CI;p -value) for the lateral compartment while varus alignment (Or 1.7 [0.9 - 8.3] 95% CI, p-value = 0.05) and with rupture of the lateral cortex (Or 2.8 [1.7 - 11.5] 95% CI, p-value = 0.02) were those of the medial compartment. Conclusion: Distal femur closing wedge osteotomy does not definitively interrupt the progression of valgus knee osteoarthritis. The factors associated with the progression of this pathology are modifiable. Taking them into account when performing this surgical technique could improve the osteotomy survival curve.

关键词： Knee Osteoarthritis Progression Osteotomy Distal Femur

Watson-Jones Anatomical Approach for Open reduction and Internal Fixation of Proximal Femoral Fractures without Image Intensifier in a Low-resource Setting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Orthopedics 2024年第4期14卷 173-186页

作者： Loïc Fonkoue Gaspary Fodjeu kennedy Olivier Muluem Olivier Ngongang Theophile Nana Marie Ange Ngo Yamben DésiréAkaba Urich Tambekou Daniel Eone Handy Department of Orthopaedics and Trauma Yaound&#233 General Hospital Yaound&#233 Cameroon. Department of Surgery and Specialities University of Yaound&#233 1 Yaound&#233 Cameroon Department of Orthopaedics and Trauma Yaound&#233 Emergency Center Yaound&#233 Cameroon Department of Orthopaedics and Trauma Yaound&#233 Central Hospital Yaound&#233 Cameroon

Introduction: Standard procedures for surgical fixation of proximal femoral fractures (PFF) require an image intensifier which in developing countries remains a luxury. We hypothesized that, with a well-codified technique, the Watson Jones approach (WJA) without image intensifier nor traction table, can allow open reduction and internal fixation (OrIF) of PFF using Dynamic hip screw (DHS), with satisfactory outcome. Patients and methods: Forty one consecutive patients (mean age 59.5 ± 21.6 years, 61% males) who were followed in a Teaching Hospital for PFF treated by OrIF using the WJA and DHS from January 2016 to December 2020 were reassessed. The outcome measures were the quality of the reduction, the positioning of the implants, the tip-apex distance (TAD), the rate and delay of consolidation, the functional results using Postel Merle d’Aubigné (PMA) score, the rate of surgical site infection (SSI) and the overall mortality. Logistic regression was used to determine factors associated with mechanical failure. results: The mean follow-up period was 33.8 ± 15.0 months. Fracture reduction was good in 31 (75.6%) cases and acceptable in 8(19.5%) cases. Implant position was fair to good in 37 (90.2%) patients. The mean TAD was 26.1 ± 3.9 mm. Three patients developed SSI. Consolidation was achieved in 38 (92.6%) patients. The functional results were good to excellent in 80.5% of patients. The overall mortality rate was 7.3%. There were an association between mechanical failure and osteoporosis (p = 0.04), fracture reduction (p = 0.003), and TAD (p = 0.025). In multivariate logistic regression, no independent factors were predictive of mechanical failure. Conclusion: This study shows that OrIF using DHS for PFF via the Watson-Jones approach without an image intensifier can give satisfactory anatomical and functional outcomes in low-resource settings. It provides and validates a reliable and reproducible technique that deserves to be diffused to surgeons in austere areas o

关键词： Proximal Femoral Fracture Watson-Jones Approach Dynamic Hip Screw Low resource Setting

Analysis of hourly generation patterns at large coal-fired units and implications of transitioning from baseload to load-following electricity supplier

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2019年第3期7卷 468-474页

作者： robert kennedy SMITH U.S. Department of Energy Office of Fossil Energy

Several factors have led to the decline of electricity generation from coal over the past decade, and projections forecast high rates of growth for wind and solar technologies in coming years. This analysis uses hourly generation data from large coal-fired power stations to determine how operations have been modified in recent years and describes the implications of these changes for plant equipment and unit reliability. The data shows increasing variability in intraday generation output that affects nearly all of the units in the sample, but the magnitude of increase varies widely among plants. Outage patterns were examined as was the relationship between renewable energy growth in a region and the changes in coal plant operations. Aggregate direct and indirect costs associated with running coal plants as load-following units have not yet been quantified in large-scale studies on a sector-wide basis, largely due to differences in how specific equipment responds to output fluctuations. Due to findings from the hourly generation data analysis and the high degree of potential impact on coal plant equipment, the study suggests the development of a new modeling tool that will represent the costs of running coal-fired power plants at lower capacity factors.

关键词： Coal generation Emission intensity Baseload power Capacity factor