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Combinatorial therapies for spinal cord injury repair

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Neural regeneration research 2025年第5期20卷 1293-1308页

作者： Carla S.sousa Andreia Monteiro António J.Salgado Nuno A.Silva life and Health Sciences research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal Michele l Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

Spent coffee grounds as a renewable source of energy: An analysis of bulk powder flowability

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Particuology 2019年第2期17卷 92-100页

作者： l. Massaro sousa M.C. Ferreira Drying Center for Pastes Suspensions and Seeds. Chemical Engineering Department Federal University of Sao Carlos. P.O. Box 676 13565-905 Sao Carlos Brazil

The main use for spent coffee grounds (SCG) produced in the soluble coffee industry is thermal energy generation in the industry itself. The SCG are processed using operations that are strongly dependent on powder flow behavior. In this study, we evaluated two classical flowability in dices of non-consolidated SCG powders: the angle of repose (Aor), and the Hausner ratio (Hr). The influences of the mean particle diameter, particle size distribution (PSD), and water content on the Aor and Hr values of SCG were analyzed for powders with a mean particle size range of 225-550 μm. For powders with a mean particle size close to 350 μm and for mixtures containing more than 40% fine particles, the Hr (>1.35) and Aor (>45 °) values were characteristic of poor flowability. The Aor was sensitive to the powder PSD, and powders with similar mean particle sizes had higher Aor values when the PSD was larger. For powders w让h water contents up to 50%, the flowability indices were not greatly affected by the water content. A modified linear-mixture packing model was used to predict the packed bed void fractions for binary and ternary mixtures of the three base powders. The model was used to construct a ternary diagram to estimate the Hr values of the mixtures. An equation was fitted to correlate Hr and Aor. The proposed diagram and the equation provide insight into flow behavior and could be used for process design of industrial plants that handle SCG.

关键词： Spent coffee ground Biomass Flowability Hausner ratio Angle of repose

Augmented reality system to assist inexperienced pool players

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Computational Visual Media 2016年第2期2卷 183-193页

作者： l.sousa r.Alves J.M.F.rodrigues lArSy S and Institute of Engineering University of the Algarve lArSy S CIAC and Institute of Engineering University of the Algarve

Pool and billiards are amongst a family of games played on a table with six pockets along the rails. This paper presents an augmented reality tool designed to assist unskilled or amateur players of such games. The system is based on a projector and a Kinect 2 sensor placed above the table, acquiring and processing the game on-the-fly. By using depth information and detecting the table's rails(borders),the balls' positions, the cue direction, and the strike of the ball, computations predict the resulting balls' trajectories after the shot is played. These results—trajectories, visual effects, and menus—are visually output by the projector, making them visible on the snooker table. The system achieves a shot prediction accuracy of 98% when no bouncing occurs.

关键词： computer vision augmented reality(Ar) Kinect pool game

Machine learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine learning(Ml)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected Ml techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** Ml-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied Ml techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Geomechanical characterization of volcanic rocks using empirical systems and data mining techniques

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Journal of rock Mechanics and Geotechnical Engineering 2018年第1期10卷 138-150页

作者： T.Miranda l.r.sousa A.T.Gomes J.Tinoco C.Ferreira University of Minho GuimarasPortugal State Key laboratory of Geomechanics and Deep Underground Engineering China University of Mining and TechnologyBeijingChina University of Porto PortoPortugal

This paper tries to characterize volcanic rocks through the development and application of an empirical geomechanical system. Geotechnical information was collected from the samples from several Atlantic Ocean islands including Madeira, Azores and Canarias archipelagos. An empirical rock classification system termed as the volcanic rock system(VrS) is developed and presented in detail. results using the VrS are compared with those obtained using the traditional rock mass rating(rMr) system. Data mining(DM) techniques are applied to a database of volcanic rock geomechanical information from the *** algorithms were developed and consequently approaches were followed for predicting rock mass classes using the VrS and rMr classification systems. Finally, some conclusions are drawn with emphasis on the fact that a better performance was achieved using attributes from VrS.

关键词： Volcanic rocks Geomechanical characterization Volcanic rock system(VrS) Data mining(DM)

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural regeneration research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBl Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Wax deposition mechanisms and the effect of emulsions and carbon dioxide injection on wax deposition: Critical review

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Petroleum 2020年第3期6卷 215-225页

作者： A.M.sousa H.A.Matos l.Guerreiro CErENA Department of Chemical Engineering Instituto Superior Técnico Universidade de Lisboa Partex Oil and Gas

Wax deposition inside the tubing walls endures being a critical operational challenge faced by the petroleum industry. The build-up of wax deposits may lead to the increase of pumping power, as well as the decrease of flow rate or, even, to the total blockage, with production losses and high operational costs. The current paper is a critical review of the main deposition mechanisms involved in wax deposition. Most of wax deposition models regard molecular diffusion as the dominant wax deposition mechanism. However, there are other deposition mechanisms which can also play a role. As most oil fields produce water along with crude oil, the deposition process for oil-water emulsions has also been investigated. Furthermore, carbon dioxide injection effects upon wax appearance temperature along its current applications onto wells have been reviewed. Having a total awareness of the wax deposition mechanisms background is the key factor to prevent the wax precipitation and control the deposition of solid wax crystals.

关键词： Wax deposition mechanism Molecular diffusion Brownian diffusion Shear dispersion Shear removal Thermal diffusion Emulsions Carbon dioxide